BSAC standardized disc susceptibility testing method (version 8) (2009)
There have been considerable changes to the format of the recommendations since the previous version (version 7). The majority of the footnotes to the tables have been removed and the notations added...
BSAC standardized disc susceptibility testing method (version 7) (2008)
The changes that have been made to the previous version of the recommendations (version 6) are as follows: medium and incubation condition for testing Acinetobacter spp. (Tables 1 and 6); use of...
Released by Environmental Chemistry/ (2007)
L. M. He, S. H. Lieberman, J. M. Andrews, E. L. Valdes, R. C. Kolb, ...
this report was performed jointly for the Office of Naval Research Environmental Quality Technology Program and the Naval Submarine Surface Warfare Center, Carderock Division by the San Diego State...
Andrews, J.M., Blythe, S.P., Gurney, W.S.C.
We examine the stability of a class of continuous age-structured models. Stability borders are established for the different parameters in the model, including levels required for viability. Two...
Andrews, J.M., Blythe, S.P., Gurney, W.S.C.
We examine the stability of a class of continuous age-structured models. Stability borders are established for the different parameters in the model, including levels required for viability. Two...
Comparative study of the in vitro activity of a new fluoroquinolone, ABT-492 (2004)
Harnett, S. J., Fraise, A. P., Andrews, J. M., Jevons, G., Brenwald, N. P., Wise, R.
Objectives: The in vitro activity of a new fluoroquinolone, ABT-492, was determined. Methods: MICs were compared with those of two &bgr;-lactams, telithromycin, ciprofloxacin and four later...
Comparative study of the in vitro activity of a new fluoroquinolone, ABT-492 (2004)
Harnett, S. J., Fraise, A. P., Andrews, J. M., Jevons, G., Brenwald, N. P., Wise, R.
Objectives: The in vitro activity of a new fluoroquinolone, ABT-492, was determined. Methods: MICs were compared with those of two β-lactams, telithromycin, ciprofloxacin and four later generation...
Feinle-Bisset, Christine, O'Donovan, D. G., Doran, S. M., Andrews, J. M., Wishart, J. M., Chapman, Ian McPhee, ...
© 2003 American Physiological Society
Treatment of functional dyspepsia (2003)
Feinle-Bisset, Christine, Andrews, J. M.
The original publication is available at www.springerlink.com
Boswell, F. J., Andrews, J. M., Jevons, G., Wise, R.
In this study the in vitro activities and pharmacodynamic properties of moxifloxacin, levofloxacin, gatifloxacin and gemifloxacin were compared on recently isolated respiratory pathogens and strains...
Effect of protein binding on the in vitro activity and pharmacodynamics of faropenem (2002)
Boswell, F. J., Ashby, J. P., Andrews, J. M., Wise, R.
The influence of protein binding upon different aspects of the in vitro activity of faropenem on recently isolated Staphylococcus aureus and respiratory pathogens was determined. The protein binding...
The in vitro activity of BMS-284756, a new des-fluorinated quinolone (2002)
Weller, T. M. A., Andrews, J. M., Jevons, G., Wise, R.
The in vitro activity of BMS-284756 (previously T-3811ME), a des-fluoro(6) quinolone, was investigated and compared with those of six other antimicrobial agents. Susceptibility tests were performed...
Boswell, F. J., Andrews, J. M., Jevons, G., Wise, R.
In this study the in vitro activities and pharmacodynamic properties of moxifloxacin, levofloxacin, gatifloxacin and gemifloxacin were compared on recently isolated respiratory pathogens and strains...
Effect of protein binding on the in vitro activity and pharmacodynamics of faropenem (2002)
Boswell, F. J., Ashby, J. P., Andrews, J. M., Wise, R.
The influence of protein binding upon different aspects of the in vitro activity of faropenem on recently isolated Staphylococcus aureus and respiratory pathogens was determined. The protein binding...
Boswell, F. J., Andrews, J. M., Jevons, G., Wise, R.
In this study the in vitro activities and pharmacodynamic properties of moxifloxacin, levofloxacin, gatifloxacin and gemifloxacin were compared on recently isolated respiratory pathogens and strains...
