Mohammed, Mazher-Iqbal, Sills, Graeme J., Brodie, Martin J., Ellis, E., Girkin, J.M.
We describe the design, construction and performance of a complete palm-sized device capable of rapid discrimination of a single nucleotide polymorphism in human DNA. The analysis of the DNA is...
Adaptive optics for deeper imaging of biological samples (2009)
Girkin, J.M., Poland, S., Wright, A.J.
Optical microscopy has been a cornerstone of life science investigations since its first practical application around 400 years ago with the goal being subcellular resolution, three-dimensional...
McCarron, John G., Olson, M., Currie, S., Wright, A., Anderson, Kurt I., Girkin, J.M.
In smooth muscle, the gating of dihydropyridine-sensitive Ca2+ channels may either be stochastic and voltage dependent or coordinated among channels and constitutively active. Each form of gating has...
A confocal micro-imaging system incorporating a thermally actuated two axis MEMS scanner (2009)
Poland, S.P., Li, L., Uttamchandani, D.G., Girkin, J.M.
For in-vivo imaging applications the use of conventional confocal microscope systems are simply not practical due to their relatively large size and weight. There is, however, great interest from...
Poland, S.P., Girkin, J.M., Li, L., Uttamchandani, D.G.
A compensatory mapping (CM) technique for external linearisation of a MEMS electrothermally actuated optical scanner is reported. Each individual axis of a two-axis MEMS scanner was linearised by the...
Non-ionising active imaging of body parts (2008)
Girkin, J.M., Poland, S.P., Longbottom, C.
A medical imager, primarily for use in oral and dental applications. The imager has a source for providing a plurality of collimated beams of non-ionising radiation, in particular near-infrared...
Rae, B.R., Griffin, C., Mckendry, J.J.D., Girkin, J.M., Zhang, H.X., Gu, E., ...
We describe a single chip approach to time resolved fluorescence measurements based on time correlated single photon counting. Using a single complementary metal oxide silicon (CMOS) chip, bump...
Liu, J.S., Caley, A.J., Gu, E., Girkin, J.M., Dawson, M.D., Taghizadeh, M.R.
Tightly focused spots with small central lobes, high central intensity and low sidelobe intensity are desirable for many light-emitting diode based micro-projection system applications. Diffractive...
Rae, B. R., Griffin, C., McKendry, J., Girkin, J. M., Zhang, H. X., Gu, E., ...
We describe a single chip approach to time resolved fluorescence measurements based on time correlated single photon counting. Using a single complementary metal oxide silicon (CMOS) chip, bump...
CMOS-integrated flip-chip micro-pixel InGaN LED arrays for on-chip microfluorimetry (2007)
Griffin, C., Mckendry, J.J.D., Zhang, H.X., Gu, E., Rae, B.R., Henderson, R.K., ...
4times16 arrays of micro-pixellated InGaN LEDs, each of diameter 72 mum, have been flip-chipped onto CMOS driver backplanes which also contain single-photon avalanche photodiodes....
Poher, V., Zhang, H., Kennedy, G.T., Griffin, C., Oddos, S., Gu, E., ...
We describe an optical sectioning microscopy system with no moving parts based on a micro-structured stripe-array light emitting diode (LED). By projecting arbitrary line or grid patterns onto the...
Poher, V., Zhang, H., Kennedy, G.T., Griffin, C., Oddos, S., Gu, E., ...
We describe an optical sectioning microscopy system with no moving parts based on a micro-structured stripe-array light emitting diode (LED). By projecting arbitrary line or grid patterns onto the...
Parametric resonance of optically trapped aerosols (2007)
Leonardo, R.Di., Ruocco, G., Leach, J., Padgett, M.J., Wright, A., Girkin, J.M., ...
The Brownian dynamics of an optically trapped water droplet are investigated across the transition from over- to underdamped oscillations. The spectrum of position fluctuations evolves from a...
Parametric resonance of optically trapped aerosols (2007)
Leonardo, R.Di., Ruocco, G., Leach, J., Padgett, M.J., Wright, A., Girkin, J.M., ...
The Brownian dynamics of an optically trapped water droplet are investigated across the transition from over- to underdamped oscillations. The spectrum of position fluctuations evolves from a...
Optical ferris wheel for ultracold atoms (2007)
Franke-Arnold, S., Leach, J., Padgett, M.J., Lembessis, D., Ellinas, D., Wright, A.J., ...
We propose a versatile optical ring lattice suitable for trapping cold and quantum degenerate atomic samples. We demonstrate the realisation of intensity patterns from pairs of Laguerre-Gauss...
Optical ferris wheel for ultracold atoms (2007)
Franke-Arnold, S., Leach, J., Padgett, M.J., Lembessis, D., Ellinas, D., Wright, A.J., ...
We propose a versatile optical ring lattice suitable for trapping cold and quantum degenerate atomic samples. We demonstrate the realisation of intensity patterns from pairs of Laguerre-Gauss...
