J. I. Mullins

Publication List Details

Period

1989 - 2008

Number

99

Co-Authors

Vector Quantization of Amino Acids: Analysis of the Human Immunodeficiency Virus V3 Loop (2007)

Cosman Rodrigo, Human Immunodeficiency, Virus V Loop, P. C. Cosman, A. G. Rodrigo, J. I. Mullins, ...

This paper is about techniques for clustering sequences such as nucleic or amino acids. Our application is to defining viral subtypes of HIV on the basis of similarities of V3 loop region amino acids...

Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression (2005)

Troyer, R. M., Collins, K. R., Abraha, A., Fraundorf, E., Moore, D. M., Krizan, R. W., ...

This study examined the relationship between ex vivo human immunodeficiency virus type 1 (HIV-1) fitness and viral genetic diversity during the course of HIV-1 disease. Primary HIV-1 isolates from 10...

Human immunodeficiency virus in plasma and genital secretions during the menstrual cycle (1996)

Gallo, D, Mullins, J I, Hanson, C V, Katzenstein, D

Six human immunodeficiency virus (HIV)-positive women were studied weekly over 8 weeks to detect HIV RNA in plasma and cervical secretions and proviral DNA in cervical, vaginal, and cervicovaginal...

Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.

McElrath, M J, Corey, L, Greenberg, P D, Matthews, T J, Montefiori, D C, Rowen, L, ...

With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether...

Feline leukemia virus subgroup C phenotype evolves through distinct alterations near the N terminus of the envelope surface glycoprotein.

Brojatsch, J, Kristal, B S, Viglianti, G A, Khiroya, R, Hoover, E A, Mullins, J I

Feline leukemia viruses (FeLVs) belonging to the C subgroup induce aplastic anemia in domestic cats and have the ability, unique among FeLV strains, to proliferate in guinea pig fibroblasts in tissue...

Sequence arrangement and biological activity of cloned feline leukemia virus proviruses from a virus-productive human cell line.

Mullins, J I, Casey, J W, Nicolson, M O, Burck, K B, Davidson, N

We examined 14 different feline leukemia virus proviruses from the productively infected human cell line RD(FeLV)-2 after cloning in the modified lambda vector Charon 4A. Each isolate was...

Alpha interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome.

Zeidner, N S, Myles, M H, Mathiason-DuBard, C K, Dreitz, M J, Mullins, J I, Hoover, E A

The therapeutic efficacies of human recombinant alpha interferon (IFN-alpha), IFN-alpha plus zidovudine (AZT), and AZT alone were evaluated in presymptomatic cats with established feline leukemia...

Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.

Iversen, A K, Shpaer, E G, Rodrigo, A G, Hirsch, M S, Walker, B D, Sheppard, H W, ...

With the goal of examining the functional diversity of human immunodeficiency virus type 1 (HIV-1) env genes within the peripheral blood mononuclear cells of an asymptomatic individual, we...

Generation and role of defective proviruses in cytopathic feline leukemia virus (FeLV-FAIDS) infections.

De Noronha, C M, Reinhart, T A, Mullins, J I

Cytopathic feline leukemia virus (FeLV) infections of feline T-cell line (FeT-cell) cultures led to the accumulation and maintenance of threefold more proviruses with deletions within the polymerase...

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys.

Yasutomi, Y, Robinson, H L, Lu, S, Mustafa, F, Lekutis, C, Arthos, J, ...

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected...

Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy.

Iversen, A K, Shafer, R W, Wehrly, K, Winters, M A, Mullins, J I, Chesebro, B, ...

Multidrug-resistant human immunodeficiency virus type 1 (HIV-1) strains with reverse transcriptase (RT) mutations at codons A62-->V, V75-->I, F77-->L, F116-->Y, and Q151-->M have been reported in...

Protection against lethal simian immunodeficiency virus SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by a gp120 subunit vaccine.

Mossman, S P, Bex, F, Berglund, P, Arthos, J, O'Neil, S P, Riley, D, ...

