Zhao, J., Moss, J., Sebire, N.J., Cui, Q.C., Seckl, M.J., Xiang, Y., ...
BACKGROUND: Familial recurrent hydatidiform mole is an extremely rare autosomal recessive condition in which affected individuals have a predisposition to molar pregnancies that are diploid but...
Zhao, J., Moss, J., Sebire, N.J., Cui, Q.C., Seckl, M.J., Xiang, Y., ...
BACKGROUND: Familial recurrent hydatidiform mole is an extremely rare autosomal recessive condition in which affected individuals have a predisposition to molar pregnancies that are diploid but...
Moss, J., Ryder, T., Aziz, T. Z., Graeber, M. B., Bain, P. G.
Summary Deep brain stimulation (DBS) is used to treat a variety of severe medically intractable movement disorders, including Parkinson's disease, tremor and dystonia. There have been few studies...
Moss, J., Ryder, T., Aziz, T. Z., Graeber, M. B., Bain, P. G.
Deep brain stimulation (DBS) is used to treat a variety of severe medically intractable movement disorders, including Parkinson's disease, tremor and dystonia. There have been few studies examining...
Moss, J., Ryder, T., Aziz, T. Z., Graeber, M. B., Bain, P. G.
Summary Deep brain stimulation (DBS) is used to treat a variety of severe medically intractable movement disorders, including Parkinson's disease, tremor and dystonia. There have been few studies...
Wilkinson, D, Hiller, J, Moss, J, Ryan, P, Worsley, T
OBJECTIVE: To describe variation in all cause and selected cause-specific mortality rates across Australia. METHODS: Mortality and population data for 1997 were obtained from the Australian Bureau of...
Wilkinson, D, Hiller, J, Moss, J, Ryan, P, Worsley, T
OBJECTIVE: To describe variation in all cause and selected cause-specific mortality rates across Australia. METHODS: Mortality and population data for 1997 were obtained from the Australian Bureau of...
Program budgeting and marginal analysis: A case study in chronic airflow limitation (1999)
Crockett, Alan Joseph, Cranston, J., Moss, J., Scown, P., Mooney, G., Alpers, John H.
Program budgeting and marginal analysis: A case study in chronic airflow limitation (1999)
Crockett, Alan Joseph, Cranston, J., Moss, J., Scown, P., Mooney, G., Alpers, John H.
Percutaneous fibrin sleeve stripping of failing haemodialysis catheters (1999)
Johnstone, R, Stewart, G, Akoh, J, Fleet, M, Akyol, M, Moss, J
Adp-ribosyltransferase type-a from turkey erythrocytes modifies actin at arg-95 and arg-372 (1995)
Just, I, Sehr, P, Jung, M, Vandamme, J, Puype, M, Van De Kerckhove, Johan; U0004569, ...
Turkey erythrocyte ADP-ribosyltransferase A catalyzes the transfer of ADP-ribose from NAD to both monomeric and polymeric skeletal muscle alpha-actin with the incorporation of 2 mol of ADP-ribose per...
Screening for colorectal cancer - What are the costs? (1995)
Weller, D., Moss, J., Hiller, J., Thomas, D., Edwards, J. B.
Screening for colorectal cancer - What are the costs? (1995)
Weller, D., Moss, J., Hiller, J., Thomas, D., Edwards, J. B.
ADP-ribosyltransferase type-A from turkey erythrocytes modifies actin at Arg-95 and Arg-372. (1995)
JUST, I, SEHR, P, JUNG, M, VANDAMME, J, Puype, Magda, Vandekerckhove, Joël, ...
HISTAMINE RELEASE DURING THE ADMINISTRATION OF ATRACURIUM OR VECURONIUM IN CHILDREN (1986)
GOUDSOUZIAN, N. G., YOUNG, E. T., MOSS, J., LIU, L. M. P.
The histamine releasing potential of equivalent bolus doses of atracurium 0.6 mg kg−1 or vecuronium 0.12 mg kg−1 was evaluated in 20 children anaesthetized with halothane. Blood samples were...
