Lacey, C.J.N., Wright, A., Weber, J.N., Profy, A.T.
OBJECTIVES: To directly measure the cervico-vaginal lavage (CVL) and plasma PRO 2000 concentrations achieved by vaginal dosing. DESIGN: A sub-study of a prospective randomized, double-blind phase 1...
Lindenburg, C.E.A., Stolte, I.S., Langendam, M.W., Miedema, F., Williams, I.G., Colebunders, R., ...
Lindenburg, C.E.A., Stolte, I.S., Langendam, M.W., Miedema, F., Williams, I.G., Colebunders, R., ...
Lindenburg, C.E.A., Stolte, I.S., Langendam, M.W., Miedema, F., Williams, I.G., Colebunders, R., ...
Lindenburg, C. E. A., Stolte, I., Langendam, M. W., Miedema, F., Williams, I. G., Colebunders, R., ...
Long-term effects of therapeutic vaccination of human immunodeficiency virus (HIV)-1-infected subjects with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) on progression to AIDS, death, a CD4 cell...
Churchill, D. R., Slade, P. M., Youle, M., Gazzard, B. G., Weber, J. N.
Eighteen patients with symptomatic HIV disease were enrolled into a phase I/II study of a microsphere formulation of the HIV protease inhibitor KNI-272, with doses escalated up to a maximum dose of...
AUTOIMMUNE DISEASE AND HTLV-1 INFECTION (1991)
BOWNESS, P., DAVIES, K. A. A., TOSSWILL, J., BUNN, C. C., MAcALPINE, L., WEBER, J. N., ...
We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be...
Taylor, G. P., Hall, S. E., Navarrete, S., Michie, C. A., Davis, R., Witkover, A. D., ...
Patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) typically have a high HTLV-1 proviral load in peripheral blood mononuclear cells...
Antigen capture ELISA for the heat shock protein (hsp60) of Chlamydia trachomatis.
Horner, P J, Ali, M, Parker, D, Weber, J N, Taylor-Robinson, D, McClure, M O
AIMS: To develop an indirect ELISA using the heat shock protein (hsp60) of Chlamydia trachomatis as antigen. METHODS: The hsp60 gene was amplified by PCR, expressed in the vector pDEV-107 and...
Role of fibreoptic bronchoscopy in management of pneumonia in acquired immune deficiency syndrome.
Warren, J B, Shaw, R J, Weber, J N, Holt, D A, Keal, E E, Pinching, A J
Taylor, G. P., Hall, S. E., Navarrete, S., Michie, C. A., Davis, R., Witkover, A. D., ...
Patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) typically have a high HTLV-1 proviral load in peripheral blood mononuclear cells...
Antigen capture ELISA for the heat shock protein (hsp60) of Chlamydia trachomatis.
Horner, P J, Ali, M, Parker, D, Weber, J N, Taylor-Robinson, D, McClure, M O
AIMS: To develop an indirect ELISA using the heat shock protein (hsp60) of Chlamydia trachomatis as antigen. METHODS: The hsp60 gene was amplified by PCR, expressed in the vector pDEV-107 and...
Role of fibreoptic bronchoscopy in management of pneumonia in acquired immune deficiency syndrome.
Warren, J B, Shaw, R J, Weber, J N, Holt, D A, Keal, E E, Pinching, A J
Kaposi's sarcoma of the bowel--presenting as apparent ulcerative colitis.
Weber, J N, Carmichael, D J, Boylston, A, Munro, A, Whitear, W P, Pinching, A J
Persistent diarrhoea with mucus-production developed in a 37 year homosexual man, and an initial diagnosis of ulcerative colitis was made after barium enema examination and rectal biopsy. The patient...
Weber, J N, Thom, S, Barrison, I, Unwin, R, Forster, S, Jeffries, D J, ...
Three patients with biopsy diagnosed invasive cytomegalovirus infection of the colon have been seen in the context of the acquired immune deficiency syndrome (AIDS). Cytomegalovirus colitis presented...
Humphry, R C, Weber, J N, Marsh, R J
Twenty-eight patients with either the acquired immune deficiency syndrome (AIDS) or persistent generalised lymphadenopathy (PGL) were studied prospectively as outpatients for up to one year. Six...
Furukawa, Y, Bangham, C R M, Taylor, G P, Weber, J N, Osame, M
Apoptosis in peripheral blood lymphocyte populations in HTLV-I-infected people in vivo was examined, to study the lymphocyte dynamics in HTLV-I infection. Freshly isolated lymphocytes from 10...
Shaunak, S, Gooderham, N J, Edwards, R J, Payvandi, N, Javan, C M, Baggett, N, ...
1. Structural analogues of a sulphated polysaccharide, dextrin sulphate, were synthesized and tested for their ability to block infection by HIV-1. Using the T-cell lines, C8166 and HPB-ALL, and the...
The value of haematological screening for AIDS in an at risk population.
Weber, J N, Walker, D, Engelkins, H, Bain, B, Harris, J R
The haematological variables measured by automated full blood count in matched homosexual and heterosexual men attending a clinic for sexually transmitted diseases (STD) were compared with those of...
Weber, J N, McCreaner, A, Berrie, E, Wadsworth, J, Jeffries, D J, Pinching, A J, ...
Fifty four sexual partners of homosexual men with the acquired immune deficiency syndrome (AIDS) were studied, of whom 32 were seropositive and 22 seronegative for human T cell lymphotropic virus...
Squamous carcinoma of the anus in young homosexual men with T helper cell depletion.
Howard, L C, Paterson-Brown, S, Weber, J N, Chan, S T, Harris, J R, Glazer, G
Two cases of squamous carcinoma of the anus in white homosexual men aged 36 and 47 years are reported, each with a short history of rapidly enlarging perianal lesions. Immunological studies showed...
Clinical aspects of the acquired immune deficiency syndrome in the United Kingdom.
Weber, J N, Carmichael, D J, Sawyer, N, Pinching, A J, Harris, J R
Between August and November 1983, seven new patients with AIDS were seen at this hospital; two with disseminated Kaposi's sarcoma, and five with opportunist infections, of whom three have died. We...
Outpatient follow-up in women with HIV infection in Parkside Health Authority (UK).
Horner, P J, McBride, M, Coker, R J, Crowley, S, Harris, J R, Murphy, S M, ...
OBJECTIVE--To describe patterns of attendance for follow-up among HIV infected women in Parkside, UK and their correlates. DESIGN--Retrospective cohort study. SUBJECTS--103 HIV infected women. MAIN...
Fatal haemorrhage following liver biopsy in patients with HIV infection.
Churchill, D R, Mann, D, Coker, R J, Miller, R F, Glazer, G, Goldin, R D, ...
A retrospective review of all 248 liver biopsies performed in patients with HIV infection at two referral centres in London over a 12 year period revealed five cases of major bleeding following...
Lyall, E. G., Stainsby, C., Taylor, G. P., Ait-Khaled, M., Bingham, S., Evans, J. A., ...
OBJECTIVES: To examine the change in uptake of interventions to reduce transmission of HIV from mothers to infants from January 1994 to July 1997. DESIGN: Review of mother-infant pairs who presented...
Fox, J, Scriba, T J, Robinson, N, Weber, J N, Phillips, R E, Fidler, Sarah
Early anti-retroviral treatment (ART) in primary human immunodeficiency virus (HIV) infection (PHI) may have unique, restorative immunological and virological benefits which could enhance clinical...