Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells (2009)
Wlodkowic, D., Skommer, J., McGuinness, D., Faley, S., Kolch, W., Darzynkiewicz, Z., ...
Cell cytotoxicity tests are among the most common bioassays using flow cytometry and fluorescence imaging analysis. The permeability of plasma membranes to charged fluorescent probes serves, in these...
Local regional stimulation of single isolated ventricular myocytes using microfluidics (2009)
Klauke, N., Smith, G.L., Cooper, J.M.
The regional manipulation of the microenvironment surrounding single adult cardiac myocytes in a microfluidic structure is described. The flow rates of laminar streams were adjusted such that the...
Faley, S.L., Copland, M., Wlodkowic, D., Kolch, W., Seale, K.T., Wikswo, J.P., ...
Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a...
A SENSOR SYSTEM ON CHIP FOR WIRELESS MICROSYSTEMS (2008)
L. Wang, N. Aydin, A. Astaras, M. Ahmadian, P. A. Hammond, T. B. Tang, ...
Recent years have seen the rapid development of microsensor technology, system on chip design, wireless technology and ubiquitous computing. When assembled into a complex microsystem the technologies...
Cooper, J.M., Schmidt, C.S., Lueck, L., Shotton, P.N., Leifert, C.
The Nafferton Factorial Systems Comparison (NFSC) experiments are part of a long-term field trial that compares organic and conventional systems of crop rotation, crop protection and fertility...
Cooper, J.M., Schmidt, C.S., Lueck, L., Shotton, P.N., Leifert, C.
The Nafferton Factorial Systems Comparison (NFSC) experiments are part of a long-term field trial that compares organic and conventional systems of crop rotation, crop protection and fertility...
Leifert, C., Ball, K., Volakakis, N., Cooper, J.M.
Risks from pathogens such as Salmonella, Yersinia, Campylobacter and Escherichia coli O157 have been identified as a particular concern for organic and ‘low input’ food production systems that...
Leifert, C., Ball, K., Volakakis, N., Cooper, J.M.
Risks from pathogens such as Salmonella, Yersinia, Campylobacter and Escherichia coli O157 have been identified as a particular concern for organic and ‘low input’ food production systems that...
The mitBASE human dataset structure (2007)
Attimonelli Cal, M. Attimonelli, D. Cal, J. M. Cooper, F. Licciulli, D. Sasanelli, ...
MitBASE is a comprehensive and integrated mitochondrial genome database funded within the EU BIOTECH PROGRAM. It is a project for the development and implementation of an integrated and comprehensive...
Zhang, X., Yin, H., Cooper, J.M., Haswell, S.J.
The integration of a range of technologies including microfluidics, surface-enhanced Raman scattering and confocal microspectroscopy has been successfully used to characterize in situ single living...
Influence of hydrodynamic conditions on quantitative cellular assays in microfluidic systems (2007)
Yin, H., Zhang, X., Pattrick, N., Klauke, N., Cordingley, H.C., Haswell, S.J., ...
Cooper, J. M., Schmidt, C. S., Lueck, L., Shotton, P. N., Turnbull, C., Leifert, C.
The effect of organic, low-input and conventional management practices on barley yield and disease incidence was assessed in field trials over two years. Conventional fertility management (based on...
Lueck, L., Schmidt, C.S., Cooper, J.M., Shotton, P.N., Hajslova, J., Schulzova, V., ...
The Nafferton factorial systems comparison (NFSC) experiments facilitate the investigation of effects of, and interaction between, three production system components - a) rotational position, b)...
Effects of organic and ‘low input’ production methods on food quality and safety (2007)
Leifert, C., Rembiałkowska, E., Nielson, J.H., Cooper, J.M., Butler, G., Lueck, L.
The intensification of agricultural production in the last century has resulted in a significant loss of biodiversity, environmental problems and associated societal costs. The use of shorter...
N released from organic amendments is affected by soil management history (2007)
Palmer, M., Cooper, J.M, Fließbach, A., Melville, J., Turnbull, C., Shotton, P., ...
