Functional role of type I and type II interferons in antiviral defense (2007)
Muller, U., Steinhoff, U., Reis, L. F., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., ...
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase (2007)
Yang, Y. L., Reis, L. F., Pavlovic, J., Aguzzi, A., Schafer, R., Kumar, A., ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Moelling, K, Pavlovic, J, Elzaouk, L, Heinzerling, L
No abstract available.
Hefti, H P, Frese, M, Landis, H, Di Paolo, C, Aguzzi, A, Haller, O, ...
The human MxA protein is part of the antiviral state induced by alpha/beta interferon (IFN-alpha/beta). MxA inhibits the multiplication of several RNA viruses in cell culture. However, its antiviral...
Measles virus spread and pathogenesis in genetically modified mice. (1998)
Mrkic, B, Pavlovic, J, Rülicke, T, Volpe, P, Buchholz, C J, Hourcade, D, ...
Attenuated Edmonston measles virus (MV-Edm) is not pathogenic in standard mice. We show here that MV-Edm inoculated via the natural respiratory route has a limited propagation in the lungs of mice...
Cathomen, T, Mrkic, B, Spehner, D, Drillien, R, Naef, R, Pavlovic, J, ...
Measles viruses (MV) can be isolated from the brains of deceased subacute sclerosing panencephalitis patients only in a cell-associated form. These viruses are often defective in the matrix (M)...
Enhanced virus resistance of transgenic mice expressing the human MxA protein.
Pavlovic, J, Arzet, H A, Hefti, H P, Frese, M, Rost, D, Ernst, B, ...
MxA is a GTPase that accumulates to high levels in the cytoplasm of interferon-treated human cells. Expression of MxA cDNA confers to transfected cell lines a high degree of resistance against...
Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells.
Schneider-Schaulies, S, Schneider-Schaulies, J, Schuster, A, Bayer, M, Pavlovic, J, Ter Meulen, V
Measles virus (MV)-specific transcription in human brain cells is characterized by particularly low abundances of the distal mRNAs encoding the MV envelope proteins. Similar transcriptional...
Schnorr, J J, Schneider-Schaulies, S, Simon-Jödicke, A, Pavlovic, J, Horisberger, M A, Ter Meulen, V
The alpha/beta (type I) interferon-inducible human MxA protein confers resistance to vesicular stomatitis virus (VSV) and influenza A virus in MxA-transfected mouse 3T3 cells (3T3/MxA). We...
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
Pitossi, F, Blank, A, Schröder, A, Schwarz, A, Hüssi, P, Schwemmle, M, ...
Mx proteins are interferon-induced GTPases that inhibit the multiplication of certain negative-stranded RNA viruses. However, it has been unclear whether GTPase activity is necessary for antiviral...
Huang, T, Pavlovic, J, Staeheli, P, Krystal, M
The murine Mx1 protein is an interferon-inducible protein which confers selective resistance to influenza virus infection both in vitro and in vivo. The precise mechanism by which the murine Mx1...
Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus.
Zürcher, T, Pavlovic, J, Staeheli, P
The interferon-induced Mx1 protein of mice confers selective resistance to influenza virus. It inhibits viral mRNA synthesis in the nucleus of influenza virus-infected cells. The related human MxA...
Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein.
The interferon-induced human MxA protein inhibits the multiplication of influenza virus and vesicular stomatitis virus (VSV) by an unknown mechanism. Here we show that MxA protein interferes with VSV...
Pavlovic, J, Zürcher, T, Haller, O, Staeheli, P
MxA and MxB are interferon-induced proteins of human cells and are related to the murine protein Mx1, which confers selective resistance to influenza virus. In contrast to the nuclear murine protein...
Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle.
Pavlovic, J, Haller, O, Staeheli, P
Human MxA and mouse Mx1 are interferon-induced proteins capable of inhibiting the multiplication of influenza virus. MxA protein is localized in the cytoplasm, whereas Mx1 protein accumulates in the...
Pavlovic, J, Banz, E, Parish, R W
The cysteine proteinase I gene of Dictyostelium discoideum is a developmentally regulated single copy gene. Specific sites in the 5' and the 3' flanking regions of the gene were cleaved by an...
The effects of transcription on the nucleosome structure of four Dictyostelium genes.
Pavlovic, J, Banz, E, Parish, R W
Micrococcal nuclease digestion of Dictyostelium discoideum nuclei from various developmental stages was used to investigate transcription-related changes in the chromatin structure of the coding...
Pavlovic, J, Haribabu, B, Dottin, R P
The signal transduction pathways that lead to gene induction are being intensively investigated in Dictyostelium discoideum. We have identified by deletion and transformation analysis a sequence...
cDNA structures and regulation of two interferon-induced human Mx proteins.
Aebi, M, Fäh, J, Hurt, N, Samuel, C E, Thomis, D, Bazzigher, L, ...
Human cells treated with interferon synthesize two proteins that exhibit high homology to murine Mx1 protein, which has previously been identified as the mediator of interferon-induced cellular...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yang, Y L, Reis, L F, Pavlovic, J, Aguzzi, A, Schäfer, R, Kumar, A, ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Mechanism of human MxA protein action: variants with changed antiviral properties.