Effect of protein binding on the in vitro activity and pharmacodynamics of faropenem (2002)
Boswell, F. J., Ashby, J. P., Andrews, J. M., Wise, R.
The influence of protein binding upon different aspects of the in vitro activity of faropenem on recently isolated Staphylococcus aureus and respiratory pathogens was determined. The protein binding...
Nutrient-induced spatial patterning of human duodenal motor function (2001)
Andrews, J. M., Doran, S. M., Hebbard, G. S., Malbert, Charles-Henri, Horowitz, Michael, Dent, John
Published abstract used with permission of the copyright owner.
Effect of a lacto-ovo vegetarian diet on fasting small intestinal motility (2001)
Andrews, J. M., Doran, S. M., Di Matteo, A. C., Leong, L., MacIntosh, C. G., Chiu, C-J., ...
Lung concentrations of telithromycin after oral dosing (2001)
Khair, O. A., Andrews, J. M., Honeybourne, D., Jevons, G., Vacheron, F., Wise, R.
Concentrations of telithromycin were measured in plasma, bronchial mucosa (BM), epithelial lining fluid (ELF) and alveolar macrophages (AM) following multiple oral doses. Concentrations were...
Pharmacokinetics and tissue penetration of gemifloxacin following a single oral dose (2001)
Gee, T., Andrews, J. M., Ashby, J. P., Marshall, G., Wise, R.
The pharmacokinetics and tissue penetration of gemifloxacin were determined during a 24 h period following oral administration of a single 320 mg dose to each of 10 healthy male volunteers....
Wise, R., Andrews, J. M., Ashby, J. P.
The in vitro activity of daptomycin was studied in comparison with other agents active against 328 recent clinical isolates of Gram-positive pathogens. MIC data showed that the addition of calcium...
The in vitro activity of ABT773, a new ketolide antimicrobial agent (2000)
Andrews, J. M., Weller, T. M. A., Ashby, J. P., Walker, R. M., Wise, R.
The in vitro activity of ABT773, a ketolide antimicrobial agent, was investigated and compared with those of seven other antibiotics. Type strains and 733 Gram-positive, Gram-negative and anaerobic...
Andrews, J. M., Boswell, F. J., Wise, R.
In this study the Oxoid Aura image antibiotic sensitivity test system, used as a stand-alone device, was compared with manual zone measurement and use of a template, for the determination of...
Andrews, J. M., Ashby, J. P., Wise, R.
A standardized method of disc testing the sensitivity of Gram-positive pathogens to dalfopristin/quinupristin was developed, and then ‘field tested’ in ten centres in the UK. For a 15 µg disc,...
Honeybourne, D., Andrews, J. M., Cunningham, B., Jevons, G., Wise, R.
The concentrations of clinafloxacin were measured in serum, bronchial mucosa, alveolar macrophages and epithelial lining fluid after single 200 mg oral doses of clinafloxacin had been administered to...
Bactericidal properties of moxifloxacin and post-antibiotic effect (1999)
Boswell, F. J., Andrews, J. M., Wise, R., Dalhoff, A.
The time–kill kinetics and post-antibiotic effect (PAE) of moxifloxacin were studied for strains of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Staphylococcus aureus...
Andrews, J. M., Ashby, J. P., Jevons, G. M., Wise, R.
Tentative MIC and zone diameter breakpoints were determined for moxifloxacin using BSAC criteria. An MIC breakpoint of ≤1 mg/L, denoting sensitivity, is suggested for Enterobacteriaceae,...
The in-vitro activity and tentative breakpoint of gemifloxacin, a new fluoroquinolone (1999)
The in-vitro activity of gemifloxacin, a new fluoroquinolone, against a wide range (c. 700) of recent clinical isolates, was compared with that of three other fluoroquinolones and other relevant...
Wise, R., Andrews, J. M., Ashby, J. P., Marshall, J.
A single 400 mg oral dose of gatifloxacin was given to each of nine healthy male volunteers and the concentrations of the drug in plasma, cantharidine-induced inflammatory fluid and urine were...
Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects. (1997)
Russo, A., Sun, W-M., Sattawatthamrong, Y., Fraser, R., Horowitz, M., Boeckxstaens, G., ...
