Indirect evidence suggests that oxidative stress may play a role in the pathogenesis of inherited muscular dystrophy, but the significance and precise extent of this contribution is poorly...
Bojes, H K, Datta, K, Xu, J, Chin, A, Simonian, P, Nuñez, G, ...
Bcl-xL and bax are bcl-2-related genes whose protein products either inhibit or promote apoptosis. Oxidative damage, including the loss of glutathione, has been implicated in the induction of...
Datta, K, Biswal, S S, Kehrer, J P
The ability of various inhibitors of lipoxygenase (LOX) enzymes and 5-lipoxygenase-activating protein (FLAP) to induce apoptosis has implicated these pathways in the mechanism(s) of this form of cell...
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
Robertson, J D, Datta, K, Biswal, S S, Kehrer, J P
Recent evidence supports a role for heat-shock protein 70 (hsp70) and the 26 S proteasome in regulating apoptosis, although the precise nature of their involvement is not known. In the present study,...
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.
Kehrer, J P, Biswal, S S, La, E, Thuillier, P, Datta, K, Fischer, S M, ...
Although MK886 was originally identified as an inhibitor of 5-lipoxygenase activating protein (FLAP), recent data demonstrate that this activity does not underlie its ability to induce apoptosis...
Indirect evidence suggests that oxidative stress may play a role in the pathogenesis of inherited muscular dystrophy, but the significance and precise extent of this contribution is poorly...
Bojes, H K, Datta, K, Xu, J, Chin, A, Simonian, P, Nuñez, G, ...
Bcl-xL and bax are bcl-2-related genes whose protein products either inhibit or promote apoptosis. Oxidative damage, including the loss of glutathione, has been implicated in the induction of...
Datta, K, Biswal, S S, Kehrer, J P
The ability of various inhibitors of lipoxygenase (LOX) enzymes and 5-lipoxygenase-activating protein (FLAP) to induce apoptosis has implicated these pathways in the mechanism(s) of this form of cell...
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
Robertson, J D, Datta, K, Biswal, S S, Kehrer, J P
Recent evidence supports a role for heat-shock protein 70 (hsp70) and the 26 S proteasome in regulating apoptosis, although the precise nature of their involvement is not known. In the present study,...
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.
Kehrer, J P, Biswal, S S, La, E, Thuillier, P, Datta, K, Fischer, S M, ...
Although MK886 was originally identified as an inhibitor of 5-lipoxygenase activating protein (FLAP), recent data demonstrate that this activity does not underlie its ability to induce apoptosis...