Zürcher, T, Pavlovic, J, Staeheli, P
Cells respond to treatment with interferons by synthesizing several induced proteins, including one or more structurally related proteins collectively called Mx. Nuclear and cytoplasmic forms of Mx...
Cathomen, T, Mrkic, B, Spehner, D, Drillien, R, Naef, R, Pavlovic, J, ...
Measles viruses (MV) can be isolated from the brains of deceased subacute sclerosing panencephalitis patients only in a cell-associated form. These viruses are often defective in the matrix (M)...
Enhanced virus resistance of transgenic mice expressing the human MxA protein.
Pavlovic, J, Arzet, H A, Hefti, H P, Frese, M, Rost, D, Ernst, B, ...
MxA is a GTPase that accumulates to high levels in the cytoplasm of interferon-treated human cells. Expression of MxA cDNA confers to transfected cell lines a high degree of resistance against...
Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells.
Schneider-Schaulies, S, Schneider-Schaulies, J, Schuster, A, Bayer, M, Pavlovic, J, Ter Meulen, V
Measles virus (MV)-specific transcription in human brain cells is characterized by particularly low abundances of the distal mRNAs encoding the MV envelope proteins. Similar transcriptional...
Schnorr, J J, Schneider-Schaulies, S, Simon-Jödicke, A, Pavlovic, J, Horisberger, M A, Ter Meulen, V
The alpha/beta (type I) interferon-inducible human MxA protein confers resistance to vesicular stomatitis virus (VSV) and influenza A virus in MxA-transfected mouse 3T3 cells (3T3/MxA). We...
A functional GTP-binding motif is necessary for antiviral activity of Mx proteins.
Pitossi, F, Blank, A, Schröder, A, Schwarz, A, Hüssi, P, Schwemmle, M, ...
Mx proteins are interferon-induced GTPases that inhibit the multiplication of certain negative-stranded RNA viruses. However, it has been unclear whether GTPase activity is necessary for antiviral...
Huang, T, Pavlovic, J, Staeheli, P, Krystal, M
The murine Mx1 protein is an interferon-inducible protein which confers selective resistance to influenza virus infection both in vitro and in vivo. The precise mechanism by which the murine Mx1...
Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus.
Zürcher, T, Pavlovic, J, Staeheli, P
The interferon-induced Mx1 protein of mice confers selective resistance to influenza virus. It inhibits viral mRNA synthesis in the nucleus of influenza virus-infected cells. The related human MxA...
Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein.
The interferon-induced human MxA protein inhibits the multiplication of influenza virus and vesicular stomatitis virus (VSV) by an unknown mechanism. Here we show that MxA protein interferes with VSV...
Pavlovic, J, Zürcher, T, Haller, O, Staeheli, P
MxA and MxB are interferon-induced proteins of human cells and are related to the murine protein Mx1, which confers selective resistance to influenza virus. In contrast to the nuclear murine protein...
Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle.
Pavlovic, J, Haller, O, Staeheli, P
Human MxA and mouse Mx1 are interferon-induced proteins capable of inhibiting the multiplication of influenza virus. MxA protein is localized in the cytoplasm, whereas Mx1 protein accumulates in the...
Pavlovic, J, Banz, E, Parish, R W
The cysteine proteinase I gene of Dictyostelium discoideum is a developmentally regulated single copy gene. Specific sites in the 5' and the 3' flanking regions of the gene were cleaved by an...
The effects of transcription on the nucleosome structure of four Dictyostelium genes.
Pavlovic, J, Banz, E, Parish, R W
Micrococcal nuclease digestion of Dictyostelium discoideum nuclei from various developmental stages was used to investigate transcription-related changes in the chromatin structure of the coding...
Pavlovic, J, Haribabu, B, Dottin, R P
The signal transduction pathways that lead to gene induction are being intensively investigated in Dictyostelium discoideum. We have identified by deletion and transformation analysis a sequence...
cDNA structures and regulation of two interferon-induced human Mx proteins.
Aebi, M, Fäh, J, Hurt, N, Samuel, C E, Thomis, D, Bazzigher, L, ...
Human cells treated with interferon synthesize two proteins that exhibit high homology to murine Mx1 protein, which has previously been identified as the mediator of interferon-induced cellular...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yang, Y L, Reis, L F, Pavlovic, J, Aguzzi, A, Schäfer, R, Kumar, A, ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Mechanism of human MxA protein action: variants with changed antiviral properties.
Zürcher, T, Pavlovic, J, Staeheli, P
Cells respond to treatment with interferons by synthesizing several induced proteins, including one or more structurally related proteins collectively called Mx. Nuclear and cytoplasmic forms of Mx...
Cathomen, T, Mrkic, B, Spehner, D, Drillien, R, Naef, R, Pavlovic, J, ...
Measles viruses (MV) can be isolated from the brains of deceased subacute sclerosing panencephalitis patients only in a cell-associated form. These viruses are often defective in the matrix (M)...