Correlation of cyclin D1 and Rb gene expression with apoptosis in invasive breast cancer.
De Jong, J S, Van Diest, P J, Michalides, R J, Van Der Valk, P, Meijer, C J, Baak, J P
BACKGROUND: In vitro studies have shown that amplification and overexpression of the cyclin D1 gene can accelerate the progress of cells through the G1 phase. Therefore, cyclin D1 may have an...
De Jong, J S, Van Diest, P J, Michalides, R J, Baak, J P
AIMS: To investigate the expression of the genes encoding cyclin D1 and p21 in proliferative and non-proliferative cells, as demonstrated by the Ki67 antibody, and to correlate these findings with...
Comparative genomic hybridisation.
Weiss, M M, Hermsen, M A, Meijer, G A, Van Grieken, N C, Baak, J P, Kuipers, E J, ...
Comparative genomic hybridisation (CGH) is a technique that permits the detection of chromosomal copy number changes without the need for cell culturing. It provides a global overview of chromosomal...
Boon, M E, Kurver, P H, Baak, J P, Ooms, E C
The morphometric differences between the urothelial cells in the voided urine of 24 patients with grade I and grade II bladder tumours were measured. In both wet-fixed Papanicolaou-stained smears as...
Prognostic value of proliferative activity in lymph node metastases of patients with breast cancer.
Van Diest, P J, Matze-Cok, E, Baak, J P
Whether the proliferative activity of distant metastases could be predicted by the proliferation in axillary lymph node metastases was investigated in 304 lymph nodes metastases of 52 patients with...
Borderline or malignant ovarian tumour? A case report of decision making with morphometry.
Baak, J P, Van Der Ley, G
A young woman presented with bilateral ovarian tumours. Multiple sections of each tumour were shown to many pathologists for consultation; some considered the tumours to be borderline, whereas others...
Van Der Linden, J C, Baak, J P, Postma, T, Lindeman, J, Meyer, C J
Serum carcinoembryonic antigen concentrations (serum CEA) in 80 patients with primary breast cancer were measured preoperatively, one month after operation, and thereafter serially every third month....
Morphometric study of histological changes in sublabial salivary glands due to aging process.
De Wilde, P C, Baak, J P, Van Houwelingen, J C, Kater, L, Slootweg, P J
The sublabial salivary glands were studied by morphometric methods in 68 healthy volunteers to establish possible changes related to age in those tissue components that are affected in Sjögren's...
Van Der Linden, H C, Baak, J P, Lindeman, J, Hermans, J, Meyer, C J
The prognostic value of clinical, quantitative, and qualitative microscopical features of both the primary tumour and also of the affected lymph nodes were investigated in 71 patients with breast...
Value of quantitative pathological variables as prognostic factors in advanced ovarian carcinoma.
Brinkhuis, M, Baak, J P, Meijer, G A, Van Diest, P J, Mogensen, O, Bichel, P, ...
AIMS: To evaluate correlations among clinical, pathological, morphometric, stereological, and DNA flow cytometric variables and their prognostic value in advanced ovarian cancer. METHODS: Tissue was...
Tumour heterogeneity of DNA cell cycle variables in breast cancer measured by flow cytometry.
Bergers, E, Van Diest, P J, Baak, J P
AIM/BACKGROUND: Conflicting results have been reported concerning the prognostic value of DNA flow cytometric variables (DNA ploidy, DNA index, %S phase fraction) in breast cancer. Selection bias and...
Meijer, G A, Hermsen, M A, Baak, J P, Van Diest, P J, Meuwissen, S G, Beliën, J A, ...
AIMS: Chromosomal gains and losses were surveyed by comparative genomic hybridisation (CGH) in a series of colorectal adenomas and carcinomas, in search of high risk genomic changes involved in...
Beliën, J A, Somi, S, De Jong, J S, Van Diest, P J, Baak, J P
BACKGROUND: Manual counting of microvessels is subjective and may lead to unacceptable interobserver variability, which may explain conflicting results. AIMS: To develop and test an automated method...
