Tyrrell, G J, Ramotar, K, Toye, B, Boyd, B, Lingwood, C A, Brunton, J L
Verotoxin 1 (VT-1) and Shiga-like toxin II (SLT-II) bind to the glycosphingolipid (GSL), globotriaosylceramide (Gb3), whereas pig edema disease toxin (VTE) binds to globotetraosylceramide (Gb4) and...
Bast, D J, Brunton, J L, Karmali, M A, Richardson, S E
The verotoxins (VT1 and VT2), produced by strains of enterohemorrhagic Escherichia coli, have been implicated in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome. To better...
Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi.
Albritton, W L, Brunton, J L, Slaney, L, MacLean, I
Clinical isolates of Haemophilus ducreyi from patients with chancroid were shown to have one or more 4.9- to 7.0-megadalton non-self-transferable plasmids and to have in vitro resistance to...
The 7.1-kilobase-pair (kbp) plasmid pFA3 specifies TEM beta-lactamase production in Neisseria gonorrhoeae. We studied the minimal region required for replication of this plasmid in Escherichia coli...
Huang, A, Friesen, J, Brunton, J L
The Shiga-like toxin 1-converting bacteriophage H-19B was recently shown to carry the structural genes for the toxin and was shown to have DNA sequence homology with phage lambda. We present evidence...
Cloning and expression of the genes specifying Shiga-like toxin production in Escherichia coli H19.
Huang, A, De Grandis, S, Friesen, J, Karmali, M, Petric, M, Congi, R, ...
Some strains of Escherichia coli produce a protein which is cytotoxic for Vero cell and HeLa cell monolayers. This toxin is very similar to the toxin of Shigella dysenteriae 1 and has been named...
Evaluation of Roche Amplicor PCR assay for Mycobacterium tuberculosis.
Wobeser, W L, Krajden, M, Conly, J, Simpson, H, Yim, B, D'costa, M, ...
The Roche Amplicor Mycobacterium tuberculosis PCR test (RMtb-PCR) was compared with mycobacterial culture, with the BACTEC 460 system and inoculation on Lowenstein-Jensen media. Results were...
Hii, J H, Gyles, C, Morooka, T, Karmali, M A, Clarke, R, De Grandis, S, ...
We and others have noted that there are serological differences between verotoxin 2 (VT2) (also known as Shiga-like toxin II) produced by Escherichia coli C600(933W) and the VT2 variant (VT2v)...
Haemophilus influenzae: comparison of respiratory tract isolates with genitourinary tract isolates.
Albritton, W L, Brunton, J L, Meier, M, Bowman, M N, Slaney, L A
Haemophilus influenzae isolates recovered from the genitourinary (GU) tract were shown to have a significantly different biotype distribution compared with respiratory tract isolates. Biotype IV...
Dytoc, M T, Ismaili, A, Philpott, D J, Soni, R, Brunton, J L, Sherman, P M
Infection of humans with verotoxin-producing Escherichia coli (VTEC) O113:H21 is associated with clinical features comparable to those associated with infection with attaching and effacing VTEC...
Cumberbatch, N, Gurwith, M J, Langston, C, Sack, R B, Brunton, J L
Ninety-six Aeromonas hydrophila isolates were tested for cytotoxin and hemolysin production. Sixty-six (69%) of the isolates were both cytotoxic and hemolytic, whereas the rest produced neither...
Murray, B E, Mederski-Samoraj, B, Foster, S K, Brunton, J L, Harford, P
A strain of Streptococcus faecalis with plasmid-mediated penicillinase production was studied further. Partially purified penicillinase from the S. faecalis strain hydrolyzed penicillin, ampicillin,...
Gilbride, K A, Rosendal, S, Brunton, J L
The genetic basis of antimicrobial resistance in Ontario isolates of Actinobacillus (Haemophilus) pleuropneumoniae was studied. Two Ontario isolates of A. pleuropneumoniae were found to be resistant...
Novel plasmid-mediated resistance to ceftazidime of a clinical isolate of Klebsiella pneumoniae.
Walmsley, S L, Kitching, D A, Low, D E, Simor, A E, Brunton, J L
Tyrrell, G J, Ramotar, K, Toye, B, Boyd, B, Lingwood, C A, Brunton, J L
Verotoxin 1 (VT-1) and Shiga-like toxin II (SLT-II) bind to the glycosphingolipid (GSL), globotriaosylceramide (Gb3), whereas pig edema disease toxin (VTE) binds to globotetraosylceramide (Gb4) and...
