J. N. Weinstein

Molecular Modeling Studies of the DNA-Topoisomerase I Ternary Cleavable Complex with Camptothecin (1999)

Y. Fan, J. N. Weinstein, K. W. Kohn, L. M. Shi, Y. Pommier

This article not subject to U.S. Copyright. Published 1998 by the American Chemical Society

Indications for lumbar spinal fusion introduction: 1995 Focus Issue Meeting on Fusion (1995)

Zdeblick, T. A., Hanley, E. N., Sonntag, V. K.H., Andersson, G. B. J., Boden, S. D., ...

Selection of the optimal procedure to achieve lumbar spinal fusion introduction: 1995 Focus Issue Meeting on Fusion (1995)

Boden, S. D., Andersson, G. B. J., Fraser, R. D., Garfin, S. R., Goel, V. K., Hanley, E. N., ...

Biomechanics introduction: 1995 Focus Issue Meeting on Fusion (1995)

Pope, M. H., Goel, V. K., Sumner, D. R., Andersson, G. B. J., Boden, S. D., Fraser, R. D., ...

Indications for lumbar spinal fusion introduction: 1995 Focus Issue Meeting on Fusion (1995)

Zdeblick, T. A., Hanley, E. N., Sonntag, V. K.H., Andersson, G. B. J., Boden, S. D., ...

Selection of the optimal procedure to achieve lumbar spinal fusion introduction: 1995 Focus Issue Meeting on Fusion (1995)

Boden, S. D., Andersson, G. B. J., Fraser, R. D., Garfin, S. R., Goel, V. K., Hanley, E. N., ...

Biomechanics introduction: 1995 Focus Issue Meeting on Fusion (1995)

Pope, M. H., Goel, V. K., Sumner, D. R., Andersson, G. B. J., Boden, S. D., Fraser, R. D., ...

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Saga, T, Neumann, R D, Heya, T, Sato, J, Kinuya, S, Le, N, ...

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous...

Relative differences in the binding free energies of human immunodeficiency virus 1 protease inhibitors: a thermodynamic cycle-perturbation approach.

Reddy, M R, Viswanadhan, V N, Weinstein, J N

Peptidomimetic inhibitors of the human immunodeficiency virus 1 protease show considerable promise for treatment of AIDS. We have, therefore, been seeking computer-assisted drug design methods to aid...

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

Ashorn, P, Moss, B, Weinstein, J N, Chaudhary, V K, FitzGerald, D J, Pastan, I, ...

We have previously described a recombinant protein, designated CD4(178)-PE40, consisting of the human immunodeficiency virus (HIV) envelope glycoprotein-binding region of human CD4 linked to the...

Effect of dipyridamole on zidovudine pharmacokinetics and short-term tolerance in asymptomatic human immunodeficiency virus-infected subjects.

Hendrix, C W, Flexner, C, Szebeni, J, Kuwahara, S, Pennypacker, S, Weinstein, J N, ...

Zidovudine delays the progression of infection and prolongs the survival of human immunodeficiency virus (HIV)-infected patients, but these benefits are limited by dose-related toxicity and the cost...

In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations.

Kageyama, S, Weinstein, J N, Shirasaka, T, Kempf, D J, Norbeck, D W, Plattner, J J, ...

C2 symmetry-based human immunodeficiency virus (HIV) protease inhibitors were examined in vitro as single agents or in combination with 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine...

Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.

Szebeni, J, Patel, S S, Hung, K, Wahl, L M, Weinstein, J N

The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed [3H]AZT...

Differential inhibition of 2'-deoxycytidine salvage as a possible mechanism for potentiation of the anti-human immunodeficiency virus activity of 2',3'-dideoxycytidine by dipyridamole.

Patel, S S, Szebeni, J, Wahl, L M, Weinstein, J N

Dipyridamole, a commonly used coronary vasodilator and antithrombotic drug, was recently shown to potentiate the activity of 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine against the human...

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages.

Szebeni, J, Wahl, S M, Popovic, M, Wahl, L M, Gartner, S, Fine, R L, ...

Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory...

Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells.

Leserman, L D, Weinstein, J N, Blumenthal, R, Terry, W D

Specific receptor-mediated delivery of the contents of small, sonicated liposomes was studied with three murine tumor cell types: an IgG Fc receptor-negative nonphagocytic line (EL4); an Fc...

Reconstitution of the hepatic asialoglycoprotein receptor with phospholipid vesicles.

Klausner, R D, Bridges, K, Tsunoo, H, Blumenthal, R, Weinstein, J N, Ashwell, G

A solubilized detergent-free preparation of the hepatic binding protein specific for asialoglycoproteins associates spontaneously with small unilamellar lipid vesicles. This process is independent of...

Liposome--lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents.

Blumenthal, R, Weinstein, J N, Sharrow, S O, Henkart, P

The water-soluble dye 6-carboxyfluorescein was trapped in the internal aqueous compartments of small sonicated dioleoyl lecithin vesicles and used to assess the kinetics of transfer of vesicle...

The folding of ovalbumin. Renaturation in vitro versus biosynthesis in vitro.