Wright, A., Poland, S.P., Vijverberg, J., Girkin, J.M.
We report on a practical method for the implementation of Adaptive Optics in optical sectioning microscopy to remove system and sample induced aberrations. Correcting for induced aberrations on a...
Girkin, J.M., Vijverberg, J., Orazio, M.A., Poland, S.P., Wright, A., Cobb, S.
Sample induced optical aberrations in slices of rat brain tissue have been corrected with a deformable membrane mirror. The aberration correction required by the DMM was determined using a genetic...
Semi-adaptive optics in confocal reflection and two photon microscopy in rat brain (2007)
Vijverberg, J., Poland, S.P., Wright, A., Girkin, J.M.
Paper concerned with semi-adaptive optics in confocal reflection and two photon microscopy in rat brain.
McConnell, G., Girkin, J.M., Poland, S
Confocal laser scanning microscopy (CLSM) has rapidly become an essential tool in the life sciences laboratory, enabling high-resolution and minimally intrusive optical sectioning of fluorescent...
Confocal and multiphoton microscopy for imaging at depth in living tissue (2006)
Girkin, J.M., Wright, A.J., Poland, S., Patterson, B.A., Padgett, M.J.
The desire to image with sub micron resolution at ever increasing depths into living samples is providing optical physicists with the latest in a long line of challenges presented by life science...
McConnell, G., Girkin, J.M., Poland, S.
Confocal laser scanning microscopy (CLSM) has rapidly become an essential tool in the life sciences laboratory, enabling high-resolution and minimally intrusive optical sectioning of fluorescent...
Confocal and multiphoton microscopy for imaging at depth in living tissue (2006)
Girkin, J.M., Wright, A.J., Poland, S., Patterson, B.A., Padgett, M.J.
The desire to image with sub micron resolution at ever increasing depths into living samples is providing optical physicists with the latest in a long line of challenges presented by life science...
McConnell, G., Girkin, J.M., Poland, S.
Confocal laser scanning microscopy (CLSM) has rapidly become an essential tool in the life sciences laboratory, enabling high-resolution and minimally intrusive optical sectioning of fluorescent...
Structured illumination microscopy using light-emitting diodes (2006)
Poher, V., Kennedy, G.T., Elson, D.S., French, P.M.W., Neil, M.A.A., Zhang, H.X., ...
This paper covers structured illumination microscopy using light-emitting diodes. It was presented at Photon06 conference, the UK's premier conference in optics and photonics.
Multiphoton microscopy: in depth, in vivo sub cellular resolution imaging (2006)
Since the advent of the optical microscope around 400 years ago there has been an increasing desire by life science researchers to image ever more deeply into samples with high resolution. More...
Multiphoton microscopy: in depth, in vivo sub cellular resolution imaging (2006)
Since the advent of the optical microscope around 400 years ago there has been an increasing desire by life science researchers to image ever more deeply into samples with high resolution. More...
Multiphoton microscopy: in depth, in vivo sub cellular resolution imaging (2006)
Since the advent of the optical microscope around 400 years ago there has been an increasing desire by life science researchers to image ever more deeply into samples with high resolution. More...
Wright, A.J., Poland, S.P., Patterson, B.A., Girkin, J.M., Gibson, G.M., Padgett, M.J.
A dynamic closed-loop method for focus tracking using a spatial light modulator and a deformable membrane mirror within a confocal microscope is described. We report that it is possible to track...
Wright, A.J., Poland, S.P., Patterson, B.A., Girkin, J.M., Gibson, G.M., Padgett, M.J.
A dynamic closed-loop method for focus tracking using a spatial light modulator and a deformable membrane mirror within a confocal microscope is described. We report that it is possible to track...
McConnell, G., Poland, S.P., Girkin, J.M
We report on the use of a computer-controlled digital micromirror device (DMD) to select discrete wavelength ranges from a white-light supercontinuum and the application of the light source to...
Wright, A.J., Patterson, B.A., Poland, S.P., Girkin, J.M., Gibson, G.M., Padgett, M.J.
A dynamic closed-loop method for focus tracking using a spatial light modulator and a deformable membrane mirror within a confocal microscope is described. We report that it is possible to track...
McConnell, G., Poland, S.P., Girkin, J.M.
We report on the use of a computer-controlled digital micromirror device (DMD) to select discrete wavelength ranges from a white-light supercontinuum and the application of the light source to...
Wright, A.J., Patterson, B.A., Poland, S.P., Girkin, J.M., Gibson, G.M., Padgett, M.J.
A dynamic closed-loop method for focus tracking using a spatial light modulator and a deformable membrane mirror within a confocal microscope is described. We report that it is possible to track...
McConnell, G., Poland, S.P., Girkin, J.M.
We report on the use of a computer-controlled digital micromirror device (DMD) to select discrete wavelength ranges from a white-light supercontinuum and the application of the light source to...