SPIN FLIP STRENGTH AT HIGH EXCITATION ENERGY IN THE 90Zr([MATH]) 90Zr REACTION (1984)
Nanda, S., Glashausser, C., Jones, K., Mcgill, J., Carey, T., Mcclelland, J.B., ...
Measurements of the cross section, analyzing power, and spin-flip probability are consistent with an M1 assignment for the 9.0 MeV peak in the 90Zr(p,p')90Zr reaction at 319 MeV, but they are not...
SPIN FLIP STRENGTH AT HIGH EXCITATION ENERGY IN THE 90Zr([MATH]) 90Zr REACTION (1984)
Nanda, S., Glashausser, C., Jones, K., Mcgill, J., Carey, T., Mcclelland, J.B., ...
Measurements of the cross section, analyzing power, and spin-flip probability are consistent with an M1 assignment for the 9.0 MeV peak in the 90Zr(p,p')90Zr reaction at 319 MeV, but they are not...
SPIN FLIP STRENGTH AT HIGH EXCITATION ENERGY IN THE 90Zr([MATH]) 90Zr REACTION (1984)
Nanda, S., Glashausser, C., Jones, K., Mcgill, J., Carey, T., Mcclelland, J.B., ...
Measurements of the cross section, analyzing power, and spin-flip probability are consistent with an M1 assignment for the 9.0 MeV peak in the 90Zr(p,p')90Zr reaction at 319 MeV, but they are not...
The $^{18}$O($\vec p$,p')$^{18}$O reaction at 800 MeV (1981)
Glashausser, C., Nanda, S., Swiniarski, R. De, Baker, F.T., Grimm, M., Love, W.G., ...
The $^{18}$O($\vec p$,p')$^{18}$O reaction at 800 MeV (1981)
Glashausser, C., Nanda, S., Swiniarski, R. De, Baker, F.T., Grimm, M., Love, W.G., ...
Tesauro, M., Thompson, W. C., Rogliani, P., Qi, L., Chaudhary, P. P., Moss, J.
An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of...
Vitale, N, Moss, J, Vaughan, M
The alpha subunits of the heterotrimeric guanine nucleotide-binding proteins (G proteins) hydrolyze GTP at a rate significantly higher than do most members of the Ras family of approximatelly 20-kDa...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins and are active in the GTP-bound state and inactive with GDP bound. ARF-GTP has a critical role in vesicular transport in...
Hong, J X, Zhang, X, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin ADP-ribosyltransferase in vitro and participate in intracellular vesicular...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins that participate in vesicular transport in the Golgi and other intracellular compartments and stimulate...
Massenburg, D, Han, J S, Liyanage, M, Patton, W A, Rhee, S G, Moss, J, ...
Two major forms of phospholipase D (PLD) activity, solubilized from rat brain membranes with Triton X-100, were separated by HPLC on a heparin-5PW column with buffer containing octyl glucoside. One...
Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase.
Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Incubations of GAPDH with...
Differential interaction of ADP-ribosylation factors 1, 3, and 5 with rat brain Golgi membranes.
Tsai, S C, Adamik, R, Haun, R S, Moss, J, Vaughan, M
Six mammalian ADP-ribosylation factors (ARFs) identified by cDNA cloning were expressed as recombinant proteins (rARFs) that stimulated cholera toxin ADP-ribosyltransferase activity. Microsequencing...
Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle.
Zolkiewska, A, Nightingale, M S, Moss, J
Mono-ADP-ribosylation is a reversible modification of proteins, with NAD:arginine ADP-ribosyltransferases (EC 2.4.2.31) and ADP-ribosylarginine hydrolases (EC 3.2.2.19) catalyzing the opposing...
Monaco, L, Murtagh, J J, Newman, K B, Tsai, S C, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa proteins that act as GTP-dependent allosteric activators of cholera toxin. With deoxyinosine-containing degenerate oligonucleotide primers...
Holodniy, M, Mole, L, Margolis, D, Moss, J, Dong, H, Boyer, E, ...
Eleven human immunodeficiency virus (HIV)-infected subjects on long-term zidovudine (ZDV) therapy had didanosine (ddI) added to their antiretroviral regimen. HIV RNA in plasma was quantitated by...
