Gwathmey, J K, Slawsky, M T, Hajjar, R J, Briggs, G M, Morgan, J P
Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability to alterations in the strength of contraction produced by...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Hajjar, R J, Gwathmey, J K, Briggs, G M, Morgan, J P
The effects of DPI, a new inotropic agent, were compared in trabeculae carneae from control and myopathic human hearts loaded with aequorin, a bioluminescent calcium indicator that emits light when...
Gwathmey, J K, Slawsky, M T, Briggs, G M, Morgan, J P
Experiments were performed to investigate the mechanism of action of DPI 201-106 on human heart muscle. In both control and myopathic muscles, DPI produced concentration-dependent increases in action...
Intracellular calcium and the relationship to contractility in an avian model of heart failure
Kim, C. S., Doye, A. A., Gwathmey, J. K., Davidoff, A. J., Maki, T. M.
Global contractile heart failure was induced in turkey poults by furazolidone feeding (700 ppm). Abnormal calcium regulation appears to be a key factor in the pathophysiology of heart failure, but...
Gwathmey, J K, Slawsky, M T, Hajjar, R J, Briggs, G M, Morgan, J P
Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability to alterations in the strength of contraction produced by...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Hajjar, R J, Gwathmey, J K, Briggs, G M, Morgan, J P
The effects of DPI, a new inotropic agent, were compared in trabeculae carneae from control and myopathic human hearts loaded with aequorin, a bioluminescent calcium indicator that emits light when...
Gwathmey, J K, Slawsky, M T, Briggs, G M, Morgan, J P
Experiments were performed to investigate the mechanism of action of DPI 201-106 on human heart muscle. In both control and myopathic muscles, DPI produced concentration-dependent increases in action...
Kihara, Y., Gwathmey, J. K., Grossman, W., Morgan, J. P.
1. We used the bioluminescent protein aequorin, which emits light when it combines with Ca2+, to test the hypothesis that the inotropic and lusitropic actions of DPI 201-106 are due to changes in...
Gwathmey, J. K., Morgan, J. P.
The effects of milrinone and piroximone were compared to those of isoprenaline, dibutyryl adenosine 3':5'-cyclic monophosphate (dibutyryl cyclic AMP), forskolin, isobutylmethylxanthine, increased...
[Ca2+]i in human heart failure: a review and discussion of current areas of controversy.
Liao, R., Helm, P. A., Hajjar, R. J., Saha, C., Gwathmey, J. K.
Multiple abnormalities have been reported in the setting of human heart failure. It is unclear whether detected changes reflect adaptive alterations in myocardium subjected to increased and sustained...