Bose-Einstein Condensation of Metastable Helium (2006)
Santos, F. Pereira Dos, Leonard, J., Wang, Junmin, Barrelet, C. J., Perales, F., Rasel, E., ...
We have observed a Bose-Einstein Condensate in a dilute gas of $^4$He in the $2^3S_1$ metastable state. We find a critical temperature of $(4.7\pm0.5) \mu$K and a typical number of atoms at the...
Cooling and trapping of ultra-cold strontium isotopic mixtures (2006)
Poli, N., Drullinger, R. E., Ferrari, G., Leonard, J., Sorrentino, F., Tino, G. M.
We present the simultaneous cooling and trapping of an isotopic mixture in a magneto-optical trap and we describe the transfer of the mixture into a conservative, far-off resonant dipole trap. The...
Bose-Einstein condensates studied with a linear accelerator. (2005)
Buggle, Ch., Leonard, J., Klitzing, W. Von, Walraven, J.T.M.
Analyses of photoassociation spectra for giant helium dimers (2004)
Leonard, J., Mosk, A.P., Walhout, M., Straten, P. Van Der, Leduc, M., Cohen-Tannoudji, C.
Explore and Return: Experimental Validation Of Real-Time Concurrent Mapping and Localization (2003)
P. Newman, J. Leonard, J. D. Tardos, J. Neira
This paper describes a real-time implementation of feature-based concurrent mapping and localization (CML) running on a mobile robot in a dynamic indoor environment. Novel characteristics of this...
Explore and Return: Experimental (2003)
P. Newman, J. Leonard, J. D. Tardos, J. Neira
This paper describes a real-time implementation of feature-based concurrent mapping and localization (CML) running on a mobile robot in a dynamic indoor environment. Novel characteristics of this...
Analysis of Photoassociation Spectra for Giant Helium Dimers (2003)
Leonard, J., Mosk, A. P., Walhout, M., Leduc, M., Cohen-Tannoudji, C.
We perform a theoretical analysis to interpret the spectra of purely long-range helium dimers produced by photoassociation (PA) in an ultra-cold gas of metastable helium atoms. The experimental...
Giant Helium Dimers Produced by Photoassociation of Ultracold Metastable Atoms (2003)
Leonard, J., Walhout, M., Mosk, A. P., Mueller, T., Leduc, M., Cohen-Tannoudji, C.
We produce giant helium dimers by photoassociation of metastable helium atoms in a magnetically trapped, ultracold cloud. The photoassociation laser is detuned red of the atomic $2^3S_1 - 2^3P_0 $...
Autonomous Feature-Based Exploration (2003)
P. Newman, M. Bosse, J. Leonard
This paper presents an algorithm for feature-based exploration of a priori unknown environments. We aim to build a robot that, unsupervised, plans its motion such that it continually increases both...
Pure Range-Only Sub-Sea SLAM (2003)
This paper is about using range-only data to navigate an autonomous underwater ve- hicle (AUV). We assume the vehicle is equipped with conventional long base line (LBL) transceiver which measures...
Hydrodynamic modes in a trapped gas of metastable helium above the Bose-Einstein transition (2002)
Leduc, M., Leonard, J., Santos, F. Pereira Dos, Jahier, E., Schwartz, S., Cohen-Tannoudji, C.
This article describes experiments performed with an ultracold gas of metastable helium above the Bose-Einstein transition. The gas is trapped in an harmonic magnetic potential and collective...
Nutrients in European ecosystems (2002)
P. Crouzet (ifen, Task Leader, J. Leonard, S. Nixon, Y. Rees, ...
this report. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the European Community or the European...
No 19 Environmental issue report Sustainable water use in Europe (2002)
C. Lallana, W. Krinner, T. Estrela, S. Nixon, J. Leonard, J. M. Berl
this report. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server (http://europa.eu.int). EEA, Copenhagen, 2001...
M. Bosse, R Rikoski, J. Leonard, S. Teller
The paper describes a system for 6 degree of freedom intertemporal stochastic mapping of an unknown environment using only odometery and omni-directional vision. The method uses a feature-based...
Penning collisions of laser-cooled metastable helium atoms (2001)
Santos, F. Pereira Dos, Perales, F., Leonard, J., Sinatra, A., Wang, Junmin, Pavone, F. S., ...