Clark, T, Gresser, I, Pfau, C, Moss, J, Woodrow, D
Infection of newborn C3HeB/FeJ mice with the arenavirus Pichinde resulted in stunted growth, severe liver cell degeneration, and death. Administration of sheep anti-mouse alpha/beta interferon...
Chang, P P, Moss, J, Twiddy, E M, Holmes, R K
Type II heat-labile enterotoxin (LT-II) from Escherichia coli causes characteristic morphological changes and accumulation of cyclic AMP in Y-1 adrenal cells, but it is not neutralized by antisera...
Price, S R, Nightingale, M, Tsai, S C, Williamson, K C, Adamik, R, Chen, H C, ...
Three (two soluble and one membrane) guanine nucleotide-binding proteins (G proteins) that enhance ADP-ribosylation of the Gs alpha stimulatory subunit of the adenylyl cyclase (EC 4.6.1.1) complex by...
Lee, C M, Chang, P P, Tsai, S C, Adamik, R, Price, S R, Kunz, B C, ...
Escherichia coli heat-labile enterotoxins (LT) are responsible in part for "traveler's diarrhea" and related diarrheal illnesses. The family of LTs comprises two serogroups termed LT-I and LT-II;...
Bobak, D A, Nightingale, M S, Murtagh, J J, Price, S R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin. Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum...
Tsai, S C, Noda, M, Adamik, R, Moss, J, Vaughan, M
Choleragen activates adenylate cyclase by catalyzing, in the presence of NAD, the ADP-ribosylation of Gs alpha, the stimulatory guanyl nucleotide-binding protein of the cyclase system. Kahn and...
Häse, C C, Thai, L S, Boesman-Finkelstein, M, Mar, V L, Burnette, W N, Kaslow, H R, ...
The catalytic A subunit of cholera toxin (CT-A) is capable of ADP-ribosylating the guanine nucleotide-binding protein, which regulates cell adenylyl cyclase, leading to the life-threatening diarrhea...
Radioligand binding studies disclosed one class of high affinity atrial natriuretic factor (ANF) receptors on human fibroblast membranes (Kd = 66 pM; maximum number of binding sites [Bmax] = 7,000...
Van Meurs, K P, Angus, C W, Lavu, S, Kung, H F, Czarnecki, S K, Moss, J, ...
A bovine retinal cDNA clone encoding the complete sequence (354 amino acids) of Go alpha, a guanine nucleotide-binding protein (G protein), was isolated by using oligonucleotide probes complementary...
Murtagh, J J, Moss, J, Vaughan, M
Go alpha a guanine nucleotide-binding (G) protein abundant in brain and other neural tissues, has been implicated in ion channel regulation. Concerted efforts in several laboratories have revealed...
An ADP-ribosyltransferase from turkey erythrocytes, which catalyzes the mono(ADP-ribosylation) of guanidino compounds such as arginine and of many purified and crude cellular proteins, appears to...
Moss, J, De Mello, M C, Vaughan, M, Beaven, M A
In man and other animals, urinary excretion of the histidine and histamine metabolite, imidazoleacetate, is increased and that of its conjugated metabolite, ribosylimidazoleacetate, decreased by...
Murtagh, J J, Eddy, R, Shows, T B, Moss, J, Vaughan, M
Go alpha, (gene symbol GNA01), a member of the signal-transducing guanine nucleotide-binding (G) protein family, has been implicated in ion channel regulation. Some tissues contain multiple Go alpha...
The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. The...
Roscher, A A, Manganiello, V C, Jelsema, C L, Moss, J
The interaction of bradykinin (BK) with its specific receptors on intact cultured human fibroblasts results in production of prostaglandins, including prostacyclin (PGI2), and accumulation of cyclic...
Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin.
Moss, J, Garrison, S, Fishman, P H, Richardson, S H
Chemically transformed mouse fibroblasts did not raise their cyclic AMP level in response to Escherichia coli heat-labile enterotoxin. These fibroblasts did, however, incorporate exogenous mono-,...
Choleragen (cholera toxin): a bacterial lectin.
