J. Kato

Publication List Details

Period

1965 - 2009

Number

100

Co-Authors

Cardiovascular reflex responses to temporal reduction in arterial pressure during dexmedetomidine infusion: a double-blind, randomized, and placebo-controlled study (2009)

Kato, J., Ogawa, Y., Kojima, W., Aoki, K., Ogawa, S., Iwasaki, K.

BackgroundThe low and moderate doses of dexmedetomidine reduce arterial pressure and heart rate (HR), suggesting attenuation of sympathetic activity and dominance of cardiac-vagal activity. These...

Superconductivity in heavily boron-doped silicon carbide (2008)

Kriener, M., Muranaka, T., Kato, J., Ren, Z. A., Akimitsu, J., Maeno, Y.

The discoveries of superconductivity in heavily boron-doped diamond (C:B) in 2004 and silicon (Si:B) in 2006 renew the interest in the superconducting state of semiconductors. Charge-carrier doping...

Superconductivity of hexagonal heavily-boron doped silicon carbide (2008)

Kriener, M., Muranaka, T., Kato, J., Akimitsu, J., Maeno, Y.

In 2004 the discovery of superconductivity in heavily boron-doped diamond (C:B) led to an increasing interest in the superconducting phases of wide-gap semiconductors. Subsequently superconductivity...

Specific heat and electronic states of superconducting boron-doped silicon carbide (2008)

Kriener, M., Maeno, Y., Oguchi, T., Kato, J., Muranaka, T., ...

The discoveries of superconductivity in the heavily-boron doped semiconductors diamond (C:B) in 2004 and silicon (Si:B) in 2006 have renewed the interest in the physics of the superconducting state...

Effect of storage on the biochemical structure and processing quality of adzuki bean (Vigna angularis) (2007)

Yousif, A. M., Kato, J., Deeth, H. C.

Storage of adzuki beans and other pulse grains causes biochemical and physical changes that affect the hydration properties of the beans. This affects the quality of products made from the beans such...

Effect of storage on the biochemical and processing quality of Adzuki Bean (Vigna angularis) (2007)

Yousif, Adel, Kato, J., Deeth, Hilton

Storage of adzuki beans and other pulse grains causes biochemical and physical changes that affect the hydration properties of the beans. This affects the quality of products made from the beans such...

Effect of storage on the biochemical structure and processing quality of adzuki bean (Vigna angularis) (2007)

Yousif, A. M., Kato, J., Deeth, H. C.

Storage of adzuki beans and other pulse grains causes biochemical and physical changes that affect the hydration properties of the beans. This affects the quality of products made from the beans such...

Effect of storage on the biochemical and processing quality of Adzuki Bean (Vigna angularis) (2007)

Yousif, Adel, Kato, J., Deeth, Hilton

Storage of adzuki beans and other pulse grains causes biochemical and physical changes that affect the hydration properties of the beans. This affects the quality of products made from the beans such...

Effect of storage time and conditions on the seed coat colour of Australian adzuki beans (2003)

Yousif, AM, Kato, J, Deeth, HC

Two varieties of adzuki beans (Vigna angularis), Bloodwood and Erimo, were stored at temperatures of 10, 20 or 30degreesC, and relative humidities (RH) 40 or 65%, and samples were analysed at 0, 1.5,...

Effect of storage time and conditions on the seed coat colour of Australian adzuki beans (2003)

Yousif, AM, Kato, J, Deeth, HC

Two varieties of adzuki beans (Vigna angularis), Bloodwood and Erimo, were stored at temperatures of 10, 20 or 30degreesC, and relative humidities (RH) 40 or 65%, and samples were analysed at 0, 1.5,...

A Probabilistic Background Model for Tracking (2000)

J. Rittscher, J. Kato, S. Joga, A. Blake

Abstract. A new probabilistic background model based on a Hidden Markov Model is presented. The hidden states of the model enable discrimination between foreground, background and shadow. This model...

Chemotaxis towards inorganic phosphate in the red tide alga Chattonella antiqua (1995)

Ikegami, S., Imai, I., Kato, J., Ohtake, H.

The red tide flagellate, Chattonella antiqua, was shown to be attracted to inorganic phosphate in both aged seawater and artificial seawater by well-test assays.

Guanylin: an endogenous activator of intestinal guanylate cyclase.

