Energy minimization using Sobolev gradients: application to phase separation and ordering (2003)
Sial, S., Neuberger, J., Lookman, T., Saxena, A.
A common problem in physics and engineering is the calculation of the minima of energy functionals. The theory of Sobolev gradients provides an efficient method for seeking the critical points of...
Inaugural dissertation.--Kgl. bayer. Julius-Maximilians-Universität Würzburg.
Mutimer, D, McCauley, B, Nightingale, P, Ryan, M, Peters, M, Neuberger, J
AIMS: To devise a computerised management system protocol which not only proposes the laboratory investigations to be performed on each patient but also performs related clinical functions. METHODS:...
Massive haemorrhagic necrosis of the liver after liver transplantation.
Hübscher, S G, Adams, D H, Buckels, J A, McMaster, P, Neuberger, J, Elias, E
Six of the first 85 patients who received the first 100 liver transplantations carried out in Birmingham developed a syndrome of fulminant liver failure with distinctive clinical and pathological...
Halothane hepatitis in children.
Kenna, J G, Neuberger, J, Mieli-Vergani, G, Mowat, A P, Williams, R
It is often stated that halothane hepatitis in children is nonexistent or extremely rare. This syndrome occurred in seven children aged between 11 months and 15 years, one of whom, a 3 1/2 year old...
Halothane hepatitis in children: : Authors' reply
Neuberger, J, Mieli-Vergani, G, Mowat, Alex P, Williams, Roger
Oral contraceptives and hepatocellular carcinoma.
Neuberger, J, Forman, D, Doll, R, Williams, R
A series of 26 white women aged under 50 who developed hepatocellular carcinoma in a non-cirrhotic liver were studied for the possible role of oral contraceptives. Eighteen of the women had used the...
Improved survival after orthotopic liver grafting.
Calne, R Y, Williams, R, Lindop, M, Farman, J V, Tolley, M E, Rolles, K, ...
A total of 108 orthotopic liver transplants have been carried out in the Cambridge/King's College Hospital series. Over 13 years, changes in patient selection, immunosuppression, and surgical and...
Mutimer, D., McCauley, B., Nightingale, P., Ryan, M., Peters, M., Neuberger, J.
AIMS: To devise a computerised management system protocol which not only proposes the laboratory investigations to be performed on each patient but also performs related clinical functions. METHODS:...
Massive haemorrhagic necrosis of the liver after liver transplantation.
Hübscher, S G, Adams, D H, Buckels, J A, McMaster, P, Neuberger, J, Elias, E
Six of the first 85 patients who received the first 100 liver transplantations carried out in Birmingham developed a syndrome of fulminant liver failure with distinctive clinical and pathological...
Halothane hepatitis in children.
Kenna, J G, Neuberger, J, Mieli-Vergani, G, Mowat, A P, Williams, R
It is often stated that halothane hepatitis in children is nonexistent or extremely rare. This syndrome occurred in seven children aged between 11 months and 15 years, one of whom, a 3 1/2 year old...
Halothane hepatitis in children: : Authors' reply
Neuberger, J, Mieli-Vergani, G, Mowat, Alex P, Williams, Roger
Oral contraceptives and hepatocellular carcinoma.
Neuberger, J, Forman, D, Doll, R, Williams, R
A series of 26 white women aged under 50 who developed hepatocellular carcinoma in a non-cirrhotic liver were studied for the possible role of oral contraceptives. Eighteen of the women had used the...
Improved survival after orthotopic liver grafting.
Calne, R Y, Williams, R, Lindop, M, Farman, J V, Tolley, M E, Rolles, K, ...
A total of 108 orthotopic liver transplants have been carried out in the Cambridge/King's College Hospital series. Over 13 years, changes in patient selection, immunosuppression, and surgical and...
Churg-Strauss vasculitis and ascaris infection.
Chauhan, A, Scott, D G, Neuberger, J, Gaston, J S, Bacon, P A
A patient with Churg-Strauss vasculitis presenting with mononeuritis multiplex, who developed obstructive jaundice, is described. On investigation the jaundice proved to be due to ascaris...
Hepatitis C virus antibody positive blood donors.
Mutimer, D, Shaw, J, Harrison, R, Ala, F, Neuberger, J, Elias, E
In an analysis of 15 blood donors referred from the Blood Transfusion Service to the Queen Elizabeth Hospital, Birmingham, more than 50% of anti-hepatitis C virus (HCV) positive patients had a...
Mutimer, D, Shaw, J, Neuberger, J, Skidmore, S, Martin, B, Hubscher, S, ...
Sporadic non-A, non-B hepatitis is the most common indication for liver transplantation in patients presenting with fulminant and subacute liver failure. This study used serological, histological,...
Fulminant hepatic failure caused by tuberculosis.
Hussain, W, Mutimer, D, Harrison, R, Hubscher, S, Neuberger, J
A 54 year old Asian woman developed fulminant hepatic failure followed by renal failure. Because of a past history of possible tuberculosis, she was given antituberculous drugs. The chest x ray was...
Neuberger, J, Mieli-Vergani, Giorgina, Tredger, J M, Davis, M, Williams, Roger
Previous investigations have shown that patients with fulminant hepatic failure after halothane anaesthesia have a circulating antibody which reacts with an antigen present on the surface of...
Effect of polyunsaturated phosphatidylcholine on immune mediated hepatocyte damage.