Infection of pigtail macaques with SIVsmmPBj14, biological clone 3 (SIV-PBj14-bc13), produces an acute and usually fatal shock-like syndrome 7 to 14 days after infection. We used this simian...

Simian immunodeficiency virus DNA vaccine trial in macaques.

Lu, S, Arthos, J, Montefiori, D C, Yasutomi, Y, Manson, K, Mustafa, F, ...

An experimental vaccine consisting of five DNA plasmids expressing different combinations and forms of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to...

Maintaining the integrity of human immunodeficiency virus sequence databases.

Learn, G H, Korber, B T, Foley, B, Hahn, B H, Wolinsky, S M, Mullins, J I

Human immunodeficiency virus type 1 (HIV-1) sequences are accumulating in the literature at a rapid pace. For this ever-expanding resource to be maximally useful, it is critical that researchers...

Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes.

Contag, C H, Ehrnst, A, Duda, J, Bohlin, A B, Lindgren, S, Learn, G H, ...

Genetic analysis of human immunodeficiency virus type 1 (HIV-1) from cases of mother-to-infant transmission were analyzed in an effort to provide insights into the viral selection that may occur...

Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.

Bachmann, M H, Mathiason-Dubard, C, Learn, G H, Rodrigo, A G, Sodora, D L, Mazzetti, P, ...

For the rapid genetic analysis of feline immunodeficiency virus (FIV), we developed a heteroduplex mobility assay (HMA) that utilizes a PCR-amplified fragment of the FIV envelope gene spanning the...

Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.

Liu, S L, Schacker, T, Musey, L, Shriner, D, McElrath, M J, Corey, L, ...

The rate of progression to AIDS in human immunodeficiency virus type 1 (HIV-1)-infected individuals is determined by a complex series of interactions between the host and virus. Here we evaluate...

Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS.

Delwart, E L, Pan, H, Sheppard, H W, Wolpert, D, Neumann, A U, Korber, B, ...

The evolution of human immunodeficiency virus type 1 (HIV-1) quasispecies at the envelope gene was studied from the time of infection in 11 men who experienced different rates of CD4+ cell count...

Genetic analysis of human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2) mixed infections in India reveals a recent spread of HIV-1 and HIV-2 from a single ancestor for each of these viruses.

Grez, M, Dietrich, U, Balfe, P, Von Briesen, H, Maniar, J K, Mahambre, G, ...

DNA sequences encoding the surface envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) were amplified by PCR from uncultured peripheral blood mononuclear cells...

Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns.

Sodora, D L, Shpaer, E G, Kitchell, B E, Dow, S W, Hoover, E A, Mullins, J I

Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats. As such, FIV appears to be a feline analog of human immunodeficiency virus (HIV). A hallmark of HIV...

Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.

Sabino, E C, Shpaer, E G, Morgado, M G, Korber, B T, Diaz, R S, Bongertz, V, ...

Sequence analysis of a human immunodeficiency virus type 1 env gene PCR amplified from a Brazilian woman's peripheral blood mononuclear cell DNA (sample RJIO1) showed that it was likely to have been...

Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.

Delwart, E L, Sheppard, H W, Walker, B D, Goudsmit, J, Mullins, J I

High mutation rates and strong selective pressures imposed on human immunodeficiency viruses in vivo result in the formation of pools of genetic variants known as quasispecies. DNA heteroduplex...

Interference with superinfection and with cell killing and determination of host range and growth kinetics mediated by feline leukemia virus surface glycoproteins.

Kristal, B S, Reinhart, T A, Hoover, E A, Mullins, J I

The functions of the surface glycoproteins (SU) of feline leukemia viruses (FeLVs) are of interest since these proteins mediate virus infection and interference and are critical determinants of...

Distinct superinfection interference properties yet similar receptor utilization by cytopathic and noncytopathic feline leukemia viruses.

Reinhart, T A, Ghosh, A K, Hoover, E A, Mullins, J I

Cell killing by cytopathic retroviruses is often associated with a delay or failure in the establishment of superinfection interference. Superinfection has been observed during T-cell killing and...

