Fukui, Y., Kawamura, A., Wong, T., Murai, M., Iritani, H., Mizuno, N., ...
We compare the CO (J = 1-0) and H I emission in the Large Magellanic Cloud in three dimensions, i.e., including a velocity axis in addition to the two spatial axes, with the aim of elucidating the...
Fukui, Y., Kawamura, A., Wong, T., Murai, M., Iritani, H., Mizuno, N., ...
We compare the CO J =(1-0) and HI emission in the Large Magellanic Cloud (LMC) in three dimensions, i.e. including a velocity axis in addition to the two spatial axes, with the aim of elucidating the...
New H_(2)O masers in Seyfert and FIR bright galaxies: III. The southern sample (2009)
Surcis, G., Tarchi, A., Ott, J., Lovell, J., Castangia, P.
Context. A relationship between the water maser detection rate and far infrared (FIR) flux densities was established as a result of two 22 GHz maser surveys in a complete sample of galaxies (Dec >...
Studies for the Search of Heavy Particles Decaying in Top Quark Pairs with the CMS Detector (2009)
In this thesis, event selection and analysis techniques are developed at the CMS detector for narrow heavy resonances in the mass range of 1 to 3 TeV which decay to top quark pairs in the muon+jets...
Henkel, C., Menten, K. M., Murphy, M. T., Jethava, N., Flambaum, V. V., Braatz, J. A., ...
Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the gravitational lens system PKS 1830–211, which is by far the best known...
Molecular and Atomic Gas in the Large Magellanic Cloud. I. Conditions for CO Detection (2009)
Wong, T., Hughes, A., Fukui, Y., Kawamura, A., Mizuno, N., Ott, J., ...
We analyze the conditions for detection of CO(1-0) emission in the Large Magellanic Cloud, using the recently completed second NANTEN CO survey. In particular, we investigate correlations between CO...
New H2O masers in Seyfert and FIR bright galaxies. III. The Southern Sample (2009)
Surcis, G., Tarchi, A., Henkel, C., Ott, J., Lovell, J., Castangia, P.
Recently, a relationship between the water maser detection rate and far infrared (FIR) flux densities has been established as a result of two 22 GHz maser surveys in a complete sample of galaxies...
Henkel, C., Menten, K. M., Murphy, M. T., Jethava, N., Flambaum, V. V., Braatz, J. A., ...
Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the gravitational lens system PKS1830-211. Obtaining average radial velocities...
Nearby Galaxies: Templates for Galaxies Across Cosmic Time (2009)
Studies of nearby galaxies including the Milky Way have provided fundamental information on the evolution of structure in the Universe, the existence and nature of dark matter, the origin and...
Molecular and Atomic Gas in the Large Magellanic Cloud - I. Conditions for CO Detection (2009)
Wong, T., Hughes, A., Fukui, Y., Kawamura, A., Mizuno, N., Ott, J., ...
We analyze the conditions for detection of CO(1-0) emission in the Large Magellanic Cloud (LMC), using the recently completed second NANTEN CO survey. In particular, we investigate correlations...
Triggered star formation and the creation of the supergiant Hi shell in IC 2574. (2009)
Weisz, D.R., Skillman, E.D., Cannon, J., Walter, F., Brinks, E., Ott, J., ...
Original article can be found at: http://www.iop.org/EJ/journal/apjl Copyright American Astronomical Society. DOI: 10.1088/0004-637x/691/1/L59 [Full text of this article is not available in the UHRA]
Acute Lung Injury is Reduced in fat-1 Mice Endogenously Synthesizing n-3 Fatty Acids (2009)
Mayer, K., Kiessling, A., Ott, J., Schaefer, M.B., Hecker, M., Henneke, I., ...
RATIONALE: acute lung injury (ALI) remains an important cause of mortality in intensive care units. Inflammation is controlled by cytokines and eicosanoids derived from the n-6 fatty acid (FA)...
Henkel, Christian, Menten, K. M., Murphy, M. T., Jethava, N., Flambaum, Victor V., Braatz, James A., ...
Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the gravitational lens system PKS 1830–211, which is by far the best known...
New H2O masers in Seyfert and FIR bright galaxies III. The southern sample (2009)
Surcis, G, Tarchi, A, Henkel, C, Ott, J, Lovell, JEJ, Castangia, P
Context. A relationship between the water maser detection rate and far infrared (FIR) flux densities was established as a result of two 22 GHz maser surveys in a complete sample of galaxies ( ) with...
