De Bock, G.H., Jacobi, C.E., Seynaeve, C., Krol-Warmerdam, E.M., Blom, J., Van Asperen, C.J., ...
ABSTRACT: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early...
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status (2006)
De Bock, G.H., Mourits, M.J., Schutte, M., Krol-Warmerdam, E.M., Seynaeve, C., Blom, J., ...
Already published data were further analyzed regarding the association between the CHEK2*1100delC germ line mutation and estrogen receptor (ER) status in patients with breast cancer. The...
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status (2006)
De Bock, G.H., Mourits, M.J., Schutte, M., Krol-Warmerdam, E.M., Seynaeve, C., Blom, J., ...
Already published data were further analyzed regarding the association between the CHEK2*1100delC germ line mutation and estrogen receptor (ER) status in patients with breast cancer. The...
Kriege, M., Oosterwijk, J.C., Tilanus-Linthorst, M.M., Meijer, S., Koning, H.J. De, Muller, S.H., ...
BACKGROUND: The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic...
Foekens, J.A., Ries, C., Look, M.P., Gippner-Steppert, C., Klijn, J.G., Jochum, M.
A variety of serine proteases, including urokinase-type plasminogen activator (uPA), plasmin,and polymorphonuclear leukocyte elastase (PMN-E), have been implicated in the processes of tumor cell...
Burger, H., Foekens, J.A., Look, M.P., Klijn, J.G., Wiemer, E.A., ...
PURPOSE: The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in...
Berns, E.M., Portengen, H., Staveren, I.L. Van, Foekens, J.A., Sweep, F.C., ...
PURPOSE: In recent studies, we showed that TP53 gene mutation or high levels of cytosolic vascular endothelial growth factor (VEGF) in estrogen receptor (ER)-alpha-positive primary breast tumors...
Look, M.P., Kueng, W., Klijn, J.G., Broet, P., Eppenberger U, Putten, W.L. Van, ...
BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor...
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling (2001)
Wetering, M. Van De, Barker, N., Harkes, I.C., Heyden, M. Van Der, Dijk, N.J., Hollestelle, A., ...
Foekens, J.A., Romain, S., Look, M.P., Martin, P.M., Klijn, J.G.
Thymidylate synthase (TS) is a crucial target for 5-fluorouracil (5-FU) in the de novo pathway of pyrimidine synthesis, which is necessary for DNA synthesis. Thymidine kinase (TK) plays a key role in...
Foekens, J.A., Peters, H.A., Grebenchtchikov, N., Look, M.P., Geurts-Moespot, A., ...
Vascular endothelial growth factor (VEGF), a potent angiogenic factor, has been reported to be associated with a poor prognosis in primary breast cancer and in several other cancer types. In the...
Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation (2001)
Meijers-Heijboer, H., Niermeijer, M.F., Klijn, J.G., Brekelmans, C.T., Geel, B. Van, Putten, W.L. Van, ...
BACKGROUND: Women with a BRCA1 or BRCA2 mutation have a high risk of breast cancer and may choose to undergo prophylactic bilateral total mastectomy. We investigated the efficacy of this procedure in...
Flier, S. Van Der, Brinkman, A., Look, M.P., Kok, E.M., Klijn, J.G., ...
BACKGROUND: The product of the Bcar1/p130Cas (breast cancer resistance/p130Crk-associated substrate) gene causes resistance to antiestrogen drugs in human breast cancer cells in vitro. To investigate...
The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients (2000)
Foekens, J.A., Henzen-Logmans, S.C., Klijn, J.G., Putten, W.L. Van, Peters, H.A., Look, M.P., ...
The antigen levels of components of the urokinase-type plasminogen activator (uPA) system of plasminogen activation are correlated with prognosis in several types of cancers, including breast cancer....
Berns, E.M., Cornelisse, C., Foekens, J.A., Vossen, R., Look, M.P., Klijn, J.G., ...
TP53 has been implicated in regulation of the cell cycle, DNA repair, and apoptosis. We studied, in primary breast tumors through direct cDNA sequencing of exons 2-11, whether TP53 gene mutations can...
Klijn, J.G., Piccart, M., Burghouts, J., Duchateau, L., Becquart, D., Mignolet, F., ...
BACKGROUND: Surgical or medical castration and antiestrogenic treatment with tamoxifen are common endocrine treatments for premenopausal women with breast cancer. However, tamoxifen therapy induces...
Lodder, L.N., Devilee, P., Niermeijer, M.F., Cornelisse, C.J., Frets, P.G., Trijsburg, R.W., ...
Presymptomatic DNA testing for autosomal dominant hereditary breast/ovarian cancer (HBOC) became an option after the identification of the BRCA1 and BRCA2 genes in 1994-1995. Healthy female mutation...
Somatostatin receptors in differentiated ovarian tumors.
Reubi, J. C., Horisberger, U., Klijn, J. G., Foekens, J. A.
The presence of somatostatin receptors was investigated in 57 primary human ovarian tumors using in vitro receptor autoradiography with three different somatostatin radioligands,...