STRESS-WAVE PROPAGATION IN ALUMINUM, (2005)
Waser,R. N., Rand,J. L., Marshall,J. M.
The one-dimensional theory of stress-wave propagation has been found to adequately represent a three dimensional experimental situation in both the elastic and plastic regimes. An air gun was used to...
The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat. (2003)
Pyner, S., Coney, A. M., Marshall, J. M.
Muscle vasodilatation evoked by systemic hypoxia is adenosine mediated and nitric oxide (NO) dependent: recent evidence suggests the increased binding of NO at complex IV of endothelial mitochondria...
The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat. (2003)
Pyner, S., Coney, A., Marshall, J. M.
Muscle vasodilatation evoked by systemic hypoxia is adenosine mediated and nitric oxide (NO) dependent: recent evidence suggests the increased binding of NO at complex IV of endothelial mitochondria...
CANCER RESEARCH 60, 4719 -- 4724, September 1, 2000] (2002)
Dermal Microvascular, Endothelial Cells Vitro, S. Tazzyman, J. M. Marshall, Claire E. Lewis
Angiogenesis, the development of new blood vessels from an existing vascular bed, is essential for the growth and spread of malignant tumors. Several endogenous angiogenesis inhibitors have been...
Quantitative studies of the vasculature of the carotid body in the chronically hypoxic rat (2000)
Clarke,J.A., Daly,M. De B., Marshall,J.M., Ead,H.W., Hennessy,E.M.
The carotid bodies of rats made chronically hypoxic by breathing 12% O2 in a normobaric chamber (inspired PO2 91 mmHg) were compared with those of controls. Serial 5-µm sections of the organs were...
DYNAMIC COMPRESSION TESTING OF A STRAIN-RATE MATERIAL, (1998)
Rand, James L., Yang, J. C. S., Marshall, J. M.
Complete compressive stress, strain and strain-rate data have been obtained at room temperature for annealed Lexan, a typical polycarbonate material, for strain-rates of 0.0016 to 4000 in./in./sec....
PLACES Aircraft Experiment Test Results. (1998)
Marshall,J. M., Solbrig,W. E., Lehman,J. W.
During December 1980 the Position Location and Communications Effects Simulations (PLACES) Experiment was conducted to investigate the effects of structured ionospheric plasmas on satellite...
Cockell, C S, Marshall, J M, Dawson, K M, Cederholm-Williams, S A, Ponting, C P
Human Glu-plasminogen adopts at least three conformations that provide a means for regulating the specificity of its activation in vivo. It has been proposed previously that the closed (alpha)...
1. In spontaneously breathing rats anaesthetized with Saffan, we have investigated the role of vasopressin in the cardiovascular responses evoked by systemic hypoxia (breathing 8 or 6% O2 for 5 min)....
Marshall, J M, Lloyd, J, Mian, R
1. In rats anaesthetized with Saffan, the spinotrapezius muscle was prepared for in vivo microscopy. Systemic hypoxia (breathing 8% O2 for 3 min) induced a fall in arterial pressure and tachycardia,...
1. In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg)...
The effects of systemic hypoxia on renal function in the anaesthetized rat.
Neylon, M, Marshall, J M, Johns, E J
1. In rats anaesthetized with Saffan, renal function was monitored from the left kidney from the 5th minute of spontaneous breathing of 12% O2 for two 20 min periods and during air breathing before,...
1. Comparative studies were performed on eighteen rats 54 days old made chronically hypoxic from birth in an hypoxic chamber at 12% O2 (CHB), and in eight weight-matched control rats (NB, 42 days...
1. We have compared the roles of adenosine in mediating dilator responses to acute hypoxia in mesenteric microcirculation of control, normoxic (N) rats and in chronically hypoxic (CH) rats kept in an...
Analysis of responses observed in mesenteric microcirculation of the rat during systemic hypoxia.
1. Direct observations were made of responses to systemic hypoxia (breathing 12 or 6% O2 for 3 min) evoked in terminal arterioles (TA, 14-30 microns internal diameter), precapillary arterioles (PCA,...
The behaviour of muscle microcirculation in chronically hypoxic rats: the role of adenosine.
1. In rats housed in a hypoxic chamber at 12% O2 for 3-5 weeks (CH) and in normal rats housed in air (N), we directly observed responses of arterial and venous vessels of the spinotrapezius muscle to...