A ryegrass bioassay was conducted to investigate the effect of soil management history on nitrogen mineralisation from composted manure and pelleted poultry manure. Soils were used from 2 field...
Wilkinson, A., Young, D., Lueck, L., Cooper, J. M., Wilkockson, S, Leifert, C.
Yield and protein content of wheat produced under organic standards was repeatedly shown to be between 20 and 40% lower than levels achieved in conventional farming systems. This is thought to be at...
Cooper, J. M., Schmidt, C. S., Lueck, L., Shotton, P. N., Turnbull, C., Leifert, C.
The effect of organic, low-input and conventional management practices on barley yield and disease incidence was assessed in field trials over two years. Conventional fertility management (based on...
Lueck, L., Schmidt, C.S., Cooper, J.M., Shotton, P.N., Hajslova, J., Schulzova, V., ...
The Nafferton factorial systems comparison (NFSC) experiments facilitate the investigation of effects of, and interaction between, three production system components - a) rotational position, b)...
N released from organic amendments is affected by soil management history (2007)
Palmer, M., Cooper, J.M, Fließbach, A., Melville, J., Turnbull, C., Shotton, P., ...
A ryegrass bioassay was conducted to investigate the effect of soil management history on nitrogen mineralisation from composted manure and pelleted poultry manure. Soils were used from 2 field...
Wilkinson, A., Young, D., Lueck, L., Cooper, J. M., Wilkockson, S, Leifert, C.
Yield and protein content of wheat produced under organic standards was repeatedly shown to be between 20 and 40% lower than levels achieved in conventional farming systems. This is thought to be at...
Effects of organic and ‘low input’ production methods on food quality and safety (2007)
Leifert, C., Rembiałkowska, E., Nielson, J.H., Cooper, J.M., Butler, G., Lueck, L.
The intensification of agricultural production in the last century has resulted in a significant loss of biodiversity, environmental problems and associated societal costs. The use of shorter...
Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments (2006)
Johannessen, E.A., Wang, L., Wyse, C., Cumming, D.R.S., Cooper, J.M.
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These...
Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons (2006)
Schapira, A.H.V., Cleeter, M.W.J., Muddle, J.R., Workman, J.M., Cooper, J.M., King, R.H.M.
Dysfunction of the ubiquitin-proteasomal system (UPS) has been implicated in the pathogenesis of Parkinson's disease. The systemic administration of UPS inhibitors has been reported to induce...
A multiplexed impedance analyzer for characterizing polymer-coated QCM sensor arrays (2006)
Mills, C.A., Chai, K.T.C., Milgrew, M.J., Glidle, A., Cooper, J.M., Cumming, D.R.S.
This paper describes the development and evaluation of a custom-built impedance analyzer, which uses a multiplexing bridge circuit to characterize an array of polymer-coated quartz crystal...
Continuous flow separation of particles within an asymmetric microfluidic device (2006)
Zhang, X., Cooper, J.M., Monaghan, P.B., Haswell, S.J.
A microfluidic based device has been developed for the continuous separation of polymer microspheres, taking advantage of the flow characteristics of systems. The chip consists of an asymmetric...
Docherty, F.T., Monaghan, P.B., McHugh, C.J., Graham, D., Smith, W.E., Cooper, J.M.
Raman spectroscopy is a form of vibrational spectroscopy that is well suited to the molecular identification of a variety of analytes, including both explosives and biologicalagents. The technique...
Docherty, F.T., Monaghan, P.B., McHugh, C.J., Graham, D., Smith, W.E., Cooper, J.M.
Raman spectroscopy is a form of vibrational spectroscopy that is well suited to the molecular identification of a variety of analytes, including both explosives and biologicalagents. The technique...
Docherty, F.T., Monaghan, P.B., McHugh, C.J., Graham, D., Smith, W.E., Cooper, J.M.
Raman spectroscopy is a form of vibrational spectroscopy that is well suited to the molecular identification of a variety of analytes, including both explosives and biologicalagents. The technique...
A programmable microsystem using system-on-chip for real-time biotelemetry (2005)
Wang, L., Johannessen, E.A., Hammond, P.A., Cui, L., Reid, S.W.J., Cooper, J.M., ...
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip...
On chip PCR with electrochemical detection for clinical diagnosis (2005)
Elejalde, N., Keay, R W, Flower, S E, Jenkins, A T A, Edwards, G, Peter, L M, ...
Role of oxidative damage in Friedreich's Ataxia (2004)
Bradley, J.L., Homayoun, S., Hart, P.E., Schapira, A.H.V., Cooper, J.M.
Plasma malondialdehyde (MDA) levels were raised in Friedreich's ataxia (FRDA) patients. These levels correlated with increasing age and disease duration, suggesting lipid peroxidation increased with...
The first SERRS multiplexing from labelled oligonucleotides in a microfluidics lab-on-a-chip (2004)
Docherty, F.T., Monaghan, P.B., Keir, R., Graham, D., Smith, W.E., Cooper, J.M.
The first simultaneous detection of three dye-labelled oligonucleotides in a microfluidics chip by SERRS is reported.
The first SERRS multiplexing from labelled oligonucleotides in a microfluidics lab-on-a-chip (2004)
Docherty, F.T., Monaghan, P.B., Keir, R., Graham, D., Smith, W.E., Cooper, J.M.
The first simultaneous detection of three dye-labelled oligonucleotides in a microfluidics chip by SERRS is reported.
The first SERRS multiplexing from labelled oligonucleotides in a microfluidics lab-on-a-chip (2004)
Docherty, F.T., Monaghan, P.B., Keir, R., Graham, D., Smith, W.E., Cooper, J.M.
The first simultaneous detection of three dye-labelled oligonucleotides in a microfluidics chip by SERRS is reported.
Dynamic in situ electrochemical neutron reflectivity measurements (2004)
Cooper, J.M., Cubitt, R., Dalgleish, R.M., Gadegaard, N., Glidle, A., Hillman, A.R., ...
Validation of a method for collection and assay of pentane in the exhaled breath of the horse (2004)
Wyse, C.A., Love, S., Christley, R.M., Yam, P.S, Cooper, J.M., Cumming, D.R.S., ...
Oxidative stress refers to an imbalance between the production of oxidising free radicals and the antioxidant defenses of the cell, and is associated with many pathogenic processes. Oxidative damage...
McNay, G., Docherty, F.T., Graham, D., Smith, W.E., Jordan, P., Padgett, M., ...
No abstract available.
Current and future uses of breath analysis as a diagnostic tool (2004)
Wyse, C.A., Preston, T., Yam, P.S., Sutton, D.G.M., Christley, R.M., Hotchkiss, J.W., ...
The analysis of exhaled breath is a potentially useful method for application in veterinary diagnostics. Breath samples can be easily collected from animals by means of a face mask on chamber with...
Wyse, C.A., Yam, P.S., Slater, C., Cooper, J.M., Preston, T.
The objective of this study was to assess post-gastric processing of octanoic acid (OA) by comparing the rate of recovery of C-13 in breath with the rate of recovery of H-2 in saliva following...
SERRS. In situ substrate formation and improved detection using microfluidics (2002)
Keir, R., Igata, E., Arundell, M., Smith, W.E., Graham, D., McHugh, C., ...
Surface-enhanced resonance Raman scattering (SERRS) of a model derivative of TNT was detected using a microflow cell designed within the framework of the lab-on-a-chip concept, using only the analyte...
SERRS. In situ substrate formation and improved detection using microfluidics (2002)
Keir, R., Igata, E., Arundell, M., Smith, W.E., Graham, D., McHugh, C., ...
Surface-enhanced resonance Raman scattering (SERRS) of a model derivative of TNT was detected using a microflow cell designed within the framework of the lab-on-a-chip concept, using only the analyte...
SERRS. In situ substrate formation and improved detection using microfluidics (2002)
Keir, R., Igata, E., Arundell, M., Smith, W.E., Graham, D., McHugh, C., ...
Surface-enhanced resonance Raman scattering (SERRS) of a model derivative of TNT was detected using a microflow cell designed within the framework of the lab-on-a-chip concept, using only the analyte...
Interconnected reversible lab on a chip technology (2002)
Arudell, M, Igata , E, Morgan, Hywel, Cooper, J.M
Interconnected lab-on-a-chip modules with minimal dead volume have been developed resulting in the plug and play concept based upon a reversible bonding process. This paper describes the detail of a...
Lodi, R., Rajagopalan, B., Blamire, A.M., Cooper, J.M., Davies, C.H., Bradley, J.L., ...
Objective: Friedreich ataxia (FRDA), the commonest form of inherited ataxia, is often associated with cardiac hypertrophy and cardiac dysfunction is the most frequent cause of death. In 97%, FRDA is...
Rafique, R., Schapira, A.H.V., Cooper, J.M.
Rats fed a vitamin E-depleted diet for 48 weeks had undetectable levels of vitamin E in the gastrocnemius muscle and liver, leading to elevated malondialdehyde levels in both tissues and an elevated...
Lodi, R., Hart, P.E., Rajagopalan, B., Taylor, D.J., Crilley, J.G., Bradley, J.L., ...
Friedreich's ataxia (FA) is the most common form of autosomal recessive spinocerebellar ataxia and is often associated with a cardiomyopathy. The disease is caused by an expanded intronic GAA repeat,...
Wyse, C.A., Preston, T., Love, S., Morrison, D.J., Cooper, J.M., Yams, P.S.
Objective—To assess the 13C-octanoic acid breath test for determining gastric emptying in dogs. Animals—6 healthy adult dogs. Procedure—Food was withheld for 12 hours before each test. Expired...
MitBASE: a comprehensive and integrated mitochondrial DNA database. The present status (2000)
Attimonelli, M., Altamatura, N., Benne, R., Brennicke, A., Cooper, J.M., D'Elia, D., ...
MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status (2000)
Attimonelli, M., Altamura, N., Benne, R., Brennicke, A., Cooper, J. M., DElia, D., ...
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects, under a single interface, databases for Plant, Vertebrate, Invertebrate, Human, Protist and Fungal mtDNA...
MitBASE: a comprehensive and integrated mitochondrial DNA database (1999)
Antimonelli, M., Altamura, N., Benne, R., Boyen, C., Brennicke, A., Carone, A., ...
Mitochondrial DNA in idiopathic cardiomyopathy (1998)
Turner, L.F., Kaddoura, S., Harrington, D., Cooper, J.M., Poole-Wilson, P.A., Schapira, A.H.V.
Aims To investigate the frequency of pathogenic mitochondrial DNA mutations in idiopathic cardiomyopathy. Methods and Results We investigated the occurrence of seven previously reported pathogenic...
The mitBASE human dataset structure © 1998 Oxford University Press (1997)
M. Attimonelli, D. Caló, J. M. Cooper, A. De Montalvo, F. Licciulli, D. Sasanelli, ...
MitBASE is a comprehensive and integrated mitochondrial genome database funded within the EU BIOTECH PROGRAM. It is a project for the development and implementation of an integrated and comprehensive...
J. M. Cooper, K. A. Enns, M. G. Shepard, J. M. Cooper, K. A. Enns, M. G. Shepard
xi British Columbia, Canada’s most westerly province, has a bounty of biological diversity. British Columbia’s snowclad peaks, rain-drenched forests, arid grasslands, all sizes of rivers, lakes,...
STATUS OF THE BAY-BREASTED WARBLER IN BRITISH COLUMBIA by (1997)
J. M. Cooper, K. A. Enns, M. G. Shepard, J. M. Cooper, K. A. Enns, M. G. Shepard, ...
xi British Columbia, Canada’s most westerly province, has a bounty of biological diversity. British Columbia’s snowclad peaks, rain-drenched forests, arid grasslands, all sizes of rivers, lakes,...
MILLER, J. D., COOPER, J. M., MILLER, H. G.
Litterfall from both control and fertilized (NPK) plots was collected over a 5-year period from trees aged 25–30 in six stands of Sitka spruce (Picea sitchensis (Bong.) Carr.) stratified by...
Ministry of Environment, Lands and Parks (1995)
J. M. Cooper, Wildlife Branch, J. M. Cooper, Wildlife Branch
i “Wildlife Working Reports frequently contain preliminary data, so conclusions based on these may be subject to change. Working Reports receive little review. They may be cited in publications,...
A new point mutation associated with mitochondrial encephalomyopathy (1993)
Morten, K.J., Cooper, J.M., Brown, G.K., Lake, B.D., PIke, D., Poulton, J.
Point mutations In the mitochondrlal gene tRNA leucine(UUR) have been associated with maternally Inherited mItochondrlal myopathies Including the MELAS syndrome (Mitochondrial Myopathy Encephalopathy...
TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE (1992)
COOPER, J. M., HAYES, D. J., CHALLISS, R. A. J., MORGAN-HUGHES, J. A., CLARK, J. B.
Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been...
TREATMENT OF EXPERIMENTAL NADH UBIQUINONE REDUCTASE DEFICIENCY WITH MENADIONE (1992)
COOPER, J. M., HAYES, D. J., CHALLISS, R. A. J., MORGAN-HUGHES, J. A., CLARK, J. B.
Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been...
MILLER, H. G., COOPER, J. M., MILLER, J. D.
Although there are many reports of growth responses to fertilizer N, P or K in young stands, and to fertilizer N in old stands, there are relatively few reported responses in pole-stage or...
Ring-width measurements on trees felled in a nitrogen-deficient pole-stage crop of Corsican pine on the sand dunes of Culbin forest (Morayshire) showed that, in addition to a growth check ascribed...
Elbert Emerson Cooper (1812-1880) was born in Kentucky and married Nancy Wann in 1833 in Tennessee. They moved to Missouri and then to Oregon. Includes Mann, Gildow, Craft and related families. At...
Elbert Emerson Cooper (1812-1880) was born in Kentucky and married Nancy Wann in 1833 in Tennessee. They moved to Missouri and then to Oregon. Includes Mann, Gildow, Craft and related families. At...
Validation of a method for collection and assay of pentane in the exhaled breath of the horse
Wyse, C.A., Love, S., Christley, R.M., Yam, P.S, Cooper, J.M., Cumming, D.R.S., ...
Oxidative stress refers to an imbalance between the production of oxidising free radicals and the antioxidant defenses of the cell, and is associated with many pathogenic processes. Oxidative damage...
Wyse, C.A., Yam, P.S., Slater, C., Cooper, J.M., Preston, T.
The objective of this study was to assess post-gastric processing of octanoic acid (OA) by comparing the rate of recovery of C-13 in breath with the rate of recovery of H-2 in saliva following...
Use of the C-13-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs
Wyse, C.A., Preston, T., Love, S., Morrison, D.J., Cooper, J.M., Yams, P.S.
Objective—To assess the 13C-octanoic acid breath test for determining gastric emptying in dogs. Animals—6 healthy adult dogs. Procedure—Food was withheld for 12 hours before each test. Expired...
Visual observations of SERRS from single silver-coated silica microparticles within optical tweezers
McNay, G., Docherty, F.T., Graham, D., Smith, W.E., Jordan, P., Padgett, M., ...
No abstract available.
Current and future uses of breath analysis as a diagnostic tool
Wyse, C.A., Preston, T., Yam, P.S., Sutton, D.G.M., Christley, R.M., Hotchkiss, J.W., ...
The analysis of exhaled breath is a potentially useful method for application in veterinary diagnostics. Breath samples can be easily collected from animals by means of a face mask on chamber with...
MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status
Attimonelli, M., Altamura, N., Benne, R., Brennicke, A., Cooper, J. M., D’Elia, D., ...
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects, under a single interface, databases for Plant, Vertebrate, Invertebrate, Human, Protist and Fungal mtDNA...
The mitBASE human dataset structure.
Attimonelli, M, Caló, D, Cooper, J M, De Montalvo, A, Licciulli, F, Sasanelli, D, ...
MitBASE is a comprehensive and integrated mitochondrial genome database funded within the EU BIOTECH PROGRAM. It is a project for the development and implementation of an integrated and comprehensive...
MitBASE: a comprehensive and integrated mitochondrial DNA database.
Attimonelli, M, Altamura, N, Benne, R, Boyen, C, Brennicke, A, Carone, A, ...
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects all available information from different organisms and from intraspecie variants and mutants. Research...
Update of the Human MitBASE database.
Attimonelli, M, Cooper, J M, D'Elia, D, De Montalvo, A, De Robertis, M, Lehväslaiho, H, ...
Human MitBASE is a database collecting human mtDNA variants. This database is part of a greater mitochondrial genome database (MitBASE) funded within the EU Biotech Program. The present paper reports...
Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication.
Bodnar, A G, Cooper, J M, Leonard, J V, Schapira, A H
We have characterized cultured skin fibroblasts from two siblings affected with a fatal mitochondrial disease caused by a nuclear genetic defect. Mitochondrial respiratory-chain function was severely...
Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency.
Rafique, R, Schapira, A H, Cooper, J M
Rats fed a vitamin E-depleted diet for 48 weeks had undetectable levels of vitamin E in the gastrocnemius muscle and liver, leading to elevated malondialdehyde levels in both tissues and an elevated...
Thomas, P K, Cooper, J M, King, R H, Workman, J M, Schapira, A H, Goss-Sampson, M A, ...
Vitamin E deficiency in rats gives rise to a neuromuscular syndrome that includes a peripheral neuropathy as well as generalised muscle wasting and weakness. This is probably related to damage by...
Nuclear complementation restores mtDNA levels in cultured cells from a patient with mtDNA depletion.
Bodnar, A G, Cooper, J M, Holt, I J, Leonard, J V, Schapira, A H
We have studied cultured skin fibroblasts from a patient with a fatal mitochondrial disease manifesting soon after birth. These fibroblasts were found to grow only in the presence of pyruvate and...
MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status
Attimonelli, M., Altamura, N., Benne, R., Brennicke, A., Cooper, J. M., D’Elia, D., ...
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects, under a single interface, databases for Plant, Vertebrate, Invertebrate, Human, Protist and Fungal mtDNA...
The mitBASE human dataset structure.
Attimonelli, M, Caló, D, Cooper, J M, De Montalvo, A, Licciulli, F, Sasanelli, D, ...
MitBASE is a comprehensive and integrated mitochondrial genome database funded within the EU BIOTECH PROGRAM. It is a project for the development and implementation of an integrated and comprehensive...
MitBASE: a comprehensive and integrated mitochondrial DNA database.
Attimonelli, M, Altamura, N, Benne, R, Boyen, C, Brennicke, A, Carone, A, ...
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects all available information from different organisms and from intraspecie variants and mutants. Research...
Update of the Human MitBASE database.
Attimonelli, M, Cooper, J M, D'Elia, D, De Montalvo, A, De Robertis, M, Lehväslaiho, H, ...
Human MitBASE is a database collecting human mtDNA variants. This database is part of a greater mitochondrial genome database (MitBASE) funded within the EU Biotech Program. The present paper reports...
Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication.
Bodnar, A G, Cooper, J M, Leonard, J V, Schapira, A H
We have characterized cultured skin fibroblasts from two siblings affected with a fatal mitochondrial disease caused by a nuclear genetic defect. Mitochondrial respiratory-chain function was severely...
Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency.
Rafique, R, Schapira, A H, Cooper, J M
Rats fed a vitamin E-depleted diet for 48 weeks had undetectable levels of vitamin E in the gastrocnemius muscle and liver, leading to elevated malondialdehyde levels in both tissues and an elevated...
Thomas, P K, Cooper, J M, King, R H, Workman, J M, Schapira, A H, Goss-Sampson, M A, ...
Vitamin E deficiency in rats gives rise to a neuromuscular syndrome that includes a peripheral neuropathy as well as generalised muscle wasting and weakness. This is probably related to damage by...
Nuclear complementation restores mtDNA levels in cultured cells from a patient with mtDNA depletion.
Bodnar, A G, Cooper, J M, Holt, I J, Leonard, J V, Schapira, A H
We have studied cultured skin fibroblasts from a patient with a fatal mitochondrial disease manifesting soon after birth. These fibroblasts were found to grow only in the presence of pyruvate and...
Hanna, M G, Nelson, I, Sweeney, M G, Cooper, J M, Watkins, P J, Morgan-Hughes, J A, ...
We report the clinical, biochemical, and molecular genetic findings in a family with an unusual mitochondrial disease phenotype harboring a novel mtDNA tRNA glutamic acid mutation at position 14709....
Validation of a method for collection and assay of pentane in the exhaled breath of the horse
Wyse, C.A., Love, S., Christley, R.M., Yam, P.S, Cooper, J.M., Cumming, D.R.S., ...
Oxidative stress refers to an imbalance between the production of oxidising free radicals and the antioxidant defenses of the cell, and is associated with many pathogenic processes. Oxidative damage...
Wyse, C.A., Yam, P.S., Slater, C., Cooper, J.M., Preston, T.
The objective of this study was to assess post-gastric processing of octanoic acid (OA) by comparing the rate of recovery of C-13 in breath with the rate of recovery of H-2 in saliva following...
Use of the C-13-octanoic acid breath test for assessment of solid-phase gastric emptying in dogs
Wyse, C.A., Preston, T., Love, S., Morrison, D.J., Cooper, J.M., Yams, P.S.
Objective—To assess the 13C-octanoic acid breath test for determining gastric emptying in dogs. Animals—6 healthy adult dogs. Procedure—Food was withheld for 12 hours before each test. Expired...
Visual observations of SERRS from single silver-coated silica microparticles within optical tweezers
McNay, G., Docherty, F.T., Graham, D., Smith, W.E., Jordan, P., Padgett, M., ...
No abstract available.
Current and future uses of breath analysis as a diagnostic tool
Wyse, C.A., Preston, T., Yam, P.S., Sutton, D.G.M., Christley, R.M., Hotchkiss, J.W., ...
The analysis of exhaled breath is a potentially useful method for application in veterinary diagnostics. Breath samples can be easily collected from animals by means of a face mask on chamber with...
A programmable microsystem using system-on-chip for real-time biotelemetry
Wang, L., Johannessen, E.A., Hammond, P.A., Cui, L., Reid, S.W.J., Cooper, J.M., ...
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip...
Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments
Johannessen, E.A., Wang, L., Wyse, C., Cumming, D.R.S., Cooper, J.M.
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These...
A multiplexed impedance analyzer for characterizing polymer-coated QCM sensor arrays
Mills, C.A., Chai, K.T.C., Milgrew, M.J., Glidle, A., Cooper, J.M., Cumming, D.R.S.
This paper describes the development and evaluation of a custom-built impedance analyzer, which uses a multiplexing bridge circuit to characterize an array of polymer-coated quartz crystal...
A programmable microsystem using system-on-chip for real-time biotelemetry
Wang, L., Johannessen, E.A., Hammond, P.A., Cui, L., Reid, S.W.J., Cooper, J.M., ...
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip...
Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments
Johannessen, E.A., Wang, L., Wyse, C., Cumming, D.R.S., Cooper, J.M.
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These...
A multiplexed impedance analyzer for characterizing polymer-coated QCM sensor arrays
Mills, C.A., Chai, K.T.C., Milgrew, M.J., Glidle, A., Cooper, J.M., Cumming, D.R.S.
This paper describes the development and evaluation of a custom-built impedance analyzer, which uses a multiplexing bridge circuit to characterize an array of polymer-coated quartz crystal...
Lab-on-a-chip technologies for proteomic analysis from isolated cells
Sedgwick, H., Caron, F., Monaghan, P.B., Kolch, W., Cooper, J.M.
Lab-on-a-chip systems offer a versatile environment in which low numbers of cells and molecules can be manipulated, captured, detected and analysed. We describe here a microfluidic device that allows...