Richards, R L, Moss, J, Alving, C R, Fishman, P H, Brady, R O
Choleragen (cholera toxin) agglutinated erythrocytes and liposomes containing the toxin receptor, galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide (ganglioside GM1)....
Angus, C W, Van Meurs, K P, Tsai, S C, Adamik, R, Miedel, M C, Pan, Y C, ...
Go alpha, a 39-kDa guanyl nucleotide-binding protein, is functionally and structurally similar to the alpha subunits of the stimulatory and inhibitory guanyl nucleotide-binding proteins (Gs alpha, Gi...
Moss, J, Jacobson, M K, Stanley, S J
Enzymes have been identified in animal tissues that catalyze the mono(ADP-ribosyl)ation of arginine and proteins. Since these NAD:arginine ADP-ribosyltransferases under physiological conditions do...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M, Manne, V, Kung, H F
The Ha-ras protooncogene product p21, which may be involved in control of cellular growth, is a membrane protein that binds guanine nucleotides and hydrolyzes GTP. p21 GTPase activity is stimulated...
Interferon induces pulmonary cysts in A2G mice.
Woodrow, D, Moss, J, Gresser, I
Suckling A2G mice were treated for the first week of life with either partially purified or electrophoretically pure mouse alpha/beta interferon. All mice subsequently developed multiple large...
Moss, J, Osborne, J C, Fishman, P H, Brewer, H B, Vaughan, M, Brady, R O
Choleragen and its A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. NADase activity was inhibited by gangliosides GM1...
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.
Moss, J, Fishman, P H, Manganiello, V C, Vaughan, M, Brady, R O
NCTC 2071 cells are unable to synthesize the monosialoganglioside GM1. When grown in chemically defined medium these cells contained no detectable GM1 and did not accumulate 3': 5'-cyclic AMP in...
Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1.
Moss, J, Fishman, P H, Richards, R L, Alving, C R, Vaughan, M, Brady, R O
125I-Labeled choleragen was bound to liposomes containing galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide (GM1), but not in large amounts to ganglioside-free...
Moss, J, Manganiello, V C, Vaughan, M
Choleragen and the isolated A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. The protein with NADase activity (NAD nucleosidase; NAD glycohydrolase, EC 3-2-2-5) migrated on...
Chu, C S, Trapnell, B C, Murtagh, J J, Moss, J, Dalemans, W, Jallat, S, ...
The predicted protein domains coded by exons 9-12 and 19-23 of the 27 exon cystic fibrosis transmembrane conductance regulator (CFTR) gene contain two putative nucleotide-binding fold regions....
Adenovirus infection of the large bowel in HIV positive patients.
Maddox, A, Francis, N, Moss, J, Blanshard, C, Gazzard, B
AIMS: To describe the microscopic appearance of adenovirus infection in the large bowel of human immunodeficiency virus (HIV) positive patients with diarrhoea. METHODS: Large bowel biopsy specimens...
Shibutani, T, Johnson, T M, Yu, Z X, Ferrans, V J, Moss, J, Epstein, S E
We demonstrated recently that the arachidonic acid (AA) cascade is involved in cytomegalovirus (CMV)-induced generation of reactive oxygen species (ROS) and the activation of nuclear factor...
Stimulation of endogenous ADP-ribosylation by brefeldin A.
De Matteis, M A, Di Girolamo, M, Colanzi, A, Pallas, M, Di Tullio, G, McDonald, L J, ...
Brefeldin A (BFA) is a fungal metabolite that exerts profound and generally inhibitory actions on membrane transport. At least some of the BFA effects are due to inhibition of the GDP-GTP exchange on...
Roscher, A A, Manganiello, V C, Jelsema, C L, Moss, J
Bradykinin receptors on cultured human fibroblasts were characterized using [2,3-prolyl-3,4-3H(N)]bradykinin as radioligand. During incubation with intact fibroblasts, intact [3H]bradykinin was lost...
Electron microscopy of undecalcified human bone.
An alternative approach for the electron microscopical examination of undecalcified human bone was investigated. The method required bone to be chilled to -70 degrees C, sectioned at 10 microns in a...
Activation and stabilization of the catalytic unit of adenylate cyclase.
