J. J. Toole

Triple helix formation inhibits transcription elongation in vitro.

Young, S L, Krawczyk, S H, Matteucci, M D, Toole, J J

We have identified a 15-nucleotide site within a G-free transcription cassette that forms triple helix with sequence-specific oligodeoxyribonucleotides. When oligodeoxynucleotides were added to...

Inhibition of Duck Hepatitis B Virus Replication by 9-(2-Phosphonylmethoxyethyl)adenine, an Acyclic Phosphonate Nucleoside Analogue

Nicoll, A. J., Colledge, D. L., Toole, J. J., Angus, P. W., Smallwood, R. A., Locarnini, S. A.

The use of regimens that use nucleoside analogues for the treatment of chronic hepatitis B virus infection is often limited because of their high relapse rates. This is thought to be due to the...

Complete cDNA and derived amino acid sequence of human factor V.

Jenny, R J, Pittman, D D, Toole, J J, Kriz, R W, Aldape, R A, Hewick, R M, ...

cDNA clones encoding human factor V have been isolated from an oligo(dT)-primed human fetal liver cDNA library prepared with vector Charon 21A. The cDNA sequence of factor V from three overlapping...

The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing 5-(1-pentynyl)-2'-deoxyuridine.

Latham, J A, Johnson, R, Toole, J J

Combinatorial libraries of nucleic acids are developing into novel sources for lead compounds in drug development. In order to diversify the pool of ss DNA sequences, we have used a modified...

Translation and developmental regulation of RNA encoded by the eukaryotic transposable element copia.

Flavell, A J, Ruby, S W, Toole, J J, Roberts, B E, Rubin, G M

copia-specific RNA was isolated from Drosophila melanogaster tissue culture cells by hybridization of cytoplasmic polyadenylylated RNA to copia DNA immobilized on cellulose. The purified RNA was...

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.

Toole, J J, Pittman, D D, Orr, E C, Murtha, P, Wasley, L C, Kaufman, R J

Factor VIII (antihemophilic factor) is a high molecular weight plasma glycoprotein that participates in the blood clotting cascade. The recent cloning and sequence analysis of the cDNA encoding human...

Triple helix formation inhibits transcription elongation in vitro.

Young, S L, Krawczyk, S H, Matteucci, M D, Toole, J J

We have identified a 15-nucleotide site within a G-free transcription cassette that forms triple helix with sequence-specific oligodeoxyribonucleotides. When oligodeoxynucleotides were added to...

Inhibition of Duck Hepatitis B Virus Replication by 9-(2-Phosphonylmethoxyethyl)adenine, an Acyclic Phosphonate Nucleoside Analogue

Nicoll, A. J., Colledge, D. L., Toole, J. J., Angus, P. W., Smallwood, R. A., Locarnini, S. A.

The use of regimens that use nucleoside analogues for the treatment of chronic hepatitis B virus infection is often limited because of their high relapse rates. This is thought to be due to the...

Complete cDNA and derived amino acid sequence of human factor V.

Jenny, R J, Pittman, D D, Toole, J J, Kriz, R W, Aldape, R A, Hewick, R M, ...

cDNA clones encoding human factor V have been isolated from an oligo(dT)-primed human fetal liver cDNA library prepared with vector Charon 21A. The cDNA sequence of factor V from three overlapping...

The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing 5-(1-pentynyl)-2'-deoxyuridine.

Latham, J A, Johnson, R, Toole, J J

Combinatorial libraries of nucleic acids are developing into novel sources for lead compounds in drug development. In order to diversify the pool of ss DNA sequences, we have used a modified...

Translation and developmental regulation of RNA encoded by the eukaryotic transposable element copia.

Flavell, A J, Ruby, S W, Toole, J J, Roberts, B E, Rubin, G M

copia-specific RNA was isolated from Drosophila melanogaster tissue culture cells by hybridization of cytoplasmic polyadenylylated RNA to copia DNA immobilized on cellulose. The purified RNA was...

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.

Toole, J J, Pittman, D D, Orr, E C, Murtha, P, Wasley, L C, Kaufman, R J

Factor VIII (antihemophilic factor) is a high molecular weight plasma glycoprotein that participates in the blood clotting cascade. The recent cloning and sequence analysis of the cDNA encoding human...