Generation of achromatic bessel beams using a compensated spatial light modulator (2006)
Leach, J., Gibson, G.M., Padgett, M.J., Esposito, E., Wright, A., Girkin, J.M., ...
We report the creation of white-light, achromatic Bessel beams using a spatial light modulator and a prism to compensate for the dispersion. Unlike the Bessel beam created by a refractive axicon,...
Poland, S.P., Burns, D., Lubeigt, W., Patterson, B.A., Valentine, G.J., Wright, A.J., ...
Confocal techniques allow the user to achieve optically sectioned images with significantly enhanced axial and improved lateral resolution compared to widefield methods. Unfortunately, as one images...
Sources come of age for multiphoton microscopy (2005)
In conventional confocal microscopes a visible light source is required that is well matched to the absorption of a specific fluorophore. Generally it will be in the UV to green portion of the...
Sources come of age for multiphoton microscopy (2005)
In conventional confocal microscopes a visible light source is required that is well matched to the absorption of a specific fluorophore. Generally it will be in the UV to green portion of the...
Sources come of age for multiphoton microscopy (2005)
In conventional confocal microscopes a visible light source is required that is well matched to the absorption of a specific fluorophore. Generally it will be in the UV to green portion of the...
Biophotonics at Strathclyde University: working at the photonics/life science interface (2005)
Wright, A.J., Hastie, J.E., Patterson, B.A., Girkin, J.M., Dawson, M.D.
We review recent developments in photonics research at Strathclyde University motivated by applications in biomedicine. Areas covered include novel sources for microscopy, micro-pixellated light...
Advances in laser sources for confocal and multiphoton microscopy (2005)
The illumination source for all high-resolution, optical sectioning, scanning microscopes is crucially important to the overall performance of the system. We examine advances that have been made in...
Advances in laser sources for confocal and multiphoton microscopy (2005)
The illumination source for all high-resolution, optical sectioning, scanning microscopes is crucially important to the overall performance of the system. We examine advances that have been made in...
Optimisation methods for adaptive optics in microscopy (2005)
Wright, A.J., Poland, S.P., Valentine, G.J., Burns, D., Girkin, J.M.
This paper is about optimisation methods for adaptive optics in microscopy. It was presented at the Focus on Microscopy conference in 2005.
Griffin, C., Gu, E., Choi, H.W., Jeon, C.W., Girkin, J.M., Dawson, G., ...
The recent development of high-density, two-dimensional arrays of micrometer-sized InGaN/GaN light-emitting diodes (micro-LEDs) with potential applications from scientific instrumentation to...
Griffin, C., Gu, E., Choi, H.W., Jeon, C.W., Girkin, J.M., Dawson, G., ...
The recent development of high-density, two-dimensional arrays of micrometer-sized InGaN/GaN light-emitting diodes (micro-LEDs) with potential applications from scientific instrumentation to...
Griffin, C., Gu, E., Choi, H.W., Jeon, C.W., Girkin, J.M., Dawson, M.D., ...
The recent development of high-density, two-dimensional arrays of micrometer-sized InGaN/GaN light-emitting diodes (micro-LEDs) with potential applications from scientific instrumentation to...
Fabrication and evaluation of GaN negative and bifocal microlenses (2005)
Choi, H.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D
Methods of fabricating negative and bifocal microlens arrays have been demonstrated in this paper. The technique of photoresist molding using a sapphire positive lens template was used for the...
Fabrication of natural diamond microlenses by plasma etching (2005)
Choi, H.W., Gu, E., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Advantageous properties including optical transparency, high thermal conductivity, and high carrier mobility make natural diamond an attractive choice for a range of optical and electrical devices....
Griffin, C., Gu, E., Choi, H.W., Jeon, C.W., Girkin, J.M., Dawson, M.D., ...
The recent development of high-density, two-dimensional arrays of micrometer-sized InGaN/GaN light-emitting diodes (micro-LEDs) with potential applications from scientific instrumentation to...
Polymer microlens arrays applicable to AllnGaN ultraviolet micro-light-emitting diodes (2005)
Jeon, C.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D
We report on the fabrication of high-optical-quality microlens arrays based on ultraviolet (UV)-curable polymer adhesive. The lenses are suitable, amongst other applications, for high-transmission...
Nitride micro-display with integrated micro-lenses (2005)
Choi, H.W., Gu, E., Girkin, J.M., Dawson, M.D
We report progress in control of the emission from both parallel-addressed and matrix-addressed micro-array light-emitting diodes (micro-LEDs), using integrated micro-lenses. The integrated...
Wright, A.J., Burns, D., Patterson, B.A., Poland, S., Valentine, G.J., Girkin, J.M
We report on the introduction of active optical elements into confocal and multiphoton microscopes in order to reduce the sample-induced aberration. Using a flexible membrane mirror as the active...
Fibre optic confocal microscopy of early caries lesions (2005)
Girkin, J.M., Hall, A.F., Strang, R., Creanor, S.L., Whitters, C.J., Rousseau, C
Examines instances of fibre optic confocal microscopy of early caries lesions.