Henkel, Christian, Menten, K. M., Murphy, M. T., Jethava, N., Flambaum, Victor V., Braatz, James A., ...
Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the gravitational lens system PKS 1830–211, which is by far the best known...
Decision support to facilitate cost-optimal response in time- and safety-critical situations (2009)
Coping with threats such as terrorism, crime, natural hazards or industrial accidents requires early detection and correct assessment of critical situations, followed by appropriate actions to avoid...
Fukui, Y., Kawamura, A., Wong, T., Murai, M., Iritani, H., Mizuno, N., ...
We compare the CO (J = 1-0) and H I emission in the Large Magellanic Cloud in three dimensions, i.e., including a velocity axis in addition to the two spatial axes, with the aim of elucidating the...
Protheroe, R. J., Ott, J., Ekers, R. D., Jones, D. I., Crocker, R. M.
Recent ammonia (1,1) inversion line data on the Galactic star-forming region Sgr B2 show that the column density is consistent with a radial Gaussian density profile with a standard deviation of 2.75...
Henkel, C., Braatz, J. A., Menten, K. M., Ott, J.
Using the Green Bank Telescope (GBT), we have detected the (J,K) = (1,1) to (10,10) ammonia inversion lines, up to 1030 K above the ground state, in a face-on spiral galaxy viewed against the radio...
Protheroe, R. J., Ott, J., Ekers, R. D., Jones, D. I., Crocker, R. M.
Recent ammonia (1,1) inversion line data on the Galactic star forming region Sgr B2 show that the column density is consistent with a radial Gaussian density profile with a standard deviation of 2.75...
Jones, P. A., Burton, M. G., Cunningham, M. R., Menten, K. M., Schilke, P., Belloche, A., ...
Using the Mopra telescope, we have undertaken a 3-mm spectral-line imaging survey of a 5 × 5 arcmin^2 area around Sgr B2. We covered almost the complete spectral range from 81.7 to 113.5 GHz, with...
Detection of amino acetonitrile in Sgr B2(N) (2008)
Belloche, A., Menten, K. M., Comito, C., Müller, H. S. P., Schilke, P., Ott, J., ...
Context. Amino acids are building blocks of proteins and therefore key ingredients for the origin of life. The simplest amino acid, glycine (NH2CH2COOH), has long been searched for in the...
Status of This Memo Requirements for Floor Control Protocols (2008)
This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Copyright Notice Copyright (C) The Internet...
Detection of amino acetonitrile in Sgr B2(N) (2008)
Belloche, A., Menten, K. M., Comito, C., Mueller, H. S. P., Schilke, P., Ott, J., ...
Amino acids are building blocks of proteins and therefore key ingredients for the origin of life. The simplest amino acid, glycine, has long been searched for in the interstellar medium but has not...
Schaefer, M.B., Pose, A., Ott, J., Hecker, M., Behnk, A., Schulz, R., ...
Acute lung injury (ALI) still represents a major cause of morbidity and mortality in intensive care units. Beneficial effects have been described after activation of the peroxisome...
Jones, P. A., Burton, M. G., Cunningham, M. R., Menten, K. M., Schilke, P., Belloche, A., ...
Using the Mopra telescope, we have undertaken a 3-mm spectral-line imaging survey of a 5 x 5 arcmin^2 area around Sgr B2. We covered almost the complete spectral the range from 81.7 to 113.5 GHz,...
Determining the relative evolutionary stages of very young massive star formation regions (2007)
Longmore, S. N., Burton, M. G., Purcell, C. R., Barnes, P., Ott, J.
We have recently completed an observing program with the Australia Telescope Compact Array towards massive star formation regions traced by 6.7 GHz methanol maser emission. We found the molecular...
R. Mahy, D. Willis, J. Ott, B. Rosen
This memo documents a process intended to apply architectural discipline to the future development of the Session Initiation Protocol (SIP). There have been concerns with regards to new SIP...
Request For Comments, L. Cline, G. Deisher, T. Gardos, C. Maciocco, D. Newell, ...
This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the...
Minamidani, T., Mizuno, N., Mizuno, Y., Kawamura, A., Onishi, T., Hasegawa, T., ...
We have carried out sub-mm 12CO(J=3-2) observations of 6 giant molecular clouds (GMCs) in the Large Magellanic Cloud (LMC) with the ASTE 10m sub-mm telescope at a spatial resolution of 5 pc and very...
Longmore, S. N., Burton, M. G., Barnes, P. J., Wong, T., Purcell, C. R., Ott, J.