Terman, B I, Bitonti, A J, Moss, J, Vaughan, M
The requirements for stability and activity of the catalytic unit (C) of adenylate cyclase were investigated. After solubilization of bovine brain membranes in the zwitterionic detergent...
Watkins, P A, Kanaho, Y, Moss, J
The bacterial toxins, choleragen and pertussis toxin, inhibit the light-stimulated GTPase activity of bovine retinal rod outer segments by catalysing the ADP-ribosylation of the alpha-subunit (T...
Saltzman, L E, Moss, J, Berg, R A, Hom, B, Crystal, R G
Cultured human lung fibroblasts were evaluated for their responsiveness to isoprenaline (isoproterenol) or prostaglandin E2 before and after chronic incubation with the agonist. Cells incubated for 6...
Akuffo, E L, Hunt, J R, Moss, J, Woodrow, D, Davies, M, Mason, R M
Rats were implanted with mini osmotic pumps delivering sodium [35S]sulphate and their newly synthesized proteoglycans were labelled over a 146 h period (steady-state labelling). Proteoglycan turnover...
Corech, R., Rao, A., Laxova, A., Moss, J., Rock, M. J., Li, Z., ...
The lungs of patients with cystic fibrosis (CF) are colonized initially by Pseudomonas aeruginosa, which is associated with progressive lung destruction and increased mortality. The pathogenicity of...
Tesauro, M., Thompson, W. C., Rogliani, P., Qi, L., Chaudhary, P. P., Moss, J.
An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of...
Vitale, N, Moss, J, Vaughan, M
The alpha subunits of the heterotrimeric guanine nucleotide-binding proteins (G proteins) hydrolyze GTP at a rate significantly higher than do most members of the Ras family of approximatelly 20-kDa...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins and are active in the GTP-bound state and inactive with GDP bound. ARF-GTP has a critical role in vesicular transport in...
Hong, J X, Zhang, X, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin ADP-ribosyltransferase in vitro and participate in intracellular vesicular...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins that participate in vesicular transport in the Golgi and other intracellular compartments and stimulate...
Massenburg, D, Han, J S, Liyanage, M, Patton, W A, Rhee, S G, Moss, J, ...
Two major forms of phospholipase D (PLD) activity, solubilized from rat brain membranes with Triton X-100, were separated by HPLC on a heparin-5PW column with buffer containing octyl glucoside. One...
Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase.
Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Incubations of GAPDH with...
Differential interaction of ADP-ribosylation factors 1, 3, and 5 with rat brain Golgi membranes.
Tsai, S C, Adamik, R, Haun, R S, Moss, J, Vaughan, M
Six mammalian ADP-ribosylation factors (ARFs) identified by cDNA cloning were expressed as recombinant proteins (rARFs) that stimulated cholera toxin ADP-ribosyltransferase activity. Microsequencing...
Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle.
Zolkiewska, A, Nightingale, M S, Moss, J
Mono-ADP-ribosylation is a reversible modification of proteins, with NAD:arginine ADP-ribosyltransferases (EC 2.4.2.31) and ADP-ribosylarginine hydrolases (EC 3.2.2.19) catalyzing the opposing...
Monaco, L, Murtagh, J J, Newman, K B, Tsai, S C, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are approximately 20-kDa proteins that act as GTP-dependent allosteric activators of cholera toxin. With deoxyinosine-containing degenerate oligonucleotide primers...
Holodniy, M, Mole, L, Margolis, D, Moss, J, Dong, H, Boyer, E, ...
Eleven human immunodeficiency virus (HIV)-infected subjects on long-term zidovudine (ZDV) therapy had didanosine (ddI) added to their antiretroviral regimen. HIV RNA in plasma was quantitated by...
Clark, T, Gresser, I, Pfau, C, Moss, J, Woodrow, D
Infection of newborn C3HeB/FeJ mice with the arenavirus Pichinde resulted in stunted growth, severe liver cell degeneration, and death. Administration of sheep anti-mouse alpha/beta interferon...
Chang, P P, Moss, J, Twiddy, E M, Holmes, R K
Type II heat-labile enterotoxin (LT-II) from Escherichia coli causes characteristic morphological changes and accumulation of cyclic AMP in Y-1 adrenal cells, but it is not neutralized by antisera...
