Density Forecasting Using Hidden Markov Experts (2008)
Shanming Shi, J. P. Morgan, Co. Inc, Andreas S. Weigend
Abstract. We present a framework for predicting the conditional distributions of future observations that is well suited for skewed, fat-tailed, and multi-modal time series. This framework allows to...
Amongst resolvable incomplete block designs, affine resolvable designs are optimal in many con-ventional senses. However, different affine resolvable designs for the same numbers of treatments,...
J. P. Morgan, Deutsche Morgan Grenfell
The benchmark for understanding credit risk • A value-at-risk (VaR) framework applicable to all institutions worldwide that carry credit risk in the course of their business. • A full portfolio...
Resolvable designs with large blocks (2007)
Resolvable designs with two blocks per replicate are studied from an optimality perspective. Because in practice the number of replicates is typically less than the number of treatments, arguments...
LIGHTWEIGHT VEHICLES ON SAND (2007)
Marilyn Elizabeth Worley, Dennis Hong, J. P. Morgan, Marilyn E. Worley, Corina Sandu Chairperson
off-road vehicle performance, coastal terrain
.36 Nested Designs 1 36 Nested Designs 36.1 NBIBDs: Definition and Example (2006)
Charles J. Colbourn, Jeffrey H. Dinitz, J. P. Morgan
36.1 Definition If the blocks of a BIBD (V, D 1) with v symbols in b1 blocks of size k1 are each partitioned into sub-blocks of size k2, and the b2 = b1k1/k2 sub-blocks themselves constitute a BIBD...
A METHOD FOR PREDICTING THERMAL RESPONSE IN SANDWICH PANELS. (2005)
KENDALL,P. J., Morgan,J. P., Chappell,T. E.
This study was undertaken to develop and demonstrate the validity of an analytical model for predicting the transient temperature response in honeycomb sandwich panels subjected to variable heat...
Lorne D. Johnson, Georgios Sakoulis, J. P Morgan, Fleming Asset Management
A large body of evidence has emerged in recent studies confirming that macroeconomic factors play an important role in determining investor risk premia and the ultimate path of equity returns. This...
Optimal design with many blocking factors (2000)
Designs for sets of experimental units with many blocking factors are studied. It is shown that if the set of blocking factors satisfies a certain simple condition then the information matrix for the...
Optimal blocked main effects plans with nested rows and columns and related designs (1996)
Optimal design is studied for factorial experiments in the nested row and column setting. The approach is analogous to that of orthogonal Latin squares: main effects plans are found by the...
Minimizing Basis Risk from Nonparallel Shifts in the Yield Curve (1996)
Eric Falkenstein, Jerry Hanweck, J. P. Morgan
this paper works for reasons illustrated by Hilliard, but our algorithm is considerably easier to implement. While Hilliard uses the present value of cash flows in his analysis, we use basis point...
Construction and optimality of affine-resolvable designs (1995)
BAILEY, R. A., MONOD, H., MORGAN, J. P.
Affine-resolvable designs are constructed from orthogonal arrays and shown to be optimal among resolvable designs with respect to the usual criteria. Tables and text show how to construct such...
Perreault, C. L., Meuse, A. J., Bentivegna, L. A., Morgan, J. P.
Acute or chronic heart failure may be caused by one or more of a variety of abnormalities including changes in excitation-contraction coupling processes (i.e. decreased availability of activator Ca2+...
xvi, 158, [1] p.
E-optimal design in irregular BIBD settings (0000)
When the necessary conditions for a BIBD are satisfied, but no BIBD exists, there is no simple answer for the optimal design problem. This paper identifies the E-optimal information matrices for any...
Optimal row-column design for three treatments (0000)
The A-optimality problem is solved for three treatments in a row-column layout. Depending on the numbers of rows and columns, the requirements for optimality can be decidedly counterintuitive:...