Transcomplementation of simian immunodeficiency virus Rev with human T-cell leukemia virus type I Rex.

Krohn, K J, Hakkarainen, K, Aavik, E, Dewhurst, S, Sadaie, R, Mullins, J I

A molecular clone of the simian immunodeficiency virus SIVSMM isolate PBj14, lacking the ATG initiation codon for Rev protein (PBj-1.5), did not produce virus or large unspliced or singly spliced...

Identification of a putative receptor for subgroup A feline leukemia virus on feline T cells.

Ghosh, A K, Bachmann, M H, Hoover, E A, Mullins, J I

Retrovirus infection is initiated by the binding of virus envelope glycoprotein to a receptor molecule present on cell membranes. To characterize a receptor for feline leukemia virus (FeLV), we...

Posttranslational modifications distinguish the envelope glycoprotein of the immunodeficiency disease-inducing feline leukemia virus retrovirus.

Poss, M L, Mullins, J I, Hoover, E A

The envelope glycoprotein (gp70) of a molecularly cloned, replication-defective feline leukemia virus (FeLV-FAIDS clone 61C) carries determinants for induction of fatal immunodeficiency disease,...

Simian immunodeficiency virus displays complex patterns of RNA splicing.

Viglianti, G A, Sharma, P L, Mullins, J I

The human and simian immunodeficiency viruses encode at least six gene products that apparently serve regulatory functions. To evaluate the regulation of simian immunodeficiency virus gene expression...

Characterization and significance of delayed processing of the feline leukemia virus FeLV-FAIDS envelope glycoprotein.

Poss, M L, Quackenbush, S L, Mullins, J I, Hoover, E A

FeLV-FAIDS, an immunodeficiency-inducing isolate of feline leukemia virus, is composed of a pathogenic but replication-defective genome (molecular clone 61C) and a replication-competent but...

Lymphocyte subset alterations and viral determinants of immunodeficiency disease induction by the feline leukemia virus FeLV-FAIDS.

Quackenbush, S L, Donahue, P R, Dean, G A, Myles, M H, Ackley, C D, Cooper, M D, ...

The FeLV-FAIDS strain of feline leukemia virus consistently induces fatal immunodeficiency. To investigate the immunopathogenesis and viral genetic determinants responsible for the induction of...

Viral genetic determinants of T-cell killing and immunodeficiency disease induction by the feline leukemia virus FeLV-FAIDS.

Donahue, P R, Quackenbush, S L, Gallo, M V, DeNoronha, C M, Overbaugh, J, Hoover, E A, ...

Within the fatal immunodeficiency disease-inducing strain of feline leukemia virus, FeLV-FAIDS, are viruses which range in pathogenicity from minimally (clone 61E is the prototype) to acutely...

Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT.

Doggett, D L, Drake, A L, Hirsch, V, Rowe, M E, Stallard, V, Mullins, J I

A myc-containing recombinant feline leukemia provirus, designated FTT, was molecularly cloned from the cat T-cell lymphoma line F422. Its transforming activity, as well as the nucleotide sequence of...

Nucleotide sequences of a feline leukemia virus subgroup A envelope gene and long terminal repeat and evidence for the recombinational origin of subgroup B viruses.

Stewart, M A, Warnock, M, Wheeler, A, Wilkie, N, Mullins, J I, Onions, D E, ...

Molecular clones of the subgroup A feline leukemia virus FeLV-A/Glasgow-1 have been obtained. Nucleotide sequence analysis of the 3' end of the proviral genome and comparison with the published...

Functional comparison of transactivation by simian immunodeficiency virus from rhesus macaques and human immunodeficiency virus type 1.

Viglianti, G A, Mullins, J I

Simian immunodeficiency virus from rhesus macaques (SIVmac), like human immunodeficiency virus type 1 (HIV-1), encodes a transactivator (tat) which stimulates long terminal repeat (LTR)-directed gene...

Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses.