Altered expression of mucins throughout the colon in ulcerative colitis. (1997)
Smithson, J. E., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., Jewell, D. P.
In-vitro activity of two glycylcyclines against enterococci resistant to other agents (1995)
Fraise, A. P., Brenwald, N., Andrews, J. M., Wise, R.
Two new glycylcyclines, CL 329, 998 and CL 331, 002, were tested for in-vitro activity against 178 clinical strains of enterococci which were resistant to one or more of the commonly used agents...
Mucosal concentration and excretion of clindamycin by the human stomach (1994)
Hextall, A., Radley, S., Andrews, J. M., Boyd, E. J. S., Donovan, I., Wise, R.
Each of 12 patients undergoing routine diagnostic upper gastrointestinal endoscopy received a single iv infusion of clindamycin phosphate 300 mg over 10min. During the endoscopy, mucosal biopsies of...
Catchpole, C., Andrews, J. M., Woodcock, J., Wise, R.
The pharmacokinetics of ciprofloxacin following single doses of 400 mg iv and 750 mg po were compared in six healthy volunteers. Concentrations of ciprofloxacin were measured in plasma, cantharides...
The in-vitro activity of FK-037, a new broad spectrum injectable cephalosporin (1994)
Wise, R., Andrews, J. M., Thornber, D.
The in-vitro activity of the parenteral cephem FK-037 was compared to those of cefpirome, ceftazidime, cefuroxime, cefixime, amoxycillin and co-amoxiclav. Against the Enterobacteriaceae FK-037 was...
The in-vitro activity of OPC-17116, a new 5-methyl substituted quinolone (1993)
Wise, R., Andrews, J. M., Brenwald, N.
The in-vitro activity of the new 5-methylated fluoroquinolone OPC-17116 was compared with that of other fluoroquinolines and β-lactams against a total of 690 bacterial strains. With the exception of...
The in-vitro activity of Bay y 3118, a new chlorofluoroquinolone (1993)
Wise, R., Andrews, J. M., Brenwald, N.
The in-vitro activity of Bay y 3118, a new quinolone antimicrobial was compared with that of ciprofloxacin, sparfioxacin and three β-lactams against 620 clinical isolates. Bay y 3118 was the most...
Lees, A. S., Andrews, J. M., Wise, R.
The pharmacokinetics of loracarbef in plasma and a mild inflammatory exudate were studied in human volunteers. After a single oral dose of 400 mg, a mean maximum drug concentration (Cmax) of 17·8...
In-vitro activity of PD 131628, a new quinolone antimicrobial agent (1992)
Cooper, M. A., Andrews, J. M., Wise, R.
The in-vitro activity of PD 131628, the active metabolite of the prodrug PD 131112, was compared with that of ciprofloxacin and members of other groups of antimicrobial agents against 701 recent...
Absence of bactericidal activity of sparfloxacin and ciprofloxacin under anaerobic conditions (1992)
Baldwin, D.R., Andrews, J.M., Wise, R., Honeybourne, D.
The concentrations of cefuroxime in human alveolar macrophages (AM), epithelial lining fluid (ELF), bronchial mucosal biopsies and serum were measured after a single dose, equivalent to 500 mg of...
In-vitro activity of tosufloxacin, a new quinolone antibacterial agent (1992)
Cooper, M. A., Andrews, J. M., Wise, R.
The in-vitro activity of tosufloxacin (A-61827) was compared with that of temafloxacin, ciprofloxacin and selected members of other groups of antimicrobial agents, against 684 recent distinct...
The in-vitro activity of two new quinolones: rufloxacin and MF 961 (1992)
Wise, R., Andrews, J. M., Matthews, R., Wolstenholme, M.
The in-vitro activity of two new quinolone antimicrobials, rufloxacin and MF 961, together with the desmethylated metabolite of rufloxacin (MF 922) were compared with other orally administered agents...
Reeves, D. S., Holt, H. A., Phillips, I., King, Anna, Miles, R. S., Paton, R., ...
MICs of penicillin, methicillin, clindamycin, erythromycin, sodium fusidate and gentamicin were determined by an agar dilution method for 300 current isolates of Staphylococcus aureus and 100 of S....