Creating permanent 3D arrangements of isolated cells using holographic optical tweezers (2005)
Jordan, P., Leach, J., Padgett, M.J., Blackburn, P., Isaacs, N., Goksor, M., ...
Reports the creation of permanent 3D configurations of cells, at predefined positions, within a gelatin matrix. The technique used holographic optical tweezers to manipulate individual E. coli within...
Fabrication and evaluation of GaN negative and bifocal microlenses (2005)
Choi, H.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D.
Methods of fabricating negative and bifocal microlens arrays have been demonstrated in this paper. The technique of photoresist molding using a sapphire positive lens template was used for the...
Fabrication of natural diamond microlenses by plasma etching (2005)
Choi, H.W., Gu, E., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Advantageous properties including optical transparency, high thermal conductivity, and high carrier mobility make natural diamond an attractive choice for a range of optical and electrical devices....
Polymer microlens arrays applicable to AllnGaN ultraviolet micro-light-emitting diodes (2005)
Jeon, C.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D.
We report on the fabrication of high-optical-quality microlens arrays based on ultraviolet (UV)-curable polymer adhesive. The lenses are suitable, amongst other applications, for high-transmission...
Adaptive optics sharpens multiphoton-microscope images (2005)
Originally developed for astronomy and military use, adaptive-optics is coming into its own for use in Âoptical-sectioning microscopy techniques such as multiphoton microscopy.
Nitride micro-display with integrated micro-lenses (2005)
Choi, H.W., Gu, E., Girkin, J.M., Dawson, M.D.
We report progress in control of the emission from both parallel-addressed and matrix-addressed micro-array light-emitting diodes (micro-LEDs), using integrated micro-lenses. The integrated...
Fibre optic confocal microscopy of early caries lesions (2005)
Girkin, J.M., Hall, A.F., Strang, R., Creanor, S.L., Whitters, C.J., Rousseau, C.
Examines instances of fibre optic confocal microscopy of early caries lesions.
Properties of natural diamond microlenses fabricated by plasma etching (2005)
Choi, H.W., Gu, E., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Refractive microlenses with diameters of between a few micrometers to a few hundred micrometers have received much attention, due to their numerous applications in, for example, optical...
Evaluation of enamel dental restoration interface by optical coherence tomography (2005)
De Araujo, R.E., Freitas, A.Z., Zezell, D.M., Vieira-Jr, N.D., Girkin, J.M., ...
Riberio, A., Rousseau, C., Girkin, J.M., Hall, A.F., Strang, R., Whitters, C.J., ...
Objective To report the use of spectroscopic analysis of dental fluorescence excited with a blue InGaN laser diode operating at 405 nm. Method The spectra resulting from three classifications of...
Creating permanent 3D arrangements of isolated cells using holographic optical tweezers (2005)
Jordan, P., Leach, J., Padgett, M.J., Blackburn, P., Isaacs, N., Goksor, M., ...
Reports the creation of permanent 3D configurations of cells, at predefined positions, within a gelatin matrix. The technique used holographic optical tweezers to manipulate individual E. coli within...
Fabrication and evaluation of GaN negative and bifocal microlenses (2005)
Choi, H.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D.
Methods of fabricating negative and bifocal microlens arrays have been demonstrated in this paper. The technique of photoresist molding using a sapphire positive lens template was used for the...
Fabrication of natural diamond microlenses by plasma etching (2005)
Choi, H.W., Gu, E., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Advantageous properties including optical transparency, high thermal conductivity, and high carrier mobility make natural diamond an attractive choice for a range of optical and electrical devices....
Polymer microlens arrays applicable to AllnGaN ultraviolet micro-light-emitting diodes (2005)
Jeon, C.W., Gu, E., Liu, C., Girkin, J.M., Dawson, M.D.
We report on the fabrication of high-optical-quality microlens arrays based on ultraviolet (UV)-curable polymer adhesive. The lenses are suitable, amongst other applications, for high-transmission...
Adaptive optics sharpens multiphoton-microscope images (2005)
Originally developed for astronomy and military use, adaptive-optics is coming into its own for use in Âoptical-sectioning microscopy techniques such as multiphoton microscopy.
Nitride micro-display with integrated micro-lenses (2005)
Choi, H.W., Gu, E., Girkin, J.M., Dawson, M.D.
We report progress in control of the emission from both parallel-addressed and matrix-addressed micro-array light-emitting diodes (micro-LEDs), using integrated micro-lenses. The integrated...
Fibre optic confocal microscopy of early caries lesions (2005)
Girkin, J.M., Hall, A.F., Strang, R., Creanor, S.L., Whitters, C.J., Rousseau, C.
Examines instances of fibre optic confocal microscopy of early caries lesions.
Properties of natural diamond microlenses fabricated by plasma etching (2005)
Choi, H.W., Gu, E., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Refractive microlenses with diameters of between a few micrometers to a few hundred micrometers have received much attention, due to their numerous applications in, for example, optical...