Donahue, P R, Hoover, E A, Beltz, G A, Riedel, N, Hirsch, V M, Overbaugh, J, ...

We report the first complete nucleotide sequence (8,440 base pairs) of a biologically active feline leukemia virus (FeLV), designated FeLV-61E (or F6A), and the molecular cloning, biological...

Molecular analysis and pathogenesis of the feline aplastic anemia retrovirus, feline leukemia virus C-Sarma.

Riedel, N, Hoover, E A, Gasper, P W, Nicolson, M O, Mullins, J I

We describe the molecular cloning of an anemogenic feline leukemia virus (FeLV), FeLV-C-Sarma, from the productively infected human rhabdomyosarcoma cell line RD(FeLV-C-S). Molecularly cloned...

Molecular cloning and characterization of endogenous feline leukemia virus sequences from a cat genomic library.

Soe, L H, Devi, B G, Mullins, J I, Roy-Burman, P

Recombinant bacteriophage lambda clones from a cat genomic library derived from placental DNA of a specific pathogen-free cat were screened to identify endogenous feline leukemia virus (FeLV)...

Pathogenic and host range determinants of the feline aplastic anemia retrovirus.

Riedel, N, Hoover, E A, Dornsife, R E, Mullins, J I

Feline leukemia virus (FeLV) C-Sarma (or FSC) is a prototype of subgroup C FeLVs, which induce fatal aplastic anemia in outbred specific-pathogen-free (SPF) cats. FeLV C isolates also possess an...

Hematopoietic target cells of anemogenic subgroup C versus nonanemogenic subgroup A feline leukemia virus.

Dean, G A, Groshek, P M, Mullins, J I, Hoover, E A

Feline leukemia viruses (FeLVs) belonging to interference subgroup C induce fatal anemia resembling human pure red cell aplasia (PRCA). Subgroup A FeLVs, although closely related genetically to FeLVs...

Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl.

Strebhardt, K, Mullins, J I, Bruck, C, Rübsamen-Waigmann, H

We report the isolation and nucleotide sequence of a 3.7-kilobase (kb) cDNA clone from chicken spleen corresponding to a previously undescribed member of the src family of protooncogenes. It encodes...

Sequence organization of feline leukemia virus DNA in infected cells.

Mullins, J I, Casey, J W, Nicolson, M O, Davidson, N

A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV. Restriction...

Selection against CpG dinucleotides in lentiviral genes: a possible role of methylation in regulation of viral expression.

Shpaer, E G, Mullins, J I

Extremely low frequencies of CpG dinucleotides are found in the genomes of the lentivirus subfamily of retroviruses, including the human, simian and feline immunodeficiency viruses (HIV1, HIV2, SIV,...

The U3 portion of feline leukemia virus DNA identifies horizontally acquired proviruses in leukemic cats.

Casey, J W, Roach, A, Mullins, J I, Burck, K B, Nicolson, M O, Gardner, M B, ...

The presence and location of DNA sequences related to the U3 and U5 portions of the infectious exogenous feline leukemia virus (FeLV) long terminal repeat (LTR) in various cat DNAs have been...

Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.

Bruck, C, Co, M S, Slaoui, M, Gaulton, G N, Smith, T, Fields, B N, ...

The monoclonal anti-idiotypic antibody (mAb2) 87.92.6 directed against the 9B.G5 antibody specific for the virus neutralizing epitope on the mammalian reovirus type 3 hemagglutinin was previously...

Cross-reactivity to human T-lymphotropic virus type III/lymphadenopathy-associated virus and molecular cloning of simian T-cell lymphotropic virus type III from African green monkeys.

Hirsch, V, Riedel, N, Kornfeld, H, Kanki, P J, Essex, M, Mullins, J I

Simian T-lymphotropic retroviruses with structural, antigenic, and cytopathic features similar to the etiologic agent of human acquired immunodeficiency syndrome, human T-lymphotropic virus type...

Correlation between phosphorylated H1 histones and satellite DNAs in Drosophila virilis.