We present observations of the (1,1), (2,2), (4,4) and (5,5) inversion transitions of para-ammonia (NH3) and 24 GHz continuum, taken with the Australia Telescope Compact Array toward 21 southern...
Longmore, S. N., Burton, M. G., Barnes, P. J., Wong, T., Purcell, C. R., Ott, J.
Methanol maser emission has proven to be an excellent signpost of regions undergoing massive star formation (MSF). To investigate their role as an evolutionary tracer, we have recently completed a...
P. Kampe, L. Giebeler, D. Samuelis, J. Kunert, A. Drochner, ...
Journal article
We present observations of the (1,1), (2,2), (4,4) and (5,5) inversion transitions of para-ammonia (NH3) and 24-GHz continuum, taken with the Australia Telescope Compact Array towards 21 southern...
We present observations of the (1,1), (2,2), (4,4) and (5,5) inversion transitions of para-ammonia (NH3) and 24-GHz continuum, taken with the Australia Telescope Compact Array towards 21 southern...
We present observations of the (1,1), (2,2), (4,4) and (5,5) inversion transitions of para-ammonia (NH3) and 24-GHz continuum, taken with the Australia Telescope Compact Array towards 21 southern...
Interstellar medium disruption in the Centaurus A group (2006)
Bouchard, A., Jerjen, H., Da Costa, G. S., Ott, J.
We present the results of a 21 cm neutral hydrogen (HI) line detection experiment in the direction of 18 low luminosity dwarf galaxies of the Centaurus A group, using the Australia Telescope National...
Extended Star Formation and Molecular Gas in the Tidal Arms near NGC3077 (2006)
Walter, F., Martin, C. L., Ott, J.
We report the detection of ongoing star formation in the prominent tidal arms near NGC 3077 (member of the M 81 triplet). In total, 36 faint compact HII regions were identified, covering an area of...
Requirements for Internet Media Guides (IMGs) (2006)
R. Walsh, J-p. Luoma, J. Ott, H. Schulzrinne
This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Copyright Notice Copyright (C) The Internet...
This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Copyright Notice Copyright (C) The Internet...
The HI content of the recently discovered field dwarf galaxy APPLES1 (2005)
Tarchi, A., Ott, J., Pasquali, A., Ferreras, I., Castangia, P., Larsen, S. S.
We present observations in a search for neutral hydrogen associated with the recently detected field dwarf galaxy APPLES1, performed with the Parkes radiotelescope. The observed radio spectrum shows...
S. J. Kang, D. Gordon, A. M. Brown, J. Ott, S. J. Finch, S. J. Kang, ...
Single nucleotide polymorphisms (SNP) may be genotyped for use in case-control designs to test for association between a SNP marker and a disease using a 2 × 3 chi-squared test of independence....
Vorobyov, E. I., Klein, U., Shchekinov, Yu. A., Ott, J.
Numerical hydrodynamical modelling of supernova-driven shell formation is performed with a purpose to reproduce a giant HI ring (diameter 1.7 kpc) in the dwarf irregular galaxy Holmberg I (Ho I). We...
Kljuic, A, Bazzi, H, Sundberg, J. P., Martinez-Mir, A., O'Shaughnessy, R., Mahoney, M. G., ...
Cell adhesion and communication are interdependent aspects of cell behavior that are critical for morphogenesis and tissue architecture. In the skin, epidermal adhesion is mediated in part by...
Association study of PHOX2B as a candidate gene for Hirschsprung's disease (2003)
Garcia-Barcelo, MM, Sham, MH, Lui, VCH, Chen, BLS, Ott, J, Tam, PKH
BACKGROUND: Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has...
This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the...
Establishing Appropriate Genome-Wide Significance Levels for Canine Linkage Analyses (2003)
Gordon, D., Corwin, M. B., Mellersh, C. S., Ostrander, E. A., Ott, J.
A threshold of 3.3 for a genome-wide maximum LOD score (MAXLOD) has been demonstrated in human linkage studies as corresponding to a type I error rate of 5%. Generalization of this work to...
ILEA Genetics Commission conference report: molecular analysis of complex genetic epilepsies (2002)
Anderson, E., Berkovic, S., Dulac, O., Gardiner, M., Jain, S., Friis, M.L., ...
Epilepsy is a diagnosis encompassing >40 clinical syndromes consisting of biochemical, anatomic, and physiologic changes that lead to recurrent seizures. Abundant evidence of a genetic contribution...