Bast, D J, Brunton, J L, Karmali, M A, Richardson, S E
The verotoxins (VT1 and VT2), produced by strains of enterohemorrhagic Escherichia coli, have been implicated in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome. To better...
Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi.
Albritton, W L, Brunton, J L, Slaney, L, MacLean, I
Clinical isolates of Haemophilus ducreyi from patients with chancroid were shown to have one or more 4.9- to 7.0-megadalton non-self-transferable plasmids and to have in vitro resistance to...
The 7.1-kilobase-pair (kbp) plasmid pFA3 specifies TEM beta-lactamase production in Neisseria gonorrhoeae. We studied the minimal region required for replication of this plasmid in Escherichia coli...
Huang, A, Friesen, J, Brunton, J L
The Shiga-like toxin 1-converting bacteriophage H-19B was recently shown to carry the structural genes for the toxin and was shown to have DNA sequence homology with phage lambda. We present evidence...
Cloning and expression of the genes specifying Shiga-like toxin production in Escherichia coli H19.
Huang, A, De Grandis, S, Friesen, J, Karmali, M, Petric, M, Congi, R, ...
Some strains of Escherichia coli produce a protein which is cytotoxic for Vero cell and HeLa cell monolayers. This toxin is very similar to the toxin of Shigella dysenteriae 1 and has been named...
Evaluation of Roche Amplicor PCR assay for Mycobacterium tuberculosis.
Wobeser, W L, Krajden, M, Conly, J, Simpson, H, Yim, B, D'costa, M, ...
The Roche Amplicor Mycobacterium tuberculosis PCR test (RMtb-PCR) was compared with mycobacterial culture, with the BACTEC 460 system and inoculation on Lowenstein-Jensen media. Results were...
Hii, J H, Gyles, C, Morooka, T, Karmali, M A, Clarke, R, De Grandis, S, ...
We and others have noted that there are serological differences between verotoxin 2 (VT2) (also known as Shiga-like toxin II) produced by Escherichia coli C600(933W) and the VT2 variant (VT2v)...
Haemophilus influenzae: comparison of respiratory tract isolates with genitourinary tract isolates.
Albritton, W L, Brunton, J L, Meier, M, Bowman, M N, Slaney, L A
Haemophilus influenzae isolates recovered from the genitourinary (GU) tract were shown to have a significantly different biotype distribution compared with respiratory tract isolates. Biotype IV...
Dytoc, M T, Ismaili, A, Philpott, D J, Soni, R, Brunton, J L, Sherman, P M
Infection of humans with verotoxin-producing Escherichia coli (VTEC) O113:H21 is associated with clinical features comparable to those associated with infection with attaching and effacing VTEC...
Cumberbatch, N, Gurwith, M J, Langston, C, Sack, R B, Brunton, J L
Ninety-six Aeromonas hydrophila isolates were tested for cytotoxin and hemolysin production. Sixty-six (69%) of the isolates were both cytotoxic and hemolytic, whereas the rest produced neither...
Murray, B E, Mederski-Samoraj, B, Foster, S K, Brunton, J L, Harford, P
A strain of Streptococcus faecalis with plasmid-mediated penicillinase production was studied further. Partially purified penicillinase from the S. faecalis strain hydrolyzed penicillin, ampicillin,...
Gilbride, K A, Rosendal, S, Brunton, J L
The genetic basis of antimicrobial resistance in Ontario isolates of Actinobacillus (Haemophilus) pleuropneumoniae was studied. Two Ontario isolates of A. pleuropneumoniae were found to be resistant...
Novel plasmid-mediated resistance to ceftazidime of a clinical isolate of Klebsiella pneumoniae.
Walmsley, S L, Kitching, D A, Low, D E, Simor, A E, Brunton, J L
Q fever: hazard from sheep used in research.
Simor, A. E., Brunton, J. L., Salit, I. E., Vellend, H., Ford-Jones, L., Spence, L. P.
The recent recognition that Q fever is endemic in Ontario and the known occupational risk of Q fever to research personnel working with sheep prompted a study to determine the prevalence of...