We present experimental results on the two-body loss rates in a magneto-optical trap of metastable helium atoms. Absolute rates are measured in a systematic way for several laser detunings ranging...
Efficient magneto-optical trapping of a metastable helium gas (2001)
Santos, F. Pereira Dos, Perales, F., Leonard, J., Sinatra, A., Wang, Junmin, Pavone, F. S., ...
This article presents a new experiment aiming at BEC of metastable helium atoms. It describes the design of a high flux discharge source of atoms and a robust laser system using a DBR diode coupled...
Bose-Einstein Condensation of Metastable Helium (2001)
Santos, F. Pereira Dos, Leonard, J., Wang, Junmin, Barrelet, C. J., Perales, F., Rasel, E., ...
We have observed a Bose-Einstein Condensate in a dilute gas of $^4$He in the $2^3S_1$ metastable state. We find a critical temperature of $(4.7\pm0.5) \mu$K and a typical number of atoms at the...
Nutrients in European ecosystems (2001)
P. Crouzet (ifen, Task Leader, J. Leonard, S. Nixon, Y. Rees, ...
this report. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the European Community or the European...
Intra-firm Wage Dispersion and Firm Performance (2000)
Rudolf Winter-ebmer, G. Baker, C. Brown, M. Brown, J. Brunner, J. Falkinger, ...
Personnel economics has put forward conflicting arguments concerning the impact of increased wage dispersion within a firm on the productivity of its workers. Besides giving more incentives, bigger...
Equilibrium Bulk Polymerization of 1,3-dioxolan, (1998)
Cationic bulk polymerization of 1,3-dioxolan has been carried out in sealed ampoules using a high vacuum technique. Specific volumes of pure monomer and polymer in solution of its own monomer have...
Equilibrium Cationic Polymerization of Tetrahydrofuran in Benzene, (1998)
The equilibrium cationic polymerization of tetrahydrofuran in benzene is investigated in the 15 to 50C range. Polymerizations are initiated with triethyloxonium hexafluorophosphate (Et3O(+)PF6(-))...
The Arctic life line /--by James Leonard Bates. (1946)
Thesis (M.A.)--University of North Carolina at Chapel Hill, 1946.
Petersen, H V, Serup, P, Leonard, J, Michelsen, B K, Madsen, O D
Insulin gene transcription is a unique feature of the pancreatic beta cells and is increased in response to glucose. The recent cloning of insulin promoter factor 1 (IPF1) and somatostatin...
Leonard, J, Serup, P, Gonzalez, G, Edlund, T, Montminy, M
Many eukaryotic genes are regulated by cAMP through a conserved cAMP response element (CRE). Here we show that, in the pancreatic islet cell line Tu6, a well-characterized CRE in the somatostatin...
Bilello, J A, Bilello, P A, Kort, J J, Dudley, M N, Leonard, J, Drusano, G L
A-77003, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is effective for both acute and chronic infection in vitro and was evaluated clinically by continuous intravenous infusion...
Bilello, J A, Bilello, P A, Stellrecht, K, Leonard, J, Norbeck, D W, Kempf, D J, ...
The therapeutic utility of a human immunodeficiency virus type 1 (HIV-1) protease inhibitor may depend on its intracellular concentration, which is a property of its uptake, metabolism, and/or...
A dominant sulfhydryl-containing protein in the outer membrane of Neisseria gonorrhoeae.
Norrod, E P, Browne, S L, Feldweg, A, Leonard, J
By using a method that labels sulfhydryl-containing proteins in situ, we have detected a major outer membrane protein of Neisseria gonorrhoeae at 41 kDa. A protein of this molecular mass has not...
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1.
Sharma, S, Jhala, U S, Johnson, T, Ferreri, K, Leonard, J, Montminy, M
The homeobox protein STF-1 appears to function as a master control switch for expression of the pancreatic program during development. Here we characterize a composite enhancer which directs STF-1...
Vicenzi, E, Dimitrov, D S, Engelman, A, Migone, T S, Purcell, D F, Leonard, J, ...
Nonoverlapping deletions that eliminated the 5' (HIV-1US/603del), middle (HIV-1U5/206del), and 3' (HIV-1U5/604del) thirds of the U5 region of the human immunodeficiency virus type 1 (HIV-1) long...
Parrott, C, Seidner, T, Duh, E, Leonard, J, Theodore, T S, Buckler-White, A, ...
