Scientific Commons: J. J. P. Kastelein

Formal modelling of L1 and L2 perceptual learning: Computational linguistics versus machine learning (2007)

Escudero, E., Kastelein, J.J.P., Weiand, K.A.

Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia (2006)

Kramer, A., Jansen, A.C.M., Tanck, M.W.T, Kastelein, J.J.P., Zwinderman, A.H.

Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (Treating to New Targets) study (2006)

Waters, D.D., LaRosa, J.C., Barter, P., Fruchart, J.C., Carter, R., ...

OBJECTIVE We sought to assess the effects on cerebrovascular events of treating patients with stable coronary disease with low-density lipoprotein cholesterol (LDL-C) levels substantially below 100...

Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis? (2006)

Leuven, S. Van, Kastelein, J.J.P., Hayden, M.R., Stroes, E.S.G.

Atherosclerotic vascular disease is a chronic disorder of the vasculature with a substantial impact on society. Although the availability of statins has represented an unparalleled improvement in the...

Atherogenesis in rheumatology (2006)

Leuven, S. Van, Kastelein, J.J.P., D'Cruz, D.P., Hughes, G.R., Stroes, E.S.G.

Atherosclerosis is a chronic inflammatory disorder characterized by immune cell activation, inflammation driven plaque formation and subsequent destabilization. In other disorders of an inflammatory...

Diagnosing familial hypercholesterolaemia: the relevance of genetic testing (2006)

Aalst-Cohen, E. Van, Jansen, A.C.M., Tanck, M.W.T., Defesche, J.C., Trip, M.D., Lansberg, P.J., ...

Aims We assembled a cohort of patients with familial hypercholesterolaemia (FH) for both basic and clinical research. We used a set of established diagnostic criteria to define FH. Some put forward...

Gene therapy with lipoprotein lipase variant S447X - Response (2006)

Ross, C.J.D., Twisk, J., Kuivenhoven, J.A., Rip, J., Kastelein, J.J.P., Hayden, M.R.

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation (2006)

Ross, C.J.D., Twisk, J., Bakker, A.C., Miao, F., Verbart, D., Rip, J., ...

Human lipoprotein lipase (hLPL) deficiency, for which there currently exists no adequate treatment, leads to excessive plasma triglycerides (TGs), recurrent abdominal pain, and life-threatening...

Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia (2006)

Roest, M., Rodenburg, J., Wiegman, A., Kastelein, J.J.P., Voorbij, H.A.M.

Background Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease. Method We have studied the contribution of PON-1 and PON-2 single...

Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings - Effect of pravastatin (2006)

Rodenburg, J., Vissers, M.N., Wiegman, A., Miller, E.R., Ridker, P.M., Witztum, J.L., ...

OBJECTIVES To assess the role of oxidized phospholipids (OxPLs) in children with familial hypercholesterolemia (FH) and the effect of pravastatin. BACKGROUND Oxidized phospholipids are a major...

AAV1-LPL (S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice (2006)

Rip, J., Dijk, K.W. Van, Sierts, J.A., Kastelein, J.J.P., Twisk, J., Kuivenhoven, J.A.

Intramuscular (IM) application of adeno-associated virus serotype 1 (AAV1) for the delivery of human lipoprotein lipase (hLPL) was previously shown efficacious in mice with chylomicronemia. The...

Lipoprotein lipase S447X - A naturally occurring gain-of-function mutation (2006)

Rip, J., Nierman, M.C., Ross, C.J., Jukema, J.W., Hayden, M.R., Kastelein, J.J.P., ...

Lipoprotein lipase ( LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic uptake of remnant lipoproteins. Since the gene was cloned in 1989, more than 100 LPL gene mutations have...

The dyslipidemia of chronic renal disease: effects of statin therapy (2006)

Ozsoy, R.C., Leuven, S. Van, Kastelein, J.J.P., Arisz, L., Koopman, M.G.

Purpose of review Dyslipidemia is a prevalent condition in patients with chronic renal disease, but is often left untreated. Statin treatment constitutes an effective way to improve lipid...