Evaluation of enamel dental restoration interface by optical coherence tomography (2005)
De Araujo, R.E., Freitas, A.Z., Zezell, D.M., Vieira-Jr, N.D., Girkin, J.M., ...
Fluorescence excitation and lifetime measurements using GaN/InGaN micro-LED arrays (2004)
Griffin, C., Gu, E., Choi, H.W., Jeon, C.W., Rolinski, E., Birch, D.J.S., ...
Experimental results on the use of micrometer-sized InGaN/GaN light-emitting diodes (micro-LEDs) for time-resolved fluorescence spectroscopy are reported.
Bi-focal and negative microlens arrays in hard optical materials (2004)
Gu, E., Choi, H.W., Liu, C., Watson, I.M., Girkin, J.M., Dawson, M.D.
Using the methods of photoresist reflow and moulding, bifocal and negative microlens arrays, with diameters down to 10 μm, have been fabricated in GaN-on-sapphire. The optical properties of these...
Adaptive optics in microscopy (2004)
Wright, A.J., Poland, S.P., Patterson, B.A., Burns, D., Valentine, G.J., Girkin, J.M.
This paper is about adaptive optics in microscopy. It was presented at Photon 2004.
Blue laser diode excited fluroescence spectroscopy of natural caries lesions (2004)
Girkin, J.M., Rousseau, C., Hall, A.F., Strang, R., Whitters, C.J., Creanor, S.L., ...
We report on the use of a blue laser diode to excite natural fluorescence from a range of dentalsamples. Sixty teeth with naturally occurring lesions were examined. The lesions were classified...
Blue laser diode excited fluroescence spectroscopy of natural caries lesions (2004)
Girkin, J.M., Rousseau, C., Hall, A.F., Strang, R., Whitters, C.J., Creanor, S.L., ...
We report on the use of a blue laser diode to excite natural fluorescence from a range of dentalsamples. Sixty teeth with naturally occurring lesions were examined. The lesions were classified...
Use of adaptive optics for improved multiphoton imaging (2004)
We report on the integration of active optical elements in a multiphoton microscope to improve theresolution and overall image quality when imaging deeply into biological samples. Optical models were...
Gu, E., Choi, H.W., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Using the method of photoresist reflow and inductively coupled plasma dry etching, we have fabricated microlens arrays in type-IIa natural single-crystal diamond, with diameters down to 10 µm. The...
Two-photon fluorescence imaging of gallium nitride micro-LED arrays (2004)
McConnell, G., Gu, E., Griffin, C., Jeon, C.W., Choi, H.W., Gurney, A.M., ...
Girkin, J.M., Gu, E., Griffin, C., Choi, H.W., Dawson, M.D., McConnell, G.
We report on the application of confocal and multiphoton microscopic techniques for the evaluation of the latest generation of micro optical components. The optical emitting characteristics of arrays...
GaN micro-light-emitting diode arrays with monolithically integrated sapphire microlenses (2004)
Choi, H.W., Liu, C., Gu, E., McConnell, G., Girkin, J.M., Watson, I.M., ...
GaN micro-light-emitting diodes (micro-LEDs) with monolithically integrated microlenses have been demonstrated. Microlenses, with a focal length of 44 µm and a root mean square roughness of ~1 nm,...
Use of adaptive optics for improved multiphoton imaging (2004)
We report on the integration of active optical elements in a multiphoton microscope to improve theresolution and overall image quality when imaging deeply into biological samples. Optical models were...
A review of other potential diagnostic modalities for caries (2004)
This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which...
A review of potential new diagnostic modalities for caries lesions (2004)
This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which...
Blue laser diode excited fluorescence spectroscopy of natural carious lesions (2004)
Girkin, J.M., Rousseau, C., Hall, A.F., Strang, R., Whitters, C.J., Creanor, S.L., ...
We report on the use of a blue laser diode to excite natural fluorescence from a range of dentalsamples. Sixty teeth with naturally occurring lesions were examined. The lesions were classified...
Gu, E., Choi, H.W., Liu, C., Griffin, C., Girkin, J.M., Watson, I.M., ...
Using the method of photoresist reflow and inductively coupled plasma dry etching, we have fabricated microlens arrays in type-IIa natural single-crystal diamond, with diameters down to 10 µm. The...
Two-photon fluorescence imaging of gallium nitride micro-LED arrays (2004)
McConnell, G., Gu, E., Griffin, C., Jeon, C.W., Choi, H.W., Gurney, A.M., ...
Girkin, J.M., Gu, E., Griffin, C., Choi, H.W., Dawson, M.D., McConnell, G.
We report on the application of confocal and multiphoton microscopic techniques for the evaluation of the latest generation of micro optical components. The optical emitting characteristics of arrays...
GaN micro-light-emitting diode arrays with monolithically integrated sapphire microlenses (2004)
Choi, H.W., Liu, C., Gu, E., McConnell, G., Girkin, J.M., Watson, I.M., ...