Price, S R, Nightingale, M, Tsai, S C, Williamson, K C, Adamik, R, Chen, H C, ...
Three (two soluble and one membrane) guanine nucleotide-binding proteins (G proteins) that enhance ADP-ribosylation of the Gs alpha stimulatory subunit of the adenylyl cyclase (EC 4.6.1.1) complex by...
Lee, C M, Chang, P P, Tsai, S C, Adamik, R, Price, S R, Kunz, B C, ...
Escherichia coli heat-labile enterotoxins (LT) are responsible in part for "traveler's diarrhea" and related diarrheal illnesses. The family of LTs comprises two serogroups termed LT-I and LT-II;...
Bobak, D A, Nightingale, M S, Murtagh, J J, Price, S R, Moss, J, Vaughan, M
ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin. Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum...
Tsai, S C, Noda, M, Adamik, R, Moss, J, Vaughan, M
Choleragen activates adenylate cyclase by catalyzing, in the presence of NAD, the ADP-ribosylation of Gs alpha, the stimulatory guanyl nucleotide-binding protein of the cyclase system. Kahn and...
Häse, C C, Thai, L S, Boesman-Finkelstein, M, Mar, V L, Burnette, W N, Kaslow, H R, ...
The catalytic A subunit of cholera toxin (CT-A) is capable of ADP-ribosylating the guanine nucleotide-binding protein, which regulates cell adenylyl cyclase, leading to the life-threatening diarrhea...
Radioligand binding studies disclosed one class of high affinity atrial natriuretic factor (ANF) receptors on human fibroblast membranes (Kd = 66 pM; maximum number of binding sites [Bmax] = 7,000...
Van Meurs, K P, Angus, C W, Lavu, S, Kung, H F, Czarnecki, S K, Moss, J, ...
A bovine retinal cDNA clone encoding the complete sequence (354 amino acids) of Go alpha, a guanine nucleotide-binding protein (G protein), was isolated by using oligonucleotide probes complementary...
Murtagh, J J, Moss, J, Vaughan, M
Go alpha a guanine nucleotide-binding (G) protein abundant in brain and other neural tissues, has been implicated in ion channel regulation. Concerted efforts in several laboratories have revealed...
An ADP-ribosyltransferase from turkey erythrocytes, which catalyzes the mono(ADP-ribosylation) of guanidino compounds such as arginine and of many purified and crude cellular proteins, appears to...
Moss, J, De Mello, M C, Vaughan, M, Beaven, M A
In man and other animals, urinary excretion of the histidine and histamine metabolite, imidazoleacetate, is increased and that of its conjugated metabolite, ribosylimidazoleacetate, decreased by...
Murtagh, J J, Eddy, R, Shows, T B, Moss, J, Vaughan, M
Go alpha, (gene symbol GNA01), a member of the signal-transducing guanine nucleotide-binding (G) protein family, has been implicated in ion channel regulation. Some tissues contain multiple Go alpha...
The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. The...
Roscher, A A, Manganiello, V C, Jelsema, C L, Moss, J
The interaction of bradykinin (BK) with its specific receptors on intact cultured human fibroblasts results in production of prostaglandins, including prostacyclin (PGI2), and accumulation of cyclic...
Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin.
Moss, J, Garrison, S, Fishman, P H, Richardson, S H
Chemically transformed mouse fibroblasts did not raise their cyclic AMP level in response to Escherichia coli heat-labile enterotoxin. These fibroblasts did, however, incorporate exogenous mono-,...
Choleragen (cholera toxin): a bacterial lectin.
Richards, R L, Moss, J, Alving, C R, Fishman, P H, Brady, R O
Choleragen (cholera toxin) agglutinated erythrocytes and liposomes containing the toxin receptor, galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide (ganglioside GM1)....
Angus, C W, Van Meurs, K P, Tsai, S C, Adamik, R, Miedel, M C, Pan, Y C, ...
Go alpha, a 39-kDa guanyl nucleotide-binding protein, is functionally and structurally similar to the alpha subunits of the stimulatory and inhibitory guanyl nucleotide-binding proteins (Gs alpha, Gi...
