A systematic review of lay views about infant size and growth (2007)
Lucas, P., Arai, L., Baird, J., Kleijnen, J., Law, C., Roberts, H.
OBJECTIVES: To understand lay views on infant size and growth and their implications for a British population. METHODS: A systematic review of parental and other lay views about the meanings and...
Lucas, P.J., Roberts, H.M., Baird, J., Kleijnen, J., Law, C.M.
BACKGROUND: Associations between growth and size during infancy and adult disease have led some to recommend that interventions in infancy might benefit lifelong health. Any such recommendations...
Predicting foot ulcers in patients with diabetes: a systematic review and meta-analysis (2007)
Crawford, F., Inkster, M., Kleijnen, J., Fahey, T.
Clinical guidelines recommend that all patients with diabetes should be screened annually to establish their risk of foot ulceration. The aim of this systematic review was to quantify the predictive...
Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies (2006)
Whiting, P.F., Weswood, M.E., Rutjes, A.W.S., Reitsma, J.B., Bossuyt, P.M.M., Kleijnen, J.
Being big or growing fast: systematic review of size and growth in infancy and later obesity (2005)
Baird, J., Fisher, D., Lucas, P., Kleijnen, J., Roberts, H., Law, C.
Objectives: To assess the association between infant size or growth and subsequent obesity and to determine if any association has been stable over time. DESIGN: Systematic review. Data sources:...
Woolacott, N., Puhan, M.A., Misso, K., Steurer, J., Kleijnen, J.
OBJECTIVE The objective of this research was to evaluate the effectiveness, clinical impact and costeffectiveness of ultrasound in screening of newborns for developmental dysplasia of the hip (DDH)....
Woolacott, N., Puhan, M.A., Misso, K., Steurer, J., Kleijnen, J.
OBJECTIVE The objective of this research was to evaluate the effectiveness, clinical impact and costeffectiveness of ultrasound in screening of newborns for developmental dysplasia of the hip (DDH)....
Woolacott, N., Puhan, M.A., Misso, K., Steurer, J., Kleijnen, J.
OBJECTIVE The objective of this research was to evaluate the effectiveness, clinical impact and costeffectiveness of ultrasound in screening of newborns for developmental dysplasia of the hip (DDH)....
Eichler, K., Wilby, J., Hempel, S., Myers, L., Kleijnen, J.
OBJECTIVE: To compare the diagnostic performance of systematic prostate biopsy schemes in men scheduled for biopsy due to suspected prostate cancer. DESIGN: Systematic review DATA SOURCES: Electronic...
Eichler, K., Wilby, J., Hempel, S., Myers, L., Kleijnen, J.
OBJECTIVE: To compare the diagnostic performance of systematic prostate biopsy schemes in men scheduled for biopsy due to suspected prostate cancer. DESIGN: Systematic review DATA SOURCES: Electronic...
Eichler, K., Wilby, J., Hempel, S., Myers, L., Kleijnen, J.
OBJECTIVE: To compare the diagnostic performance of systematic prostate biopsy schemes in men scheduled for biopsy due to suspected prostate cancer. DESIGN: Systematic review DATA SOURCES: Electronic...
Woolacott, N.F., Puhan, M.A., Steurer, J., Kleijnen, J.
Objective To assess the accuracy and effectiveness of the screening of all newborn infants for developmental dysplasia of the hip (DDH) using ultrasound imaging, as is standard practice in some...
How does study quality affect the results of a diagnostic meta-analysis? (2005)
Westwood, M.E., Whiting, P.F., Kleijnen, J.
Background: The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Although the primary diagnostic literature is extensive, studies are often...
How does study quality affect the results of a diagnostic meta-analysis? (2005)
Westwood, M.E., Whiting, P.F., Kleijnen, J.
Background: The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Although the primary diagnostic literature is extensive, studies are often...
How does study quality affect the results of a diagnostic meta-analysis? (2005)
Westwood, M.E., Whiting, P.F., Kleijnen, J.
Background: The use of systematic literature review to inform evidence based practice in diagnostics is rapidly expanding. Although the primary diagnostic literature is extensive, studies are often...
Woolacott, N.F., Puhan, M.A., Steurer, J., Kleijnen, J.
Objective: To assess the accuracy and effectiveness of the screening of all newborn infants for developmental dysplasia of the hip (DDH) using ultrasound imaging, as is standard practice in some...
