J. J. DeVoss

Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp. (2007)

Matovic, N., Matthias, A., Gertsch, J., Raduner, S., Bone, K. M., Lehmann, R. P., ...

A divergent synthesis of (2E, 4E, 8E, 10E)- and ( 2E, 4E, 8E, 10Z)- N-isobutyldodeca- 2,4,8,10-tetraenamides from pent-4-yn-1-ol allowed identification of the ( 2E, 4E, 8E, 10Z)- isomer for the first...

Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites (2006)

Avent, K. M., DeVoss, J. J., Gillam, E. M. J.

Haloperidol ( HP) has been reported to undergo cytochrome P450 (P450)-mediated metabolism to potentially neurotoxic pyridinium metabolites; however, the chemical pathways and specific enzymes...

Assessment of Arginine 97 and Lysine 72 as Determinants of Substrate Specificity in Cytochrome P450 2C9 (CYP2C9) (2004)

Davies, C., Witham, K., Scott, J.R., Pearson, A., DeVoss, J.J., Graham, S.E., ...

This paper refuted a previous study which proposed Arg 97 was responsible for the preference of P450 2C9 for negatively charged substrates. Our findings were subsequently shown to be correct when the...

Assessment of Arginine 97 and Lysine 72 as Determinants of Substrate Specificity in Cytochrome P450 2C9 (CYP2C9) (2004)

Davies, C., Witham, K., Scott, J.R., Pearson, A., DeVoss, J.J., Graham, S.E., ...

This paper refuted a previous study which proposed Arg 97 was responsible for the preference of P450 2C9 for negatively charged substrates. Our findings were subsequently shown to be correct when the...

The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations (2004)

He, X, Cryle, M. J., DeVoss, J. J.

Formation of indigo by recombinant mammalian cytochrome P450 (2000)

Kim, D., Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Mundkowski, R. G., Volkov, A. A., ...

The development of bicistronic systems for coexpression of recombinant human cytochrome P450 enzymes (P450s) with their redox partner, NADPH-cytochrome P450 reductase (NPR), has enabled P450 activity...

Formation of indigo by recombinant mammalian cytochrome P450 (1999)

Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., ...

The development of bicistronic systems for coexpression of recombinant human cytochrome P450 enzymes (P450s) with their redox partner, NADPH-cytochrome P450 reductase (NPR), has enabled P450 activity...