Evidence for BlowOut in the Low-Mass Dwarf Galaxy Holmberg I (2001)
Ott, J., Walter, F., Brinks, E., Van Dyk, S.D., Dirsch, B., Klein, U.
Very large conferences on the Internet: the Internet Multimedia Conferencing Architecture. (1999)
Handley Crowcroft, Conferencing Architecture, J. Crowcroft, C. Bormann, J. Ott
In this paper we provide an overview of multimedia conferencing on the Internet. The protocols mentioned are all specified elsewhere as internet-drafts or RFCs. Each RFC gives details of the protocol...
Methods of analysis and resources available for genetic trait mapping (1999)
Methods of genetic linkage analysis are reviewed and put in context with other mapping techniques. Sources of information are outlined (books, web sites, computer programs). Special consideration is...
Kester, O, Sieber, T, Kolbe, A, Ott, J, Bollen, G, ...
The Radioactive beam Experiment (REX-ISOLDE) (D. Habs et al., Proposal to the ISOLDE committee, CERN-ISC94-25) a pilot experiment testing a new concept of post acceleration of radioactive ions at...
Single particle excitations in $^{129}$Ba from a ($\vec d$,t) reaction study (1998)
Bucurescu, D., Ott, J., Schauer, W., Von Egidy, T., Gollwitzer, A., Hertenberger, R., ...
Single particle excitations in $^{129}$Ba from a ($\vec d$,t) reaction study (1998)
Bucurescu, D., Ott, J., Schauer, W., Von Egidy, T., Gollwitzer, A., Hertenberger, R., ...
Experiments with accelerated fission fragments (1997)
Egidy, T. Von, Koester, U., Steichele, E., Habs, D., Kester, O., Ott, J., ...
Experiments with accelerated fission fragments (1997)
Egidy, T. Von, Koester, U., Steichele, E., Habs, D., Kester, O., Ott, J., ...
MTP-2: towards achieving the s.e.r.o. properties for multicast transport (1994)
C. Bormann, J. Ott, T. Kerschat, N. Seifert
Existing reliable multicast transport protocols have focused on achieving reliability from the point of view of senders of messages. Many applications in the area of synchronous groupware do not need...
Beaudet, A, Bowcock, A, Buchwald, M, Cavalli-Sforza, L, Farrall, M, King, MC, ...
A collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an...
Pr.
Scan statistics to scan markers for susceptibility genes
Scan statistics are applied to combine information on multiple contiguous genetic markers used in a genome screen for susceptibility loci. This information may be, for example, allele sharing...
Ott, J, Bhattacharya, S, Chen, J D, Denton, M J, Donald, J, Dubay, C, ...
Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliably...
The p53MH algorithm and its application in detecting p53-responsive genes
Hoh, J., Jin, S., Parrado, T., Edington, J., Levine, A. J., Ott, J.
A computer algorithm, p53MH, was developed, which identifies putative p53 transcription factor DNA-binding sites on a genomewide scale with high power and versatility. With the sequences from the...
Computer-simulation methods in human linkage analysis.
In human linkage analysis, many statistical problems without analytical solution could be solved by ad hoc Monte Carlo procedures were efficient computer-simulation methods available for members of...
The influence of exocyclic substituents of purine bases on DNA curvature.
Diekmann, S, Von Kitzing, E, McLaughlin, L, Ott, J, Eckstein, F
Complementary oligonucleotides with 5' overhanging deoxyguanosine or deoxycytidine stretches, respectively, of the general form 5'-d(GGGCAARAAC).5'-d(CCCGTTYTTG), where R represents the bases adenine...
Taylor, J W, Ott, J, Eckstein, F
M13 RF IV DNA may be prepared in vitro to contain phosphorothioate-modified internucleotidic linkages in the (-)strand only. Certain restriction enzymes react with this modified DNA to hydrolyze the...
Filter disc supported oligonucleotide synthesis by the phosphite method.
The phosphite approach to oligodeoxynucleotide synthesis has been applied to the filter disc support. The method is exemplified here by the preparation of eight decadeoxynucleotides.
Poly(adenylic acids) containing the antibiotic tubercidin (7-deazaadenosine) form double strands with poly(uridylic acid) by Watson-Crick base pairing. The stability of these complexes is enhanced by...
The 31P-NMR spectrum of the dodecamer d(GACGATATCGTC).
Ott, J, Eckstein, F, Connolly, B A
The resonances in the 31P-NMR spectrum of the dodecamer d(GACGATATCGTC) have been assigned by regiospecific labelling with oxygen-17. All 11 resonances are clearly resolved at 26 degrees C. Most...