Xiao, Y F, Kang, J X, Morgan, J P, Leaf, A
Recent evidence indicates that polyunsaturated long-chain fatty acids (PUFAs) prevent lethal ischemia-induced cardiac arrhythmias in animals and probably in humans. To increase understanding of the...
Black, A C, Luo, J, Watanabe, C, Chun, S, Bakker, A, Fraser, J K, ...
Efficient expression of human T-cell leukemia virus (HTLV) and human immunodeficiency virus structural proteins requires Rx and Rev proteins, respectively. Decreased expression of Gag and Env appears...
Kihara, Y, Sasayama, S, Inoko, M, Morgan, J P
We tested the hypothesis that the intracellular Ca2+ overload of ventricular myocardium during the period of posthypoxic reoxygenation is mediated by transsarcolemmal Ca2+ influx via Na+/Ca2+...
Effects of cocaine on excitation-contraction coupling of aortic smooth muscle from the ferret.
Egashira, K, Morgan, K G, Morgan, J P
The mechanism by which cocaine alters vascular tone is not fully understood. We determined the effects of cocaine on excitation-contraction coupling of isolated ferret aorta. Cocaine in...
Egashira, K, Pipers, F S, Morgan, J P
The purpose of this study was to determine the effects of cocaine on vasoreactivity in the swine model. Eight miniature pigs underwent regional endothelial denudation of the left anterior descending...
Amende, I, Bentivegna, L A, Zeind, A J, Wenzlaff, P, Grossman, W, Morgan, J P
Ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([Ca2+]i). The present study was...
Gwathmey, J K, Slawsky, M T, Hajjar, R J, Briggs, G M, Morgan, J P
Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability to alterations in the strength of contraction produced by...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Hajjar, R J, Gwathmey, J K, Briggs, G M, Morgan, J P
The effects of DPI, a new inotropic agent, were compared in trabeculae carneae from control and myopathic human hearts loaded with aequorin, a bioluminescent calcium indicator that emits light when...
Gwathmey, J K, Slawsky, M T, Briggs, G M, Morgan, J P
Experiments were performed to investigate the mechanism of action of DPI 201-106 on human heart muscle. In both control and myopathic muscles, DPI produced concentration-dependent increases in action...
Perreault, C L, Shannon, R P, Komamura, K, Vatner, S F, Morgan, J P
24 d of rapid ventricular pacing induced dilated cardiomyopathy with both systolic and diastolic dysfunction in conscious, chronically instrumented dogs. We studied mechanical properties and...
Sadoshima, J, Qiu, Z, Morgan, J P, Izumo, S
Hypotonic stress causes rapid cell swelling and initiates various cellular adaptive processes. However, it is unknown how cells initially sense low osmolarity and convert it into intracellular...
Stretch-induced VEGF expression in the heart.
Li, J, Hampton, T, Morgan, J P, Simons, M
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen involved in vascular development and angiogenesis. Recently we have observed increased VEGF expression in the normal...
Chicken phosvitin was prepared from egg yolk by a variety of published methods, including a modification of our own original procedure. Yolk granules and all phosvitin preparations have been...
Re-engineering ventilatory support to decrease days and improve resource utilization.
Kirton, O C, DeHaven, C B, Hudson-Civetta, J, Morgan, J P, Windsor, J, Civetta, J M
OBJECTIVE: The objective of this study was to describe the development of a cost-effective ventilatory strategy using a portable microprocessor-controlled respiratory monitor (Bicore CP-100; Allied...
Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein.
Aequorin was loaded into cells of the ferret portal vein in order to follow intracellular Ca2+ levels during smooth muscle contraction. In response to a single d.c. pulse, the aequorin signal reaches...
Alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret.
Aequorin was used as an indicator of cytoplasmic Ca2+ levels during the action of vasodilators in potassium-depolarized strips of ferret portal vein. Moderate concentrations of isoprenaline produced...
Stover, S M, Pool, R R, Martin, R B, Morgan, J P
The dorsal cortex of the equine third metacarpal mid-diaphyseal bone was characterised during growth by the histological and microradiographic examination of specimens from 30 horses ranging in age...
