Breakdown of gastric mucus in presence of Helicobacter pylori.
Sidebotham, R L, Batten, J J, Karim, Q N, Spencer, J, Baron, J H
The potential of Helicobacter pylori to degrade gastric mucus was examined. Colonies of H pylori cultured from antral mucosal biopsy specimens of patients with non-autoimmune gastritis were washed...
Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection.
Harris, A W, Walker, M M, Smolka, A, Waller, J M, Baron, J H, Misiewicz, J J
AIM: To investigate the prevalence, and relation to Helicobacter pylori, of parietal cells in the duodenal bulb using a monoclonal antibody directed against H+,K(+)-ATPase (HK12.18). METHODS: Twenty...
Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection.
Francis, N D, Logan, R P, Walker, M M, Polson, R J, Boylston, A W, Pinching, A J, ...
Fifty one patients with human immuno-deficiency virus (HIV-1) infection who had been consecutively endoscoped for upper gastrointestinal symptoms were biopsied (stomach or duodenum, or both) and...
Detecting alcohol consumption as a cause of emergency general medical admissions.
Lockhart, S P, Carter, Y H, Straffen, A M, Pang, K K, McLoughlin, J, Baron, J H
In a general medical unit 27% of 104 admissions and 17% of bed occupancy were attributed to alcohol consumption, although only 10 of these 28 patients had classical alcohol-related conditions....
The characteristics of adult patients admitted for self-poisoning to an inner London district general hospital were examined during 1971/72 and 1983/84. The incidence of self-poisoning halved over...
An inner-city general medical ward round in the mid-1980s.
Few patients seen in 1983 on a general medical ward round in an inner-city hospital presented difficulty in diagnosis or management. Most had major social problems, especially from alcohol,...
Anticoagulation control with warfarin by junior hospital doctors.
Anticoagulation control in hospital inpatients was monitored in a prospective study. Only 47% of the blood results were within the therapeutic range which is presently recommended.
Why do hospital doctors wear white coats?
Seventy-two per cent of all hospital doctors and medical students wear white coats and most wear them greater than 75% of the time. White coats are worn chiefly for easy recognition by colleagues and...
Pancreatic Exocrine Function in Maturity Onset Diabetes Mellitus
Baron, J. H., Nabarro, J. D. N.
Exocrine pancreatic function was studied in 14 inpatients with newly diagnosed maturity onset diabetes mellitus. Five patients had clinical and biochemical evidence of pancreatic disease (two...
Peptic ulceration, gastric secretion, and renal transplantation.
Chisholm, G D, Mee, A D, Williams, G, Castro, J E, Baron, J H
Fifty-four patients on haemodialysis for chronic renal failure underwent renal transplantation. Basal and maximum acid output and the incidence of peptic ulcer before transplantation were not...
Simultaneous Combined Pancreatic Test
Nundy, S., Shirley, D., Beales, J. S. M., O'Higgins, N., Heaf, R., Pearse, E. E., ...
A simultaneous combined pancreatic test can be performed in one morning with only one intubation of the duodenum. The test includes the measurement of exocrine pancreatic secretion of bicarbonate,...
Breakdown of gastric mucus in presence of Helicobacter pylori.
Sidebotham, R L, Batten, J J, Karim, Q N, Spencer, J, Baron, J H
The potential of Helicobacter pylori to degrade gastric mucus was examined. Colonies of H pylori cultured from antral mucosal biopsy specimens of patients with non-autoimmune gastritis were washed...
Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection.
Harris, A W, Walker, M M, Smolka, A, Waller, J M, Baron, J H, Misiewicz, J J
AIM: To investigate the prevalence, and relation to Helicobacter pylori, of parietal cells in the duodenal bulb using a monoclonal antibody directed against H+,K(+)-ATPase (HK12.18). METHODS: Twenty...
Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection.
Francis, N D, Logan, R P, Walker, M M, Polson, R J, Boylston, A W, Pinching, A J, ...
Fifty one patients with human immuno-deficiency virus (HIV-1) infection who had been consecutively endoscoped for upper gastrointestinal symptoms were biopsied (stomach or duodenum, or both) and...