Currie, M G, Fok, K F, Kato, J, Moore, R J, Hamra, F K, Duffin, K L, ...

Intestinal guanylate cyclase mediates the action of the heat-stable enterotoxin to cause a decrease in intestinal fluid absorption and to increase chloride secretion, ultimately causing diarrhea. An...

Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor.

Xiong, L, Kasuya, J, Li, S L, Kato, J, Fujita-Yamaguchi, Y

Monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor I (IGF-I) receptors were prepared and characterized. Three IgG mAbs were specific for the human IGF-I receptor...

Purification of the regulatory protein AlgR1 and its binding in the far upstream region of the algD promoter in Pseudomonas aeruginosa.

Kato, J, Chakrabarty, A M

A regulatory protein AlgR1, previously suggested to be a member of a two-component sensory transduction system because of its homology to OmpR and NtrC and its ability to allow activation of the algD...

AlgR3, a protein resembling eukaryotic histone H1, regulates alginate synthesis in Pseudomonas aeruginosa.

Kato, J, Misra, T K, Chakrabarty, A M

A regulatory mutation (alg52) in a Pseudomonas aeruginosa alginate-negative mutant (strain 8882) is complemented efficiently by the gene algR2 and somewhat inefficiently by a second gene termed...

Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.

Tsukamoto, Y, Kato, J, Ikeda, H

Hdf1 is the yeast homologue of the mammalian 70 kDa subunit of Ku-protein, which has DNA end-binding activity and is involved in DNA double-strand break repair and V(D)J recombination. To examine...

Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers.

Chiba, K, Tsuchiya, M, Kato, J, Ochi, K, Kawa, Z, Ishizaki, T

Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However,...

Isolation and characterization of chemotaxis mutants and genes of Pseudomonas aeruginosa.

Masduki, A, Nakamura, J, Ohga, T, Umezaki, R, Kato, J, Ohtake, H

Two chemotaxis-defective mutants of Pseudomonas aeruginosa, designated PC1 and PC2, were selected by the swarm plate method after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis. These mutants were...

Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa.

Kuroda, A, Kumano, T, Taguchi, K, Nikata, T, Kato, J, Ohtake, H

A Pseudomonas aeruginosa mutant, defective in taxis toward L-serine but responsive to peptone, was selected by the swarm plate method after N-methyl-N'-nitrosoguanidine mutagenesis. The mutant,...

Fis is required for illegitimate recombination during formation of lambda bio transducing phage.

Shanado, Y, Kato, J, Ikeda, H

Specialized transducing particles of phage lambda are formed by illegitimate recombination during prophage induction. We examined the effects of an Esherichia coli int, xis, himA, himD, or fis...

Isolation and characterization of Enterobacter cloacae mutants which are defective in chemotaxis toward inorganic phosphate.

Kusaka, K, Shibata, K, Kuroda, A, Kato, J, Ohtake, H

Enterobacter cloacae IFO3320 is attracted to Pi when cells are starved for Pi. Two Tn1737KH-induced mutants, which were constitutive for alkaline phosphatase, failed to exhibit Pi taxis even under...

Genetic improvement of Escherichia coli for enhanced biological removal of phosphate from wastewater.

Kato, J, Yamada, K, Muramatsu, A, Ohtake, H

The ability of Escherichia coli MV1184 to accumulate inorganic phosphate (Pi) was enhanced by manipulating the genes involved in the transport and metabolism of Pi. The high-level Pi accumulation was...

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition.

Hoshino, K, Kitamura, A, Morrissey, I, Sato, K, Kato, J, Ikeda, H

In order to examine the inhibitory activities of quinolones against topoisomerase IV, both subunits of this enzyme, ParC and ParE, were purified from Escherichia coli. The specific activity of...

Cloning and characterization of a Pseudomonas aeruginosa gene involved in the negative regulation of phosphate taxis.

Kato, J, Sakai, Y, Nikata, T, Ohtake, H

Pseudomonas aeruginosa PAO1 exhibited a positive chemotactic response to P(i). The chemotactic response was induced by P(i) limitation. An alkaline phosphatase (AP) constitutive mutant showed a...

Production and release of polyphosphate by a genetically engineered strain of Escherichia coli.

Yamada, K, Shinjo, H, Kato, J, Ohtake, H

A recombinant strain of Escherichia coli MV1184, which contains plasmid-borne genes encoding the phosphate-specific transport (Pst) system and polyphosphate (polyP) kinase, accumulated high levels of...