In-vitro activity and {beta}-lactamase stability of SR 44337, a new long acting cephalosporin (1991)
Cooper, M. A., Andrews, J. M., Baldwin, D. R., Thornber, D., Wise, R.
The in-vitro activity of SR 44337 was compared with that of other broad-spectrum parenteral cephalosporins, plus imipenem and co-amoxiclav. SR 44337 showed good activity against the...
The in-vitro activity of cefdinir (FK482), a new oral cephalosporin (1991)
Wise, R., Andrews, J. M., Thbornber, D.
The in-vitro activity of cefdinir (FK482), an orally absorbed aminothiazolyl cephalosporin, was compared with that of cefuroxime, cefixime, cephalexin, cefaclor and co-amoxiclav. Cefdinir was highly...
The penetration of cefpirome into the potential sites of pulmonary infection (1991)
Baldwin, D. R., Maxwell, S. R. J., Honeybourne, D., Andrews, J. M., Ashby, J. P., Wise, R.
The concentrations of cefpirome, a new semi-synthetic cephalosponn, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed...
Bactericidal activity of sparfloxacin and ciprofloxacin under anaerobic conditions (1991)
Cooper, M. A., Andrews, J. M., Wise, R.
The kill kinetics of sparfloxacin and ciprofloxacin have been investigated under anaerobic conditions against Bacteroides fragilis and Escherichia coli. The results for E. coli were compared with...
In-vitro susceptibility of Chlamydia pneumoniae (TWAR) to seven antibiotics (1991)
Cooper, M. A., Baldwin, D., Matthews, R. S., Andrews, J. M., Wise, R.
A modification of an immunofluorescence method previously used to study the in-vitro antimicrobial susceptibilities of Chlamydia trachomatis was used to investigate the activity of seven...
Wise, R., Johnson, J., O'Sullivan, N., Andrews, J. M., Imbimbo, B. P.
The pharmacokinetics of rufloxacin after a single 400 mg oral dose were studied in eight volunteers, measuring plasma, inflammatory fluid and urine concentrations. Mean peak plasma concentrations of...
Logan, M. N., Ashby, J. P., Andrews, J. M., Wise, R.
The in-vitro antibacterial activity of clarithromycin, its 14-hydroxy metabolite and a combination containing clarithromycin and the 14-hydroxy metabolite in a ratio of three parts of the former to...
Pharmacokinetics and tissue penetration of cefprozil (1990)
Nye, K., O'Neill, P., Andrews, J. M., Wise, R.
The pharmacokinetics of cefprozil after a single 500 mg oral dose were studied, measuring plasma, inflammatory fluid and urine concentrations. Mean peak plasma concentrations of 9.6mg/l (measured...
The in-vitro activity of cefpodoxime: a comparison with other oral cephalosporins (1990)
Wise, R., Andrews, J. M., Ashby, J. P., Thornber, D.
The in-vitro activity of cefpodoxime was studied in 529 clinical isolates and compared with the activity of other oral β-lactams. Amongst the Enterobacteriaceae cefpodoxime was very active...
Couraud, L., Andrews, J. M., Lecoeur, H., Sultan, E., Lenfant, B.
Eighteen patients undergoing thoracotomy for suspected pulmonary neoplasia were given 200 mg cefpodoxime equivalent by mouth, before operation. Plasma samples were obtained before dose...
Dumont, R., Guetat, F., Andrews, J. M., Sultan, E., Lenfant, B.
Eighteen patients of either sex with pleural effusions underwent aspiration 3, 6 or 12 h after receiving a single oral dose of cefpodoxime proxetil equivalent to 200 mg cefpodoxime. The mean...
Gehanno, P., Andrews, J. M., Ichou, F., Sultan, E., Lenfant, B.
Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations...
In-vitro comparison of the postantibiotic effect of vancomycin and teicoplanin (1990)
Cooper, M. A., Ashby, J. P., Andrews, J. M., Wise, R.
The post-antibiotic effect (PAE) of teicoplanin was compared with that of vancomycin for five selected Gram-positive cocci. Two concentrations of each antibiotic were investigated, with the test...