The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1. In order to investigate the role that the Sp1-binding sites...
Leonard, J, Parrott, C, Buckler-White, A J, Turner, W, Ross, E K, Martin, M A, ...
Mutations were introduced into the regulatory sequences in the long terminal repeat of an infectious molecular clone of the human immunodeficiency virus. Viruses in which the NF-kappa B binding sites...
Activation of the human immunodeficiency virus by herpes simplex virus type 1.
Ostrove, J M, Leonard, J, Weck, K E, Rabson, A B, Gendelman, H E
Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and the replication of...
Gonzalez, G A, Menzel, P, Leonard, J, Fischer, W H, Montminy, M R
Cyclic AMP mediates the hormonal stimulation of a number of eukaryotic genes by directing the protein kinase A (PK-A)-dependent phosphorylation of transcription factor CREB. We have previously...
Serup, P, Petersen, H V, Pedersen, E E, Edlund, H, Leonard, J, Petersen, J S, ...
The mouse homeodomain protein insulin promoter factor-1 (IPF-1) and the rat homologue somatostatin transactivating factor-1 (STF-1) are involved in early pancreatic development and have been...
Carcinoembryonic Antigen in Management of Colorectal Carcinoma
Booth, S. N., Jamieson, G. C., King, J. P. G., Leonard, J., Oates, G. D., Dykes, P. W.
Carcinoembryonic antigen (C.E.A.) estimation has been used in the preoperative assessment of colorectal carcinoma patients and has been shown to give a useful guide to the presence of metastatic...
Petersen, H V, Serup, P, Leonard, J, Michelsen, B K, Madsen, O D
Insulin gene transcription is a unique feature of the pancreatic beta cells and is increased in response to glucose. The recent cloning of insulin promoter factor 1 (IPF1) and somatostatin...
Leonard, J, Serup, P, Gonzalez, G, Edlund, T, Montminy, M
Many eukaryotic genes are regulated by cAMP through a conserved cAMP response element (CRE). Here we show that, in the pancreatic islet cell line Tu6, a well-characterized CRE in the somatostatin...
Bilello, J A, Bilello, P A, Kort, J J, Dudley, M N, Leonard, J, Drusano, G L
A-77003, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is effective for both acute and chronic infection in vitro and was evaluated clinically by continuous intravenous infusion...
Bilello, J A, Bilello, P A, Stellrecht, K, Leonard, J, Norbeck, D W, Kempf, D J, ...
The therapeutic utility of a human immunodeficiency virus type 1 (HIV-1) protease inhibitor may depend on its intracellular concentration, which is a property of its uptake, metabolism, and/or...
A dominant sulfhydryl-containing protein in the outer membrane of Neisseria gonorrhoeae.
Norrod, E P, Browne, S L, Feldweg, A, Leonard, J
By using a method that labels sulfhydryl-containing proteins in situ, we have detected a major outer membrane protein of Neisseria gonorrhoeae at 41 kDa. A protein of this molecular mass has not...
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1.
Sharma, S, Jhala, U S, Johnson, T, Ferreri, K, Leonard, J, Montminy, M
The homeobox protein STF-1 appears to function as a master control switch for expression of the pancreatic program during development. Here we characterize a composite enhancer which directs STF-1...
Vicenzi, E, Dimitrov, D S, Engelman, A, Migone, T S, Purcell, D F, Leonard, J, ...
Nonoverlapping deletions that eliminated the 5' (HIV-1US/603del), middle (HIV-1U5/206del), and 3' (HIV-1U5/604del) thirds of the U5 region of the human immunodeficiency virus type 1 (HIV-1) long...
Parrott, C, Seidner, T, Duh, E, Leonard, J, Theodore, T S, Buckler-White, A, ...
The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1. In order to investigate the role that the Sp1-binding sites...
Leonard, J, Parrott, C, Buckler-White, A J, Turner, W, Ross, E K, Martin, M A, ...
Mutations were introduced into the regulatory sequences in the long terminal repeat of an infectious molecular clone of the human immunodeficiency virus. Viruses in which the NF-kappa B binding sites...
Activation of the human immunodeficiency virus by herpes simplex virus type 1.
Ostrove, J M, Leonard, J, Weck, K E, Rabson, A B, Gendelman, H E
Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and the replication of...