Poly(2-methylthio-7-deazainosinic acid) [poly(ms2c7I)] was enzymatically synthesized by polymerization of 2-methylthio-7-deazainosine 5'-diphosphate with polynucleotide phosphorylase from Micrococcus...
Strategies for multilocus linkage analysis in humans.
Lathrop, G M, Lalouel, J M, Julier, C, Ott, J
The increasing number of DNA polymorphisms characterized in humans will soon allow the construction of fine genetic maps of human chromosomes. This advance calls for a reexamination of current...
Rossen, R D, Brewer, E J, Sharp, R M, Ott, J, Templeton, J W
The occurrence of a chronic seronegative polyarthritis has been studied in four families in which the proband presented with some form of juvenile rheumatoid arthritis. In these families,...
Family cell lines available for research--an endangered resource?
Lernmark, A, Eisenbarth, G, Ducat, L, Erlich, H A, Faustman, D, Maclaren, N K, ...
Tsou, H C, Teng, D H, Ping, X L, Brancolini, V, Davis, T, Hu, R, ...
Cowden syndrome (CS) is an autosomal dominant disorder associated with the development of hamartomas and benign tumors in a variety of tissues, including the skin, thyroid, breast, endometrium, and...
McGee, T L, Devoto, M, Ott, J, Berson, E L, Dryja, T P
A subset of families with autosomal dominant retinitis pigmentosa (RP) display reduced penetrance with some asymptomatic gene carriers showing no retinal abnormalities by ophthalmic examination or by...
Knowles, J A, Rao, P A, Cox-Matise, T, Loth, J E, De Jesus, G M, Levine, L, ...
Bipolar affective disorder (BP) is a major neuropsychiatric disorder with high heritability and complex inheritance. Previously reported linkage between BP and DNA markers in the pericentromeric...
Simonic, I, Gericke, G S, Ott, J, Weber, J L
Because gene-mapping efforts, using large kindreds and parametric methods of analysis, for the neurologic disorder Tourette syndrome have failed, efforts are being redirected toward association...
A novel locus (RP24) for X-linked retinitis pigmentosa maps to Xq26-27.
Gieser, L, Fujita, R, Göring, H H, Ott, J, Hoffman, D R, Cideciyan, A V, ...
Two genetic loci, RP2 and RP3, for X-linked retinitis pigmentosa (XLRP) have been localized to Xp11.3-11.23 and Xp21.1, respectively. RP3 appears to account for 70% of XLRP families; however,...
Stibůrková, B, Majewski, J, Sebesta, I, Zhang, W, Ott, J, Kmoch, S
Familial juvenile hyperuricemic nephropathy (FJHN), is an autosomal dominant renal disease characterized by juvenile onset of hyperuricemia, gouty arthritis, and progressive renal failure at an early...
Detection of Genetic Interference: Simulation Studies and Mouse Data
Weeks, D. E., Ott, J., Lathrop, G. M.
Genetic chiasma interference occurs when the occurrence of one crossover (or chiasma) influences the probability of another crossover occurring nearby. We investigated, by simulation studies, the...
The Effect of Marker Heterozygosity on the Power to Detect Linkage Disequilibrium
The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests...
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits.
Schork, N J, Boehnke, M, Terwilliger, J D, Ott, J
Recent advances in molecular biology have provided geneticists with ever-increasing numbers of highly polymorphic genetic markers that have made possible linkage mapping of loci responsible for many...
Brzustowicz, L M, Mérette, C, Xie, X, Townsend, L, Gilliam, T C, Ott, J
Errors in genotyping data have been shown to have a significant effect on the estimation of recombination fractions in high-resolution genetic maps. Previous estimates of errors in existing databases...
Gabizon, R, Rosenmann, H, Meiner, Z, Kahana, I, Kahana, E, Shugart, Y, ...
The inherited prion diseases are neurodegenerative disorders which are not only genetic but also transmissible. More than a dozen mutations in the prion protein gene that result in nonconservative...
Ellison, K A, Fill, C P, Terwilliger, J, DeGennaro, L J, Martin-Gallardo, A, Anvret, M, ...
Rett syndrome is a neurologic disorder characterized by early normal development followed by regression, acquired deceleration of head growth, autism, ataxia, and stereotypic hand movements. The...
Strategies for characterizing highly polymorphic markers in human gene mapping.
