Fillastre, J. P., Godin, M., Legallicier, B., Chretien, P., Bidault, R., GillotiiT, C., ...
The pharmacokinetics of a single oral 200 mg dose of netivudine (1-(β-D-arabino-furanosyl)-5-(1-propynyl)uracil), a nucleoside analogue under development for use in varicella zoster virus...
Pharmacokinetics of netivudine in haemodialysis patients (1996)
ROY, F. LE, GODIN, M., LEGALLICLER, B., FILLASTRE, J. P., BIDAULT, R., POSNER, J., ...
Lack of effect of ketoprofen on the pharmacokinetics of pefloxacin and ofloxacin (1993)
FILLASTRE, J. P., LEROY, A., BORSA-LEBAS, F., ETIENNE, I., GY, C., HUMBERT, G.
Renal Granulomatous Sarcoidosis: Report of Six Cases (1990)
Hannedouche, T., Grateau, G., Noël, L. H., Godin, M., Fillastre, J. P., Grünfeld, J. P., ...
Six cases of chronic renal failure related to granulomatous renal sarcoidosis are reported and compared with data in the literature. The particular features of sarcoidosis granulomatous interstitial...
Pharmacokinetics of quinolones in renal insufficiency (1990)
Fillastre, J. P., Leroy, A., Moulin, B., Dhib, M., Borsa-Lebas, F., Humbert, G.
The pharmacokinetics of the new fluoroquinolone derivatives have been extensively studied in patients with various degrees of chronic renal insufficiency during the last few years. Their kinetic...
Influence of Muzolimine, A New Diuretic, on Experimental Gentamicin Nephrotoxicity (1987)
Toutain, H., Olier, B., Fillastre, J. P., Morin, J. P.
The administration of diuretic drugs increases the nephrotoxicity of aminoglycosides. Muzolimine is a new diuretic which acts on the ascending limb of the loop of Henle and on the distal tubule. It...
Pharmacokinetics of ceftazidime in renal failure (1983)
FILLASTRE, J.P., HUMBERT, G., OLIER, B., LEGUY, F., BORSA, F., SPENSER, G.R.
Pharmacokinetics of cefadroxil in patients with impaired renal function (1982)
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of cefadroxil were studied in patients with different degrees of renal impairment after a single oral dose of 1000 mg. The standard open one-compartment model was used to...
Viotte, G., Morin, J. P., Godin, M., Fillastre, J. P.
Functional, histological and biochemical changes of the renal cortex were studied after treatment of Wistar female rats with 400 mg/kg cefoxitin for eight days. This treatment was composed with...
Pharmacokinetics of cefotaxime in subjects with normal and impaired renal function (1980)
Fillastre, J. P., Leroy, A., Humbert, G., Godin, M.
The pharmacokinetics of cefotaxime was investigated in 6 healthy subjects and in 22 uraemic patients with various degrees of renal insufficiency. After i.v. bolus injection of a single 15 mg/kg dose,...
Pharmacokinetics of dibekacin in normal subjects and in patients with renal failure (1980)
Leroy, A., Humbert, G., Fillastre, J. P.
A pharmacokinetic study of dibekacin, 3′-4′-4-dideoxykanamycin B, was conducted in 5 healthy subjects and 23 subjects with chronic renal failure. After i.v. bolus injection and i.m. injection of...
Lean body mass and amikacin dosage (1980)
HALLYNCK, T. H., SOEP, H. H., THOMIS, J. A., BOELAERT, J., DANEELS, R., RUBINSTEIN, E., ...
Pharmacokinetics of cefoxitin sodium in normal subjects and in uraemic patients (1978)
Fillastre, J. P, Leroy, A., Godin, M., Oksenhendler, G., Humbert, G.
Pharmacokinetics data of cefoxitin sodium were determined in normal subjects and in uraemic patients. All subjects (5 normal and 20 uraemic) received 30 mg/kg of cefoxitin i.v. in 30-min. infusions....
Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function.
Leroy, A, Fillastre, J P, Humbert, G
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma...
Thauvin, C, Lemeland, J F, Humbert, G, Fillastre, J P
The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination...
Borsa, F, Leroy, A, Fillastre, J P, Godin, M, Moulin, B
The pharmacokinetics of two oral forms of fosfomycin, tromethamine (trometamol) salt and calcium salt, were studied in five young (age, 29 +/- 3 [standard deviation] years) and eight elderly (age, 72...
Fillastre, J P, Moulin, B, Godin, M, Frelon, J H
Apalcillin is a new semisynthetic penicillin used as a sodium salt. More than 4,000 patients have been treated with this antibiotic, but increased serum creatinine levels were noted in 18 cases. In 5...
Ofloxacin pharmacokinetics in renal failure.
Fillastre, J P, Leroy, A, Humbert, G
The pharmacokinetics of ofloxacin were investigated in 12 normal subjects and 21 uremic patients after the administration of a single oral 200-mg dose. An open three-compartment body model was used...
Pharmacokinetics of habekacin in patients with renal insufficiency.
Fillastre, J P, Leroy, A, Humbert, G, Moulin, B, Bernadet, P, Josse, S
The pharmacokinetics of habekacin, a new semisynthetic aminoglycoside antibiotic, were investigated in six healthy subjects and 25 uremic patients (six of whom were on hemodialysis) after...
Pharmacokinetics of moxalactam in subjects with normal and impaired renal function.
Leroy, A, Humbert, G, Fillastre, J P
The pharmacokinetics of moxalactam were investigated in five subjects with normal renal function and 21 uremic patients. Normal subjects were given intravenous doses of 7.5 and 15 mg of the drug per...
Pharmacokinetics of ceftazidime in normal and uremic subjects.