Wise, R., Andrews, J. M., Ashby, J. P., Thornber, D.
The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral β-lactam agents. Ceftibuten displayed high activity against Haemophilus...
In-vitro activity of cefodizime against respiratory pathogens (1990)
Wise, R., Andrews, J. M., Ashby, J. P.
The in-vitro activity of cefodizime was studied against respiratory pathogens and was compared with the activity of other β-lactams, ciprofloxacin and erythromycin. Cefodizime displayed high...
In-vitro activity of sparfloxacin, a new quinolone antimicrobial agent (1990)
Cooper, M. A., Andrews, J. M., Ashby, J. P., Matthews, R. S., Wise, R.
The in-vitro activity of sparfloxacin (AT-4140), a new difluorinated quinolone, was compared with those of ciprofloxacin, temafloxacin and selected members of other groups of antimicrobial agents,...
Chadha, D., Wise, R., Baldwin, D. R., Andrews, J. M., Ashby, J. P., Honeybonrne, D.
The concentrations of cefepime in bronchial mucosa were measured after intravenous administration of a single 2 g dose in 20 patients undergoing diagnostic fibreoptic bronchoscopy. These...
The antibacterial activity of meropenem in combination with gentamicin or vancomycin (1989)
Wise, R., Ashby, J. P., Andrews, J. M.
The kinetics of bacterial killing by meropenem alone and in combination with gentamicin (for Pseudomonas aeruginosa) and vancomycin (for Staphylococcus aweus) were studied for two strains of each...
The in-vitro activity, pharmacokinetics and tissue penetration of temafloxacin (1989)
Nye, K., Shi, Y. G., Andrews, J. M., Ashby, J. P., Wise, R.
The in-vitro activity of temafloxacin compared with other quinolone antibiotics was evaluated using 579 bacterial strains and three isolates of Chlamydia trachomatis. The MICs of temafloxacin for...
Pharmacokinetics and tissue penetration of cefepime (1989)
Nye, K. J., Shi, Y. G., Andrews, J. M., Wise, R.
The pharmacokinetics of cefepime were studied following a 2 g intravenous infusion, by measuring concentrations in plasma, inflammatory fluid and urine. Mean peak plasma concentrations of 193·1...
Cefixime, in-vitro activity, pharmacokinetics and tissue penetration (1989)
Stone, J. W., Linong, Guan, Andrews, J. M., Wise, R.
The in-vitro activity of cefixime was studied with clinical isolates and compared with that of other agents. Cefixime exhibited good activity against the Enterobacteriaceae, Haemophilus influenzae,...
The penetration of fleroxacin into bronchial mucosa (1988)
Wise, R., Honeybourne, D., Andrews, J. M., Ashby, J. P.
Twenty patients undergoing fibreoptic endoscopy received 400 mg of fleroxacin once a day for four days. Bronchial biopsies were performed 2.7–5.9 h following the final dose of fleroxacin. A...
Webberley, J. M., Wise, R., Andrews, J. M., Ashby, J. P., Wallbridge, D.
One gram each of FCE 22101 and its acetoxymethyl ester (FCE 22891) were administered sequentially to six healthy volunteers. After intravenous administration Cmax was 167 mg/l, and the...
The pharmacokinetics and tissue penetration of intravenously administered CGP 31608 (1988)
Wise, R., Webberley, J. M., Andrews, J. M., Ashby, J. P.
The pharmacokinetics of CGP 31608, a new injectable penem antibiotic, were studied following a 1 g intravenous infusion. Concentrations were determined in serum, urine and cantharidin-induced...
Pharmacokinetics and tissue penetration of cefpirome, a new cephalosporin (1988)
Kavi, J., Andrews, J. M., Ashby, J. P., Hillman, G., Wise, R.
The pharmacokinetics and tissue penetration (as measured by a blister fluid model) of cefpirome were studied in six male volunteers following a 1 g intravenous dose. A mean peak serum concentration...
Factors affecting the in-vitro activity of roxithromycin (1987)
Andrews, J.M., Ashby, J.P., Wise, R.
