Rutherford, R A, Matsuda, Y, Wilkins, M R, Polak, J M, Wharton, J
1. The renal actions of natriuretic peptides are dictated by the distribution of guanylyl cyclase-linked (NPRA and NPRB) and non-guanylyl cyclase-linked (NPRC) receptors. Natriuretic peptide...
Desai, K M, Warner, T D, Bishop, A E, Polak, J M, Vane, J R
1. Nitric oxide synthase (NOS) was localized in the guinea pig stomach by immunocytochemistry. In vitro experiments were carried out on the isolated stomach of the guinea pig to study any possible...
Walsh, D A, Salmon, M, Featherstone, R, Wharton, J, Church, M K, Polak, J M
1. The distribution and characteristics of tachykinin NK1 binding sites have been compared in human and guinea pig lung using quantitative in vitro receptor autoradiography with [125I]-Bolton...
Palmer, J. B., Cuss, F. M., Mulderry, P. K., Ghatei, M. A., Springall, D. R., Cadieux, A., ...
In human airways synthetic human sequence calcitonin gene-related peptide (hCGRP), a novel peptide produced by alternative processing of mRNA from the calcitonin gene, caused concentration-dependent...
Turner, N. C., Power, R. F., Polak, J. M., Bloom, S. R., Dollery, C. T.
1. The presence of specific binding sites and the contractile activity of the novel peptide, endothelin have been investigated in rat trachea. 2. Endothelin (10(-8)-10(-5) M) induced long-lasting...
Localization and characterization of neuropeptide Y binding sites in porcine and human colon.
Walsh, D. A., Wharton, J., Blake, D. R., Polak, J. M.
1. We have used quantitative receptor autoradiography to investigate the localization and characteristics of binding sites for 125Iodine-Bolton Hunter-labelled human neuropeptide Y ([125I]-BH-NPY) in...
Lawrence, E., Siney, L., Wilsoncroft, P., Knock, G. A., Terenghi, G., Polak, J. M., ...
1. The relative contribution of ETA and ETB receptors in the response of rat skin to endothelins was investigated by use of the selective ETB agonist IRL-1620 and the selective ETA antagonist BQ-123....
Rutherford, R. A., McCarthy, A., Sullivan, M. H., Elder, M. G., Polak, J. M., Wharton, J.
1. It has been suggested that a deficiency of nitric oxide (NO) may explain many of the pathophysiological features of pre-eclampsia (PE) and intra-uterine (foetal) growth retardation (IUGR). To...
AT1 receptor characteristics of angiotensin analogue binding in human synovium.
Walsh, D. A., Suzuki, T., Knock, G. A., Blake, D. R., Polak, J. M., Wharton, J.
1. Angiotensin II (AII) reduces blood flow, modulates vascular remodelling and is a growth factor. Human inflammatory arthritides are characterized by synovial hypoperfusion, hypoxia and...
Barnes, P. J., Cadieux, A., Carstairs, J. R., Greenberg, B., Polak, J. M., Rhoden, K.
The role of vasoactive intestinal peptide (VIP) in the control of pulmonary vascular tone was investigated by functional response, immunocytochemical localisation and receptor autoradiography in...
Differential localization of endothelin ETA and ETB binding sites in human placenta.
Rutherford, R. A., Wharton, J., McCarthy, A., Gordon, L., Sullivan, M. H., Elder, M. G., ...
1. The localization and differential distribution of endothelin (ET) receptor subtypes (ETA and ETB) was investigated in sections of human placenta by use of quantitative in vitro autoradiography and...
Sheppard, M N, Kurian, S S, Henzen-Logmans, S C, Michetti, F, Cocchia, D, Cole, P, ...
Lung innervation has been studied in the past by methylene blue staining and silver impregnation and more recently by histochemical methods. These techniques give only a partial picture of the total...
Sheppard, M N, Polak, J M, Allen, J M, Bloom, S R
Neuropeptide tyrosine (NPY), a newly discovered peptide known to modulate blood vessel diameter and smooth muscle tone, has been found in many mammalian organs. Its distribution is similar to that of...
Distribution of galanin immunoreactivity in the respiratory tract of pig, guinea pig, rat, and dog.
Cheung, A, Polak, J M, Bauer, F E, Cadieux, A, Christofides, N D, Springall, D R, ...
Galanin, a newly discovered peptide isolated from porcine intestine, is known to cause contraction in rat smooth muscle preparations and to induce hyperglycaemia in dogs. By the use of...
Regulatory peptides in the respiratory tract of Macaca fascicularis.
Ghatei, M A, Springall, D R, Richards, I M, Oostveen, J A, Griffin, R L, Cadieux, A, ...
The quantitative distribution and localisation of seven regulatory peptides (vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM), calcitonin gene related peptide (CGRP), galanin,...
Springall, D R, Bhatnagar, M, Wharton, J, Hamid, Q, Gulbenkian, S, Hedges, M, ...
Atrial natriuretic peptide is a peptide regulating salt and water balance, originally isolated from the cardiac atrium, where it is synthesised as part of a precursor molecule in specialised...
Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.
Woo, D, Scopes, J W, Polak, J M
Two sibs who sustained severe hypoglycaemia in the neonatal period are reported. In spite of treatment with frequent feeds intravenous glucose, glucagon, hydrocortisone, and diazoxide, hypoglycaemia...
Aynsley-Green, A, Polak, J M, Bloom, S R, Gough, M H, Keeling, J, Ashcroft, S J, ...
Three newborn infants are reported who developed severe non-ketotic hypoglycaemia (blood glucose less than 1.1 mmol/l; 19.8 mg/100 ml) within 6 hours of birth. All had inappropriately raised plasma...
DIDMOAD syndrome with megacystis and megaureter.
Chu, P., Staff, W. G., Morris, J. A., Polak, J. M.
A case of DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and nerve deafness) is described. There was unusually severe urinary tract dilatation which led to an ileal conduit...
The Zollinger-Ellison syndrome and ectopic gastric mucosa
Galland, R. B., Fletcher, D. R., Evans, D. J., Shlugman, D., Polak, J. M., Baron, J. H., ...
Ectopic gastric mucosa in an intramesenteric ileal diverticulum caused fatal bleeding after total gastrectomy in a patient with the Zollinger-Ellison syndrome (ZES).
Ghatei, M. A., Stratton, M. R., Allen, J. M., Joplin, G. F., Polak, J. M., Bloom, S. R.
A carcinoid tumour presenting as Cushing's syndrome is reported. Although no tumour mass could be initially identified the patient returned with first a liver and subsequently a cerebellar mass both...