GaN micro-light-emitting diodes (micro-LEDs) with monolithically integrated microlenses have been demonstrated. Microlenses, with a focal length of 44 µm and a root mean square roughness of ~1 nm,...
Use of adaptive optics for improved multiphoton imaging (2004)
We report on the integration of active optical elements in a multiphoton microscope to improve theresolution and overall image quality when imaging deeply into biological samples. Optical models were...
A review of other potential diagnostic modalities for caries (2004)
This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which...
Use of adaptive optics for enhanced multiphoton microscopy (2004)
We report on the integration of active optical elements in a multiphoton microscope to improve theresolution and overall image quality when imaging deeply into biological samples. Optical modelswere...
McConnell, G., Smith, G.L., Girkin, J.M., Gurney, A.M., Ferguson, A.I.
We report a robust and reliable platform source for visible-wavelength multiphoton microscopy that is based on nonlinear optical methods. We demonstrate a synchronously pumped, singly resonant...
McConnell, G., Smith, G.L., Girkin, J.M., Gurney, A.M., Ferguson, A.I.
We report a robust and reliable platform source for visible-wavelength multiphoton microscopy that is based on nonlinear optical methods. We demonstrate a synchronously pumped, singly resonant...
Optical physics enables advances in multiphoton imaging (2003)
Since the initial images were taken using a multiphoton imaging technique the method has rapidly established itself as the preferred method for imaging deeply into biological samples with micron...
Optical physics enables advances in multiphoton imaging (2003)
Since the initial images were taken using a multiphoton imaging technique the method has rapidly established itself as the preferred method for imaging deeply into biological samples with micron...
McConnell, G., Gu, E., Griffin, C., Jeon, C.W., Choi, H.W., Girkin, J.M., ...
We present a simple and powerful two-photon fluorescence imaging technique for noninvasive spatial evaluation of the gallium nitride (GaN) based structure deep within a micro- LED array. The GaN...
Biocatalysis in reaction mictures with undissolved solid substrates and products (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Enzymatic synthesis in reaction mixtures with mainly undissolved substrates and / or products is a synthetic strategy in which the compounds are present mostly as pure solids. It retains the main...
McConnell, G., Smith, G.L., Girkin, J.M., Gurney, A.M., Ferguson, A.I.
We report a robust and reliable platform source for visible-wavelength multiphoton microscopy that is based on nonlinear optical methods. We demonstrate a synchronously pumped, singly resonant...
Two photon microscopy to spatially resolve and quantify fluorophores in single bead chemistry (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Solid-phase chemistry on polymer beads is widely used in the production and biological screening of combinatorial libraries of compounds.1 Since a lot of analytical methods used in solution chemistry...
Measuring enzymatic reaction rates on polymer supported substrates by two photon microscopy (2003)
Bosma, A.Y., Ulijn, R.V., McConnell, G., Girkin, J.M., Halling, P.J., Flitsch, S.L.
Two-photon fluorescence microscopy was introduced as a tool to assess enzyme accessibility and to quantify enzyme reactions rates on solid supports.
Practical implementation of adaptive optics in multiphoton microscopy (2003)
Marsh, P.N., Burns, D., Girkin, J.M.
A dedicated two-photon microscope incorporating adaptive-optic correction of specimen-induced aberrations is presented. Wavefront alteration of the scanning laser beam was achieved by use of a...
Biocatalysis in reaction mictures with undissolved solid substrates and products (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Enzymatic synthesis in reaction mixtures with mainly undissolved substrates and / or products is a synthetic strategy in which the compounds are present mostly as pure solids. It retains the main...
Fibre-optic confocal microscopy of early caries lesions (2003)
Girkin, J.M., Hall, A.F., Strang, R., Creanor, S.L., Whitters, C.J., Rousseau, C.
No abstract available.
McConnell, G., Smith, G.L., Girkin, J.M., Gurney, A.M., Ferguson, A.I.
We report a robust and reliable platform source for visible-wavelength multiphoton microscopy that is based on nonlinear optical methods. We demonstrate a synchronously pumped, singly resonant...
Two photon microscopy to spatially resolve and quantify fluorophores in single bead chemistry (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Solid-phase chemistry on polymer beads is widely used in the production and biological screening of combinatorial libraries of compounds.1 Since a lot of analytical methods used in solution chemistry...
Measuring enzymatic reaction rates on polymer supported substrates by two photon microscopy (2003)
Bosman, A.Y., Ulijn, R.V., McConnell, G., Girkin, J.M., Halling, P.J., Flitsch, S.L.
Two-photon fluorescence microscopy was introduced as a tool to assess enzyme accessibility and to quantify enzyme reactions rates on solid supports.
Practical implementation of adaptive optics in multiphoton microscopy (2003)
Marsh, P.N., Burns, D., Girkin, J.M.
A dedicated two-photon microscope incorporating adaptive-optic correction of specimen-induced aberrations is presented. Wavefront alteration of the scanning laser beam was achieved by use of a...
