Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis (2005)
Howell, W.M., Pead, P.J., Shek, F.W., Rose-Zerilli, M.J., Armstrong, T., Johnson, C.D., ...
Aims: To test the hypothesis that single nucleotide polymorphisms (SNPs) within genes (or their promoter regions) encoding cytokines, growth factors, and intercellular adhesion molecules modulate the...
Guha, I.N., Stedman, B., Iredale, J.P., Sheron, N.
We describe the case of a 55-year-old lady who presented with accelerated hepatic decompensation from an arterioportal fistula (APF). There is histological evidence the APF proceeded a percutaneous...
Campbell, S.J., Hughes, P.M., Iredale, J.P., Wilcockson, D.C., Waters, S., Docagne, F., ...
Following injury or infection, the liver releases acute-phase proteins (APP). After a severe focal injury, this systemic response can be excessive and may lead to multiorgan dysfunction (MODS)....
Gaca, M.D., Zhou, X., Issa, R., Kiriella, K., Iredale, J.P., Benyon, R.C.
During liver fibrosis hepatic stellate cells become activated, transforming into proliferative myofibroblastic cells expressing type I collagen and α-smooth muscle actin. They become the major...
Bateman, A.C., Turner, S.M., Thomas, K.S., McCrudden, P.R., Fine, D.R., Johnson, P.A., ...
BACKGROUND: Chronic pancreatitis is characterised clinically by early exocrine insufficiency, with diabetes mellitus occurring as a late phenomenon. This is mirrored pathologically by extensive...
Issa, R., Williams, E., Trim, N., Kendall, T., Arthur, M.J.P., Reichen, J., ...
Background: Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix degrading...
Williams, E.J., Benyon, R.C., Trim, N., Hadwin, R., Grove, B.H., Arthur, M.J.P., ...
Background: Following liver injury, hepatic stellate cells (HSC) transform into myofibroblast-like cells (activation) and are the major source of type I collagen and the potent collagenase inhibitors...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, ...
Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, ...
Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Thrombotic thrombocytopenic purpura mimicking acute small bowel Crohn's disease.
Winwood, P J, Iredale, J P, Williamson, P J, Lesna, M, Loehry, C A
A 39 year old woman presented with a short history of bloody diarrhoea. She subsequently developed microangiopathic haemolysis, platelet consumption, and renal impairment. Initial investigations...
Familial and idiopathic colonic varices: an unusual cause of lower gastrointestinal haemorrhage.
Iredale, J P, Ridings, P, McGinn, F P, Arthur, M J
A patient is described presenting with an acute lower gastrointestinal haemorrhage as a result of extensive colonic varices. Further investigation revealed that there were no oesophageal varices or...
Bateman, A C, Turner, S M, Thomas, K S A, McCrudden, P R, Fine, D R, Johnson, P A, ...
Background: Chronic pancreatitis is characterised clinically by early exocrine insufficiency, with diabetes mellitus occurring as a late phenomenon. This is mirrored pathologically by extensive...
Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
Howell, W M, Pead, P J, Shek, F W, Rose-Zerilli, M J, Armstrong, T, Johnson, C D, ...
Aims: To test the hypothesis that single nucleotide polymorphisms (SNPs) within genes (or their promoter regions) encoding cytokines, growth factors, and intercellular adhesion molecules modulate the...
Williams, E. J., Iredale, J. P.
Liver fibrosis and its related complications continue to represent a significant worldwide healthcare burden. Over the past decade there has been considerable improvement in our understanding of the...