Meijer, G A, Schroeijers, A B, Flens, M J, Meuwissen, S G, Van Der Valk, P, Baak, J P, ...
AIM: To analyse the expression of multidrug resistance (MDR) related proteins at different steps in colorectal carcinogenesis. METHODS: The presence of three MDR related proteins (Pgp, MRP1, and...
Morphometric and flow cytometric analysis of small cell undifferentiated carcinoma of the bladder.
Blomjous, C E, Vos, W, Schipper, N W, De Voogt, H J, Baak, J P, Meijer, C J
Eighteen cases of primary small cell carcinoma of the bladder were studied. Three patients survived for two years and one survived for five years, which was significantly worse when compared with...
Prognostic value of nucleolar morphometric variables in cytological breast cancer specimens.
Van Diest, P J, Mouriquand, J, Schipper, N W, Baak, J P
In a retrospective study on cytological specimens from 86 patients with histologically confirmed invasive breast cancer, the prognostic value of nucleolar morphometric variables was studied and...
AIM--Proliferative activity of tumours reflects their malignant potential. In colorectal adenomas, a subjective impression of the number of mitoses is a criterion often used to assess the degree of...
Morphometric data to FIGO stage and histological type and grade for prognosis of ovarian tumours.
Baak, J P, Wisse-Brekelmans, E C, Langley, F A, Talerman, A, Delemarre, J F
The prognostic value of using histological typing, grading, and morphology, in addition to clinical staging, was assessed in 98 cases of invasive ovarian cancer of the common epithelial types...
Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer.
Van Der Linden, J C, Baak, J P, Lindeman, J, Hermans, J, Meyer, C J
In a prospective study the predictive value of a multivariate morphometric prognostic index was evaluated in 195 patients with primary breast cancer who had not been treated with any form of...
Uyterlinde, A M, Schipper, N W, Baak, J P
In 65 patients with primary invasive ductal breast carcinoma the relation between classic prognosticators describing the extent of disease (lymph node metastases and tumour size) and newer promising...
Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma.
Blomjous, C E, Schipper, N W, Baak, J P, Van Galen, E M, De Voogt, H J, Meyer, C J
Cellular DNA content was determined by flow cytometry on routinely processed paraffin sections of 61 primary and untreated transitional cell carcinomas of the urinary bladder, and correlated with...
Reproducibility of flow cytometric assessment of follicular tumours of the thyroid.
Van Thiel, T P, Van Der Linden, J C, Baak, J P, Van De Sandt, M M, Van Galen, C, Bezemer, P D
The reproducibility of the DNA index of paraffin wax sections from 44 follicular tumours of the thyroid (18 follicular adenomas and 26 follicular carcinomas), which had been assessed by flow...
Correlation of cyclin D1 and Rb gene expression with apoptosis in invasive breast cancer.
De Jong, J S, Van Diest, P J, Michalides, R J, Van Der Valk, P, Meijer, C J, Baak, J P
BACKGROUND: In vitro studies have shown that amplification and overexpression of the cyclin D1 gene can accelerate the progress of cells through the G1 phase. Therefore, cyclin D1 may have an...
De Jong, J S, Van Diest, P J, Michalides, R J, Baak, J P
AIMS: To investigate the expression of the genes encoding cyclin D1 and p21 in proliferative and non-proliferative cells, as demonstrated by the Ki67 antibody, and to correlate these findings with...
Comparative genomic hybridisation.
Weiss, M M, Hermsen, M A, Meijer, G A, Van Grieken, N C, Baak, J P, Kuipers, E J, ...
Comparative genomic hybridisation (CGH) is a technique that permits the detection of chromosomal copy number changes without the need for cell culturing. It provides a global overview of chromosomal...
