HHV8 and Kaposi's sarcoma: a time cohort study.
Kennedy, M M, Lucas, S B, Jones, R R, Howells, D D, Picton, S J, Hanks, E E, ...
AIMS: The recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an...
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
Kennedy, M M, Cooper, K, Howells, D D, Picton, S, Biddolph, S, Lucas, S B, ...
AIMS: Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction...
Kennedy, M M, O'Leary, J J, Oates, J L, Lucas, S B, Howells, D D, Picton, S, ...
AIMS: Human herpes virus 8 (HHV-8) is the infectious agent implicated in the pathogenesis of Kaposi's sarcoma, although its mode of action is unclear. Recent work indicates that the HHV-8 genome...
A novel, rapid in cell RNA amplification technique for the detection of low copy mRNA transcripts.
Uhlmann, V, Rolfs, A, Mix, E, Silva, I, Hully, J, Lu, L, ...
Growing interest now focuses on improvements of in situ polymerase chain reaction (PCR) technology for the detection of DNA and RNA cellular sequences. In this study, reverse transcription PCR in...
O'Leary, J J, Silva, I, Uhlmann, V, Prasad, M, Luttich, K, Maffei, A, ...
CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
AIMS: Human herpesvirus 8 (HHV-8) is now acknowledged as the infective cofactor in the pathogenesis of Kaposi's sarcoma. The mode by which HHV-8 causes Kaposi's sarcoma is unresolved and it is...
Abl expression, tumour grade, and apoptosis in chondrosarcoma.
O'Donovan, M, Russell, J M, O'Leary, J J, Gillan, J A, Lawler, M P, Gaffney, E F
AIMS: To determine whether Abl immunoreactivity correlates with grade and cell kinetics (apoptosis and mitosis) in chondrosarcoma. METHODS: Sections from 16 chondrosarcomas were stained...
Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma.
O'Leary, J J, Landers, R J, Crowley, M, Healy, I, Kealy, W F, Hogan, J, ...
AIMS: To examine human papillomavirus (HPV) positive and negative squamous cell carcinomas of the cervix for structural alterations in exon 1 c-myc; and to investigate the expression pattern of p62,...
Genotypic mapping of HPV and assessment of EBV prevalence in endocervical lesions.
O'Leary, J J, Landers, R J, Crowley, M, Healy, I, Kealy, W F, Hogan, J, ...
AIMS: To examine the prevalence of human papillomavirus (HPV) and Epstein-Barr virus (EBV) in low grade glandular intraepithelial lesions of the cervix, adenocarcinoma with high grade glandular...
O'Leary, J J, Landers, R J, Silva, I, Uhlmann, V, Crowley, M, Healy, I, ...
AIM: To examine the prevalence of genital type human papilloma virus (HPV) and mutations at codons 12, 13, and 61 in H, Ki, and N-ras in CIN III and early invasive squamous cell carcinomas of the...
Cyclin D1 expression and HHV8 in Kaposi sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins...
Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervix.
Landers, R J, O'Leary, J J, Crowley, M, Healy, I, Annis, P, Burke, L, ...
AIM--To detect the presence or absence of Epstein-Barr virus (EBV) in cervical lesions ranging from normality to invasive malignancy. METHODS--Eighteen randomly selected cases of invasive squamous...
PCR in situ hybridisation detection of HPV 16 in fixed CaSki and fixed SiHa cell lines.
O'Leary, J J, Browne, G, Johnson, M I, Landers, R J, Crowley, M, Healy, I, ...
AIMS--To investigate the feasibility of using fixed cells with the polymerase chain reaction (PCR) in situ hybridisation and to investigate possible reasons for reaction failure. METHODS--Fixed SiHa...
Chetty, R, O'Leary, J J, Biddolph, S C, Gatter, K C
AIMS--To investigate whether immunohistochemical staining using p53 and/or bcl-2 distinguishes between florid Hashimoto's thyroiditis and low grade mucosa associated lymphoid tissue (MALT) lymphoma...
Localisation of HHV-8 in AIDS related lymphadenopathy
O'Leary, J J, Kennedy, M, Luttich, K, Uhlmann, V, Silva, I, Russell, J, ...
Background—Many lymph node abnormalities have been described in AIDS. These include opportunistic infections that sometimes result in spindle cell pseudotumours, Kaposi's sarcoma (KS), malignant...
Uhlmann, V, Prasad, M, Silva, I, Luettich, K, Grande, L, Alonso, L, ...
Peptide nucleic acid technology (PNA) has become an extremely useful tool and promises to impact on molecular biology and diagnostics. These synthetic DNA analogues pair with DNA and RNA molecules...
O'Donovan, M, Silva, I, Uhlmann, V, Bermingham, N, Luttich, K, Martin, C, ...
Aims—Pyothorax associated lymphoma (PAL) occurs in a clinical setting of longstanding pyothorax or chronic inflammation of the pleura. Like primary effusion lymphoma, it has an association with...
Potential viral pathogenic mechanism for new variant inflammatory bowel disease
Uhlmann, V, Martin, C M, Sheils, O, Pilkington, L, Silva, I, Killalea, A, ...
Aims: A new form of inflammatory bowel disease (ileocolonic lymphonodular hyperplasia) has been described in a cohort of children with developmental disorder. This study investigates the presence of...
HHV8 and Kaposi's sarcoma: a time cohort study.
Kennedy, M M, Lucas, S B, Jones, R R, Howells, D D, Picton, S J, Hanks, E E, ...
AIMS: The recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an...