Moss, J, Jacobson, M K, Stanley, S J
Enzymes have been identified in animal tissues that catalyze the mono(ADP-ribosyl)ation of arginine and proteins. Since these NAD:arginine ADP-ribosyltransferases under physiological conditions do...
Tsai, S C, Adamik, R, Moss, J, Vaughan, M, Manne, V, Kung, H F
The Ha-ras protooncogene product p21, which may be involved in control of cellular growth, is a membrane protein that binds guanine nucleotides and hydrolyzes GTP. p21 GTPase activity is stimulated...
Interferon induces pulmonary cysts in A2G mice.
Woodrow, D, Moss, J, Gresser, I
Suckling A2G mice were treated for the first week of life with either partially purified or electrophoretically pure mouse alpha/beta interferon. All mice subsequently developed multiple large...
Moss, J, Osborne, J C, Fishman, P H, Brewer, H B, Vaughan, M, Brady, R O
Choleragen and its A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. NADase activity was inhibited by gangliosides GM1...
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness.
Moss, J, Fishman, P H, Manganiello, V C, Vaughan, M, Brady, R O
NCTC 2071 cells are unable to synthesize the monosialoganglioside GM1. When grown in chemically defined medium these cells contained no detectable GM1 and did not accumulate 3': 5'-cyclic AMP in...
Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1.
Moss, J, Fishman, P H, Richards, R L, Alving, C R, Vaughan, M, Brady, R O
125I-Labeled choleragen was bound to liposomes containing galactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosylglucosylceramide (GM1), but not in large amounts to ganglioside-free...
Moss, J, Manganiello, V C, Vaughan, M
Choleragen and the isolated A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. The protein with NADase activity (NAD nucleosidase; NAD glycohydrolase, EC 3-2-2-5) migrated on...
Chu, C S, Trapnell, B C, Murtagh, J J, Moss, J, Dalemans, W, Jallat, S, ...
The predicted protein domains coded by exons 9-12 and 19-23 of the 27 exon cystic fibrosis transmembrane conductance regulator (CFTR) gene contain two putative nucleotide-binding fold regions....
Adenovirus infection of the large bowel in HIV positive patients.
Maddox, A., Francis, N., Moss, J., Blanshard, C., Gazzard, B.
AIMS: To describe the microscopic appearance of adenovirus infection in the large bowel of human immunodeficiency virus (HIV) positive patients with diarrhoea. METHODS: Large bowel biopsy specimens...
Shibutani, T, Johnson, T M, Yu, Z X, Ferrans, V J, Moss, J, Epstein, S E
We demonstrated recently that the arachidonic acid (AA) cascade is involved in cytomegalovirus (CMV)-induced generation of reactive oxygen species (ROS) and the activation of nuclear factor...
Stimulation of endogenous ADP-ribosylation by brefeldin A.
De Matteis, M A, Di Girolamo, M, Colanzi, A, Pallas, M, Di Tullio, G, McDonald, L J, ...
Brefeldin A (BFA) is a fungal metabolite that exerts profound and generally inhibitory actions on membrane transport. At least some of the BFA effects are due to inhibition of the GDP-GTP exchange on...
Roscher, A A, Manganiello, V C, Jelsema, C L, Moss, J
Bradykinin receptors on cultured human fibroblasts were characterized using [2,3-prolyl-3,4-3H(N)]bradykinin as radioligand. During incubation with intact fibroblasts, intact [3H]bradykinin was lost...
Electron microscopy of undecalcified human bone.
An alternative approach for the electron microscopical examination of undecalcified human bone was investigated. The method required bone to be chilled to -70 degrees C, sectioned at 10 microns in a...
Activation and stabilization of the catalytic unit of adenylate cyclase.
Terman, B I, Bitonti, A J, Moss, J, Vaughan, M
The requirements for stability and activity of the catalytic unit (C) of adenylate cyclase were investigated. After solubilization of bovine brain membranes in the zwitterionic detergent...
Watkins, P A, Kanaho, Y, Moss, J
The bacterial toxins, choleragen and pertussis toxin, inhibit the light-stimulated GTPase activity of bovine retinal rod outer segments by catalysing the ADP-ribosylation of the alpha-subunit (T...