Phosphate taxis in Pseudomonas aeruginosa.

Kato, J, Ito, A, Nikata, T, Ohtake, H

Pseudomonas aeruginosa was shown to be attracted to phosphate. The chemotactic response was induced by phosphate starvation. The specificity of chemoreceptors for phosphate was high so that no other...

Genetic analysis of an invasion region by use of a Tn3-lac transposon and identification of a second positive regulator gene, invE, for cell invasion of Shigella sonnei: significant homology of invE with ParB of plasmid P1.

Watanabe, H, Arakawa, E, Ito, K, Kato, J, Nakamura, A

We have previously cloned two distinct regions of the Shigella sonnei form I plasmid pSS120, a 37-kilobase-pair DNA region and a virF region, which were found to be essential for cell invasion in...

Genetic analyses of processing involving C-terminal cleavage in penicillin-binding protein 3 of Escherichia coli.

Hara, H, Nishimura, Y, Kato, J, Suzuki, H, Nagasawa, H, Suzuki, A, ...

The processing of Escherichia coli penicillin-binding protein 3 (PBP 3) was investigated by gene manipulation for producing hybrid and truncated PBP 3 molecules. The hybrid PBP 3 was processed when...

Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli.

Kato, J, Nishimura, Y, Yamada, M, Suzuki, H, Hirota, Y

A new mutation, parC, causing abnormal chromosome segregation was identified in two thermosensitive mutants of Escherichia coli. The thermosensitive growth of the mutants was corrected by pLC4-14 in...

Conversion of the alpha component of penicillin-binding protein 1b to the beta component in Escherichia coli.

Suzuki, H, Kato, J, Sakagami, Y, Mori, M, Suzuki, A, Hirota, Y

Among components alpha, beta, and gamma of penicillin-binding protein 1b, the alpha and gamma components were confirmed to represent the primary gene products by agreement of their N-terminal amino...

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

Kawanishi, J, Kato, J, Sasaki, K, Fujii, S, Watanabe, N, Niitsu, Y

Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression...

Increase in arginine and citrulline production by 6-azauracil-resistant mutants of Bacillus subtilis.

Kato, J, Kisumi, M, Takagi, T, Chibata, I

In the arginine producer AHr-5, an L-arginine hydroxamate-resistant mutant of Bacillus subtilis, accumulation of N8-acetyl-L-ornithine increased as the level of L-arginine accumulation increased in...

Characterization of partially activated p60c-src in chicken embryo fibroblasts.

Sato, M, Kato, J, Takeya, T

Previous studies identified the amino acid changes involved in the activation of p60c-src and revealed that the activation accompanies an alteration of its tyrosine-phosphorylation site. We show here...

Cloning of regions required for contact hemolysis and entry into LLC-MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes.

Kato, J, Ito, K, Nakamura, A, Watanabe, H

Two distinct regions required for both contact hemolysis and entry into LLC-MK2 cells were cloned into Escherichia coli from the Shigella sonnei form I plasmid, pSS120. The first region was cloned...

Cloning and nucleotide sequence of a heat-stable enterotoxin gene from Vibrio cholerae non-O1 isolated from a patient with traveler's diarrhea.

Ogawa, A, Kato, J, Watanabe, H, Nair, B G, Takeda, T

We determined the nucleotide sequence of the heat-stable enterotoxin (STa) gene of the Vibrio cholerae non-O1 strain NRT36 isolated from a patient with traveler's diarrhea. The gene is chromosomally...

Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients.

May, T B, Shinabarger, D, Maharaj, R, Kato, J, Chu, L, DeVault, J D, ...

Pulmonary infection by mucoid, alginate-producing Pseudomonas aeruginosa is the leading cause of mortality among patients suffering from cystic fibrosis. Alginate-producing P. aeruginosa is uniquely...

Substitution of Ser-17 of pp60c-src: biological and biochemical characterization in chicken embryo fibroblasts.

Hirota, Y, Kato, J, Takeya, T

pp60c-src is phosphorylated mainly on Ser-17 and Tyr-527 in vivo. In this study, we examined the effect of the phosphorylation of Ser-17 on the properties of pp60c-src by introducing Rous sarcoma...

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Kitagawa, M, Higashi, H, Jung, H K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, ...