Blumenfeld, M, Orf, J W, Sina, B J, Kreber, R A, Callahan, M A, Mullins, J I, ...

Drosophila virilis DNA contains satellites I, II, and III. D. novamexicana DNA contains satellite I. D. virilis H1 histone contains subfractions a, b, c, d, and e; D. novamexicana H1 contains...

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope

Doria-Rose, N. A., Learn, G. H., Rodrigo, A. G., Nickle, D. C., Li, F., Mahalanabis, M., ...

Human immunodeficiency virus type 1 (HIV-1) is a difficult target for vaccine development, in part because of its ever-expanding genetic diversity and attendant capacity to escape immunologic...

Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.

McElrath, M J, Corey, L, Greenberg, P D, Matthews, T J, Montefiori, D C, Rowen, L, ...

With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether...

Feline leukemia virus subgroup C phenotype evolves through distinct alterations near the N terminus of the envelope surface glycoprotein.

Brojatsch, J, Kristal, B S, Viglianti, G A, Khiroya, R, Hoover, E A, Mullins, J I

Feline leukemia viruses (FeLVs) belonging to the C subgroup induce aplastic anemia in domestic cats and have the ability, unique among FeLV strains, to proliferate in guinea pig fibroblasts in tissue...

Sequence arrangement and biological activity of cloned feline leukemia virus proviruses from a virus-productive human cell line.

Mullins, J I, Casey, J W, Nicolson, M O, Burck, K B, Davidson, N

We examined 14 different feline leukemia virus proviruses from the productively infected human cell line RD(FeLV)-2 after cloning in the modified lambda vector Charon 4A. Each isolate was...

Alpha interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome.

Zeidner, N S, Myles, M H, Mathiason-DuBard, C K, Dreitz, M J, Mullins, J I, Hoover, E A

The therapeutic efficacies of human recombinant alpha interferon (IFN-alpha), IFN-alpha plus zidovudine (AZT), and AZT alone were evaluated in presymptomatic cats with established feline leukemia...

Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.

Iversen, A K, Shpaer, E G, Rodrigo, A G, Hirsch, M S, Walker, B D, Sheppard, H W, ...

With the goal of examining the functional diversity of human immunodeficiency virus type 1 (HIV-1) env genes within the peripheral blood mononuclear cells of an asymptomatic individual, we...

Generation and role of defective proviruses in cytopathic feline leukemia virus (FeLV-FAIDS) infections.

De Noronha, C M, Reinhart, T A, Mullins, J I

Cytopathic feline leukemia virus (FeLV) infections of feline T-cell line (FeT-cell) cultures led to the accumulation and maintenance of threefold more proviruses with deletions within the polymerase...

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys.

Yasutomi, Y, Robinson, H L, Lu, S, Mustafa, F, Lekutis, C, Arthos, J, ...

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected...

Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy.

Iversen, A K, Shafer, R W, Wehrly, K, Winters, M A, Mullins, J I, Chesebro, B, ...

Multidrug-resistant human immunodeficiency virus type 1 (HIV-1) strains with reverse transcriptase (RT) mutations at codons A62-->V, V75-->I, F77-->L, F116-->Y, and Q151-->M have been reported in...

Protection against lethal simian immunodeficiency virus SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by a gp120 subunit vaccine.

Mossman, S P, Bex, F, Berglund, P, Arthos, J, O'Neil, S P, Riley, D, ...

Infection of pigtail macaques with SIVsmmPBj14, biological clone 3 (SIV-PBj14-bc13), produces an acute and usually fatal shock-like syndrome 7 to 14 days after infection. We used this simian...

Simian immunodeficiency virus DNA vaccine trial in macaques.

Lu, S, Arthos, J, Montefiori, D C, Yasutomi, Y, Manson, K, Mustafa, F, ...

An experimental vaccine consisting of five DNA plasmids expressing different combinations and forms of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to...

Maintaining the integrity of human immunodeficiency virus sequence databases.