No role for quality scores in systematic reviews of diagnostic accuracy studies (2005)
Whiting, P., Harbord, R., Kleijnen, J.
Background: There is a lack of consensus regarding the use of quality scores in diagnostic systematic reviews. The objective of this study was to use different methods of weighting items included in...
No role for quality scores in systematic reviews of diagnostic accuracy studies (2005)
Whiting, P., Harbord, R., Kleijnen, J.
Background: There is a lack of consensus regarding the use of quality scores in diagnostic systematic reviews. The objective of this study was to use different methods of weighting items included in...
No role for quality scores in systematic reviews of diagnostic accuracy studies (2005)
Whiting, P., Harbord, R., Kleijnen, J.
Background: There is a lack of consensus regarding the use of quality scores in diagnostic systematic reviews. The objective of this study was to use different methods of weighting items included in...
Reactions to treatment debriefing among the participants of a placebo controlled trial (2005)
Di Blasi, Z., Crawford, F., Bradley, C., Kleijnen, J.
Background: A significant proportion of trial participants respond to placebos for a variety of conditions. Despite the common conduct of these trials and the strong emphasis placed on informed...
Reactions to treatment debriefing among the participants of a placebo controlled trial (2005)
Di Blasi, Z., Crawford, F., Bradley, C., Kleijnen, J.
Background: A significant proportion of trial participants respond to placebos for a variety of conditions. Despite the common conduct of these trials and the strong emphasis placed on informed...
Reactions to treatment debriefing among the participants of a placebo controlled trial (2005)
Di Blasi, Z., Crawford, F., Bradley, C., Kleijnen, J.
Background: A significant proportion of trial participants respond to placebos for a variety of conditions. Despite the common conduct of these trials and the strong emphasis placed on informed...
Whiting, P., Westwood, M., Watt, I., Cooper, J., Kleijnen, J.
Background: Urinary tract infection (UTI) is one of the most common sources of infection in children under five. Prompt diagnosis and treatment is important to reduce the risk of renal scarring....
Whiting, P., Westwood, M., Watt, I., Cooper, J., Kleijnen, J.
Background: Urinary tract infection (UTI) is one of the most common sources of infection in children under five. Prompt diagnosis and treatment is important to reduce the risk of renal scarring....
Whiting, P., Westwood, M., Watt, I., Cooper, J., Kleijnen, J.
Background: Urinary tract infection (UTI) is one of the most common sources of infection in children under five. Prompt diagnosis and treatment is important to reduce the risk of renal scarring....
Westwood, M.E., Whiting, P.F., Cooper, J., Watt, I.S., Kleijnen, J.
Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective...
Westwood, M.E., Whiting, P.F., Cooper, J., Watt, I.S., Kleijnen, J.
Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective...
Westwood, M.E., Whiting, P.F., Cooper, J., Watt, I.S., Kleijnen, J.
Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective...
Nixon, J., Duffy, S., Armstrong, N., Craig, D., Glanville, J., Christie, J., ...
OBJECTIVES: Health-care technology reviews now increasingly include outcome costs as well as clinical effects. This study reports the findings and implications of a survey to explore the usefulness...
Nixon, J., Duffy, S., Armstrong, N., Craig, D., Glanville, J., Christie, J., ...
OBJECTIVES: Health-care technology reviews now increasingly include outcome costs as well as clinical effects. This study reports the findings and implications of a survey to explore the usefulness...
Nixon, J., Duffy, S., Armstrong, N., Craig, D., Glanville, J., Christie, J., ...
OBJECTIVES: Health-care technology reviews now increasingly include outcome costs as well as clinical effects. This study reports the findings and implications of a survey to explore the usefulness...
Sources of variation and bias in studies of diagnostic accuracy: a systematic review (2004)
Whiting, P., Rutjes, A.W.S., Reitsma, J.B., Glas, A.S., Bossuyt, P.M.M., Kleijnen, J.
Informing participants of allocation to placebo at trial closure: postal survey (2002)
Di Blasi, Z., Kaptchuk, T.J., Weinman, J., Kleijnen, J.
OBJECTIVES: To assess whether and how investigators of placebo controlled randomised trials inform participants of their treatment allocation at trial closure and to assess barriers to feedback....
Informing participants of allocation to placebo at trial closure: postal survey (2002)
Di Blasi, Z., Kaptchuk, T.J., Weinman, J., Kleijnen, J.
OBJECTIVES: To assess whether and how investigators of placebo controlled randomised trials inform participants of their treatment allocation at trial closure and to assess barriers to feedback....
