J. M. Leiper

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility (2007)

Wojciak-Stothard, B., Torondel, B., Tsang, L.Y.F., Fleming, I., Fisslthaler, B., Leiper, J.M., ...

Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action of ADMA is not well understood....

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis. (2007)

Hartzoulakis, B., Rossiter, S., Gill, H., Steinke, E., Gane, P.J., Hurtado-Guerrero, R., ...

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA (2005)

Smith, C.L., Anthony, S., Hubank, M., Leiper, J.M., Vallance, P.

Background Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and...

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. (2005)

Rossiter, S., Smith, C.L., Malaki, M., Nandi, M., Gill, H., Leiper, J.M., ...

Original article can be found at: http://pubs.acs.org/journal/jmcmar Copyright American Chemical Society DOI: 10.1021/jm050187a [Full text of this article is not available in the UHRA]

Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia (2003)

Arrigoni, F.I., Vallance, P., Haworth, S.G., Leiper, J.M.

Background: Nitric oxide (NO) plays an important part in lowering pulmonary vascular resistance after birth, and in persistent pulmonary hypertension of the newborn (PPHN), NO-mediated dilation is...

Outcome of Pregnancy in Insulin-dependent (Type 1) Diabetic Women between 1971 and 1984 (1986)

SMALL, M., CASSIDY, L., LEIPER, J. M., PATERSON, K. R., LUNAN, C. B., MacCUISH, A. C.

We have looked at the outcome of pregnancy in women with type 1 (insulin-dependent) diabetes mellitus who were confined at Glasgow Royal Maternity Hospital between 1971 and 1984. Of 134 pregnancies,...

Glycosylated Albumin and Glycosylated Proteins: Rapidly Changing Indices of Glycaemia in Diabetic Pregnancy (1985)

LEIPER, J. M., TALWAR, D., ROBB, D. A., LUNAN, C. B., MacCUISH, A. C.

Serial measurements of glycosylated albumin (GAlb), glycosylated plasma proteins (GPP) and glycosylated haemoglobin (GHb) were performed by affinity chromatography throughout the course of pregnancy...

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.

Leiper, J M, Santa Maria, J, Chubb, A, MacAllister, R J, Charles, I G, Whitley, G S, ...

Methylarginines inhibit nitric oxide synthases (NOS). Cellular concentrations of methylarginines are determined in part by the activity of dimethylarginine dimethylaminohydrolase (DDAH; EC 3.5.3....

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.

Leiper, J M, Santa Maria, J, Chubb, A, MacAllister, R J, Charles, I G, Whitley, G S, ...

Methylarginines inhibit nitric oxide synthases (NOS). Cellular concentrations of methylarginines are determined in part by the activity of dimethylarginine dimethylaminohydrolase (DDAH; EC 3.5.3....