Restoration of endothelial function after infusion of reconstituted high-density lipoprotein in subjects with type 2 diabetes mellitus (2006)

Nieuwdorp, M., Bisoendial, R.J., Roodt, J. Op 't, Vergeer, M., Levels, J.M., Birjmohun, R.S., ...

And then there were acyl coenzyme A : cholesterol acyl transferase inhibitors (2006)

Meumese, M.C., Franssen, R., Stroes, E.S.G., Kastelein, J.J.P.

Purpose of review The reputation of acyl coenzyme A:cholesterol acyltransferase (ACAT) inhibitors has changed profoundly from promising new drugs for cardiovascular prevention to drugs without...

Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS) (2006)

Jukema, J.W., Zwinderman, A.H., Hallman, D.M., Boer, A. De, Kastelein, J.J.P., ...

Objectve - The influence of ApoE polymorphism on the efficacy of statins in lowering plasma lipids and lipoproteins and improving angiographic parameters was assessed. Methods: ApoE genotypes were...

A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia (2006)

Dallinga-Thie, G.M., Steyerberg, E.W., Defesche, J.C., Kastelein, J.J.P., ...

Context: Individuals with the functional ER22/23EK variant in the glucocorticoid receptor gene are relatively resistant to the downstream consequences of glucocorticoids. Evidence suggests that...

Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels - Pathways by which modulation of CETP activity may alter atherogenesis (2006)

Harchaoui, K. El, Boekholdt, S.M., Stroes, E.S.G., Kastelein, J.J.P., ...

Raising high-density lipoprotein cholesterol (HDL-C) is a promising strategy in the struggle to prevent cardiovascular disease, and cholesteryl ester transfer protein ( CETP) inhibitors have been...

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B (2006)

Kastelein, J.J.P., Wedel, M.K., Baker, B.F., Su, J., Bradley, J.D., Yu, R.Z., ...

Background - Apolipoprotein B ( apoB) is an important structural component of low-density lipoprotein cholesterol (LDL-C) and plays a key role in LDL-C transport and removal. Reduction in apoB...

Plant stanols do not restore endothelial function in prepubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels (2006)

Jakulj, L., Vissers, M.N., Rodenburg, J., Wiegman, A., Trip, M.D., Kastelein, J.J.P.

Objective To examine the effect of plant stanols on lipids and endothelial function in pre-pubertal children with familial hypercholesterolemia (FH). Study design Children with FH (n = 42), aged 7-12...

Results from a rosuvastatin historical cohort study in more than 45 000 Dutch statin users, a PHARMO study (2006)

Goettsch, W.G., Heintjes, E.M., Kastelein, J.J.P., Rabelink, T.J., Johansson, S., Herings, R.M.C.

Purpose Clinical benefits of statin therapy are accepted, but their safety profiles have been under scrutiny, particularly for the recently introduced statin, rosuvastatin, relating to serious...

Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study (2006)

Deedwania, P., Barter, P., Carmena, R., Fruchart, J.C., Grundy, S.M., Haffner, S., ...

Background Despite the prognostic value of metabolic syndrome for predicting cardiovascular events, few trials have investigated the effects of statin therapy on cardiovascular morbidity and...

Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease (2006)

Barter, P.J., Kastelein, J.J.P.

Epidemiologic studies have shown that the concentration of high-density lipoprotein cholesterol (HDL-C) is a strong, independent, inverse predictor of coronary heart disease risk. This identifies...

Translating today's science into clinical practice (2006)

Barter, P., Kastelein, J.J.P.

Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia (2006)

Graaf, A. Van Der, Hutten, B.A., Kastelein, J.J.P., Vissers, M.N.

Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes (2006)

Nieuwdorp, M., Mooij, H.L., Kroon, J., Atasever, B., Spaan, J.A.E., Ince, C., ...

Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: Influence of early repair (2006)

Vriend, J.W.J., Groot, E. De, Waal, T.T. De, Zijta, F.M., Kastelein, J.J.P., Mulder, B.J.M.