Learn, G H, Korber, B T, Foley, B, Hahn, B H, Wolinsky, S M, Mullins, J I

Human immunodeficiency virus type 1 (HIV-1) sequences are accumulating in the literature at a rapid pace. For this ever-expanding resource to be maximally useful, it is critical that researchers...

Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes.

Contag, C H, Ehrnst, A, Duda, J, Bohlin, A B, Lindgren, S, Learn, G H, ...

Genetic analysis of human immunodeficiency virus type 1 (HIV-1) from cases of mother-to-infant transmission were analyzed in an effort to provide insights into the viral selection that may occur...

Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.

Bachmann, M H, Mathiason-Dubard, C, Learn, G H, Rodrigo, A G, Sodora, D L, Mazzetti, P, ...

For the rapid genetic analysis of feline immunodeficiency virus (FIV), we developed a heteroduplex mobility assay (HMA) that utilizes a PCR-amplified fragment of the FIV envelope gene spanning the...

Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.

Liu, S L, Schacker, T, Musey, L, Shriner, D, McElrath, M J, Corey, L, ...

The rate of progression to AIDS in human immunodeficiency virus type 1 (HIV-1)-infected individuals is determined by a complex series of interactions between the host and virus. Here we evaluate...

Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS.

Delwart, E L, Pan, H, Sheppard, H W, Wolpert, D, Neumann, A U, Korber, B, ...

The evolution of human immunodeficiency virus type 1 (HIV-1) quasispecies at the envelope gene was studied from the time of infection in 11 men who experienced different rates of CD4+ cell count...

Genetic analysis of human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2) mixed infections in India reveals a recent spread of HIV-1 and HIV-2 from a single ancestor for each of these viruses.

Grez, M, Dietrich, U, Balfe, P, Von Briesen, H, Maniar, J K, Mahambre, G, ...

DNA sequences encoding the surface envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) were amplified by PCR from uncultured peripheral blood mononuclear cells...

Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns.

Sodora, D L, Shpaer, E G, Kitchell, B E, Dow, S W, Hoover, E A, Mullins, J I

Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats. As such, FIV appears to be a feline analog of human immunodeficiency virus (HIV). A hallmark of HIV...

Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil.

Sabino, E C, Shpaer, E G, Morgado, M G, Korber, B T, Diaz, R S, Bongertz, V, ...

Sequence analysis of a human immunodeficiency virus type 1 env gene PCR amplified from a Brazilian woman's peripheral blood mononuclear cell DNA (sample RJIO1) showed that it was likely to have been...

Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.

Delwart, E L, Sheppard, H W, Walker, B D, Goudsmit, J, Mullins, J I

High mutation rates and strong selective pressures imposed on human immunodeficiency viruses in vivo result in the formation of pools of genetic variants known as quasispecies. DNA heteroduplex...

Interference with superinfection and with cell killing and determination of host range and growth kinetics mediated by feline leukemia virus surface glycoproteins.

Kristal, B S, Reinhart, T A, Hoover, E A, Mullins, J I

The functions of the surface glycoproteins (SU) of feline leukemia viruses (FeLVs) are of interest since these proteins mediate virus infection and interference and are critical determinants of...

Distinct superinfection interference properties yet similar receptor utilization by cytopathic and noncytopathic feline leukemia viruses.

Reinhart, T A, Ghosh, A K, Hoover, E A, Mullins, J I

Cell killing by cytopathic retroviruses is often associated with a delay or failure in the establishment of superinfection interference. Superinfection has been observed during T-cell killing and...

Transcomplementation of simian immunodeficiency virus Rev with human T-cell leukemia virus type I Rex.

Krohn, K J, Hakkarainen, K, Aavik, E, Dewhurst, S, Sadaie, R, Mullins, J I

A molecular clone of the simian immunodeficiency virus SIVSMM isolate PBj14, lacking the ATG initiation codon for Rev protein (PBj-1.5), did not produce virus or large unspliced or singly spliced...

Identification of a putative receptor for subgroup A feline leukemia virus on feline T cells.