The effect of human serum and CO2 on the activity of roxithromycin and erythromycin was assessed. Protein binding of roxithromycin in serum from various animal sources, acid αl-glycoprotein and...
The pharmacokinetics and tissue penetration of teicoplanin (1986)
McNulty, C. A. M., Garden, G. M. F., Wise, R., Andrews, J. M.
The pharmacokinetics of teicoplanin were studied following a 440 mg intravenous dose in six male volunteers. The levels of the compound were measured in serum, blister fluid and urine. The mean serum...
The antimicrobial activity of cefpirome, a new cephalosporin (1985)
Wise, R., Andrews, J. M., Cross, C., Piddock, L. J. V.
The activity of the extended spectrum cephalosponn cefpirome (HR 810) was compared with that of other /Mactams and gentamicin. A total of 524 clinical isolates and strains known to be resistant...
Wise, R., Andrews, J. M., Piddock, L. J. V.
The susceptibility of 554 recent clinical isolates and known resistant bacterial strains to the new monocyclic β-lactam Ro 17–2301 were studied and compared to that to other β-lactams (including...
Polarization fluoroimmunoassay (Abbott TDX) and the homogeneous enzyme immunoassay (Syva, EMIT) both allowed the rapid, accurate and precise assay of gentamicin. The presence of other antibiotics,...
Wise, R., Andrews, J. M., Danks, G.
The in-vitro activity of enoxacin (CI-919), a new synthetic quinoline derivative was compared with that of three other quinolines ofloxacin, norfloxacin and nalidixic acid. In addition β-lactams and...
International collaborative study on standardization of bacterial sensitivity to fosfomycin (1983)
Andrews, J. M., Baquero, F., Beltran, J. M., Canton, E., Crokaert, F., Gobernado, M., ...
An international collaborative study was undertaken involving 6 working groups to correlate the zone sizes obtained with 50 μg fosfomycin+25 μg glucose-6-phosphate (G6P) and 50 μg fosfomycin...
The penetration of amoxycillin/clavulanic acid into peritoneal fluid (1983)
Wise, R., Donovan, I.A., Drumm, J., Andrews, J.M., Stephenson, P.
Thirty patients undergoing elective abdominal surgery were given 1 g amoxycillin plus 0.2 g clavulanic acid as a single intravenous injection at varying times prior to the operation. Sterile assay...
Brown, R. M., Wise, R., Andrews, J. M.
Sch 29482 (SCH) is a penem antibiotic and its in-vitro activity was compared with other β-lactams including N-formimidoyl-thienamycin (MK 0787) and the novel monobactam SQ 26776 (azthreonam). SCH...
The activity of mezlocillin was compared with that of carbenicillin, ticarcillin and azlocillin against a wide range of Gram-negative organisms. Meziocillin was considerably more active than...
Brown, R. M., Wise, R., Andrews, J. M.
The in-vitro activity of temocillin was studied using recent clinical isolates and its activity was compared with that of other agents. Temocillin was active against the Enterobacteriaceae (the...
Wise, R., Andrews, J. M., Patel, N.
The in-vitro activities of N-formimidoyl-thienamycin were compared with those of other β-lactam antibiotics. N-formimidoyl-thienamycin was highly active against Enterobacteriaceae (MIC90 0·5 to 8...
6-{beta}-Bromo- and 6-{beta}-iodo penicillanic acid, two novel {beta}-lactamase inhibitors (1981)
Wise, R., Andrews, J. M., Patel, N.
6-β-bromo penicillanic acid and 6-β-iodo penicillanic acid, two simple penicillanic acid derivatives were compared with clavulanic acid and sulbactam as to their β-lactamase inhibitory properties....
Cefoperazone and cefotiam--two new cephalosporins: an in-vitro comparison (1981)
Wise, R., Andrews, J. M., Bedford, K. A.
The in vitro activity of cefoperazone (CPZ) and cefotiam (CTM) was compared to other available cephalosporins. Using an agar dilution procedure both CTM and CPZ were more active against the...
Effect of food on the bioavailability of alafosfalin, a new antibacterial agent (1980)
Welling, P. G., Kendall, M. J., Dean, S., Wise, R., Andrews, J. M.