Elnazir, B, Marshall, J M, Kumar, P
1. In 3-day-old and 3-week-old spontaneously breathing piglets anaesthetized with Saffan, we have studied ventilatory and cardiovascular responses evoked by 5 min periods of hypoxia (breathing 10 and...
1. We have investigated the roles of adenosine in regulating the respiratory and cardiovascular systems of rats that were made chronically hypoxic for 3-4 weeks from 6 weeks of age (CH rats) in an...
The effects of chronic hypoxia on renal function in the rat.
Neylon, M, Marshall, J M, Johns, E J
1. Studies were performed on rats that had been made chronically hypoxic (CH rats) in a normoxic chamber at 12% O2 for 3-5 weeks. Under Saffan anaesthesia, respiratory and cardiovascular variables,...
Marshall, J M, Thomas, T, Turner, L
1. In anaesthetized rats, systemic hypoxia evoked hyperventilation, tachycardia, a fall in arterial pressure, vasodilatation in skeletal muscle and increases in K+ concentration measured in arterial...
1. In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5...
1. In experiments on anaesthetized rats, we have studied the role of adenosine in mediating responses induced in individual arterioles and venules of the spinotrapezius muscle by systemic hypoxia. 2....
The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat.
1. In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked...
1. In rats anaesthetized with Saffan, responses induced in individual arterial and venous vessels of the spinotrapezius muscle by systemic hypoxia (breathing 12 or 6% O2 for 3 min) were directly...
1. Studies have been made in the anaesthetized rat of the roles played by alpha- and beta-adrenoreceptor stimulation in determining diameter changes induced in individual arterioles and venules of...
Effects of systemic hypoxia on the distribution of cardiac output in the rat.
1. Studies were made in unanaesthetized rats of cardiovascular responses induced during 3 min periods of systemic hypoxia (inspirate 8 or 6% O2). Arterial pressure and heart rate were recorded...
1. A study has been made on isolated sections of rabbit femoral, renal and saphenous arteries of the effects of graded hypoxia (reducing bath PO2 from 110 mmHg, normoxia, to 55, 23 and 6 mmHg) upon...
1. Comparisons have been made between rabbit thoracic aorta and main pulmonary artery of the effects of hypoxia upon contractions evoked by noradrenaline (NA) and KCl (K+). 2. Contractions were...
1. In spontaneously breathing, anaesthetized rats, a study was made of the effects upon the graded cardiovascular responses to systemic hypoxia (inspiratory fractional O2 concentration, Fi, O2: 0.15,...
1. In cats anaesthetized with Saffan, which does not block afferent activation of the brain stem defence areas, we have analysed the cardiovascular changes induced by 3 min periods of graded systemic...
Analysis of the cardiovascular changes induced in the rat by graded levels of systemic hypoxia.
1. In rats anaesthetized with Saffan, we have further analysed the respiratory, cardiac and regional vascular responses induced by 3 min periods of graded hypoxia (breathing 15, 12, 8 or 6% O2 in...
Cardiovascular changes associated with augmented breaths in normoxia and hypoxia in the rat.
1. In the present study, anaesthetized rats showed respiratory gasps (augmented breaths) at regular intervals during air breathing and at increased frequency during hypoxia (breathing 15, 12, 8 or 6%...
Direct observations of effects of baroreceptor stimulation on mesenteric circulation of the rat.
1. In anaesthetized rats, supramaximal baroreceptor stimulation by carotid sinus inflation evoked a reflex fall in systemic arterial pressure and an increase in gross mesenteric vascular conductance,...
1. In anaesthetized rats, supramaximal baroreceptor stimulation by carotid sinus inflation evoked a reflex fall in arterial pressure and an increase in vascular conductance and flow of muscles of the...
1. Comparisons have been made between rats anaesthetized with pentobarbitone and Saffan (Glaxovet), of respiratory and cardiovascular changes evoked by (1) brief stimulation of carotid body...
The responses of mesenteric microcirculation of the rat to circulating noradrenaline were studied by in vivo microscopy, using a photo-electric device placed on a television monitor to measure...
Hilton, S M, Marshall, J M, Timms, R J
In cats anaesthetized with Althesin, the efferent descending pathway from the brain-stem defence areas has been traced through the medulla by identifying sites at which electrical stimulation evoked...
Direct observations have been made of responses of individual arterioles and venules of rat spinotrapezius muscle to contraction of the skeletal muscle fibres. Stimuli of 4-6 V intensity, 0.1 ms...
The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat.
1. The pattern of cardiovascular response evoked by carotid chemoreceptor stimulation has been investigated in cats anesthetized by continuous infusion of Althesin (Glaxo). 2. A variety of...
Dorsal root vasodilatation in cat skeletal muscle.
1. A study has been made, in the cat anaesthetized with chloralose, of the effects of antidromic stimulation of dorsal roots L6-S1 on the blood flow through the gastrocnemius muscle. 2. Stimulation...
Possible mediators of functional hyperaemia in skeletal muscle.
Hilton, S M, Hudlická, O, Marshall, J M
1. (a) In experiments on gastrocnemius muscles of the cat performing external work, the work was graded, either by altering the intensity of motor nerve stimulation or by changing the load. Only...
1. In spontaneously breathing rats anaesthetized with Saffan, we have investigated the role of vasopressin in the cardiovascular responses evoked by systemic hypoxia (breathing 8 or 6% O2 for 5 min)....
Marshall, J M, Lloyd, J, Mian, R
1. In rats anaesthetized with Saffan, the spinotrapezius muscle was prepared for in vivo microscopy. Systemic hypoxia (breathing 8% O2 for 3 min) induced a fall in arterial pressure and tachycardia,...
1. In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg)...
The effects of systemic hypoxia on renal function in the anaesthetized rat.
Neylon, M, Marshall, J M, Johns, E J
1. In rats anaesthetized with Saffan, renal function was monitored from the left kidney from the 5th minute of spontaneous breathing of 12% O2 for two 20 min periods and during air breathing before,...
1. Comparative studies were performed on eighteen rats 54 days old made chronically hypoxic from birth in an hypoxic chamber at 12% O2 (CHB), and in eight weight-matched control rats (NB, 42 days...
1. We have compared the roles of adenosine in mediating dilator responses to acute hypoxia in mesenteric microcirculation of control, normoxic (N) rats and in chronically hypoxic (CH) rats kept in an...
Analysis of responses observed in mesenteric microcirculation of the rat during systemic hypoxia.
1. Direct observations were made of responses to systemic hypoxia (breathing 12 or 6% O2 for 3 min) evoked in terminal arterioles (TA, 14-30 microns internal diameter), precapillary arterioles (PCA,...
The behaviour of muscle microcirculation in chronically hypoxic rats: the role of adenosine.
1. In rats housed in a hypoxic chamber at 12% O2 for 3-5 weeks (CH) and in normal rats housed in air (N), we directly observed responses of arterial and venous vessels of the spinotrapezius muscle to...
Elnazir, B, Marshall, J M, Kumar, P
1. In 3-day-old and 3-week-old spontaneously breathing piglets anaesthetized with Saffan, we have studied ventilatory and cardiovascular responses evoked by 5 min periods of hypoxia (breathing 10 and...
1. We have investigated the roles of adenosine in regulating the respiratory and cardiovascular systems of rats that were made chronically hypoxic for 3-4 weeks from 6 weeks of age (CH rats) in an...
The effects of chronic hypoxia on renal function in the rat.
Neylon, M, Marshall, J M, Johns, E J
1. Studies were performed on rats that had been made chronically hypoxic (CH rats) in a normoxic chamber at 12% O2 for 3-5 weeks. Under Saffan anaesthesia, respiratory and cardiovascular variables,...
Marshall, J M, Thomas, T, Turner, L
1. In anaesthetized rats, systemic hypoxia evoked hyperventilation, tachycardia, a fall in arterial pressure, vasodilatation in skeletal muscle and increases in K+ concentration measured in arterial...
1. In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5...
1. In experiments on anaesthetized rats, we have studied the role of adenosine in mediating responses induced in individual arterioles and venules of the spinotrapezius muscle by systemic hypoxia. 2....
The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat.
1. In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked...
1. In rats anaesthetized with Saffan, responses induced in individual arterial and venous vessels of the spinotrapezius muscle by systemic hypoxia (breathing 12 or 6% O2 for 3 min) were directly...
1. Studies have been made in the anaesthetized rat of the roles played by alpha- and beta-adrenoreceptor stimulation in determining diameter changes induced in individual arterioles and venules of...
Effects of systemic hypoxia on the distribution of cardiac output in the rat.
1. Studies were made in unanaesthetized rats of cardiovascular responses induced during 3 min periods of systemic hypoxia (inspirate 8 or 6% O2). Arterial pressure and heart rate were recorded...
1. A study has been made on isolated sections of rabbit femoral, renal and saphenous arteries of the effects of graded hypoxia (reducing bath PO2 from 110 mmHg, normoxia, to 55, 23 and 6 mmHg) upon...
1. Comparisons have been made between rabbit thoracic aorta and main pulmonary artery of the effects of hypoxia upon contractions evoked by noradrenaline (NA) and KCl (K+). 2. Contractions were...
1. In spontaneously breathing, anaesthetized rats, a study was made of the effects upon the graded cardiovascular responses to systemic hypoxia (inspiratory fractional O2 concentration, Fi, O2: 0.15,...
1. In cats anaesthetized with Saffan, which does not block afferent activation of the brain stem defence areas, we have analysed the cardiovascular changes induced by 3 min periods of graded systemic...
Analysis of the cardiovascular changes induced in the rat by graded levels of systemic hypoxia.
1. In rats anaesthetized with Saffan, we have further analysed the respiratory, cardiac and regional vascular responses induced by 3 min periods of graded hypoxia (breathing 15, 12, 8 or 6% O2 in...
Cardiovascular changes associated with augmented breaths in normoxia and hypoxia in the rat.
1. In the present study, anaesthetized rats showed respiratory gasps (augmented breaths) at regular intervals during air breathing and at increased frequency during hypoxia (breathing 15, 12, 8 or 6%...
Direct observations of effects of baroreceptor stimulation on mesenteric circulation of the rat.
1. In anaesthetized rats, supramaximal baroreceptor stimulation by carotid sinus inflation evoked a reflex fall in systemic arterial pressure and an increase in gross mesenteric vascular conductance,...
1. In anaesthetized rats, supramaximal baroreceptor stimulation by carotid sinus inflation evoked a reflex fall in arterial pressure and an increase in vascular conductance and flow of muscles of the...
1. Comparisons have been made between rats anaesthetized with pentobarbitone and Saffan (Glaxovet), of respiratory and cardiovascular changes evoked by (1) brief stimulation of carotid body...
The responses of mesenteric microcirculation of the rat to circulating noradrenaline were studied by in vivo microscopy, using a photo-electric device placed on a television monitor to measure...
Hilton, S M, Marshall, J M, Timms, R J
In cats anaesthetized with Althesin, the efferent descending pathway from the brain-stem defence areas has been traced through the medulla by identifying sites at which electrical stimulation evoked...
Direct observations have been made of responses of individual arterioles and venules of rat spinotrapezius muscle to contraction of the skeletal muscle fibres. Stimuli of 4-6 V intensity, 0.1 ms...
Cockell, C S, Marshall, J M, Dawson, K M, Cederholm-Williams, S A, Ponting, C P
Human Glu-plasminogen adopts at least three conformations that provide a means for regulating the specificity of its activation in vivo. It has been proposed previously that the closed (alpha)...
The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat.
1. The pattern of cardiovascular response evoked by carotid chemoreceptor stimulation has been investigated in cats anesthetized by continuous infusion of Althesin (Glaxo). 2. A variety of...
Dorsal root vasodilatation in cat skeletal muscle.
1. A study has been made, in the cat anaesthetized with chloralose, of the effects of antidromic stimulation of dorsal roots L6-S1 on the blood flow through the gastrocnemius muscle. 2. Stimulation...
Possible mediators of functional hyperaemia in skeletal muscle.
Hilton, S M, Hudlická, O, Marshall, J M
1. (a) In experiments on gastrocnemius muscles of the cat performing external work, the work was graded, either by altering the intensity of motor nerve stimulation or by changing the load. Only...
The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis
Ewer, A K, Al-Salti, W, Coney, A M, Marshall, J M, Ramani, P, Booth, I W
Background and aims: Necrotising enterocolitis (NEC) is a potentially devastating disorder of preterm infants but its aetiology remains unclear. The aim of these studies was to develop a neonatal...
1. Direct observations were made of the rat mesenteric vasculature in vivo. They showed a gradual increase in the sensitivity to topically applied noradrenaline from the larger arteries to the...
Parrado, J., Conejero-Lara, F., Smith, R. A., Marshall, J. M., Ponting, C. P., Dobson, C. M.
Streptococcus equisimilis streptokinase (SK) is a bacterial protein of unknown tertiary structure and domain organization that is used extensively to treat acute myocardial infarction following...
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine
In anaesthetised rats, the increase in femoral vascular conductance (FVC) evoked by moderate systemic hypoxia is mediated by adenosine acting on A1 receptors. It is also nitric o