Ghosh, A K, Bachmann, M H, Hoover, E A, Mullins, J I

Retrovirus infection is initiated by the binding of virus envelope glycoprotein to a receptor molecule present on cell membranes. To characterize a receptor for feline leukemia virus (FeLV), we...

Posttranslational modifications distinguish the envelope glycoprotein of the immunodeficiency disease-inducing feline leukemia virus retrovirus.

Poss, M L, Mullins, J I, Hoover, E A

The envelope glycoprotein (gp70) of a molecularly cloned, replication-defective feline leukemia virus (FeLV-FAIDS clone 61C) carries determinants for induction of fatal immunodeficiency disease,...

Simian immunodeficiency virus displays complex patterns of RNA splicing.

Viglianti, G A, Sharma, P L, Mullins, J I

The human and simian immunodeficiency viruses encode at least six gene products that apparently serve regulatory functions. To evaluate the regulation of simian immunodeficiency virus gene expression...

Characterization and significance of delayed processing of the feline leukemia virus FeLV-FAIDS envelope glycoprotein.

Poss, M L, Quackenbush, S L, Mullins, J I, Hoover, E A

FeLV-FAIDS, an immunodeficiency-inducing isolate of feline leukemia virus, is composed of a pathogenic but replication-defective genome (molecular clone 61C) and a replication-competent but...

Lymphocyte subset alterations and viral determinants of immunodeficiency disease induction by the feline leukemia virus FeLV-FAIDS.

Quackenbush, S L, Donahue, P R, Dean, G A, Myles, M H, Ackley, C D, Cooper, M D, ...

The FeLV-FAIDS strain of feline leukemia virus consistently induces fatal immunodeficiency. To investigate the immunopathogenesis and viral genetic determinants responsible for the induction of...

Viral genetic determinants of T-cell killing and immunodeficiency disease induction by the feline leukemia virus FeLV-FAIDS.

Donahue, P R, Quackenbush, S L, Gallo, M V, DeNoronha, C M, Overbaugh, J, Hoover, E A, ...

Within the fatal immunodeficiency disease-inducing strain of feline leukemia virus, FeLV-FAIDS, are viruses which range in pathogenicity from minimally (clone 61E is the prototype) to acutely...

Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT.

Doggett, D L, Drake, A L, Hirsch, V, Rowe, M E, Stallard, V, Mullins, J I

A myc-containing recombinant feline leukemia provirus, designated FTT, was molecularly cloned from the cat T-cell lymphoma line F422. Its transforming activity, as well as the nucleotide sequence of...

Nucleotide sequences of a feline leukemia virus subgroup A envelope gene and long terminal repeat and evidence for the recombinational origin of subgroup B viruses.

Stewart, M A, Warnock, M, Wheeler, A, Wilkie, N, Mullins, J I, Onions, D E, ...

Molecular clones of the subgroup A feline leukemia virus FeLV-A/Glasgow-1 have been obtained. Nucleotide sequence analysis of the 3' end of the proviral genome and comparison with the published...

Functional comparison of transactivation by simian immunodeficiency virus from rhesus macaques and human immunodeficiency virus type 1.

Viglianti, G A, Mullins, J I

Simian immunodeficiency virus from rhesus macaques (SIVmac), like human immunodeficiency virus type 1 (HIV-1), encodes a transactivator (tat) which stimulates long terminal repeat (LTR)-directed gene...

Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses.

Donahue, P R, Hoover, E A, Beltz, G A, Riedel, N, Hirsch, V M, Overbaugh, J, ...

We report the first complete nucleotide sequence (8,440 base pairs) of a biologically active feline leukemia virus (FeLV), designated FeLV-61E (or F6A), and the molecular cloning, biological...

Molecular analysis and pathogenesis of the feline aplastic anemia retrovirus, feline leukemia virus C-Sarma.

Riedel, N, Hoover, E A, Gasper, P W, Nicolson, M O, Mullins, J I

We describe the molecular cloning of an anemogenic feline leukemia virus (FeLV), FeLV-C-Sarma, from the productively infected human rhabdomyosarcoma cell line RD(FeLV-C-S). Molecularly cloned...