Boon, M E, Kurver, P H, Baak, J P, Ooms, E C
The morphometric differences between the urothelial cells in the voided urine of 24 patients with grade I and grade II bladder tumours were measured. In both wet-fixed Papanicolaou-stained smears as...
Prognostic value of proliferative activity in lymph node metastases of patients with breast cancer.
Van Diest, P J, Matze-Cok, E, Baak, J P
Whether the proliferative activity of distant metastases could be predicted by the proliferation in axillary lymph node metastases was investigated in 304 lymph nodes metastases of 52 patients with...
Borderline or malignant ovarian tumour? A case report of decision making with morphometry.
Baak, J P, Van Der Ley, G
A young woman presented with bilateral ovarian tumours. Multiple sections of each tumour were shown to many pathologists for consultation; some considered the tumours to be borderline, whereas others...
Van Der Linden, J C, Baak, J P, Postma, T, Lindeman, J, Meyer, C J
Serum carcinoembryonic antigen concentrations (serum CEA) in 80 patients with primary breast cancer were measured preoperatively, one month after operation, and thereafter serially every third month....
Morphometric study of histological changes in sublabial salivary glands due to aging process.
De Wilde, P C, Baak, J P, Van Houwelingen, J C, Kater, L, Slootweg, P J
The sublabial salivary glands were studied by morphometric methods in 68 healthy volunteers to establish possible changes related to age in those tissue components that are affected in Sjögren's...
Van Der Linden, H C, Baak, J P, Lindeman, J, Hermans, J, Meyer, C J
The prognostic value of clinical, quantitative, and qualitative microscopical features of both the primary tumour and also of the affected lymph nodes were investigated in 71 patients with breast...
Value of quantitative pathological variables as prognostic factors in advanced ovarian carcinoma.
Brinkhuis, M, Baak, J P, Meijer, G A, Van Diest, P J, Mogensen, O, Bichel, P, ...
AIMS: To evaluate correlations among clinical, pathological, morphometric, stereological, and DNA flow cytometric variables and their prognostic value in advanced ovarian cancer. METHODS: Tissue was...
Tumour heterogeneity of DNA cell cycle variables in breast cancer measured by flow cytometry.
Bergers, E, Van Diest, P J, Baak, J P
AIM/BACKGROUND: Conflicting results have been reported concerning the prognostic value of DNA flow cytometric variables (DNA ploidy, DNA index, %S phase fraction) in breast cancer. Selection bias and...
Meijer, G A, Hermsen, M A, Baak, J P, Van Diest, P J, Meuwissen, S G, Beliën, J A, ...
AIMS: Chromosomal gains and losses were surveyed by comparative genomic hybridisation (CGH) in a series of colorectal adenomas and carcinomas, in search of high risk genomic changes involved in...
Beliën, J A, Somi, S, De Jong, J S, Van Diest, P J, Baak, J P
BACKGROUND: Manual counting of microvessels is subjective and may lead to unacceptable interobserver variability, which may explain conflicting results. AIMS: To develop and test an automated method...
Meijer, G A, Schroeijers, A B, Flens, M J, Meuwissen, S G, Van Der Valk, P, Baak, J P, ...
AIM: To analyse the expression of multidrug resistance (MDR) related proteins at different steps in colorectal carcinogenesis. METHODS: The presence of three MDR related proteins (Pgp, MRP1, and...
Morphometric and flow cytometric analysis of small cell undifferentiated carcinoma of the bladder.
Blomjous, C E, Vos, W, Schipper, N W, De Voogt, H J, Baak, J P, Meijer, C J
Eighteen cases of primary small cell carcinoma of the bladder were studied. Three patients survived for two years and one survived for five years, which was significantly worse when compared with...
Prognostic value of nucleolar morphometric variables in cytological breast cancer specimens.
Van Diest, P J, Mouriquand, J, Schipper, N W, Baak, J P
In a retrospective study on cytological specimens from 86 patients with histologically confirmed invasive breast cancer, the prognostic value of nucleolar morphometric variables was studied and...