Informing participants of allocation to placebo at trial closure: postal survey (2002)
Di Blasi, Z., Kaptchuk, T.J., Weinman, J., Kleijnen, J.
OBJECTIVES: To assess whether and how investigators of placebo controlled randomised trials inform participants of their treatment allocation at trial closure and to assess barriers to feedback....
Quality of Cochrane reviews: assessment of sample from 1998 (2001)
Olsen, O., Middleton, P., Ezzo, J., Gotzsche, P., Hadhazy, V., Herxheimer, A., ...
Objective: To assess the quality of Cochrane reviews. Design: Ten methodologists affiliated with the Cochrane Collaboration independently examined, in a semistructured way, the quality of reviews...
Association of Down's syndrome and water fluoride level: a systematic review of the evidence (2001)
Whiting, P., McDonagh, M., Kleijnen, J.
BACKGROUND: A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence supported a beneficial effect of...
Association of Down's syndrome and water fluoride level: a systematic review of the evidence (2001)
Whiting, P., McDonagh, M., Kleijnen, J.
BACKGROUND: A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence supported a beneficial effect of...
Association of Down's syndrome and water fluoride level: a systematic review of the evidence (2001)
Whiting, P., McDonagh, M., Kleijnen, J.
BACKGROUND: A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence supported a beneficial effect of...
Summarising economic evaluations in systematic reviews: a new approach (2001)
Nixon, J., Khan, K.S, Kleijnen, J.
Systematic reviews of healthcare interventions, which are aimed at informing health policy, increasingly include economic evaluations in addition to evaluations of clinical effectiveness.1-3 The...
Quality of Cochrane reviews: assessment of sample from 1998 (2001)
Olsen, O., Middleton, Philippa Fairfax, Ezzo J,, Gøtzsche, P. C., Hadhazy, V., Herxheimer, A., ...
© 2001 BMJ Publishing Group
Quality of Cochrane reviews: assessment of sample from 1998 (2001)
Olsen, O., Middleton, Philippa Fairfax, Ezzo J,, Gøtzsche, P. C., Hadhazy, V., Herxheimer, A., ...
© 2001 BMJ Publishing Group
Fluoridation of Drinking Water: a systematic review of its efficacy and safety (2000)
McDonagh, M., Whiting, P., Bradley, M., Cooper, J., Sutton, A., Chestnutt, I., ...
This systematic review has been commissioned by the Chief Medical Officer of the Department Health to ‘carry out an up to date expert scientific review of fluoride and health’ (Paragraph...
Fluoridation of Drinking Water: a systematic review of its efficacy and safety (2000)
McDonagh, M., Whiting, P., Bradley, M., Cooper, J., Sutton, A., Chestnutt, I., ...
This systematic review has been commissioned by the Chief Medical Officer of the Department Health to ‘carry out an up to date expert scientific review of fluoride and health’ (Paragraph...
Fluoridation of Drinking Water: a systematic review of its efficacy and safety (2000)
McDonagh, M., Whiting, P., Bradley, M., Cooper, J., Sutton, A., Chestnutt, I., ...
This systematic review has been commissioned by the Chief Medical Officer of the Department Health to ‘carry out an up to date expert scientific review of fluoride and health’ (Paragraph...
The UK NHS Economic Evaluation Database: Economic: Issues in evaluations of health technology (2000)
Nixon, J., Stoykova, B., Christie, J., Glanville, J.M., Drummond, M., Kleijnen, J.
OBJECTIVE: The U.K. NHS Economic Evaluation Database (EED) project is commissioned to identify papers on economic evaluations of health technologies and to disseminate their findings to NHS decision...
The UK NHS Economic Evaluation Database: Economic: Issues in evaluations of health technology (2000)
Nixon, J., Stoykova, B., Christie, J., Glanville, J.M., Drummond, M., Kleijnen, J.
OBJECTIVE: The U.K. NHS Economic Evaluation Database (EED) project is commissioned to identify papers on economic evaluations of health technologies and to disseminate their findings to NHS decision...
The UK NHS Economic Evaluation Database: Economic: Issues in evaluations of health technology (2000)
Nixon, J., Stoykova, B., Christie, J., Glanville, J.M., Drummond, M., Kleijnen, J.
OBJECTIVE: The U.K. NHS Economic Evaluation Database (EED) project is commissioned to identify papers on economic evaluations of health technologies and to disseminate their findings to NHS decision...
