Modulators of Gap Junction Function: The Scientific Basis of Epigenetic Toxicology, (2005)
Trosko, J. E., Chang, C. C., Madhukar, B. V., Oh, S. Y.
Noting that the current paradigm in the field of carcinogenesis, and to a significant extent in the broad field of toxicology, places a major role for DNA damage and mutagenesis ( genotoxicity ) as...
Symposium: Cell Communication in Normal and Uncontrolled Growth. (2005)
Trosko, J. E., Chang, C. C., Madhukar, B. V.
Carcinogenesis is a multistep process, involving the irreversible conversion of a stem cell to a terminal-differentiation-resistant cell ( initiation ), followed by the clonal expansion of this cell...
Nicolson, G L, Dulski, K M, Trosko, J E
A series of rat 13762NF mammary adenocarcinoma cell sublines and clones of various spontaneous pulmonary metastatic potentials from the mammary fat pads of syngeneic rats were examined for their...
Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.
Warren, S T, Schultz, R A, Chang, C C, Wade, M H, Trosko, J E
The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to...
Glover, T W, Chang, C C, Trosko, J E, Li, S S
The UV induction of diphtheria toxin-resistant (DTr) mutants in normal and xeroderma pigmentosum human fibroblasts has been quantitatively characterized. A concentration of diphtheria toxin at which...
Chang, C C, Trosko, J E, Kung, H J, Bombick, D, Matsumura, F
The effects of the src gene on the activity of protein kinase C and intercellular communication have been studied in transformed NIH/3T3 clones isolated from soft agar following transfection with the...
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.
Liu, P K, Chang, C C, Trosko, J E, Dube, D K, Martin, G M, Loeb, L A
The Chinese hamster V79 cell mutant aphr-4-2, selected for its resistance to aphidicolin, a specific inhibitor of DNA polymerase alpha (DNA nucleotidyltransferase, EC 2.7.7.7), is characterized by...
Chen, G, Upham, B L, Sun, W, Chang, C C, Rothwell, E J, Chen, K M, ...
Whether exposure of humans to extremely low frequency electromagnetic fields (ELF-EMF) can cause cancer is controversial and therefore needs further research. We used a Friend erythroleukemia cell...
Kang, K S, Wilson, M R, Hayashi, T, Chang, C C, Trosko, J E
Chemical pollutants in the Great Lakes have found their way through the food chain into humans because of their environmental persistence and lipophilicity. Some epidemiological studies have claimed...
Weis, L M, Rummel, A M, Masten, S J, Trosko, J E, Upham, B L
Many polycyclic aromatic hydrocarbons (PAHs) are known carcinogens, and a considerable amount of research has been devoted to predicting the tumor-initiating potential of PAHs based on chemical...
During evolution in an aerobic environment, multicellular organisms survived by adaptive responses to both the endogenous oxidative metabolism in the cells of the organism and the chemicals and...
Upham, B L, Weis, L M, Trosko, J E
Cancer is a multistage multimechanism process involving gene and/or chromosomal mutations (genotoxic events), altered gene expression at the transcriptional, translational, and post-translational...
Comments on "What is a tumor promoter?".
Comments on Tennant's article: What is a tumor promoter? [Editorial]. Environ Health Perspect 107:A390-A391 (1999).
Loch-Caruso, R, Trosko, J E, Corcos, I A
Intercellular communication most likely plays a significant coordinating role in morphogenesis. Blockage of a specific type of intercellular communication, that mediated by gap junctions, has been...
Trosko, J E, Dawson, B, Chang, C C
Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells....
Nicolson, G L, Dulski, K M, Trosko, J E
A series of rat 13762NF mammary adenocarcinoma cell sublines and clones of various spontaneous pulmonary metastatic potentials from the mammary fat pads of syngeneic rats were examined for their...
Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.
Warren, S T, Schultz, R A, Chang, C C, Wade, M H, Trosko, J E
The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to...
Glover, T W, Chang, C C, Trosko, J E, Li, S S
The UV induction of diphtheria toxin-resistant (DTr) mutants in normal and xeroderma pigmentosum human fibroblasts has been quantitatively characterized. A concentration of diphtheria toxin at which...
Chang, C C, Trosko, J E, Kung, H J, Bombick, D, Matsumura, F
The effects of the src gene on the activity of protein kinase C and intercellular communication have been studied in transformed NIH/3T3 clones isolated from soft agar following transfection with the...
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.
Liu, P K, Chang, C C, Trosko, J E, Dube, D K, Martin, G M, Loeb, L A
The Chinese hamster V79 cell mutant aphr-4-2, selected for its resistance to aphidicolin, a specific inhibitor of DNA polymerase alpha (DNA nucleotidyltransferase, EC 2.7.7.7), is characterized by...
Chen, G, Upham, B L, Sun, W, Chang, C C, Rothwell, E J, Chen, K M, ...
Whether exposure of humans to extremely low frequency electromagnetic fields (ELF-EMF) can cause cancer is controversial and therefore needs further research. We used a Friend erythroleukemia cell...
Kang, K S, Wilson, M R, Hayashi, T, Chang, C C, Trosko, J E
Chemical pollutants in the Great Lakes have found their way through the food chain into humans because of their environmental persistence and lipophilicity. Some epidemiological studies have claimed...
Weis, L M, Rummel, A M, Masten, S J, Trosko, J E, Upham, B L
Many polycyclic aromatic hydrocarbons (PAHs) are known carcinogens, and a considerable amount of research has been devoted to predicting the tumor-initiating potential of PAHs based on chemical...
During evolution in an aerobic environment, multicellular organisms survived by adaptive responses to both the endogenous oxidative metabolism in the cells of the organism and the chemicals and...
Upham, B L, Weis, L M, Trosko, J E
Cancer is a multistage multimechanism process involving gene and/or chromosomal mutations (genotoxic events), altered gene expression at the transcriptional, translational, and post-translational...
Comments on "What is a tumor promoter?".
Comments on Tennant's article: What is a tumor promoter? [Editorial]. Environ Health Perspect 107:A390-A391 (1999).
Loch-Caruso, R, Trosko, J E, Corcos, I A
Intercellular communication most likely plays a significant coordinating role in morphogenesis. Blockage of a specific type of intercellular communication, that mediated by gap junctions, has been...
Trosko, J E, Dawson, B, Chang, C C
Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells....