In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.
Kessler, R E, Fung-Tomc, J, Kolek, B, Minassian, B, Huczko, E, Gradelski, E, ...
The in vitro activities of the carbapenem BMS-181139 were determined in comparison with those of imipenem, meropenem, ciprofloxacin, ceftriaxone, and vancomycin. BMS-181139 was the most active...
Antibacterial activity of BMS-180680, a new catechol-containing monobactam.
Fung-Tomc, J, Bush, K, Minassian, B, Kolek, B, Flamm, R, Gradelski, E, ...
The in vitro activities of a new catechol-containing monobactam, BMS-180680 (SQ 84,100), were compared to those of aztreonam, ceftazidime, imipenem, piperacillin-tazobactam, ciprofloxacin, amikacin,...
Tomatsu, K, Masuyoshi, S, Hirano, M, Kawaguchi, H, Oki, T, Fung-Tomc, J, ...
The in vitro activity of a new cephalosporin, BMY-28232 (7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[ (Z)-1- propenyl]-3-cephem-4-carboxylic acid), was compared with those of...
Fung-Tomc, J, Dougherty, T J, DeOrio, F J, Simich-Jacobson, V, Kessler, R E
One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains...
Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime.
Fung-Tomc, J, Huczko, E, Pearce, M, Kessler, R E
The selection frequencies of cefepime (BMY 28142), ceftazidime, and cefotaxime resistance among Pseudomonas aeruginosa strains were determined. Cefepime-resistant mutants were not selected by...
Mamber, S W, Kolek, B, Brookshire, K W, Bonner, D P, Fung-Tomc, J
Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate...
Fung-Tomc, J, Kolek, B, Bonner, D P
The effects of ciprofloxacin on the rates of development of low-level resistance to other antibiotics were determined in vitro. Three methicillin-resistant Staphylococcus aureus and two Pseudomonas...
Fung-Tomc, J, Huczko, E, Kolek, B, Thater, C, Kessler, R E
The in vitro activity of cefepime was compared with those of ceftazidime, cefotaxime, and cefpirome against aminoglycoside-resistant gram-negative bacteria. Cefepime was the most active...
Inability of cephalothin testing to predict cefprozil susceptibility.
Fung-Tomc, J, Stickle, T, Doyle, C, Huczko, E, Kessler, R E
The 30-micrograms cefprozil disk and the cephalosporin class (30-micrograms cephalothin) disk were compared for their abilities to predict cefprozil susceptibility by agar disk diffusion testing....
Emergence of homogeneously methicillin-resistant Staphylococcus aureus.
Fung-Tomc, J, Huczko, E, Gradelski, E, Denbleyker, K, Bonner, D P, Kessler, R E
Forty-seven clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), collected between 1986 and 1990 from 29 institutions, were analyzed for susceptibility to various antibiotics....
In vitro and in vivo antibacterial activities of BMY 40062, a new fluoronaphthyridone.
Fung-Tomc, J, Desiderio, J V, Tsai, Y H, Warr, G, Kessler, R E
The in vitro and in vivo activities of a new naphthyridone, BMY 40062, were compared with those of ciprofloxacin and ofloxacin. BMY 40062 showed about threefold more activity than ciprofloxacin...
In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.
Kessler, R E, Fung-Tomc, J, Kolek, B, Minassian, B, Huczko, E, Gradelski, E, ...
The in vitro activities of the carbapenem BMS-181139 were determined in comparison with those of imipenem, meropenem, ciprofloxacin, ceftriaxone, and vancomycin. BMS-181139 was the most active...
Antibacterial activity of BMS-180680, a new catechol-containing monobactam.
Fung-Tomc, J, Bush, K, Minassian, B, Kolek, B, Flamm, R, Gradelski, E, ...
The in vitro activities of a new catechol-containing monobactam, BMS-180680 (SQ 84,100), were compared to those of aztreonam, ceftazidime, imipenem, piperacillin-tazobactam, ciprofloxacin, amikacin,...
Tomatsu, K, Masuyoshi, S, Hirano, M, Kawaguchi, H, Oki, T, Fung-Tomc, J, ...
The in vitro activity of a new cephalosporin, BMY-28232 (7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[ (Z)-1- propenyl]-3-cephem-4-carboxylic acid), was compared with those of...
Fung-Tomc, J, Dougherty, T J, DeOrio, F J, Simich-Jacobson, V, Kessler, R E
One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains...
Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime.
Fung-Tomc, J, Huczko, E, Pearce, M, Kessler, R E
The selection frequencies of cefepime (BMY 28142), ceftazidime, and cefotaxime resistance among Pseudomonas aeruginosa strains were determined. Cefepime-resistant mutants were not selected by...
Mamber, S W, Kolek, B, Brookshire, K W, Bonner, D P, Fung-Tomc, J
Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate...
Fung-Tomc, J, Kolek, B, Bonner, D P
The effects of ciprofloxacin on the rates of development of low-level resistance to other antibiotics were determined in vitro. Three methicillin-resistant Staphylococcus aureus and two Pseudomonas...
Fung-Tomc, J, Huczko, E, Kolek, B, Thater, C, Kessler, R E
The in vitro activity of cefepime was compared with those of ceftazidime, cefotaxime, and cefpirome against aminoglycoside-resistant gram-negative bacteria. Cefepime was the most active...
Inability of cephalothin testing to predict cefprozil susceptibility.
Fung-Tomc, J, Stickle, T, Doyle, C, Huczko, E, Kessler, R E
The 30-micrograms cefprozil disk and the cephalosporin class (30-micrograms cephalothin) disk were compared for their abilities to predict cefprozil susceptibility by agar disk diffusion testing....
Emergence of homogeneously methicillin-resistant Staphylococcus aureus.
Fung-Tomc, J, Huczko, E, Gradelski, E, Denbleyker, K, Bonner, D P, Kessler, R E
Forty-seven clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), collected between 1986 and 1990 from 29 institutions, were analyzed for susceptibility to various antibiotics....
In vitro and in vivo antibacterial activities of BMY 40062, a new fluoronaphthyridone.
Fung-Tomc, J, Desiderio, J V, Tsai, Y H, Warr, G, Kessler, R E
The in vitro and in vivo activities of a new naphthyridone, BMY 40062, were compared with those of ciprofloxacin and ofloxacin. BMY 40062 showed about threefold more activity than ciprofloxacin...