AIM--Proliferative activity of tumours reflects their malignant potential. In colorectal adenomas, a subjective impression of the number of mitoses is a criterion often used to assess the degree of...
Morphometric data to FIGO stage and histological type and grade for prognosis of ovarian tumours.
Baak, J P, Wisse-Brekelmans, E C, Langley, F A, Talerman, A, Delemarre, J F
The prognostic value of using histological typing, grading, and morphology, in addition to clinical staging, was assessed in 98 cases of invasive ovarian cancer of the common epithelial types...
Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer.
Van Der Linden, J C, Baak, J P, Lindeman, J, Hermans, J, Meyer, C J
In a prospective study the predictive value of a multivariate morphometric prognostic index was evaluated in 195 patients with primary breast cancer who had not been treated with any form of...
Uyterlinde, A M, Schipper, N W, Baak, J P
In 65 patients with primary invasive ductal breast carcinoma the relation between classic prognosticators describing the extent of disease (lymph node metastases and tumour size) and newer promising...
Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma.
Blomjous, C E, Schipper, N W, Baak, J P, Van Galen, E M, De Voogt, H J, Meyer, C J
Cellular DNA content was determined by flow cytometry on routinely processed paraffin sections of 61 primary and untreated transitional cell carcinomas of the urinary bladder, and correlated with...
Reproducibility of flow cytometric assessment of follicular tumours of the thyroid.
Van Thiel, T P, Van Der Linden, J C, Baak, J P, Van De Sandt, M M, Van Galen, C, Bezemer, P D
The reproducibility of the DNA index of paraffin wax sections from 44 follicular tumours of the thyroid (18 follicular adenomas and 26 follicular carcinomas), which had been assessed by flow...
Scheper, R J, Baak, J P, Hiisivara, S, Veldhuizen, R W
Rabbit erythrocyte (RRBC) and EAC rosette formation, for detection of T and B lymphocytes respectively, was studied in thymus, lymph nodes and peripheral blood of guinea-pigs. Using two different...
Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.
Van Diest, P. J., Michalides, R. J., Jannink, L., Van Der Valk, P., Peterse, H. L., De Jong, J. S., ...
Cyclin D1 overexpression, detected by standard immunohistochemistry, was correlated with other prognostic variables and its prognostic value was evaluated in a group of 148 invasive breast cancers...
Thunnissen, F. B., Van Eijk, J., Baak, J. P., Schipper, N. W., Uyterlinde, A. M., Breederveld, R. S., ...
Bronchopulmonary carcinoid tumors are tumors with a low malignant potential. They metastasize in 5-15% of cases. Accurate histologic preoperative prediction of the presence of regional lymph node...
Van Den Brule, A. J., Cromme, F. V., Snijders, P. J., Smit, L., Oudejans, C. B., Baak, J. P., ...
Paraffin-embedded squamous cell carcinomas of the uterine cervix selected for the presence of human papillomavirus (HPV) genotype 16 (n = 19) by polymerase chain reaction, were studied for...
Prognostic factors following enucleation of 111 uveal melanomas.
Coleman, K, Baak, J P, Van Diest, P, Mullaney, J, Farrell, M, Fenton, M
Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival...
Syntactic structure analysis in uveal melanomas.
Coleman, K, Van Diest, P J, Baak, J P, Mullaney, J
Syntactic structure analysis was carried out successfully on 92 paraffin embedded uveal melanomas, taken from patients with a minimum follow up of 5 years. This simple, fast, and reproducible method...
Second primary lung cancer: importance of long term follow up.
Van Bodegom, P C, Wagenaar, S S, Corrin, B, Baak, J P, Berkel, J, Vanderschueren, R G
Review of histopathological and clinical data showed that 153 patients at one hospital developed a second primary lung cancer during 1980-6, 10% of all those with lung carcinoma. There were 64...