Before new markers are thoroughly characterized, they are usually screened for high polymorphism on the basis of a small panel of individuals. Four commonly used screening strategies are compared in...
Vilkki, J, Ott, J, Savontaus, M L, Aula, P, Nikoskelainen, E K
Leber hereditary optic neuroretinopathy (LHON) is a maternally inherited disease, probably transmitted by mutations in mtDNA. The variation in the clinical expression of the disease among family...
Ikonen, E, Palo, J, Ott, J, Gusella, J, Somer, H, Karila, L, ...
The question about heterogeneity of Huntington disease (HD) at the DNA level can be approached by analyzing the RFLP haplotypes formed by several RFLP loci of the diseased chromosome in different...
Family cell lines available for research.
Lernmark, A, Ducat, L, Eisenbarth, G, Ott, J, Permutt, M A, Rubenstein, P, ...
The number of families required to detect or exclude linkage heterogeneity.
Under the assumption of two family types, one with linkage and one without linkage, the number of phase-known double-backcross families required to detect heterogeneity is investigated. The case of...
Beaudet, A., Bowocock, A., Buchwald, M., Cavalli-Sforza, L., Farrall, M., ...
A collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an...
Heterogeneity analysis of breast cancer families by using age at onset as a covariate.
An extension of the usual mixture model of heterogeneity (two family types, one with and one without linkage) is proposed by introducing age at onset as a covariate. The extended model defines...
Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.
Lathrop, G M, Lalouel, J M, Julier, C, Ott, J
Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a...
Y-linkage and pseudoautosomal linkage.
Presently existing computer program allow for an autosomal or an X-linked mode of inheritance of loci to be analyzed for genetic linkage. They do not, however, specifically allow for more general...
Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1.
Bird, T D, Ott, J, Giblett, E R
A linkage study was performed on three families with classic Charcot-Marie-Tooth (CMT) hereditary neuropathy with clinical manifestations of autosomal dominant inheritance, distal muscle weakness and...
For pedigree data, the maximum likelihood estimates of the parameters in polygenic and mixed models are derived analytically although not in closed form but in terms of "counting equations" allowing...
Scan statistics to scan markers for susceptibility genes
Scan statistics are applied to combine information on multiple contiguous genetic markers used in a genome screen for susceptibility loci. This information may be, for example, allele sharing...
Ott, J, Bhattacharya, S, Chen, J D, Denton, M J, Donald, J, Dubay, C, ...
Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliably...
The p53MH algorithm and its application in detecting p53-responsive genes
Hoh, J., Jin, S., Parrado, T., Edington, J., Levine, A. J., Ott, J.
A computer algorithm, p53MH, was developed, which identifies putative p53 transcription factor DNA-binding sites on a genomewide scale with high power and versatility. With the sequences from the...
Computer-simulation methods in human linkage analysis.
In human linkage analysis, many statistical problems without analytical solution could be solved by ad hoc Monte Carlo procedures were efficient computer-simulation methods available for members of...
The influence of exocyclic substituents of purine bases on DNA curvature.
Diekmann, S, Von Kitzing, E, McLaughlin, L, Ott, J, Eckstein, F
Complementary oligonucleotides with 5' overhanging deoxyguanosine or deoxycytidine stretches, respectively, of the general form 5'-d(GGGCAARAAC).5'-d(CCCGTTYTTG), where R represents the bases adenine...
Taylor, J W, Ott, J, Eckstein, F
M13 RF IV DNA may be prepared in vitro to contain phosphorothioate-modified internucleotidic linkages in the (-)strand only. Certain restriction enzymes react with this modified DNA to hydrolyze the...
Filter disc supported oligonucleotide synthesis by the phosphite method.
The phosphite approach to oligodeoxynucleotide synthesis has been applied to the filter disc support. The method is exemplified here by the preparation of eight decadeoxynucleotides.
Poly(adenylic acids) containing the antibiotic tubercidin (7-deazaadenosine) form double strands with poly(uridylic acid) by Watson-Crick base pairing. The stability of these complexes is enhanced by...
The 31P-NMR spectrum of the dodecamer d(GACGATATCGTC).
Ott, J, Eckstein, F, Connolly, B A
The resonances in the 31P-NMR spectrum of the dodecamer d(GACGATATCGTC) have been assigned by regiospecific labelling with oxygen-17. All 11 resonances are clearly resolved at 26 degrees C. Most...