Leroy, A, Leguy, F, Borsa, F, Spencer, G R, Fillastre, J P, Humbert, G
The pharmacokinetics of ceftazidime, administered as a single intravenous dose of 15 mg/kg given in a bolus injection over 3 min, were investigated in 5 normal subjects and in 19 uremic patients. The...
Leroy, A, Fillastre, J P, Borsa-Lebas, F, Etienne, I, Humbert, G
The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a single...
Pharmacokinetics of Azlocillin in Subjects with Normal and Impaired Renal Function
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal...
Pharmacokinetics of sparfloxacin in patients with renal impairment.
Fillastre, J P, Montay, G, Bruno, R, Etienne, I, Dhib, M, Vivier, N, ...
The pharmacokinetics of sparfloxacin were studied in 14 renal failure patients (group I, 7 with creatinine clearance of > 10 to 30 ml/min; and group II, 7 with creatinine clearance of < or = 10...
Pharmacokinetics of Netilmicin in the Presence of Normal or Impaired Renal Function
Humbert, G., Leroy, A., Fillastre, J. P., Oksenhendler, G.
A pharmacokinetic study of netilmicin was conducted in 12 healthy subjects and 24 subjects with chronic renal failure. After intramuscular administrations of 2 and 3 mg of netilmicin per kg in normal...
Pharmacokinetics of Amoxicillin: Dosage Nomogram for Patients with Impaired Renal Function
Humbert, Guy, Spyker, Daniel A., Fillastre, J. P., Leroy, Annie
Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery...
Acute Renal Failure Associated with Combined Gentamicin and Cephalothin Therapy
Fillastre, J. P., Laumonier, R., Humbert, G., Dubois, D., Metayer, J., Delpech, A., ...
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6...
Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function.
Leroy, A, Fillastre, J P, Humbert, G
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma...
Thauvin, C, Lemeland, J F, Humbert, G, Fillastre, J P
The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination...
Borsa, F, Leroy, A, Fillastre, J P, Godin, M, Moulin, B
The pharmacokinetics of two oral forms of fosfomycin, tromethamine (trometamol) salt and calcium salt, were studied in five young (age, 29 +/- 3 [standard deviation] years) and eight elderly (age, 72...
Fillastre, J P, Moulin, B, Godin, M, Frelon, J H
Apalcillin is a new semisynthetic penicillin used as a sodium salt. More than 4,000 patients have been treated with this antibiotic, but increased serum creatinine levels were noted in 18 cases. In 5...
Ofloxacin pharmacokinetics in renal failure.
Fillastre, J P, Leroy, A, Humbert, G
The pharmacokinetics of ofloxacin were investigated in 12 normal subjects and 21 uremic patients after the administration of a single oral 200-mg dose. An open three-compartment body model was used...
Pharmacokinetics of habekacin in patients with renal insufficiency.
Fillastre, J P, Leroy, A, Humbert, G, Moulin, B, Bernadet, P, Josse, S
The pharmacokinetics of habekacin, a new semisynthetic aminoglycoside antibiotic, were investigated in six healthy subjects and 25 uremic patients (six of whom were on hemodialysis) after...
Pharmacokinetics of moxalactam in subjects with normal and impaired renal function.
Leroy, A, Humbert, G, Fillastre, J P
The pharmacokinetics of moxalactam were investigated in five subjects with normal renal function and 21 uremic patients. Normal subjects were given intravenous doses of 7.5 and 15 mg of the drug per...
Pharmacokinetics of ceftazidime in normal and uremic subjects.
Leroy, A, Leguy, F, Borsa, F, Spencer, G R, Fillastre, J P, Humbert, G
The pharmacokinetics of ceftazidime, administered as a single intravenous dose of 15 mg/kg given in a bolus injection over 3 min, were investigated in 5 normal subjects and in 19 uremic patients. The...
Leroy, A, Fillastre, J P, Borsa-Lebas, F, Etienne, I, Humbert, G
The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a single...
Pharmacokinetics of Azlocillin in Subjects with Normal and Impaired Renal Function
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal...
Pharmacokinetics of sparfloxacin in patients with renal impairment.
Fillastre, J P, Montay, G, Bruno, R, Etienne, I, Dhib, M, Vivier, N, ...
The pharmacokinetics of sparfloxacin were studied in 14 renal failure patients (group I, 7 with creatinine clearance of > 10 to 30 ml/min; and group II, 7 with creatinine clearance of < or = 10...
Pharmacokinetics of Netilmicin in the Presence of Normal or Impaired Renal Function
Humbert, G., Leroy, A., Fillastre, J. P., Oksenhendler, G.
A pharmacokinetic study of netilmicin was conducted in 12 healthy subjects and 24 subjects with chronic renal failure. After intramuscular administrations of 2 and 3 mg of netilmicin per kg in normal...
Pharmacokinetics of Amoxicillin: Dosage Nomogram for Patients with Impaired Renal Function
Humbert, Guy, Spyker, Daniel A., Fillastre, J. P., Leroy, Annie
Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery...
Acute Renal Failure Associated with Combined Gentamicin and Cephalothin Therapy
Fillastre, J. P., Laumonier, R., Humbert, G., Dubois, D., Metayer, J., Delpech, A., ...
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6...
Pharmacokinetics and safety of cicloprolol in uraemic patients.
Fillastre, J P, Aparicio, M, Porquet, C, Dubruc, C, Rosenzweig, P, Morselli, P L
Pharmacokinetics of cilazapril in patients with renal failure
Fillastre, J. P., Moulin, B., Godin, M., Williams, P. E. O., Brown, A. N., Francis, R. J., ...
1 The pharmacokinetics of a single 1 mg dose of cilazapril were determined in six subjects with normal renal function and in 19 uraemic patients with various degrees of renal impairment.