Biocatalysis in reaction mictures with undissolved solid substrates and products (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Enzymatic synthesis in reaction mixtures with mainly undissolved substrates and / or products is a synthetic strategy in which the compounds are present mostly as pure solids. It retains the main...
Two-photon microscopy to spatially resolve and quantify fluorophores in single-bead chemistry (2003)
Ulijn, R.V., Brazendale, I., Margetts, G., Flitsch, S.L., McConnell, G., Girkin, J.M., ...
Solid-phase chemistry on polymer beads is widely used in the production and biological screening of combinatorial libraries of compounds. Since a lot of analytical methods used in solution chemistry...
Two-photon fluorescence imaging of GaN micro-LED arrays (2003)
McConnell, G., Gu, E., Griffin, C., Jeon, C.W., Choi, H.W., Gurney, A.M., ...
This paper presents a simple yet powerful two-photon fluorescence imagining technique for minimally invasive evaluation of the gallium nitride based-structure deep within a Micro-LED array. By...
Lubeigt, W., Valentine, G.J., Burns, D., Girkin, J.M.
Preliminary investigations into the potential for automatic spatial-mode optimization in tehrmally distorted soild-sate lasers using deformable mirrors are presented. A 37 element adaptive optic...
Lubeigt, W., Valentine, G., Girkin, J.M., Burns, D.
This paper is about automatic transverse mode optimization of an all-solid-state laser using an adaptive-optic mirror. It was presented at the international conference on lasers, applications, and...
Biophotonics: a marriage of sciences (2002)
Biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light. Photonics...
Lubeigt, W., Valentine, G.J., Girkin, J.M., Burns, D.
A 37 element adaptive optic mirror has been used intracavity to control the oscillation mode profile of a diode-laser pumped Nd:YVO4 laser. Mode and power optimisation are demonstrated by closed loop...
Biophotonics: a marriage of sciences (2002)
Biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light. Photonics...
The effect of dentine on fluorescence measurements of enamel lesions in vitro (2002)
Rousseau, C., Vaidya, S., Creanor, S.L., Hall, A.F., Girkin, J.M., Whitters, C.J., ...
This study aimed to determine the contribution of the underlying dentine and the enamel-dentine junction to measurements of mineral loss from enamel recorded using quantitative light fluorescence...
Application of a novel confocal imaging technique for the early detection of dental decay (2002)
Rousseau, C., Girkin, J.M., Hall, A.F., Hall, A.F., Strang, R., Vaidya, S.
In order to stop or prevent the progression of dental disease, early detection and quantification of decay are crucially important. Dental decay (caries) detection methods have traditionally involved...
Lubeigt, W., Valentine, G.J., Girkin, J.M., Bente, E., Burns, D.
A 37 element adaptive optic mirror has been used intracavity to control the oscillation mode profile of a diode-laser pumped Nd:YVO4 laser. Mode and power optimisation are demonstrated by closed loop...
Biophotonics: a marriage of sciences (2002)
Biophotonics denotes a combination of biology and photonics, with photonics being the science and technology of generation, manipulation, and detection of photons, quantum units of light. Photonics...
Lubeigt, W., Burns, D., Valentine, G.J., Girkin, J.M.
Transverse mode control of an all-solid-state laser using an intracavity adaptive-optic mirror was presented. A high-reflector was used as an output coupler giving 5 mW output when optimized without...
In situ and ex situ evaluation of mechanisms of lateral epitaxial overgrowth (2001)
Watson, I.M., Liu, C., Kim, K.S., Kim, H.S., Deatcher, C.J., Girkin, J.M., ...
Metal organic chemical vapour deposition was used for lateral epitaxial overgrowth of GaN on stripe-patterned SiO2 masks 200 and 500 nm in thickness. Overgrowths were conducted under constant...
In situ and ex situ evaluation of mechanisms of lateral epitaxial overgrowth (2001)
Watson, I.M., Liu, C., Kim, K.S., Kim, H.S., Deatcher, C.J., Girkin, J.M., ...
Metal organic chemical vapour deposition was used for lateral epitaxial overgrowth of GaN on stripe-patterned SiO2 masks 200 and 500 nm in thickness. Overgrowths were conducted under constant...
In-situ reflectometry based studies of lateral epitaxial overgrowth (2001)
Watson, I.M., Kim, K.S., Kim, H.S., Liu, C., Deatcher, C.J., Girkin, J.M., ...
This paper covers in-situ reflectometry based studies of lateral epitaxial overgrowth. It was presented at the 2001 UK Nitrides consortium.
Full system considerations for multiphoton microscopy (2001)
A most-important-variables analysis of practical, successful multiphoton excitation fluorescence microscopy is presented. The key strength of multiphoton imaging -- localization of the excitation...
Full system considerations for multiphoton microscopy (2001)
A most-important-variables analysis of practical, successful multiphoton excitation fluorescence microscopy is presented. The key strength of multiphoton imaging -- localization of the excitation...
