Roiser, J.P., Levy, J., Fromm, S.J., Wang, H., Hasler, G., Sahakian, B.J., ...
The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural...
Ersche, K.D., Roiser, J.P., Robbins, T.W., Sahakian, B.J.
Rationale Chronic drug use has been associated with increased impulsivity and maladaptive behaviour, but the underlying mechanisms of this impairment remain unclear. We investigated the ability to...
Roiser, J.P., Müller , U., Clark, L., Sahakian, B.J.
Polymorphism at the serotonin transporter linked polymorphic region (5-HTTLPR) has been associated with neuroticism, increased risk for affective disorders and greater vulnerability to mood change...
Neuropsychological function in ecstasy users: a study controlling for polydrug use (2007)
Roiser, J.P., Rogers, R.D., Sahakian, B.J.
Rationale A number of studies have compared ecstasy users to control groups on various measures of neuropsychological function in order to determine whether ecstasy use results in lasting cognitive...
Ersche, K.D., Fletcher, P.C., Roiser, J.P., Fryer, T.D., London, M., Robbins, T.W., ...
Objective: Previously, we reported that opiate users enrolled in methadone treatment made ‘risky’ choices on a decision-making task following a loss of points compared with heroin users and...
Roiser, J.P., Rogers, R.D., Cook, L.J., Sahakian, B.J.
Rationale 3, 4-Methylenedioxymethamphetamine (MDMA or “ecstasy”) is a popular drug of abuse known to result in depletions of the serotonin (5-HT) system. A number of studies have reported that...
Roiser, J.P., Blackwell, A.D., Cools, R., Clark, L., Rubinsztein, D.C., Robbins, T.W., ...
The serotonin (5-HT) system is implicated in incentive motivational processes. The present study utilized the acute tryptophan depletion (ATD) procedure to investigate the effect of temporarily...
Clark, L., Roiser, J.P., Cools, R., Rubinsztein, D.C., Sahakian, B.J., Robbins, T.W.
Rationale: Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear....
Ersche, K.D., Roiser, J.P., Clark, L., London, M., Robbins, T.W., Sahakian, B.J.
Reinforcing properties of psychoactive substances are considered to be critically involved in the development and maintenance of substance dependence. While accumulating evidence suggests that the...
Roiser, J.P., Cook, L.J., Cooper, J.D., Rubinsztein, D.C., Sahakian, B.J.
Objective: The long-term effects of the use of 3,4-methylenedioxymethamphetamine (MDMA, or Ecstasy) in humans are controversial and unclear. The authors’ goal was to assess the contribution of a...
Roiser, J.P., McLean, A., Ogilvie, A.D., Blackwell, A.D., Bamber, D.J., Goodyer, I., ...
Although there is evidence for the involvement of dopamine (DA) in unipolar depression, no published study has yet used the technique of acute phenylalanine and tyrosine depletion (APTD), a dietary...
Relationship between ecstasy use and depression: a study controlling for poly-drug use (2004)
Rationale 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous...