Radiation-induced transgenerational alterations in genome stability and DNA damage. (2006)
Barber, R.C., Hickenbotham, P., Hatch, T., Kelly, D., Topchiy, N., Almeida, Gabriela M., ...
Radiation-induced transgenerational alterations in genome stability and DNA damage. (2006)
Barber, R.C., Hickenbotham, Peter, Hatch, T., Kelly, D., Topchiy, N., Almeida, Gabriela M., ...
Jenkins, G. J. S., D'Souza, F. R., Suzen, H. S., Eltahir, Z. S., James, S. A., Parry, J. M., ...
Bile acids are often refluxed into the lower oesophagus and are candidate carcinogens in the development of oesophageal adenocarcinoma. We show here that the secondary bile acid, deoxycholic acid...
Molecular Engineering of Pt-Based Electrocatalysts for Hydrocarbon Fuel Cell Electrodes. (2005)
Giner, J., Parry, J. M., Smith, S. M.
This report describes continued studies of the factors controlling the activity of Pt black catalysts for the anodic oxidation of hydrocarbons. Throughout this work particular attention has been...
Molecular Engineering of Pt-Based Electrocatalysts for Hydrocarbon Fuel Cell Electrodes. (2005)
Giner,J., Parry,J. M., Leung,C., Smith,S. M., Turchan,M.
The program was concerned with relating the activity of platinum black catalysts for the anodic oxidation of propane in 85% H3PO4 at 150C to their physical characteristics. The first phase consisted...
ELECTROCHEMICAL OXIDATION OF SATURATED HYDROCARBONS. (2005)
A study was undertaken to define and analyze the factors controlling the catalytic activity of platinum black toward the anodic oxidation of saturated hydrocarbons. The objective was to develop a...
MOLECULAR ENGINEERING OF PT-BASED ELECTROCATALYSTS FOR HYDROCARBON FUEL CELL ELECTRODES. (2005)
Giner, J., Parry, J. M., Smith, S. M.
The activity of practical (high surface area) Pt catalysts for the anodic oxidation of propane is strongly dependent on the method of preparation. An examination was made of changes in activity and...
Do dose response thresholds exist for genotoxic alkylating agents? (2005)
Jenkins, G. J. S., Doak, S. H., Johnson, G. E., Quick, E., Waters, E. M., Parry, J. M.
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we test the hypothesis that direct-acting...
Do dose response thresholds exist for genotoxic alkylating agents? (2005)
Jenkins, G. J. S., Doak, S. H., Johnson, G. E., Quick, E., Waters, E. M., Parry, J. M.
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we test the hypothesis that direct-acting...
Do dose response thresholds exist for genotoxic alkylating agents? (2005)
Jenkins, G.J.S., Doak, S.H., Johnson, G.E., Quick, E., Waters, E.M., Parry, J.M.
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we test the hypothesis that direct-acting...
In silico p53 mutation hotspots in lung cancer (2004)
For cancer one of the primary aims of molecular epidemiology is to identify the endogenous or exogenous cause of mutations within a gene. Regarding exogenous mutagens, much mutation data has become...
In silico p53 mutation hotspots in lung cancer (2004)
For cancer one of the primary aims of molecular epidemiology is to identify the endogenous or exogenous cause of mutations within a gene. Regarding exogenous mutagens, many mutation data have become...
Jenkins, G.J.S., Harries, K., Doak, S.H., Wilmes, A., Griffiths, A.P., Baxter, J.N., ...
Barrett's oesophagus patients accumulate chromosomal defects during the histological progression to cancer, one of the most prominent of which is the amplification of the whole of chromosome 4. We...
Jenkins, G. J. S., Harries, K., Doak, S. H., Wilmes, A., Griffiths, A. P., Baxter, J. N., ...
Barrett's oesophagus patients accumulate chromosomal defects during the histological progression to cancer, one of the most prominent of which is the amplification of the whole of chromosome 4. We...
Jenkins, G. J. S., Harries, K., Doak, S. H., Wilmes, A., Griffiths, A. P., Baxter, J. N., ...
Barrett's oesophagus patients accumulate chromosomal defects during the histological progression to cancer, one of the most prominent of which is the amplification of the whole of chromosome 4. We...
Detection and characterization of mechanisms of action of aneugenic chemicals (2002)
Parry, E.M., Parry, J.M., Corso, C., Doherty, A., Haddad, F., Hermine, T.F., ...
A comprehensive evaluation of the genotoxic potential of chemicals requires the assessment of the ability to induce gene mutations and structural chromosome (clastogenic activity) and numerical...
Vulnerability of Airborne Cryogenic Fuel Tanks. (2002)
Ruccia,F. E., Allan,D. S., Dale,S. E., Parry,J. M.
This report examines certain aspects of cryogenic fuel tankage specifically liquid hydrogen (LH2) use in aircraft. These aspects include background properties, production methods and cost of LH2;...
Detection and characterization of mechanisms of action of aneugenic chemicals (2002)
Parry, E.M., Parry, J.M., Corso, C., Doherty, A., Haddad, F., Hermine, T.F., ...
A comprehensive evaluation of the genotoxic potential of chemicals requires the assessment of the ability to induce gene mutations and structural chromosome (clastogenic activity) and numerical...
Lewis, P.D., Harvey, J.S., Waters, E.M., Skibinski, D.O.F., Parry, J.M.
The last decade has seen a dramatic accumulation of mutation data from reporter genes utilized in mutagenesis experiments involving DNA reactive agents allowing comparisons for the mutagenic...
Song, H. L., Jenkins, G. J. S., Ashby, J., Tinwell, H., Parry, J. M.
Transgenic mouse modelling has provided a new approach to study the various steps involved in spontaneous and induced mutagenesis in rodent somatic and germline tissues in vivo. However, the...
The Mammalian Gene Mutation Database (2000)
Lewis, P.D., Harvey, J.S., Waters, E.M., Parry, J.M.
The Mammalian Gene Mutation Database (MGMD) is a comprehensive collection of published mutation data from the open literature on mammalian cell-based gene model mutation detection systems. The...
Ramírez, M.J., Puerto, S., Galofré, P., Parry, E.M., Parry, J.M., Creus, A., ...
Simultaneous labelling of 17cen and the p53 locus by multicolour FISH was used to monitor radioactive iodine-induced structural and numerical chromosome abnormalities in buccal cells from 29...
Dixon, D.R., Wilson, J.T., Pascoe, P.L., Parry, J.M.
The marine environment receives a wide variety of chemical inputs, many of which have the potential to damage DNA or interfere with the process of cell division. Here we describe a new assay based on...
Jenkins, G.J.S., Suzen, H.S., Sueiro, R.A., Parry, J.M.
The restriction site mutation (RSM) assay has been employed in our laboratory, as a mutation detection system, since its first description in 1990. In principle the technique is capable of detecting...
MOLECULAR ENGINEERING OF PT-BASED ELECTROCATALYSTS FOR HYDROCARBON FUEL CELL ELECTRODES. (1998)
Giner, J., Parry, J. M., Smith, S. M.
The main objective of this work is to correlate the physical parameters of Pt-catalysts of very different characteristics with their activity for anodic propane oxidation. In particular, the effect...
MOLECULAR ENGINEERING OF PT-BASED ELECTROCATALYSTS FOR HYDROCARBON FUEL CELL ELECTRODES. (1998)
Giner, J., Parry, J. M., Smith, S. M.
This report describes continued studies of the factors influencing the activity of platinum black catalysts for the electrochemical oxidation of propane. Two factors are considered in detail--the...
Molecular Engineering of Pt-Based Electrocatalysts for Hydrocarbon Fuel Cell Electrodes. (1998)
Giner, J., Parry, J. M., Smith, S. M.
The report describes continued studies of the factors controlling the activity of Pt black catalysts for the anodic oxidation of hydrocarbons. Particular attention has been given to the separation of...
Parry, J. M., Foy, R. C., Woodman, C. B. J.
Background Recent guidelines have suggested that testing young dyspeptic patients for Helicobacter pylori infection will produce more appropriate referrals for endoscopic investigation. Our aim was...
The detectioon of genotoxin-induced DNA adducts in the common mussel Mytilus edulis (1997)
In order to establish the capacity of Mytilus spp. to form genotoxin–DNA adducts, a series of in vitro and in vivo studies were conducted in which tissue samples and animals were exposed to five...
Doherty, Ann T., Ellard, Sian, Parry, Elizabeth M., Parry, J.M.
We have investigated the induction of micronuclei by 15 chlorinated hydrocarbons in the cytochalasin B-blocked micronucleus assay utilizing genetically engineered cell lines. The human lymphoblastoid...
Kirsch-Volders, M., Tallon, I., Tanzarella, C., Sgura, A., Hermine, T., Parry, E.M., ...
A collaborative study of three laboratories compared the induction of aneuploidy by X-rays in human lymphocytes and fibroblasts. The induction of non-disjunction versus chromosome loss by X-rays was...
The restriction site mutation (RSM) assay has been developed as a methodology for the study of base changes induced in restriction enzyme recognition sequences. In principle, the RSM methodology may...
Ashby, J., Short, J.M., Jones, N.J., Lefevre, P.A., Provost, G.S., Rogers, B J., ...
Earlier studies have established that the rodent bladder carcinogen o-anisidine (OA) gives negative results hi all of the standard rodent genetic toxicity assays. In the present study, a single oral...