Novel compact sources for multiphoton microscopy (2001)
Most multiphoton imaging has been undertaken using tuneable femtosecond Ti:Sapphire lasers which are large, expensive and require a level of laser expertise to operate. Although new commercial,...
Full system considerations for multiphoton microscopy (2001)
A most-important-variables analysis of practical, successful multiphoton excitation fluorescence microscopy is presented. The key strength of multiphoton imaging -- localization of the excitation...
Novel compact sources for multiphoton microscopy (2001)
Most multiphoton imaging has been undertaken using tuneable femtosecond Ti:Sapphire lasers which are large, expensive and require a level of laser expertise to operate. Although new commercial,...
Stevenson, D., Wokosin, D.L., Girkin, J.M., Grant, J.
Reduced glutathione (GSH) plays a central role in protecting cells from oxidative and chemical damage by conjugating with free radicals and electrophilic xenobiotics, and by reducing hydrogen...
Stevenson, D., Wokosin, D.L., Girkin, J.M., Grant, J.
Reduced glutathione (GSH) plays a central role in protecting cells from oxidative and chemical damage by conjugating with free radicals and electrophilic xenobiotics, and by reducing hydrogen...
Confocal microscopy using an InGaN laser diode at 406nm (2001)
Girkin, J.M., Ferguson, A.I., Wokosin, D.L., Gurney, A.M.
We report on the application of a novel blue laser diode source to confocal microscopy. The source has the potential to be a replacement for argon lasers in a range of fluorescence based imaging...
Confocal Microscopy using an InGaN violet laser diode at 406nm (2000)
Girkin, J.M., Ferguson, A.I., Wokosin, D.L., Gurney, A.M.
We report on the application of a novel all-solid-state violet laser diode source to confocal microscopy. The source has the potential to replace argon ion lasers in a range of fluorescence based...
Fluorescence spectroscopy of natural carious lesions (2000)
Hall, A.F., Riberio, A., Girkin, J.M., Strang, R., Creanor, S.L., Whitters, C.J., ...
No abstract available.
Confocal Microscopy using an InGaN violet laser diode at 406nm (2000)
Girkin, J.M., Ferguson, A.I., Wokosin, D.L., Gurney, A.M.
We report on the application of a novel all-solid-state violet laser diode source to confocal microscopy. The source has the potential to replace argon ion lasers in a range of fluorescence based...
A review of potential new diagnostic modalities for caries lesions
This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which...
A preliminary investigation of a spectroscopic technique for the diagnosis of natural caries lesions
Riberio, A., Rousseau, C., Girkin, J.M., Hall, A.F., Strang, R., Whitters, C.J., ...
Objective To report the use of spectroscopic analysis of dental fluorescence excited with a blue InGaN laser diode operating at 405 nm. Method The spectra resulting from three classifications of...
The effect of dentine on fluorescence measurements of enamel lesions in vitro
Rousseau, C., Vaidya, S., Creanor, S.L., Hall, A.F., Girkin, J.M., Whitters, C.J., ...
This study aimed to determine the contribution of the underlying dentine and the enamel-dentine junction to measurements of mineral loss from enamel recorded using quantitative light fluorescence...
Fibre-optic confocal microscopy of early caries lesions
Girkin, J.M., Hall, A.F., Strang, R., Creanor, S.L., Whitters, C.J., Rousseau, C.
No abstract available.
Blue laser diode excited fluorescence spectroscopy of natural carious lesions
Girkin, J.M., Rousseau, C., Hall, A.F., Strang, R., Whitters, C.J., Creanor, S.L., ...
We report on the use of a blue laser diode to excite natural fluorescence from a range of dentalsamples. Sixty teeth with naturally occurring lesions were examined. The lesions were classified...
Fluorescence spectroscopy of natural carious lesions
Hall, A.F., Riberio, A., Girkin, J.M., Strang, R., Creanor, S.L., Whitters, C.J., ...
No abstract available.
Application of a novel confocal imaging technique for the early detection of dental decay
Rousseau, C., Girkin, J.M., Hall, A.F., Hall, A.F., Strang, R., Vaidya, S.
In order to stop or prevent the progression of dental disease, early detection and quantification of decay are crucially important. Dental decay (caries) detection methods have traditionally involved...
Diffractive optical elements for beam shaping of monochromatic spatially incoherent light
Liu, J.S., Taghizadeh, M.R., Gu, E., Girkin, J.M., Dawson, M.D.
Diffractive optical elements (DOEs) for beam shaping of spatially incoherent light into an output spot with arbitrary intensity profile, particularly into a tightly focused output spot are...
Structured illumination microscopy using micro-pixellated light-emitting diodes
Poher, V., Kennedy, G.T., Elson, D.S., French, P.M.W., Neil, M.A.A., Zhang, H.Z., ...
Paper discussing structured illumination microscopy using micro-pixellated light-emitting diodes.