Saltzman, L E, Moss, J, Berg, R A, Hom, B, Crystal, R G
Cultured human lung fibroblasts were evaluated for their responsiveness to isoprenaline (isoproterenol) or prostaglandin E2 before and after chronic incubation with the agonist. Cells incubated for 6...
Akuffo, E L, Hunt, J R, Moss, J, Woodrow, D, Davies, M, Mason, R M
Rats were implanted with mini osmotic pumps delivering sodium [35S]sulphate and their newly synthesized proteoglycans were labelled over a 146 h period (steady-state labelling). Proteoglycan turnover...
Corech, R., Rao, A., Laxova, A., Moss, J., Rock, M. J., Li, Z., ...
The lungs of patients with cystic fibrosis (CF) are colonized initially by Pseudomonas aeruginosa, which is associated with progressive lung destruction and increased mortality. The pathogenicity of...
Venables, P J, Yi, T, Woodrow, D F, Moss, J, Maini, R N
Antibodies to nuclear ribonucleoprotein (nRNP), Sm, SS-A, and SS-B, were studied by a quantitative immunodiffusion technique in 48 patients with systemic lupus erythematosus (SLE). There was no...
Moss, J., Shore, I., Woodrow, D., Gresser, I.
Newborn Swiss mice were injected daily for the first week of life with mouse interferon alpha/beta. This treatment resulted in a delay in the maturation of the kidney and the development of...
Wilkinson, D, Hiller, J, Moss, J, Ryan, P, Worsley, T
OBJECTIVE: To describe variation in all cause and selected cause-specific mortality rates across Australia. METHODS: Mortality and population data for 1997 were obtained from the Australian Bureau of...
Gresser, I., Moss, J., Woodrow, D., Le Bousse, C., Maury, C., Proietti, E., ...
Friend erythroleukemia cells (FLC) passaged in mice are highly tumorigenic and multiply extensively in the livers of suckling DBA/2 mice without differentiating. In contrast, in vitro passaged FLCs...
Is thickening of the basal lamina in the saphenous vein a hallmark of smoking?
Higman, D. J., Powell, J. T., Greenhalgh, R. M., Coady, A., Moss, J.
OBJECTIVE--To investigate whether smoking causes ultrastructural changes in the intima of the proximal saphenous vein. DESIGN--Proximal saphenous veins from heavy smokers and non-smokers were...
Gresser, I., Woodrow, D., Moss, J., Maury, C., Tavernier, J., Fiers, W.
Newborn Swiss and A2G mice were given daily subcutaneous injections for 1 week of highly purified recombinant mouse tumor necrosis factor (TNF) or mouse interferon alpha/beta. Both treatments...
Congenital insensitivity to pain: a 20 year follow up.
Larner, A J, Moss, J, Rossi, M L, Anderson, M
The exact nosological status of "congenital insensitivity to pain" remains in doubt. Possible pathological correlates of this clinical syndrome include sensory neuropathy, central lesions at the...
Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome
Lane, R., Barrett, M., Woodrow, D., Moss, J., Fletcher, R., Archard, L.
OBJECTIVES—To examine the proportions of type 1 and type 2 muscle fibres and the degree of muscle fibre atrophy and hypertrophy in patients with chronic fatigue syndrome in relation to lactate...
Description and evaluation of a freshman orientation program
A freshman orientation program was developed to assist first year students in adjusting to student life at the Canadian Memorial Chiropractic College. The orientation program consisted of an...
Cognitive processes in learning chiropractic skills: The role of imagery
Josefowitz, N., Stermac, L., Grice, A., Fligg, B., Moss, J., Szaraz, Z.
The role of imagery in learning a chiropractic adjustment was examined. Thirty students from C.M.C.C. were randomly divided into two groups and exposed to two different types of imagery. The first...
The operating room charge nurse: coordinator and communicator.
Moss, J., Xiao, Y., Zubaidah, S.
To achieve the potential inherent in the use of computer applications in distributed environments, we need to understand the information needs of users. The purpose of this descriptive study was to...