Parry, J. M., Shamsher, M., Skibinski, D. O. F.
We propose a methodology for the detection of DNA base changes in restriction enzyme recognition sites. The restriction site mutation (RSM) technique is based upon the detection of DNA sequences...
Ashby, J., Paton, D., Wilcox, P., Parry, J.M.
1,6-Dinitropyrene elicits a potent mutagenic response in a range of microorganisms in the absence of auxiliary metabolism (S9 mix). This activity is considered to be dependent upon nitroreductase...
Kelly, S.L., Tippins, R.S., Parry, J.M., Waters, R.
In the yeast Saccharomyces cerevisiae enhanced nuclear mutagenesis was found during mitotic DNA synthesis after treatment with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), but not during meiotic...
Turnbull, P C, Jørgensen, K, Kramer, J M, Gilbert, R J, Parry, J M
Twenty-one cases of infection with Bacillus cereus are summarised. The histories supplied showed that at least 15 of these were associated with severe or potentially severe symptoms including two...
Parry, J M, Foy, R C, Woodman, C B
The availability of non-invasive tests for the detection of Helicobactor pylori infection in primary care is increasing. However, the World Health Organization (WHO) has recently labelled H. pylori...
Development of screening tests for aneuploidy induction by environmental pollutants.
When legally required mutagenicity testing of chemicals is undertaken, the important genetic end point of aneuploidy is not included because validated test methods are lacking. Therefore, the...
Detection of mitotic and meiotic aneuploidy in the yeast Saccharomyces cerevisiae.
Parry, J M, Sharp, D, Parry, E M
A number of genetic systems are described which involve the use of the yeast Saccharomyces cerevisiae. The systems may be used to detect the production of aneuploid cells produced during both mitotic...
Turnbull, P C, Jørgensen, K, Kramer, J M, Gilbert, R J, Parry, J M
Twenty-one cases of infection with Bacillus cereus are summarised. The histories supplied showed that at least 15 of these were associated with severe or potentially severe symptoms including two...
Parry, J M, Foy, R C, Woodman, C B
The availability of non-invasive tests for the detection of Helicobactor pylori infection in primary care is increasing. However, the World Health Organization (WHO) has recently labelled H. pylori...
Development of screening tests for aneuploidy induction by environmental pollutants.
When legally required mutagenicity testing of chemicals is undertaken, the important genetic end point of aneuploidy is not included because validated test methods are lacking. Therefore, the...
Detection of mitotic and meiotic aneuploidy in the yeast Saccharomyces cerevisiae.
Parry, J M, Sharp, D, Parry, E M
A number of genetic systems are described which involve the use of the yeast Saccharomyces cerevisiae. The systems may be used to detect the production of aneuploid cells produced during both mitotic...
Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett’s oesophagus
Doak, S H, Jenkins, G J S, Parry, E M, D’Souza, F R, Griffiths, A P, Toffazal, N, ...
Background and aims: Characterisation of the underlying molecular mechanisms that promote Barrett’s progression may ultimately lead to identification of potential predictive genetic markers that...
Site distribution of oesophagogastric cancer
Byrne, J P, Mathers, J M, Parry, J M, Attwood, S E A, Bancewicz, J, Woodman, C B J
Aims: It has been suggested that adenocarcinomas of the lower oesophagus and gastric cardia should be reclassified as oesophagogastric junction (OGJ) cancers. This study aimed to define the frequency...
Hazards of horse-riding as a popular sport.
The increasing incidence of horse-riding accidents, which are often severe in nature, prompted a pilot study of a questionnaire designed to elucidate the cause of such accidents. It was hoped that,...
Testing for Helicobacter pylori in primary care: trouble in store?
Foy, R., Parry, J. M., Murray, L., Woodman, C. B.
STUDY OBJECTIVE: To assess the role of testing for Helicobacter pylori in the management of dyspeptic patients in primary care. DESIGN: Selective review of literature frequently quoted to support use...
Williams, L, Jenkins, G J S, Doak, S H, Fowler, P, Parry, E M, Brown, T H, ...
In this series of experiments, a novel protocol was developed whereby gastric cells were collected using endoscopic cytology brush techniques, and prepared, such that interphase fluorescence in situ...
Detection of p53 mutations in precancerous gastric tissue
Morgan, C, Jenkins, G J S, Ashton, T, Griffiths, A P, Baxter, J N, Parry, E M, ...
Jenkins, G J S, Doak, S H, Griffiths, A P, Tofazzal, N, Shah, V, Baxter, J N, ...
Barrett's oesophagus is a premalignant condition whose incidence is rising dramatically. Molecular markers are urgently needed to identify Barrett's patients at the highest risk of cancer...