Poly(2-methylthio-7-deazainosinic acid) [poly(ms2c7I)] was enzymatically synthesized by polymerization of 2-methylthio-7-deazainosine 5'-diphosphate with polynucleotide phosphorylase from Micrococcus...
Strategies for multilocus linkage analysis in humans.
Lathrop, G M, Lalouel, J M, Julier, C, Ott, J
The increasing number of DNA polymorphisms characterized in humans will soon allow the construction of fine genetic maps of human chromosomes. This advance calls for a reexamination of current...
Rossen, R D, Brewer, E J, Sharp, R M, Ott, J, Templeton, J W
The occurrence of a chronic seronegative polyarthritis has been studied in four families in which the proband presented with some form of juvenile rheumatoid arthritis. In these families,...
Detection of Genetic Interference: Simulation Studies and Mouse Data
Weeks, D. E., Ott, J., Lathrop, G. M.
Genetic chiasma interference occurs when the occurrence of one crossover (or chiasma) influences the probability of another crossover occurring nearby. We investigated, by simulation studies, the...
The Effect of Marker Heterozygosity on the Power to Detect Linkage Disequilibrium
The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests...
Knowles, J A, Rao, P A, Cox-Matise, T, Loth, J E, De Jesus, G M, Levine, L, ...
Bipolar affective disorder (BP) is a major neuropsychiatric disorder with high heritability and complex inheritance. Previously reported linkage between BP and DNA markers in the pericentromeric...
Simonic, I, Gericke, G S, Ott, J, Weber, J L
Because gene-mapping efforts, using large kindreds and parametric methods of analysis, for the neurologic disorder Tourette syndrome have failed, efforts are being redirected toward association...
A novel locus (RP24) for X-linked retinitis pigmentosa maps to Xq26-27.
Gieser, L, Fujita, R, Göring, H H, Ott, J, Hoffman, D R, Cideciyan, A V, ...
Two genetic loci, RP2 and RP3, for X-linked retinitis pigmentosa (XLRP) have been localized to Xp11.3-11.23 and Xp21.1, respectively. RP3 appears to account for 70% of XLRP families; however,...
Stibůrková, B, Majewski, J, Sebesta, I, Zhang, W, Ott, J, Kmoch, S
Familial juvenile hyperuricemic nephropathy (FJHN), is an autosomal dominant renal disease characterized by juvenile onset of hyperuricemia, gouty arthritis, and progressive renal failure at an early...
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits.
Schork, N J, Boehnke, M, Terwilliger, J D, Ott, J
Recent advances in molecular biology have provided geneticists with ever-increasing numbers of highly polymorphic genetic markers that have made possible linkage mapping of loci responsible for many...
Brzustowicz, L M, Mérette, C, Xie, X, Townsend, L, Gilliam, T C, Ott, J
Errors in genotyping data have been shown to have a significant effect on the estimation of recombination fractions in high-resolution genetic maps. Previous estimates of errors in existing databases...
Gabizon, R, Rosenmann, H, Meiner, Z, Kahana, I, Kahana, E, Shugart, Y, ...
The inherited prion diseases are neurodegenerative disorders which are not only genetic but also transmissible. More than a dozen mutations in the prion protein gene that result in nonconservative...
Ellison, K A, Fill, C P, Terwilliger, J, DeGennaro, L J, Martin-Gallardo, A, Anvret, M, ...
Rett syndrome is a neurologic disorder characterized by early normal development followed by regression, acquired deceleration of head growth, autism, ataxia, and stereotypic hand movements. The...
Strategies for characterizing highly polymorphic markers in human gene mapping.
Before new markers are thoroughly characterized, they are usually screened for high polymorphism on the basis of a small panel of individuals. Four commonly used screening strategies are compared in...
Vilkki, J, Ott, J, Savontaus, M L, Aula, P, Nikoskelainen, E K
Leber hereditary optic neuroretinopathy (LHON) is a maternally inherited disease, probably transmitted by mutations in mtDNA. The variation in the clinical expression of the disease among family...
Ikonen, E, Palo, J, Ott, J, Gusella, J, Somer, H, Karila, L, ...
The question about heterogeneity of Huntington disease (HD) at the DNA level can be approached by analyzing the RFLP haplotypes formed by several RFLP loci of the diseased chromosome in different...
Family cell lines available for research.
Lernmark, A, Ducat, L, Eisenbarth, G, Ott, J, Permutt, M A, Rubenstein, P, ...
The number of families required to detect or exclude linkage heterogeneity.