Xiao, Y F, Kang, J X, Morgan, J P, Leaf, A
Recent evidence indicates that polyunsaturated long-chain fatty acids (PUFAs) prevent lethal ischemia-induced cardiac arrhythmias in animals and probably in humans. To increase understanding of the...
Black, A C, Luo, J, Watanabe, C, Chun, S, Bakker, A, Fraser, J K, ...
Efficient expression of human T-cell leukemia virus (HTLV) and human immunodeficiency virus structural proteins requires Rx and Rev proteins, respectively. Decreased expression of Gag and Env appears...
Kihara, Y, Sasayama, S, Inoko, M, Morgan, J P
We tested the hypothesis that the intracellular Ca2+ overload of ventricular myocardium during the period of posthypoxic reoxygenation is mediated by transsarcolemmal Ca2+ influx via Na+/Ca2+...
Effects of cocaine on excitation-contraction coupling of aortic smooth muscle from the ferret.
Egashira, K, Morgan, K G, Morgan, J P
The mechanism by which cocaine alters vascular tone is not fully understood. We determined the effects of cocaine on excitation-contraction coupling of isolated ferret aorta. Cocaine in...
Egashira, K, Pipers, F S, Morgan, J P
The purpose of this study was to determine the effects of cocaine on vasoreactivity in the swine model. Eight miniature pigs underwent regional endothelial denudation of the left anterior descending...
Amende, I, Bentivegna, L A, Zeind, A J, Wenzlaff, P, Grossman, W, Morgan, J P
Ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([Ca2+]i). The present study was...
Gwathmey, J K, Slawsky, M T, Hajjar, R J, Briggs, G M, Morgan, J P
Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability to alterations in the strength of contraction produced by...
Gwathmey, J K, Warren, S E, Briggs, G M, Copelas, L, Feldman, M D, Phillips, P J, ...
We tested the hypothesis that intracellular Ca++ [( Ca++]i) overload underlies the diastolic dysfunction of patients with hypertrophic cardiomyopathy. Myocardial tissue was obtained at the time of...
Hajjar, R J, Gwathmey, J K, Briggs, G M, Morgan, J P
The effects of DPI, a new inotropic agent, were compared in trabeculae carneae from control and myopathic human hearts loaded with aequorin, a bioluminescent calcium indicator that emits light when...
Gwathmey, J K, Slawsky, M T, Briggs, G M, Morgan, J P
Experiments were performed to investigate the mechanism of action of DPI 201-106 on human heart muscle. In both control and myopathic muscles, DPI produced concentration-dependent increases in action...
Perreault, C L, Shannon, R P, Komamura, K, Vatner, S F, Morgan, J P
24 d of rapid ventricular pacing induced dilated cardiomyopathy with both systolic and diastolic dysfunction in conscious, chronically instrumented dogs. We studied mechanical properties and...
Sadoshima, J, Qiu, Z, Morgan, J P, Izumo, S
Hypotonic stress causes rapid cell swelling and initiates various cellular adaptive processes. However, it is unknown how cells initially sense low osmolarity and convert it into intracellular...
Stretch-induced VEGF expression in the heart.
Li, J, Hampton, T, Morgan, J P, Simons, M
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen involved in vascular development and angiogenesis. Recently we have observed increased VEGF expression in the normal...
Chicken phosvitin was prepared from egg yolk by a variety of published methods, including a modification of our own original procedure. Yolk granules and all phosvitin preparations have been...
Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein.
Aequorin was loaded into cells of the ferret portal vein in order to follow intracellular Ca2+ levels during smooth muscle contraction. In response to a single d.c. pulse, the aequorin signal reaches...
Alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret.
Aequorin was used as an indicator of cytoplasmic Ca2+ levels during the action of vasodilators in potassium-depolarized strips of ferret portal vein. Moderate concentrations of isoprenaline produced...
