J. J. van Dongen

Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins (2003)

Maia, A.T., Harrison, C. J., Szczepanski, T., Williams, M.D., Griffiths, M.J., ...

Studies in identical twins and with neonatal blood spots (Guthrie cards) have backtracked the origin of childhood acute leukemia and their associated chromosomal translocations to before birth. High...

Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease (1998)

Langerak, A W, Wolvers-Tettero, I L, Ossenkoppele, G J, Stul, M, ...

In order to gain insight into immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements in adult acute lymphoblastic leukemia (ALL), we studied 48 adult patients: 26 with precursor-B-ALL and...

The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice.

Gold, D P, Van Dongen, J J, Morton, C C, Bruns, G A, Geurts Van Kessel, A H, ...

The T3 complex is composed of three polypeptide chains that are both structurally and functionally associated with the receptor for antigen on the surface of human T lymphocytes. In a series of...

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.

Blom, B, Heemskerk, M H, Verschuren, M C, Van Dongen, J J, Stegmann, A P, Bakker, A Q, ...

Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell...

Localization of the ICF syndrome to chromosome 20 by homozygosity mapping.

Wijmenga, C, Van Den Heuvel, L P, Strengman, E, Luyten, J A, Van Der Burgt, I J, De Groot, R, ...

Immunodeficiency in association with centromere instability of chromosomes 1, 9, and 16 and facial anomalies (ICF syndrome) is a rare autosomal recessive disorder. ICF patients show marked...

The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice.

Gold, D P, Van Dongen, J J, Morton, C C, Bruns, G A, Geurts Van Kessel, A H, ...

The T3 complex is composed of three polypeptide chains that are both structurally and functionally associated with the receptor for antigen on the surface of human T lymphocytes. In a series of...

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.

Blom, B, Heemskerk, M H, Verschuren, M C, Van Dongen, J J, Stegmann, A P, Bakker, A Q, ...

Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell...

Localization of the ICF syndrome to chromosome 20 by homozygosity mapping.

Wijmenga, C, Van Den Heuvel, L P, Strengman, E, Luyten, J A, Van Der Burgt, I J, De Groot, R, ...

Immunodeficiency in association with centromere instability of chromosomes 1, 9, and 16 and facial anomalies (ICF syndrome) is a rare autosomal recessive disorder. ICF patients show marked...

T-cell receptor V delta-J alpha rearrangements in human thymocytes: the role of V delta-J alpha rearrangements in T-cell receptor-delta gene deletion.

Verschuren, M C, Wolvers-Tettero, I L, Breit, T M, Van Dongen, J J

The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta...

Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.

Mason, D. Y., Comans-Bitter, W. M., Cordell, J. L., Verhoeven, M. A., Van Dongen, J. J.

Monoclonal antibody L26 is a highly selective marker of B cells and B-cell neoplasms in paraffin-embedded tissues, but it suffers from the drawback that the target molecule has not been identified....

De novo deletion (2) (p11.2p13): clinical, cytogenetic, and immunological data.

Los, F J, Van Hemel, J O, Jacobs, H J, Drop, S L, Van Dongen, J J

We report a case of a boy with a de novo interstitial deletion of chromosome (2) (p11.2p13). Clinical features included dysmorphism of the face, genital region, and limbs, psychomotor retardation,...