Klausner, R D, Kempf, C, Weinstein, J N, Blumenthal, R, Van Renswoude, J

Hen ovalbumin, the major secretory product of oviduct cells, is a 43 000-dalton glycoprotein. Many studies have led to controversy over the question of whether ovalbumin (OA) can be fully renatured...

Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection.

Lotze, M T, Carrasquillo, J A, Weinstein, J N, Bryant, G J, Perentesis, P, Reynolds, J C, ...

Fab fragments of monoclonal antibodies (MoAb) to melanoma, radiolabeled with 131I, were evaluated as diagnostic reagents to determine their ability to localize systemic--MoAb injected intravenously...

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Saga, T, Neumann, R D, Heya, T, Sato, J, Kinuya, S, Le, N, ...

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous...

Relative differences in the binding free energies of human immunodeficiency virus 1 protease inhibitors: a thermodynamic cycle-perturbation approach.

Reddy, M R, Viswanadhan, V N, Weinstein, J N

Peptidomimetic inhibitors of the human immunodeficiency virus 1 protease show considerable promise for treatment of AIDS. We have, therefore, been seeking computer-assisted drug design methods to aid...

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

Ashorn, P, Moss, B, Weinstein, J N, Chaudhary, V K, FitzGerald, D J, Pastan, I, ...

We have previously described a recombinant protein, designated CD4(178)-PE40, consisting of the human immunodeficiency virus (HIV) envelope glycoprotein-binding region of human CD4 linked to the...

Effect of dipyridamole on zidovudine pharmacokinetics and short-term tolerance in asymptomatic human immunodeficiency virus-infected subjects.

Hendrix, C W, Flexner, C, Szebeni, J, Kuwahara, S, Pennypacker, S, Weinstein, J N, ...

Zidovudine delays the progression of infection and prolongs the survival of human immunodeficiency virus (HIV)-infected patients, but these benefits are limited by dose-related toxicity and the cost...

In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations.

Kageyama, S, Weinstein, J N, Shirasaka, T, Kempf, D J, Norbeck, D W, Plattner, J J, ...

C2 symmetry-based human immunodeficiency virus (HIV) protease inhibitors were examined in vitro as single agents or in combination with 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine...

Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.

Szebeni, J, Patel, S S, Hung, K, Wahl, L M, Weinstein, J N

The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed [3H]AZT...

Differential inhibition of 2'-deoxycytidine salvage as a possible mechanism for potentiation of the anti-human immunodeficiency virus activity of 2',3'-dideoxycytidine by dipyridamole.

Patel, S S, Szebeni, J, Wahl, L M, Weinstein, J N

Dipyridamole, a commonly used coronary vasodilator and antithrombotic drug, was recently shown to potentiate the activity of 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine against the human...

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages.

Szebeni, J, Wahl, S M, Popovic, M, Wahl, L M, Gartner, S, Fine, R L, ...

Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory...

Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells.

Leserman, L D, Weinstein, J N, Blumenthal, R, Terry, W D

Specific receptor-mediated delivery of the contents of small, sonicated liposomes was studied with three murine tumor cell types: an IgG Fc receptor-negative nonphagocytic line (EL4); an Fc...

Reconstitution of the hepatic asialoglycoprotein receptor with phospholipid vesicles.

Klausner, R D, Bridges, K, Tsunoo, H, Blumenthal, R, Weinstein, J N, Ashwell, G

A solubilized detergent-free preparation of the hepatic binding protein specific for asialoglycoproteins associates spontaneously with small unilamellar lipid vesicles. This process is independent of...

Liposome--lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents.

Blumenthal, R, Weinstein, J N, Sharrow, S O, Henkart, P

The water-soluble dye 6-carboxyfluorescein was trapped in the internal aqueous compartments of small sonicated dioleoyl lecithin vesicles and used to assess the kinetics of transfer of vesicle...

The folding of ovalbumin. Renaturation in vitro versus biosynthesis in vitro.

Klausner, R D, Kempf, C, Weinstein, J N, Blumenthal, R, Van Renswoude, J

Hen ovalbumin, the major secretory product of oviduct cells, is a 43 000-dalton glycoprotein. Many studies have led to controversy over the question of whether ovalbumin (OA) can be fully renatured...

Monoclonal antibody imaging of human melanoma. Radioimmunodetection by subcutaneous or systemic injection.

Lotze, M T, Carrasquillo, J A, Weinstein, J N, Bryant, G J, Perentesis, P, Reynolds, J C, ...

Fab fragments of monoclonal antibodies (MoAb) to melanoma, radiolabeled with 131I, were evaluated as diagnostic reagents to determine their ability to localize systemic--MoAb injected intravenously...

Postural variation in von Willebrand factor antigen.

Blann, A, Jayson, M I, Pope, M H, Kaigle, A M, Wilder, D, Weinstein, J N

Revision Total Joint Arthroplasty Facilitated by Extracorporeal Shockwave Lithotripsy: A Case Report

Weinstein, J.N., Wroble, R.R., Loening, S.

Posterolateral approach for anterior resection and posterior stabilization of the upper cervical spine: a case report.

Hart, R. A., Weinstein, J. N., Menezes, A. H.

Surgical approaches to atlanto-axial lesions are generally accomplished by either anterior (transoral) or posterior approaches as dictated by the location of the lesion. In certain patients, these...