Behandeling van leeftijdsgerelateerde geheugenklachten met een Ginkgo-biloba extract. (1999)
BRAUTIGAM, M, BLOMMAERT, FA, Verleye, Greta, CASTERMANS, J, JANSEN STEUR, ENH, KLEIJNEN, J
Validation of simulation models : regression analysis revisited (1996)
Kleijnen, J., Bettonville, B., Groenendaal, W. Van
This paper proves that it is wrong to require that regressing a model's outputs on the observed real outcomes gives a 45 degrees line through the origin (unit slope, zero intercept). Therefore this...
Steroid injections for shoulder disorders: a systematic review of randomized clinical trials.
Van Der Heijden, G J, Van Der Windt, D A, Kleijnen, J, Koes, B W, Bouter, L M
BACKGROUND: Patients with shoulder disorders are believed to benefit considerably from steroid injections. However, the controversy about their efficacy persists. AIM: The study was designed to...
A meta-analysis of studies into the effect of acupuncture on addiction.
Ter Riet, G, Kleijnen, J, Knipschild, P
A literature search revealed 22 controlled clinical studies on the efficacy of acupuncture in three fields of addiction: cigarette smoking (15), heroin (five), and alcohol (two). These studies were...
Clinical trials of homoeopathy.
Kleijnen, J, Knipschild, P, Ter Riet, G
OBJECTIVE--To establish whether there is evidence of the efficacy of homoeopathy from controlled trials in humans. DESIGN--Criteria based meta-analysis. Assessment of the methodological quality of...
Steroid injections for shoulder disorders: a systematic review of randomized clinical trials.
Van Der Heijden, G J, Van Der Windt, D A, Kleijnen, J, Koes, B W, Bouter, L M
BACKGROUND: Patients with shoulder disorders are believed to benefit considerably from steroid injections. However, the controversy about their efficacy persists. AIM: The study was designed to...
A meta-analysis of studies into the effect of acupuncture on addiction.
Ter Riet, G, Kleijnen, J, Knipschild, P
A literature search revealed 22 controlled clinical studies on the efficacy of acupuncture in three fields of addiction: cigarette smoking (15), heroin (five), and alcohol (two). These studies were...
Clinical trials of homoeopathy.
Kleijnen, J, Knipschild, P, Ter Riet, G
OBJECTIVE--To establish whether there is evidence of the efficacy of homoeopathy from controlled trials in humans. DESIGN--Criteria based meta-analysis. Assessment of the methodological quality of...
Kleijnen, J, Knipschild, P, Ter Riet, G
1. Claims for beneficial effects on cholesterol levels, fibrinolytic activity, and platelet aggregation are attributed both to fresh garlic and onions (or their extracts) and to commercially...
Ginkgo biloba for cerebral insufficiency.
1. By means of a critical review we tried to establish whether there is evidence from controlled trials in humans on the efficacy of Ginkgo biloba extracts in cerebral insufficiency. 2. The...
Acupuncture and asthma: a review of controlled trials.
Kleijnen, J, Ter Riet, G, Knipschild, P
BACKGROUND: Published controlled trials of acupuncture in asthma have often contained a small number of subjects and the results are contradictory. Controlled trials have been reviewed to determine...
O'Meara, S, Wilson, P, Bridle, C, Wright, K, Kleijnen, J
The research evidence on the effectiveness of homoeopathy presented in a recent issue of Effective Health Care is reviewed.
De Craen, A. J., Di Giulio, G., Lampe-Schoenmaeckers, J. E., Kessels, A. G., Kleijnen, J.
OBJECTIVES--To assess whether adding codeine to paracetamol has an additive analgesic effect; to assess the safety of paracetamol-codeine combinations versus paracetamol alone. DESIGN--Systematic...
De Craen, A. J., Roos, P. J., Kleijnen, J.
OBJECTIVE: To assess the impact of the colour of a drug's formulation on its perceived effect and its effectiveness and to examine whether antidepressant drugs available in the Netherlands are...
Validation of simulation models : regression analysis revisited
Kleijnen, J., Bettonville, B., Groenendaal, W. Van
This paper proves that it is wrong to require that regressing a model's outputs on the observed real outcomes gives a 45 degrees line through the origin (unit slope, zero intercept). Therefore this...
Management of gynaecological cancers
Melville, A., Eastwood, A., Kleijnen, J., Kitchener, H., Martin-Hirsch, P., Nelson, L.