J. P. de Villartay

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J

Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...

Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency.

Cavazzana-Calvo, M, Le Deist, F, De Saint Basile, G, Papadopoulo, D, De Villartay, J P, Fischer, A

We studied the radiosensitivity of granulocyte macrophage colony-forming units (GM-CFU) in patients with a severe combined immunodeficiency (SCID). Three patients lacking both mature T and B cells...

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).

De Saint-Basile, G, Le Deist, F, De Villartay, J P, Cerf-Bensussan, N, Journet, O, Brousse, N, ...

We report the immunological characteristics of five patients with Omenn's syndrome, a rare inherited immunodeficiency also known as combined immunodeficiency with hypereosinophilia. The syndrome is...

Deletional rearrangement in the human T-cell receptor alpha-chain locus.

De Villartay, J P, Lewis, D, Hockett, R, Waldmann, T A, Korsmeyer, S J, Cohen, D I

The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed alpha and beta. In the course of characterizing human T-cell tumors with an...

High level transient gene expression in human lymphoid cells by SV40 large T antigen boost.

De Chasseval, R, De Villartay, J P

High level transient gene expression in lymphoid cells has always been challenging because of the difficulty to efficiently transfect such cells. This has precluded any attempt to clone cDNA encoding...

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.

Rieux-Laucat, F, Bahadoran, P, Brousse, N, Selz, F, Fischer, A, Le Deist, F, ...

Omenn's syndrome is an inherited human combined immunodeficiency condition characterized by the presence of a large population of activated and tissue-infiltrating T cells. Analysis of the TCRB...

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J

Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...

Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency.

Cavazzana-Calvo, M, Le Deist, F, De Saint Basile, G, Papadopoulo, D, De Villartay, J P, Fischer, A

We studied the radiosensitivity of granulocyte macrophage colony-forming units (GM-CFU) in patients with a severe combined immunodeficiency (SCID). Three patients lacking both mature T and B cells...

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).

De Saint-Basile, G, Le Deist, F, De Villartay, J P, Cerf-Bensussan, N, Journet, O, Brousse, N, ...

We report the immunological characteristics of five patients with Omenn's syndrome, a rare inherited immunodeficiency also known as combined immunodeficiency with hypereosinophilia. The syndrome is...

Deletional rearrangement in the human T-cell receptor alpha-chain locus.

De Villartay, J P, Lewis, D, Hockett, R, Waldmann, T A, Korsmeyer, S J, Cohen, D I

The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed alpha and beta. In the course of characterizing human T-cell tumors with an...

High level transient gene expression in human lymphoid cells by SV40 large T antigen boost.

De Chasseval, R, De Villartay, J P

High level transient gene expression in lymphoid cells has always been challenging because of the difficulty to efficiently transfect such cells. This has precluded any attempt to clone cDNA encoding...

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.

Rieux-Laucat, F, Bahadoran, P, Brousse, N, Selz, F, Fischer, A, Le Deist, F, ...

Omenn's syndrome is an inherited human combined immunodeficiency condition characterized by the presence of a large population of activated and tissue-infiltrating T cells. Analysis of the TCRB...

Dissociation between onset of natural killer E-rosette forming cells and of T3-positive cells following HLA-mismatched T cell depleted bone marrow transplantation.

De Villartay, J P, Le Deist, F, Griscelli, C, Fischer, A

We have studied immunological reconstitution following partially HLA-incompatible T cell depleted bone marrow transplantation, compared with reconstitution following HLA identical T cell depleted and...