C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: The EPIC-Norfolk prospective population study 1993-2003 (2006)

Boekholdt, S.M., Hack, C.E., Sandhu, M.S., Luben, R., Bingham, S.A., Wareham, N.J., ...

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study (2006)

Vaessen, S.F.C., Schaap, F.G., Kuivenhoven, J.A., Groen, A.K., Hutten, B.A., Boekholdt, S.M., ...

Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia (2006)

Rana, J.S., Jansen, A.C.M., Zwinderman, A.H., Nieuwdorp, M., Aalst-Cohen, E. Van, Jukema, J.W., ...

Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1 (2006)

Wijpkema, J.S., Haelst, P.L. Van, Monraats, P.S., Bruinenberg, M., Zwinderman, A.H., Zijlstra, F., ...

Increased inflammatory markers in children with familial hypercholesterolaemia (2006)

Ueland, T., Vissers, M.N., Wiegman, A., Rodenburg, J., Hutten, B.A., Gullestad, L., ...

Lipoprotein (a) and risk of cardiovascular disease in patients with metabolic syndrome in a population of familial hypercholesterolaemia [research letter] (2006)

Rana, J.S., Jansen, A.C.M., Zwinderman, A.H., Aalst-Cohen, E. Van, Jukema, J.W., Trip, M.D., ...

Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels (2006)

Boekholdt, S.M., Souverein, O.W., Tanck, M.W.T., Hovingh, G.K., Kuivenhoven, J.A., Peters, R.J.G., ...

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo (2006)

Nieuwdorp, M., Haeften, T.W. Van, Mooij, H.L., Lieshout, M.H.P., Levi, M.M., ...

Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles? (2006)

Leuven, S. Van, Kastelein, J.J.P., Allison, C., Hayden, M.R., Stroes, E.S.G.

Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study. (2006)

Rip, J., Nierman, M.C., Wareham, N.J., Luben, R., Bingham, S.A., Day, N.E., ...

Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: Influence of early repair (2006)

Vriend, J.W.J., Groot, E. De, Waal, T.T. De, Zijta, F.M., Kastelein, J.J.P., Mulder, B.J.M.

Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease( REGRESS). (2006)

Jukema, J.W., Zwinderman, A.H., Hallman, D.M., Boer, A. De, Kastelein, J.J.P., ...

OBJECTVE: The influence ofApoE polymorphism on the efficacy of statins in lowering plasma lipids and lipoproteins and improving angiographic parameters was assessed. METHODS: ApoE genotypes were...

Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia (2006)

Kramer, A., Jansen, A.C.M., Aalst-Cohen, E. Van, Tanck, M.W.T., Kastelein, J.J.P., Zwinderman, A.H.

Background: Smoking history is often di- or trichotomized into for example "never, ever or current smoking". However, smoking must be treated as a time-dependent covariate when lifetime data is...

Age at repair and left ventricular mass in patients after repair of aortic coarctation [brief communication] (2005)

Vriend, J.W.J., Engelfriet, P.M., Groot, E. De, Elsen, B.M., Kastelein, J.J.P., Mulder, B.J.M.

Update of the molecular basis of familial hypercholesterolemlia in The Netherlands (2005)

Fouchier, S.W., Kastelein, J.J.P., Defesche, J.C.

Gene therapy for lipoprotein lipase deficiency: Working toward clinical application (2005)

Rip, J., Nierman, M.C., Sierts, J.A., Petersen, W., Oever, K. Van Den, Raalte, D., ...

Letter to the editor (2005)

Bisoendial, R.J., Birjmohun, R.S., Keller, T., Leuven, S. Van, Levels, J.H.M., Levi, M.M., ...

Achieving lipid goals in real life: the Dutch DISCOVERY Study (2005)

Bots, A.F.E., Kastelein, J.J.P.

Increasing high-density lipoprotein cholesterol through cholesteryl ester transfer protein inhibition: a next step in the fight against cardiovascular disease? (2005)

El-Harchaoui, K., Kuivenhoven, J.A., Kastelein, J.J.P.