Alafosfalin, a new antibacterial agent, is a dipeptide mimetic which is rapidly but incompletely absorbed. Since the first pass loss could be caused by digestion of the drug by intestinal peptidases,...
Wise, R., Andrews, J. M., Bedford, K. A.
Two β-lactamase inhibitors, clavulanic acid and CP-45, 899 were compared in vitro. Against a wide range of Gram-negative and positive organisms both compounds, when combined with a β-lactam...
Wise, R., Gillett, A. P., Andrews, J. M., Bedford, K. A.
The activity of the new cephalosporin Ro 13–9904 (Ro) was compared with other β-lactams against 303 clinical bacterial isolates. Against the Enterobacteriaceae Ro was highly active, 90% of...
The in vitro activity of mezlocillin when combined with cefoxitin or clavulanic acid (1979)
Wise, R., Gillett, A. P., Andrews, J. M.
Mezlocillin is a potent broad spectrum antimicrobial but is susceptible to a wide range of β-lactamases. In this investigation the combination of cefoxitin and clavulanic acid upon the in vitro...
Mezlocillin and azlocillin: an evaluation of two new {beta}-lactam antibiotics (1979)
Ellis, C. J., Geddes, A. M., Darey, P. G., Wise, R., Andrews, J. M, Grimley, R. P.
Mezlocillin and azlocillin are broad spectrum penicillins for parenteral administration. In this study it was shown that they were very active against a wide range of pathogenic bacteria. Thirty-five...
A pharmacological and in vitro comparison of three oral cephalosporins (1979)
Wise, R., Andrews, J. M., Dean, S., Welling, P. G., Kendall, M. J.
The pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. Cefaclor was absorbed rapidly and was cleared from the serum more rapidly than...
A pharmacological study of UK-18,892 and amikacin (1978)
Kendall, M. J., Wise, R., Andrews, J. M., Bedford, K. A.
UK-18,892 is a new broad spectrum aminoglycoside structurally related to amikacin. In an 8 volunteer single blind cross-over study the pharmacology of UK-18,892 was compared with amikacin. A 250-mg...
Pirbenicillin-a semi-synthetic penicillin with antipseudomonal activity (1977)
Wise, R., Andrews, J. M., Bedford, K. A.
Pirbenidihin, a semi-synthetic penicillin, structurally related to ampicillin, was investigated as to its in vitro activity. The drug was found to exhibit a higher degree of activity against...
The antimicrobial effect of combinations of clindamycin and metronidazole with spectinomycinn (1975)
Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa.
Honeybourne, D, Andrews, J M, Ashby, J P, Lodwick, R, Wise, R
The concentrations of two antibiotics, amoxycillin and ciprofloxacin, were measured by microbiological assay in serum and in bronchial mucosa obtained at fibreoptic bronchoscopy in 38 patients...
Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens.
Baldwin, D R, Andrews, J M, Ashby, J P, Wise, R, Honeybourne, D
In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The...
Microlavage: a technique for determining the volume of epithelial lining fluid.
Baldwin, D R, Wise, R, Andrews, J M, Honeybourne, D
A new technique ("microlavage") was used to determine the volume of epithelial lining fluid recovered by bronchoalveolar lavage. A standard bronchial brush tube is used to lavage a peripheral lung...
Quantitative morphology and water distribution of bronchial biopsy samples.
Baldwin, D R, Wise, R, Andrews, J M, Honeybourne, D
BACKGROUND: An approach to the study of the pharmacokinetics of drugs in the lung is to measure their concentrations in bronchial biopsy specimens. The main criticism of this technique is that...
Cook, P J, Andrews, J M, Woodcock, J, Wise, R, Honeybourne, D
BACKGROUND--The efficacy of an antibiotic is usually predicted from serum levels and MIC90 values for likely pathogens, but in the lung tissue concentrations may be more informative. This study...
Effects of suspended residual spraying and of imported malaria on malaria control in the USA
Andrews, J. M., Grant, Jean S., Fritz, R. F.
The activities of the National Malaria Eradication Programme, a co-operative campaign inaugurated in July 1947 by the United States Public Health Service and certain State and local health agencies,...