Cyclin D-Cdk4/6 and cyclin A/E-Cdk2 are suggested to be involved in phosphorylation of the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is unclear why...

Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats.

Kato, J, Kobune, M, Kohgo, Y, Sugawara, N, Hisai, H, Nakamura, T, ...

Several clinical studies have suggested that excess hepatic iron accumulation is a progressive factor in some liver diseases including chronic viral hepatitis and hemochromatosis. However, it is not...

Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis.

Tatebayashi, K, Kato, J, Ikeda, H

The fission yeast DNA repair gene rad21+ is essential for cell growth. To investigate the function essential for cell proliferation, we have isolated a temperature-sensitive mutant of the rad21+...

Guanylin: an endogenous activator of intestinal guanylate cyclase.

Currie, M G, Fok, K F, Kato, J, Moore, R J, Hamra, F K, Duffin, K L, ...

Intestinal guanylate cyclase mediates the action of the heat-stable enterotoxin to cause a decrease in intestinal fluid absorption and to increase chloride secretion, ultimately causing diarrhea. An...

Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor.

Xiong, L, Kasuya, J, Li, S L, Kato, J, Fujita-Yamaguchi, Y

Monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor I (IGF-I) receptors were prepared and characterized. Three IgG mAbs were specific for the human IGF-I receptor...

Purification of the regulatory protein AlgR1 and its binding in the far upstream region of the algD promoter in Pseudomonas aeruginosa.

Kato, J, Chakrabarty, A M

A regulatory protein AlgR1, previously suggested to be a member of a two-component sensory transduction system because of its homology to OmpR and NtrC and its ability to allow activation of the algD...

AlgR3, a protein resembling eukaryotic histone H1, regulates alginate synthesis in Pseudomonas aeruginosa.

Kato, J, Misra, T K, Chakrabarty, A M

A regulatory mutation (alg52) in a Pseudomonas aeruginosa alginate-negative mutant (strain 8882) is complemented efficiently by the gene algR2 and somewhat inefficiently by a second gene termed...

Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.

Tsukamoto, Y, Kato, J, Ikeda, H

Hdf1 is the yeast homologue of the mammalian 70 kDa subunit of Ku-protein, which has DNA end-binding activity and is involved in DNA double-strand break repair and V(D)J recombination. To examine...

Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers.

Chiba, K, Tsuchiya, M, Kato, J, Ochi, K, Kawa, Z, Ishizaki, T

Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However,...

Isolation and characterization of chemotaxis mutants and genes of Pseudomonas aeruginosa.

Masduki, A, Nakamura, J, Ohga, T, Umezaki, R, Kato, J, Ohtake, H

Two chemotaxis-defective mutants of Pseudomonas aeruginosa, designated PC1 and PC2, were selected by the swarm plate method after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis. These mutants were...

Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa.

Kuroda, A, Kumano, T, Taguchi, K, Nikata, T, Kato, J, Ohtake, H

A Pseudomonas aeruginosa mutant, defective in taxis toward L-serine but responsive to peptone, was selected by the swarm plate method after N-methyl-N'-nitrosoguanidine mutagenesis. The mutant,...

Fis is required for illegitimate recombination during formation of lambda bio transducing phage.

Shanado, Y, Kato, J, Ikeda, H

Specialized transducing particles of phage lambda are formed by illegitimate recombination during prophage induction. We examined the effects of an Esherichia coli int, xis, himA, himD, or fis...

Isolation and characterization of Enterobacter cloacae mutants which are defective in chemotaxis toward inorganic phosphate.

Kusaka, K, Shibata, K, Kuroda, A, Kato, J, Ohtake, H

Enterobacter cloacae IFO3320 is attracted to Pi when cells are starved for Pi. Two Tn1737KH-induced mutants, which were constitutive for alkaline phosphatase, failed to exhibit Pi taxis even under...

Genetic improvement of Escherichia coli for enhanced biological removal of phosphate from wastewater.

Kato, J, Yamada, K, Muramatsu, A, Ohtake, H

The ability of Escherichia coli MV1184 to accumulate inorganic phosphate (Pi) was enhanced by manipulating the genes involved in the transport and metabolism of Pi. The high-level Pi accumulation was...

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition.