Re-engineering ventilatory support to decrease days and improve resource utilization.
Kirton, O C, DeHaven, C B, Hudson-Civetta, J, Morgan, J P, Windsor, J, Civetta, J M
OBJECTIVE: The objective of this study was to describe the development of a cost-effective ventilatory strategy using a portable microprocessor-controlled respiratory monitor (Bicore CP-100; Allied...
Stover, S M, Pool, R R, Martin, R B, Morgan, J P
The dorsal cortex of the equine third metacarpal mid-diaphyseal bone was characterised during growth by the histological and microradiographic examination of specimens from 30 horses ranging in age...
L-dopa treatment failure: explanation and correction.
Rivera-Calimlim, L., Dujovne, C. A., Morgan, J. P., Lasagna, L., Bianchine, J. R.
S antigen specific effector T cell activation detected by cytokine flow cytometry
Morgan, J P, Robins, R A, Dua, H S, Tighe, P J
Background/aims: Effector T cell activation is particularly important in the initiation of autoimmune uveitis. This pilot study seeks to demonstrate activation of human peripheral effector T cells in...
Kihara, Y., Gwathmey, J. K., Grossman, W., Morgan, J. P.
1. We used the bioluminescent protein aequorin, which emits light when it combines with Ca2+, to test the hypothesis that the inotropic and lusitropic actions of DPI 201-106 are due to changes in...
Perreault, C. L., Hague, N. L., Loh, E., Hunneyball, I. M., Sim, M. F., Morgan, J. P.
1. In right ventricular papillary muscles from control ferrets, flosequinan (10(-7)-10(-4) M) produced a concentration-dependent positive inotropic effect (10(-5) M = 153 +/- 24, 10(-4) M = 198 +/-...
Miao, L., Núñez, B. D., Susulic, V., Wheeler, S., Carrozza, J. P., Ross, J. N., ...
1. Systemic and coronary haemodynamics were measured in 6 Yorkshire swine and 6 Yucatan miniature swine under isoflurane anaesthesia to investigate the influence of cocaine following its intravenous...
Gwathmey, J. K., Morgan, J. P.
The effects of milrinone and piroximone were compared to those of isoprenaline, dibutyryl adenosine 3':5'-cyclic monophosphate (dibutyryl cyclic AMP), forskolin, isobutylmethylxanthine, increased...
Perreault, C. L., Hague, N. L., Ransil, B. J., Morgan, J. P.
1. When ferret right ventricular papillary muscles were stimulated with threshold punctate pulses (0.33 Hz; 30 degrees C), cocaine, 10(-5) M, increased peak tension development from 815 +/- 120 to...
Cellular mechanism of the positive inotropic effect of hydralazine in mammalian myocardium.
Hurrell, D. G., Perreault, C. L., Miao, L., Ransil, B. J., Morgan, J. P.
1. The purpose of this study was to elucidate the cellular mechanism of the positive inotropic effect of hydralazine, a vasodilator widely used for afterload reduction in patients with heart failure...
1. Isolated cardiac myocytes of the ferret were used to investigate the influence of cocaine and cocaethylene on the intracellular Ca2+ transient indicated by the indo-1 405/480 nm ratio signal, and...
Cocaine alters heart rate dynamics in conscious ferrets.
Stambler, B. S., Morgan, J. P., Mietus, J., Moody, G. B., Goldberger, A. L.
This study was designed to test the hypothesis that cocaine intoxication induces distinctive alterations in sinus rhythm heart rate dynamics. Time-series and spectral analysis techniques were used to...
E-optimal design in irregular BIBD settings
When the necessary conditions for a BIBD are satisfied, but no BIBD exists, there is no simple answer for the optimal design problem. This paper identifies the E-optimal information matrices for any...
Optimal row-column design for three treatments
The A-optimality problem is solved for three treatments in a row-column layout. Depending on the numbers of rows and columns, the requirements for optimality can be decidedly counterintuitive:...