Gonzalez, G A, Menzel, P, Leonard, J, Fischer, W H, Montminy, M R
Cyclic AMP mediates the hormonal stimulation of a number of eukaryotic genes by directing the protein kinase A (PK-A)-dependent phosphorylation of transcription factor CREB. We have previously...
Serup, P, Petersen, H V, Pedersen, E E, Edlund, H, Leonard, J, Petersen, J S, ...
The mouse homeodomain protein insulin promoter factor-1 (IPF-1) and the rat homologue somatostatin transactivating factor-1 (STF-1) are involved in early pancreatic development and have been...
Carcinoembryonic Antigen in Management of Colorectal Carcinoma
Booth, S. N., Jamieson, G. C., King, J. P. G., Leonard, J., Oates, G. D., Dykes, P. W.
Carcinoembryonic antigen (C.E.A.) estimation has been used in the preoperative assessment of colorectal carcinoma patients and has been shown to give a useful guide to the presence of metastatic...
Suitters, A J, Shaw, S, Wales, M R, Porter, J P, Leonard, J, Woodger, R, ...
Steroid hormones, such as glucocorticoids (GC), influence immune and inflammatory responses through their suppressive actions. Recent evidence suggests that another steroid hormone,...
Progression of disease in ocular cicatricial pemphigoid.
Elder, M J, Bernauer, W, Leonard, J, Dart, J K
BACKGROUND: Ocular cicatricial pemphigoid (OCP) is a sight threatening autoimmune disease that can lead to severe conjunctival cicatrisation and keratopathy. It has a variable course and little is...
Sulphapyridine--a new agent for the treatment of ocular cicatricial pemphigoid.
Elder, M. J., Leonard, J., Dart, J. K.
AIMS--Ocular cicatricial pemphigoid (OCP) is a severe, potentially sight threatening systemic disease that sometimes requires systemic immunosuppression. This study assessed the clinical outcome of...
Byrne, M A, Walker, M M, Leonard, J, Pryce, D, Taylor-Robinson, D
A vulval colposcopy clinic was established in the sexually transmitted diseases (STD) clinic of St Mary's Hospital, London, to investigate patients with chronic symptoms (mean duration 3 1/2 years)....
Design of a safer approach to intravenous drug infusions: failure mode effects analysis
Apkon, M, Leonard, J, Probst, L, DeLizio, L, Vitale, R
Objectives: A set of standard processes was developed for delivering continuous drug infusions in order to improve (1) patient safety; (2) efficiency in staff workflow; (3) hemodynamic stability...
Comprehensive management of children on a paediatric ward: a family approach.
Bingley, L, Leonard, J, Hensman, S, Lask, B, Wolff, O
A team approach in the comprehensive management of children on a general paediatric ward is described. The team comprises paediatricians, nurses, a child psychiatrist, and a social worker, with a...
Neurological outcome of methylmalonic acidaemia
Nicolaides, P, Leonard, J, Surtees, R
OBJECTIVE—To assess the long term outcome of patients with methylmalonic acidaemia in a cross sectional study. PATIENTS—All 35 patients with methylmalonic acidaemia seen at Great Ormond Street...
Clinical and laboratory findings in referrals for mitochondrial DNA analysis
Lamont, P, Surtees, R, Woodward, C, Leonard, J, Wood, N, Harding, A
BACKGROUND—Increasingly, mutations of mitochondrial DNA (mtDNA) are being considered when investigating the aetiology of neurological diseases in childhood. However, they are often difficult to...
Prospective surveillance study of medium chain acyl-CoA dehydrogenase deficiency in the UK
BACKGROUND—Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is a common disorder of fatty acid oxidation in north west Europe. It is very variable in its clinical consequences and is believed...
Clayton, P., Doig, M., Ghafari, S., Meaney, C., Taylor, C., Leonard, J., ...
OBJECTIVE—To establish criteria for the diagnosis of medium chain acyl-CoA dehydrogenase (MCAD) deficiency in the UK population using a method in which carnitine species eluted from blood spots are...
Recommendations for the management of galactosaemia
Walter, J, Collins, J, Leonard, J, CHISWICK, M, MARCOVITCH, H
Outcome of medium chain acyl-CoA dehydrogenase deficiency after diagnosis
Wilson, C., Champion, M., Collins, J., Clayton, P., Leonard, J.
BACKGROUND—Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inborn error of fatty acid metabolism. Undiagnosed, it has a mortality rate of 20-25%. Neonatal screening for the...