Hoshino, K, Kitamura, A, Morrissey, I, Sato, K, Kato, J, Ikeda, H

In order to examine the inhibitory activities of quinolones against topoisomerase IV, both subunits of this enzyme, ParC and ParE, were purified from Escherichia coli. The specific activity of...

Cloning and characterization of a Pseudomonas aeruginosa gene involved in the negative regulation of phosphate taxis.

Kato, J, Sakai, Y, Nikata, T, Ohtake, H

Pseudomonas aeruginosa PAO1 exhibited a positive chemotactic response to P(i). The chemotactic response was induced by P(i) limitation. An alkaline phosphatase (AP) constitutive mutant showed a...

Production and release of polyphosphate by a genetically engineered strain of Escherichia coli.

Yamada, K, Shinjo, H, Kato, J, Ohtake, H

A recombinant strain of Escherichia coli MV1184, which contains plasmid-borne genes encoding the phosphate-specific transport (Pst) system and polyphosphate (polyP) kinase, accumulated high levels of...

Phosphate taxis in Pseudomonas aeruginosa.

Kato, J, Ito, A, Nikata, T, Ohtake, H

Pseudomonas aeruginosa was shown to be attracted to phosphate. The chemotactic response was induced by phosphate starvation. The specificity of chemoreceptors for phosphate was high so that no other...

Genetic analysis of an invasion region by use of a Tn3-lac transposon and identification of a second positive regulator gene, invE, for cell invasion of Shigella sonnei: significant homology of invE with ParB of plasmid P1.

Watanabe, H, Arakawa, E, Ito, K, Kato, J, Nakamura, A

We have previously cloned two distinct regions of the Shigella sonnei form I plasmid pSS120, a 37-kilobase-pair DNA region and a virF region, which were found to be essential for cell invasion in...

Genetic analyses of processing involving C-terminal cleavage in penicillin-binding protein 3 of Escherichia coli.

Hara, H, Nishimura, Y, Kato, J, Suzuki, H, Nagasawa, H, Suzuki, A, ...

The processing of Escherichia coli penicillin-binding protein 3 (PBP 3) was investigated by gene manipulation for producing hybrid and truncated PBP 3 molecules. The hybrid PBP 3 was processed when...

Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli.

Kato, J, Nishimura, Y, Yamada, M, Suzuki, H, Hirota, Y

A new mutation, parC, causing abnormal chromosome segregation was identified in two thermosensitive mutants of Escherichia coli. The thermosensitive growth of the mutants was corrected by pLC4-14 in...

Conversion of the alpha component of penicillin-binding protein 1b to the beta component in Escherichia coli.

Suzuki, H, Kato, J, Sakagami, Y, Mori, M, Suzuki, A, Hirota, Y

Among components alpha, beta, and gamma of penicillin-binding protein 1b, the alpha and gamma components were confirmed to represent the primary gene products by agreement of their N-terminal amino...

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

Kawanishi, J, Kato, J, Sasaki, K, Fujii, S, Watanabe, N, Niitsu, Y

Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression...

Increase in arginine and citrulline production by 6-azauracil-resistant mutants of Bacillus subtilis.

Kato, J, Kisumi, M, Takagi, T, Chibata, I

In the arginine producer AHr-5, an L-arginine hydroxamate-resistant mutant of Bacillus subtilis, accumulation of N8-acetyl-L-ornithine increased as the level of L-arginine accumulation increased in...

Characterization of partially activated p60c-src in chicken embryo fibroblasts.

Sato, M, Kato, J, Takeya, T

Previous studies identified the amino acid changes involved in the activation of p60c-src and revealed that the activation accompanies an alteration of its tyrosine-phosphorylation site. We show here...

Cloning of regions required for contact hemolysis and entry into LLC-MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes.

Kato, J, Ito, K, Nakamura, A, Watanabe, H

Two distinct regions required for both contact hemolysis and entry into LLC-MK2 cells were cloned into Escherichia coli from the Shigella sonnei form I plasmid, pSS120. The first region was cloned...

Cloning and nucleotide sequence of a heat-stable enterotoxin gene from Vibrio cholerae non-O1 isolated from a patient with traveler's diarrhea.

Ogawa, A, Kato, J, Watanabe, H, Nair, B G, Takeda, T

We determined the nucleotide sequence of the heat-stable enterotoxin (STa) gene of the Vibrio cholerae non-O1 strain NRT36 isolated from a patient with traveler's diarrhea. The gene is chromosomally...

Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients.

May, T B, Shinabarger, D, Maharaj, R, Kato, J, Chu, L, DeVault, J D, ...

Pulmonary infection by mucoid, alginate-producing Pseudomonas aeruginosa is the leading cause of mortality among patients suffering from cystic fibrosis. Alginate-producing P. aeruginosa is uniquely...

Substitution of Ser-17 of pp60c-src: biological and biochemical characterization in chicken embryo fibroblasts.

Hirota, Y, Kato, J, Takeya, T

pp60c-src is phosphorylated mainly on Ser-17 and Tyr-527 in vivo. In this study, we examined the effect of the phosphorylation of Ser-17 on the properties of pp60c-src by introducing Rous sarcoma...

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Kitagawa, M, Higashi, H, Jung, H K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, ...

Cyclin D-Cdk4/6 and cyclin A/E-Cdk2 are suggested to be involved in phosphorylation of the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is unclear why...

Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats.

Kato, J, Kobune, M, Kohgo, Y, Sugawara, N, Hisai, H, Nakamura, T, ...

Several clinical studies have suggested that excess hepatic iron accumulation is a progressive factor in some liver diseases including chronic viral hepatitis and hemochromatosis. However, it is not...

Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis.

Tatebayashi, K, Kato, J, Ikeda, H

The fission yeast DNA repair gene rad21+ is essential for cell growth. To investigate the function essential for cell proliferation, we have isolated a temperature-sensitive mutant of the rad21+...

Effect of storage time and conditions on the seed coat colour of Australian adzuki beans

Yousif, AM, Kato, J, Deeth, HC

Two varieties of adzuki beans (Vigna angularis), Bloodwood and Erimo, were stored at temperatures of 10, 20 or 30degreesC, and relative humidities (RH) 40 or 65%, and samples were analysed at 0, 1.5,...

Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells

Sakamaki, S, Takayanagi, N, Yoshizaki, N, Hayashi, S, Takayama, T, Kato, J, ...

BACKGROUND AND AIMS—Recent studies suggest that tropomyosin (TM) may act as a putative autoantigen in ulcerative colitis (UC). Recently, we identified, by computer homology analysis, a specific...

Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload

Miyazaki, E, Kato, J, Kobune, M, Okumura, K, Sasaki, K, Shintani, N, ...

Background and aims: Iron is stored in hepatocytes in the form of ferritin and haemosiderin. There is a marked increase in iron rich haemosiderin in iron overloaded livers, and ferric iron in amounts...

Argon plasma coagulation for successful treatment of early gastric cancer with intramucosal invasion

Sagawa, T, Takayama, T, Oku, T, Hayashi, T, Ota, H, Okamoto, T, ...

Background: In recent years, there has been an increasing number of cases of early gastric cancer (T1, NX) with intramucosal invasion, which are untreatable by surgical or endoscopic mucosal...

Platelet-derived growth factor indirectly stimulates angiogenesis in vitro.

Sato, N., Beitz, J. G., Kato, J., Yamamoto, M., Clark, J. W., Calabresi, P., ...

We evaluated the effect of platelet-derived growth factor (PDGF) on capillary formation using an in vitro angiogenesis model system in which microvascular fragments and myofibroblasts (Mfs) isolated...

Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue.

Mahara, K., Kato, J., Terui, T., Takimoto, R., Horimoto, M., Murakami, T., ...

To explore the mechanism of increased collagen deposition in scirrhous carcinoma of the stomach, an attempt was made to define the role of transforming growth factor beta 1 (TGF-beta 1), secreted...

Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line.

Horimoto, M., Kato, J., Takimoto, R., Terui, T., Mogi, Y., Niitsu, Y.

It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells...

Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features

Harada, K, Hiraoka, S, Kato, J, Horii, J, Fujita, H, Sakaguchi, K, ...

Activation of RAS signalling induced by K-ras/BRAF mutations is a hallmark of colorectal tumours. In addition, Ras association domain families 1 and 2 (RASSF1 and RASSF2), the negative regulators of...

Phase I study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer

Takayama, T, Sato, Y, Sagawa, T, Okamoto, T, Nagashima, H, Takahashi, Y, ...

The aim of this dose escalation study was to determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs) and preliminary efficacy of docetaxel, S-1 and cisplatin combination...