Molecular cloning and characterization of endogenous feline leukemia virus sequences from a cat genomic library.

Soe, L H, Devi, B G, Mullins, J I, Roy-Burman, P

Recombinant bacteriophage lambda clones from a cat genomic library derived from placental DNA of a specific pathogen-free cat were screened to identify endogenous feline leukemia virus (FeLV)...

Pathogenic and host range determinants of the feline aplastic anemia retrovirus.

Riedel, N, Hoover, E A, Dornsife, R E, Mullins, J I

Feline leukemia virus (FeLV) C-Sarma (or FSC) is a prototype of subgroup C FeLVs, which induce fatal aplastic anemia in outbred specific-pathogen-free (SPF) cats. FeLV C isolates also possess an...

Hematopoietic target cells of anemogenic subgroup C versus nonanemogenic subgroup A feline leukemia virus.

Dean, G A, Groshek, P M, Mullins, J I, Hoover, E A

Feline leukemia viruses (FeLVs) belonging to interference subgroup C induce fatal anemia resembling human pure red cell aplasia (PRCA). Subgroup A FeLVs, although closely related genetically to FeLVs...

Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl.

Strebhardt, K, Mullins, J I, Bruck, C, Rübsamen-Waigmann, H

We report the isolation and nucleotide sequence of a 3.7-kilobase (kb) cDNA clone from chicken spleen corresponding to a previously undescribed member of the src family of protooncogenes. It encodes...

Sequence organization of feline leukemia virus DNA in infected cells.

Mullins, J I, Casey, J W, Nicolson, M O, Davidson, N

A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV. Restriction...

Selection against CpG dinucleotides in lentiviral genes: a possible role of methylation in regulation of viral expression.

Shpaer, E G, Mullins, J I

Extremely low frequencies of CpG dinucleotides are found in the genomes of the lentivirus subfamily of retroviruses, including the human, simian and feline immunodeficiency viruses (HIV1, HIV2, SIV,...

The U3 portion of feline leukemia virus DNA identifies horizontally acquired proviruses in leukemic cats.

Casey, J W, Roach, A, Mullins, J I, Burck, K B, Nicolson, M O, Gardner, M B, ...

The presence and location of DNA sequences related to the U3 and U5 portions of the infectious exogenous feline leukemia virus (FeLV) long terminal repeat (LTR) in various cat DNAs have been...

Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.

Bruck, C, Co, M S, Slaoui, M, Gaulton, G N, Smith, T, Fields, B N, ...

The monoclonal anti-idiotypic antibody (mAb2) 87.92.6 directed against the 9B.G5 antibody specific for the virus neutralizing epitope on the mammalian reovirus type 3 hemagglutinin was previously...

Cross-reactivity to human T-lymphotropic virus type III/lymphadenopathy-associated virus and molecular cloning of simian T-cell lymphotropic virus type III from African green monkeys.

Hirsch, V, Riedel, N, Kornfeld, H, Kanki, P J, Essex, M, Mullins, J I

Simian T-lymphotropic retroviruses with structural, antigenic, and cytopathic features similar to the etiologic agent of human acquired immunodeficiency syndrome, human T-lymphotropic virus type...

Correlation between phosphorylated H1 histones and satellite DNAs in Drosophila virilis.

Blumenfeld, M, Orf, J W, Sina, B J, Kreber, R A, Callahan, M A, Mullins, J I, ...

Drosophila virilis DNA contains satellites I, II, and III. D. novamexicana DNA contains satellite I. D. virilis H1 histone contains subfractions a, b, c, d, and e; D. novamexicana H1 contains...

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope

Doria-Rose, N. A., Learn, G. H., Rodrigo, A. G., Nickle, D. C., Li, F., Mahalanabis, M., ...

Human immunodeficiency virus type 1 (HIV-1) is a difficult target for vaccine development, in part because of its ever-expanding genetic diversity and attendant capacity to escape immunologic...