Under the assumption of two family types, one with linkage and one without linkage, the number of phase-known double-backcross families required to detect heterogeneity is investigated. The case of...
Beaudet, A., Bowocock, A., Buchwald, M., Cavalli-Sforza, L., Farrall, M., ...
A collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an...
Heterogeneity analysis of breast cancer families by using age at onset as a covariate.
An extension of the usual mixture model of heterogeneity (two family types, one with and one without linkage) is proposed by introducing age at onset as a covariate. The extended model defines...
Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.
Lathrop, G M, Lalouel, J M, Julier, C, Ott, J
Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a...
Y-linkage and pseudoautosomal linkage.
Presently existing computer program allow for an autosomal or an X-linked mode of inheritance of loci to be analyzed for genetic linkage. They do not, however, specifically allow for more general...
Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1.
Bird, T D, Ott, J, Giblett, E R
A linkage study was performed on three families with classic Charcot-Marie-Tooth (CMT) hereditary neuropathy with clinical manifestations of autosomal dominant inheritance, distal muscle weakness and...
For pedigree data, the maximum likelihood estimates of the parameters in polygenic and mixed models are derived analytically although not in closed form but in terms of "counting equations" allowing...
Zoghbi, H Y, Sandkuyl, L A, Ott, J, Daiger, S P, Pollack, M, O'Brien, W E, ...
A 7-generation kindred with the HLA-linked form of spinocerebellar ataxia (SCA1) was studied to determine whether the SCA1 gene maps centromeric or telomeric to the HLA loci. The DNA markers flanking...
Family cell lines available for research--an endangered resource?
Lernmark, A, Eisenbarth, G, Ducat, L, Erlich, H A, Faustman, D, Maclaren, N K, ...
Tsou, H C, Teng, D H, Ping, X L, Brancolini, V, Davis, T, Hu, R, ...
Cowden syndrome (CS) is an autosomal dominant disorder associated with the development of hamartomas and benign tumors in a variety of tissues, including the skin, thyroid, breast, endometrium, and...
McGee, T L, Devoto, M, Ott, J, Berson, E L, Dryja, T P
A subset of families with autosomal dominant retinitis pigmentosa (RP) display reduced penetrance with some asymptomatic gene carriers showing no retinal abnormalities by ophthalmic examination or by...
Linkage studies in a large kindred with familial hypercholesterolemia.
Ott, J, Schrott, H G, Goldstein, J L, Hazzard, W R, Allen, F H, Falk, C T, ...
Fine genetic mapping of a gene for autosomal recessive retinitis pigmentosa on chromosome 6p21.
Shugart, Y Y, Banerjee, P, Knowles, J A, Lewis, C A, Jacobson, S G, Matise, T C, ...
Noponen-Hietala, N, Kyllonen, E, Mannikko, M, Ilkko, E, Karppinen, J, Ott, J, ...
Background: Degenerative lumbar spinal stenosis (LSS) is usually caused by disc herniation or degeneration. Several genetic factors have been implicated in disc disease. Tryptophan alleles in COL9A2...
Association study of PHOX2B as a candidate gene for Hirschsprung’s disease
Garcia-Barceló, M, Sham, M H, Lui, V C H, Chen, B L S, Ott, J, Tam, P K H
Background: Hirschsprung’s disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has...
Fujita, R., Bingham, E., Forsythe, P., McHenry, C., Aita, V., Navia, B. A., ...
Genetic loci for X-linked retinitis pigmentosa (XLRP) have been mapped between Xp11.22 and Xp22.13 (RP2, RP3, RP6, and RP15). The RP3 gene, which is responsible for the predominant form of XLRP in...
A likelihood approach to calculating risk support intervals.
Genetic risks are usually computed under the assumption that genetic parameters, such as the recombination fraction, are known without error. Uncertainty in the estimates of these parameters must...
Osteopenia in 37 members of seven families: analysis based on a model of dominant inheritance.
Spotila, L. D., Caminis, J., Devoto, M., Shimoya, K., Sereda, L., Ott, J., ...
BACKGROUND: The genetic factors involved in determining bone mineral density (BMD) have not been fully elucidated. We have begun genetic linkage analysis of seven families in which many members are...
Genetic and phenotypic heterogeneity in pattern dystrophy
Francis, P J, Schultz, D W, Gregory, A M, Schain, M B, Barra, R, Majewski, J, ...
Background: The pattern dystrophies (PD) represent a clinically heterogeneous family of inherited macular diseases frequently caused by mutations in the peripherin/RDS gene. Most previous studies...