Detecting alcohol consumption as a cause of emergency general medical admissions.
Lockhart, S P, Carter, Y H, Straffen, A M, Pang, K K, McLoughlin, J, Baron, J H
In a general medical unit 27% of 104 admissions and 17% of bed occupancy were attributed to alcohol consumption, although only 10 of these 28 patients had classical alcohol-related conditions....
The characteristics of adult patients admitted for self-poisoning to an inner London district general hospital were examined during 1971/72 and 1983/84. The incidence of self-poisoning halved over...
An inner-city general medical ward round in the mid-1980s.
Few patients seen in 1983 on a general medical ward round in an inner-city hospital presented difficulty in diagnosis or management. Most had major social problems, especially from alcohol,...
Anticoagulation control with warfarin by junior hospital doctors.
Anticoagulation control in hospital inpatients was monitored in a prospective study. Only 47% of the blood results were within the therapeutic range which is presently recommended.
Why do hospital doctors wear white coats?
Seventy-two per cent of all hospital doctors and medical students wear white coats and most wear them greater than 75% of the time. White coats are worn chiefly for easy recognition by colleagues and...
Pancreatic Exocrine Function in Maturity Onset Diabetes Mellitus
Baron, J. H., Nabarro, J. D. N.
Exocrine pancreatic function was studied in 14 inpatients with newly diagnosed maturity onset diabetes mellitus. Five patients had clinical and biochemical evidence of pancreatic disease (two...
Peptic ulceration, gastric secretion, and renal transplantation.
Chisholm, G D, Mee, A D, Williams, G, Castro, J E, Baron, J H
Fifty-four patients on haemodialysis for chronic renal failure underwent renal transplantation. Basal and maximum acid output and the incidence of peptic ulcer before transplantation were not...
Simultaneous Combined Pancreatic Test
Nundy, S., Shirley, D., Beales, J. S. M., O'Higgins, N., Heaf, R., Pearse, E. E., ...
A simultaneous combined pancreatic test can be performed in one morning with only one intubation of the duodenum. The test includes the measurement of exocrine pancreatic secretion of bicarbonate,...
Use of Gastric Function Tests by British Gastroenterologists
Baron, J. H., Williams, J. Alexander
A questionnaire was used to study the choice and use of gastric function tests by members of the British Society of Gastroenterology.
Bowling, T E, Hadjiminas, C L, Polson, R J, Baron, J H, Foale, R A
To investigate the effects of supplemental oxygen on cardiac rhythm during gastroscopy, 103 patients aged over 60 were randomised to receive either supplemental oxygen or air at 2 litres/minute...
Eradication of Helicobacter pylori with clarithromycin and omeprazole.
Logan, R P, Gummett, P A, Schaufelberger, H D, Greaves, R R, Mendelson, G M, Walker, M M, ...
Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter...
One week's anti-Helicobacter pylori treatment for duodenal ulcer.
Logan, R P, Gummett, P A, Misiewicz, J J, Karim, Q N, Walker, M M, Baron, J H
This open study tested whether eradication of Helicobacter pylori (H pylori) heals duodenal ulcers as well as decreasing recurrence. H pylori was detected in patients with endoscopic duodenal ulcers...
Jacyna, M R, Parkin, J, Goldin, R, Baron, J H
Chronic cryptosporidial infection in man usually occurs in those who are immunocompromised. We report a patient with a one year history of bowel symptoms resulting from persistent cryptosporidial...
Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol.
Playford, R J, Batten, J J, Freeman, T C, Beardshall, K, Vesey, D A, Fenn, G C, ...
Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which...
Logan, R P, Polson, R J, Misiewicz, J J, Rao, G, Karim, N Q, Newell, D, ...
There is no ideal method for detecting Helicobacter pylori. The 'standard' 13Carbon urea breath test (13C-UBT), which involves collecting eight to 15 breath samples and subsequent costly analysis,...
Duodenal ulcer: a model of impaired mucosal defence.
Gompertz, R H, Michalowski, A S, Man, W K, Spencer, J, Baron, J H
There is a new model of chronic duodenal ulcer in which the ulcer is generated by irradiating the lower mediastinum of mice with a single dose of 18 Gy 250 kV x rays. Single ulcers develop in the...
Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole.
Logan, R P, Walker, M M, Misiewicz, J J, Gummett, P A, Karim, Q N, Baron, J H
Omeprazole is a powerful inhibitor of gastric acid and may suppress Helicobacter pylori by effecting the pKa of H pylori urease, by altering the pattern of infection, or by promoting overgrowth of...
Harris, A W, Gummett, P A, Misiewicz, J J, Baron, J H
BACKGROUND--Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear. AIM--To discover if...
Harris, A W, Gummett, P A, Walker, M M, Misiewicz, J J, Baron, J H
BACKGROUND: Factors that determine gastric metaplasia in the duodenal bulb are ill defined. It is more common and extensive in the presence of high acid output and possibly in the presence of...
Hamer, D B, Price, A B, Baron, J H
UK-9040, a derivative of the antihistamine triprolidine, is a potent gastric secretory inhibitor. Given orally to dogs it reduced gastric acid, pepsin and volume output in response to food, insulin,...
Effect of carbenoxolone sodium on human gastric acid secretion.
Neither basal nor peak acid output changed significantly after treatment for four weeks with carbenoxolone sodium as Biogastrone tablets in patients with gastric ulcer or Duogastrone capsules in...
Baron, J H, Gribble, R J, Holdstock, D J, Misiewicz, J J
In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer.
Barros D'sa, A A, Bloom, S R, Baron, J H
Somatostatin (cyclic growth-hormone release-inhibiting hormone--GH-RIH) was infused into dogs with gastric fistulae. Somatostatin inhibited gastric acid response to four gastric stimulants--insulin,...
Baron, J H, Gribble, J N, Rhodes, C, Wright, P A
The absorption of carbenoxolone sodium has been studied in 15 patients with gastric ulcer and eight patients with duodenal ulcer treated for four weeks. Blood levels of carbenoxolone showed a log...
Serum gastrin in duodenal ulcer: Part II Effect of insulin hypoglycaemia
Hansky, J., Korman, M. G., Cowley, D. J., Baron, J. H.
Serum gastrin has been measured by radioimmunoassay in normal subjects and patients with proven duodenal ulcer in response to insulin hypoglycaemia in conjunction with manoeuvres to decrease the...
Twenty-four hour gastric acidity after vagotomy.
McCloy, R F, Girvan, D P, Baron, J H
Twenty-four hour intragastric pH during normal daily activity has been studied by nasogastric intubation and aspiration of gastric samples in seven patients four years after vagotomy (four truncal,...
Royston, C M, Polak, J, Bloom, S R, Cooke, W M, Russell, R C, Pearse, A G, ...
Estimates of the G cell population were made in 24 resected human pyloric antra from counts of cells in multiple samples and from measurements of antral size. Measurements had been made previously in...
Gutierrez, L. V., Baron, J. H.
The effects of single intravenous injections of 1 u/kg body weight Boots and 1 u/kg GIH secretin were compared in 10 male control subjects and five men with chronic pancreatitis. The duodenum was...
An evaluation of the Hollander test by graded vagotomy in the dog
Hollander's insulin test was evaluated by performing successively partial denervation of the parietal cell area, highly selective, selective, and truncal vagotomy operations on three dogs. The rise...
Colonic irritability due to a mercurial bacteriostat in retention enemata
Matts, S. G. Flavell, Baron, J. H., Connell, A. M., Lennard-Jones, J. E.
These observations show that thiomersal, used as a bacteriostatic agent for retention enema solutions, irritates the colon. Investigations leading to the choice of a non-irritant bacteriostatic agent...
Gastric secretion in relation to subsequent duodenal ulcer and familial history
This paper reports a follow-up of 91 healthy men who had a histamine gastric function test performed 28 years ago and relates the original gastric function test to the subsequent development of...
Lennard-Jones, J. E., Baron, J. H., Connell, A. M., Jones, F. Avery
A double blind trial of prednisolone suppositories in out-patients with idiopathic proctitis is reported. Significant improvement was noted. When prednisolone suppositories were given after the...