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
Kennedy, M M, Cooper, K, Howells, D D, Picton, S, Biddolph, S, Lucas, S B, ...
AIMS: Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction...
Kennedy, M M, O'Leary, J J, Oates, J L, Lucas, S B, Howells, D D, Picton, S, ...
AIMS: Human herpes virus 8 (HHV-8) is the infectious agent implicated in the pathogenesis of Kaposi's sarcoma, although its mode of action is unclear. Recent work indicates that the HHV-8 genome...
A novel, rapid in cell RNA amplification technique for the detection of low copy mRNA transcripts.
Uhlmann, V, Rolfs, A, Mix, E, Silva, I, Hully, J, Lu, L, ...
Growing interest now focuses on improvements of in situ polymerase chain reaction (PCR) technology for the detection of DNA and RNA cellular sequences. In this study, reverse transcription PCR in...
O'Leary, J J, Silva, I, Uhlmann, V, Prasad, M, Luttich, K, Maffei, A, ...
CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
AIMS: Human herpesvirus 8 (HHV-8) is now acknowledged as the infective cofactor in the pathogenesis of Kaposi's sarcoma. The mode by which HHV-8 causes Kaposi's sarcoma is unresolved and it is...
Abl expression, tumour grade, and apoptosis in chondrosarcoma.
O'Donovan, M, Russell, J M, O'Leary, J J, Gillan, J A, Lawler, M P, Gaffney, E F
AIMS: To determine whether Abl immunoreactivity correlates with grade and cell kinetics (apoptosis and mitosis) in chondrosarcoma. METHODS: Sections from 16 chondrosarcomas were stained...
Alterations in exon 1 of c-myc and expression of p62c-myc in cervical squamous cell carcinoma.
O'Leary, J J, Landers, R J, Crowley, M, Healy, I, Kealy, W F, Hogan, J, ...
AIMS: To examine human papillomavirus (HPV) positive and negative squamous cell carcinomas of the cervix for structural alterations in exon 1 c-myc; and to investigate the expression pattern of p62,...
Genotypic mapping of HPV and assessment of EBV prevalence in endocervical lesions.
O'Leary, J J, Landers, R J, Crowley, M, Healy, I, Kealy, W F, Hogan, J, ...
AIMS: To examine the prevalence of human papillomavirus (HPV) and Epstein-Barr virus (EBV) in low grade glandular intraepithelial lesions of the cervix, adenocarcinoma with high grade glandular...
O'Leary, J J, Landers, R J, Silva, I, Uhlmann, V, Crowley, M, Healy, I, ...
AIM: To examine the prevalence of genital type human papilloma virus (HPV) and mutations at codons 12, 13, and 61 in H, Ki, and N-ras in CIN III and early invasive squamous cell carcinomas of the...
Cyclin D1 expression and HHV8 in Kaposi sarcoma.
Kennedy, M M, Biddolph, S, Lucas, S B, Howells, D D, Picton, S, McGee, J O, ...
BACKGROUND: Human herpesvirus 8 (HHV8) appears to be the agent responsible for Kaposi sarcoma. The mechanism remains undetermined but may involve cell cycle regulating genes including D type cyclins...
Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervix.
Landers, R J, O'Leary, J J, Crowley, M, Healy, I, Annis, P, Burke, L, ...
AIM--To detect the presence or absence of Epstein-Barr virus (EBV) in cervical lesions ranging from normality to invasive malignancy. METHODS--Eighteen randomly selected cases of invasive squamous...
PCR in situ hybridisation detection of HPV 16 in fixed CaSki and fixed SiHa cell lines.
O'Leary, J J, Browne, G, Johnson, M I, Landers, R J, Crowley, M, Healy, I, ...
AIMS--To investigate the feasibility of using fixed cells with the polymerase chain reaction (PCR) in situ hybridisation and to investigate possible reasons for reaction failure. METHODS--Fixed SiHa...
Chetty, R, O'Leary, J J, Biddolph, S C, Gatter, K C
AIMS--To investigate whether immunohistochemical staining using p53 and/or bcl-2 distinguishes between florid Hashimoto's thyroiditis and low grade mucosa associated lymphoid tissue (MALT) lymphoma...
Localisation of HHV-8 in AIDS related lymphadenopathy
O'Leary, J J, Kennedy, M, Luttich, K, Uhlmann, V, Silva, I, Russell, J, ...
Background—Many lymph node abnormalities have been described in AIDS. These include opportunistic infections that sometimes result in spindle cell pseudotumours, Kaposi's sarcoma (KS), malignant...
Uhlmann, V, Prasad, M, Silva, I, Luettich, K, Grande, L, Alonso, L, ...
Peptide nucleic acid technology (PNA) has become an extremely useful tool and promises to impact on molecular biology and diagnostics. These synthetic DNA analogues pair with DNA and RNA molecules...
O'Donovan, M, Silva, I, Uhlmann, V, Bermingham, N, Luttich, K, Martin, C, ...
Aims—Pyothorax associated lymphoma (PAL) occurs in a clinical setting of longstanding pyothorax or chronic inflammation of the pleura. Like primary effusion lymphoma, it has an association with...
Potential viral pathogenic mechanism for new variant inflammatory bowel disease
Uhlmann, V, Martin, C M, Sheils, O, Pilkington, L, Silva, I, Killalea, A, ...
Aims: A new form of inflammatory bowel disease (ileocolonic lymphonodular hyperplasia) has been described in a cohort of children with developmental disorder. This study investigates the presence of...