Neuberger, J, Hegarty, J E, Eddleston, A L, Williams, R
Studies were carried out to investigate the mechanisms underlying the reduction of hepatocellular necrosis observed when polyunsaturated phosphatidylcholine was administered to patients with HBsAg...
Antibodies to alcohol altered liver cell determinants in patients with alcoholic liver disease.
Neuberger, J, Crossley, I R, Saunders, J B, Davis, M, Portmann, B, Eddleston, A L, ...
Circulating antibodies reacting specifically with hepatocytes isolated from ethanol pretreated rabbits have been demonstrated by two techniques - induced cytotoxicity and immunofluorescence. In the...
Mononuclear cell complement receptor blockade in primary biliary cirrhosis.
Al-Aghbar, M N, Neuberger, J, Williams, R, Eddleston, A L
Peripheral blood monocyte and lymphocyte receptors for Fc and C3b fragments were examined in vitro in patients with primary biliary cirrhosis and other chronic liver diseases using sheep red blood...
Double blind controlled trial of d-penicillamine in patients with primary biliary cirrhosis.
Neuberger, J, Christensen, E, Portmann, B, Caballeria, J, Rodes, J, Ranek, L, ...
One hundred and eighty nine patients with primary biliary cirrhosis were entered into a double blind, placebo controlled randomised trial starting in January 1978 to assess the therapeutic value of...
Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity.
Neuberger, J, Kenna, J G, Nouri Aria, K, Williams, R
To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of...
Ethanol metabolism in the generation of new antigenic determinants on liver cells.
Crossley, I R, Neuberger, J, Davis, M, Williams, R, Eddleston, A L
Antibodies directed against ethanol altered liver cell components have been detected in the serum of nearly 50% of patients with alcoholic liver disease although the pathogenetic mechanisms are...
Al-Aghbar, M N, Alexander, G J, Nouri-Aria, K T, Neuberger, J, Eddleston, A L, Williams, R
The in vitro effect of Cyclosporin A on the regulation of immunoglobulin production was investigated in 16 patients with primary biliary cirrhosis. A significant improvement in concanavalin A induced...
Immune mechanisms in tienilic acid associated hepatotoxicity.
In order to investigate the mechanisms underlying the hepatotoxicity associated with tienilic acid (Ticrynafen) ingestion we have looked for evidence of sensitisation to drug altered liver cell...
Patterns of alcohol consumption after liver transplantation
Tang, H, Boulton, R, Gunson, B, Hubscher, S, Neuberger, J
Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
Effect on outcome of the lengthening waiting list for liver transplantation
RANSFORD, R, GUNSON, B, MAYER, D, NEUBERGER, J, CHRISTENSEN, E
Primary biliary cirrhosis: seeking the silent partner of autoimmunity
Primary biliary cirrhosis is a disorder characterised by an intense inflammatory response in the septal and interlobular bile ducts and is considered to be an autoimmune disease. Evidence to suggest...
The Tomlinson report, with its emphasis on primary and community care, offers great scope to community health services, for long the poor relation of the NHS, and particularly poorly resourced in...
In vitro studies on the mechanism of increased serum IgM levels in primary biliary cirrhosis.
Nouri-Aria, K T, Hegarty, J E, Neuberger, J, Eddleston, A L, Williams, R
To evaluate the mechanisms underlying the increase in serum IgM in primary biliary cirrhosis (PBC) studies were designed to examine IgM production in vitro and to assess the relative contribution of...
The effect of prednisolone in vitro on immunoglobulin production in primary biliary cirrhosis.
Al-Aghbar, M N, Alexander, G J, Neuberger, J, Nouri-Aria, K T, Eddleston, A L, Williams, R
Immunoglobulin production and its regulation have been investigated in 36 untreated patients with primary biliary cirrhosis and 14 healthy controls. Using a haemolytic plaque assay, the number of...
Immunosuppression: towards a logical approach in liver transplantation
Over the last two decades there has been a significant increase in the number and types of immunosuppressive agents that have been available to clinicians. The protocols for immunosuppression used in...
Pharmacokinetic study of cyclosporin A (Sandimmun) in patients with primary biliary cirrhosis.
Robson, S, Neuberger, J, Keller, H P, Abisch, E, Neiderberger, W, Von Graffenried, B, ...
The pharmacokinetics of cyclosporin A (CS-A) were studied in 10 patients with primary biliary cirrhosis (PBC) after oral administration in steady state. Mean values for area under the blood...
Bilateral sixth cranial nerve palsy in infectious mononucleosis.
A 15-year-old girl who presented with a bilateral sixth nerve palsy caused by infectious mononucleosis is described. The neurological presentation of infectious mononucleosis is discussed.
Elective ventilation of potential organ donors.
Riad, H., Nicholls, A., Neuberger, J., Willatts, S. M., Sells, R. A., Jones, M. A., ...
Elective ventilation describes the procedure of transferring selected patients dying from rapidly progressive intracranial haemorrhage from general medical wards to intensive care units for a brief...
La Puma, J., Stocking, C. B., Rhoades, W. D., Darling, C. M., Ferner, R. E., Neuberger, J., ...
Postmarketing research, often called phase IV trials, is intended to familiarise doctors and patients with newly approved drugs. La Puma and colleagues, in Chicago, studied doctors' and patients'...