Studies of basal and peak acid output with an augmented histamine test
On the basis that the most repeatable measurement of acid output of the stomach is the peak half hour after an augmented dose of histamine, the author suggests a modification of the Kay test,...
Patients with peptic ulcer, radiologically negative dyspepsia, and gastric carcinoma have been studied with the modified augmented histamine test described in the previous paper. For each disease a...
McCloy, R F, Greenberg, G R, Baron, J H
Intraluminal duodenal pH was recorded using a combined miniature electrode and logged digitally every 10 or 20 seconds for five hours (basal/meal/drink) in eight control subjects and 11 patients with...
Thompson, J N, Barr, J A, Collier, N, Spencer, J, Bush, A, Cope, L, ...
Gastric secretion was measured in nine patients with duodenal ulcer before, and after treatment for four weeks with omeprazole 20 mg or 40 mg daily. Basal acidity and acid output were affected...
Man, W K, Thompson, J N, Baron, J H, Spencer, J
Gastric mucosal concentrations of histamine and of its metabolic enzyme, histamine methyltransferase activity, were measured in patients with duodenal ulcer disease and patients with an apparently...
Baron, J H, Barr, J, Batten, J, Sidebotham, R, Spencer, J
Basal and pentagastrin stimulated gastric secretion was measured in seven patients with duodenal, and six with gastric ulcers before and after four weeks' treatment with colloidal bismuth subcitrate...
Lean body mass, gastric acid, and peptic ulcer
Peak acid outputs in normal subjects and patients with duodenal and gastric ulcer were significantly (and similarly) correlated with body weight and calculated lean body mass.
Dose response relationships of insulin hypoglycaemia and gastric acid in man
Fourteen studies of gastric acid secretion in a basal hour and in the two hours after a single intravenous injection of soluble insulin (0·01 to 0·40 units/kg) were performed in a healthy man. The...
The occurrence of peptic ulcer increased rapidly in all Western countries from the 19th to the 20th century, attributed to a possible epidemic of Helicobacter pylori, a new pathogenic strain, or a...
Out-patient Treatment of Ulcerative Colitis
Baron, J. H., Connell, A. M., Kanaghinis, T. G., Lennard-Jones, J. E., Jones, F. Avery
Metabolic Studies, Aldosterone Secretion Rate, and Plasma Renin after Carbenoxolone Sodium
Baron, J. H., Nabarro, J. D. N., Slater, J. D. H., Tuffley, R.
A formal metabolic study of carbenoxolone sodium (Biogastrone) 300 mg./day has been performed for 17 days on a woman with gastric ulcer who in a previous 21-day trial, on a 52-mEq sodium diet, showed...
Axon, A. T., O'Moráin, C. A., Bardhan, K. D., Crowe, J. P., Beattie, A. D., Thompson, R. P., ...
OBJECTIVE: To determine whether eradication of Helicobacter pylori infection reduces recurrence of benign gastric ulceration. DESIGN: Randomised, double blind, controlled study. Patients were...
Briggs, A. H., Sculpher, M. J., Logan, R. P., Aldous, J., Ramsay, M. E., Baron, J. H.
OBJECTIVE--To assess the cost effectiveness of screening for and eradicating Helicobacter pylori in patients under 45 years of age presenting with dyspepsia. DESIGN--A decision analytic model...
Peptic ulcers can now be cured without operation.
Duodenum exposed to above threshold gastric acid secretion may ulcerate if infected with Helicobacter pylori. Duodenal ulcers can be healed by suppressing acid secretion medically or surgically;...
Hunterian peptic ulcers and Helicobacter pylori.
Gastric spiral organisms were first described in man in 1939 and identified as Helicobacter pylori causing peptic ulcers in the early 1980s. Surgical specimens of gastric resections from 1939 showed...
The Zollinger-Ellison syndrome and ectopic gastric mucosa
Galland, R. B., Fletcher, D. R., Evans, D. J., Shlugman, D., Polak, J. M., Baron, J. H., ...
Ectopic gastric mucosa in an intramesenteric ileal diverticulum caused fatal bleeding after total gastrectomy in a patient with the Zollinger-Ellison syndrome (ZES).