Tarpey, Patrick, Raymond, F Lucy, O'Meara, Sarah, Edkins, Sarah, Teague, Jon, Butler, A., ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Tarpey, Patrick, Raymond, F Lucy, O'Meara, Sarah, Edkins, Sarah, Teague, Jon, Butler, A., ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Raymond, F. Lucy, Tarpey, Patrick, Edkins, Sarah, Tofts, C., O'Meara, Sarah, Teague, Jon, ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Tarpey, Patrick, Raymond, F Lucy, Nguyen, Lam S., Rodriguez, Jayson, Hackett, Anna, Vandeleur, Lucianne, ...
Patrick S Tarpey, F Lucy Raymond, Lam S Nguyen, Jayson Rodriguez, Anna Hackett, Lucianne Vandeleur, Raffaella Smith, Cheryl Shoubridge, Sarah Edkins, Claire Stevens, Sarah O'Meara, Calli Tofts, Syd...
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly (2007)
Field, Michael, Tarpey, Patrick, Smith, Raffaella, Edkins, Sarah, O'Meara, Sarah, Stevens, Claire, ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Raymond, F. Lucy, Tarpey, Patrick, Edkins, Sarah, Tofts, C., O'Meara, Sarah, Teague, Jon, ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Tarpey, Patrick, Raymond, F Lucy, Nguyen, Lam S., Rodriguez, Jayson, Hackett, Anna, Vandeleur, Lucianne, ...
Patrick S Tarpey, F Lucy Raymond, Lam S Nguyen, Jayson Rodriguez, Anna Hackett, Lucianne Vandeleur, Raffaella Smith, Cheryl Shoubridge, Sarah Edkins, Claire Stevens, Sarah O'Meara, Calli Tofts, Syd...
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly (2007)
Field, Michael, Tarpey, Patrick, Smith, Raffaella, Edkins, Sarah, O'Meara, Sarah, Stevens, Claire, ...
Copyright © 2007 The American Society of Human Genetics. All rights reserved.
Patterns of somatic mutation in human cancer genomes (2007)
Greenman, C, Stephens, P, Smith, R, Dalgliesh, GL, Hunter, C, Bignell, G, ...
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for...
Global Maps of foF2 Derived from Observations and Theoretical Values (2006)
Anderson, D. N., Rush, C. M., Pokempner, M., Perry, J., Stewart, F. G.
Observations of the F2-region critical frequency, foF2, and values determined from the time-dependent continuity equation for ions and electrons in the ionosphere have been used to develop a new set...
Major depressive disorder: Genetic association analyses using subphenotypes (2006)
Prokopenko, I., Tozzi, F., Vicentini, E., Vanzo, A., Brewster, S., Perry, J., ...
Charman, T., Neilson, T.C.S., Mash, V., Archer, H., Gardiner, M.T., Knudsen, G.P.S., ...
We aimed to improve the understanding of genotype–phenotype correlations in Rett syndrome (RS) by adopting a novel approach to categorising phenotypic dimensions – separating typicality of...
QCDgrid: A grid resource for quantum chromodynamics (2005)
Perry, J., Smith, L., Jackson, A.N., Kenway, R.D., Joo, B., Maynard, C.M., ...
Quantum Chromodynamics (QCD) is an application area that requires access to large supercomputing resources and generates large amounts of raw data. The UK's national lattice QCD collaboration UKQCD...
Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., ...
We examined the coding sequence of 518 protein kinases, 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with...
Cassini Imaging Science: Initial Results on Saturn's Rings and Small Satellites (2005)
Porco, C.C., Baker, E., Barbara, J., Beurle, K., Brahic, A., Burns, J.A., ...
Images acquired of Saturn's rings and small moons by the Cassini Imaging Science Subsystem (ISS) during the first 9 months of Cassini operations at Saturn have produced many new findings. These...
Cassini Imaging Science: Initial Results on Phoebe and Iapetus (2005)
Porco, C.C., Baker, E., Barbara, J., Beurle, K., Brahic, A., Burns, J.A., ...
The Cassini Imaging Science Subsystem acquired high-resolution imaging data on the outer Saturnian moon, Phoebe, during Cassini's close flyby on 11 June 2004 and Iapetus during a flyby on 31 december...
Cassini Imaging Science: Initial Results on Saturn's Atmosphere (2005)
Porco, C.C., Baker, E., Barbara, J., Beurle, K., Brahic, A., Burns, J.A., ...
The Cassini Imaging Science Subsystem (ISS) began observing Saturn in early February 2004. From analysis of cloud motions through October 2004, we report vertical wind shear in Saturn's equatorial...
Imaging of Titan from the Cassini spacecraft (2005)
Porco, C., Baker, E., Barbara, J., Beurle, K., Brahic, A., Burns, J.A., ...
Titan, the largest moon of Saturn, is the only satellite in the Solar System with a substantial atmosphere. The atmosphere is poorly understood and obscures the surface, leading to intense...
Cassini-ISS observations of medium-sized Saturnian satellites (2005)
Denk, T., Neukum, G., Helfenstein, P., Thomas, P.C., Veverka, J., Giese, B., ...
Geological Features and Terrains on Enceladus as seen by Cassini ISS (2005)
Helfenstein, P., Thomas, P., Veverka, J., Squyres, S., Rathbun, J., Denk, T., ...
Stephens, P, Edkins, S, Davies, H, Greenman, C, Cox, C, Hunter, C, ...
We examined the coding sequence of 518 protein kinases, similar to 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic...
Somatic mutations of the protein kinase gene family in human lung cancer (2005)
Davies, H, Hunter, C, Smith, R, Stephens, P, Greenman, C, Bignell, G, ...
Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We screened the coding sequences of 518 protein kinases...
Hyperpolarizabilities of Push-Pull Polyenes: Experimental Results and a New Two-State Model (2004)
Perry, J., Bourhill, G., Marder, S., Lu, D., Chen, G., Goddard, W.
Recent work has demonstrated a correlation between the geometry (i.e., the bond length alteration, BLA) and the first and second hyperpolarizabilities (betta and gamma) of donor-acceptor substituted...
Skindhoj, J., Bourhill, G., Gilmour, S., Tiemann, B., Mansour, K., Perry, K., ...
the electro-optic r33, coefficients of poled poly(methylmethacrylate) films containing dyes with first hyperpolarizabilities that span nearly two orders of magnitude have been determined at 820 and...
Lung cancer: Intragenic ERBB2 kinase mutations in tumours (2004)
Stephens, P., Hunter, C., Bignell, G., Edkins, S., Davies, H., Teague, J., ...
The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour...
Anderson, G, Barton, S, Blake, P, Blewett, K, Bloomer, M, Colley, H, ...
Research in practice: Experiences, insights and interventions from the project Transforming Learning Cultures in Further Education, David James, University of the West of England, Bristol Executive...
Revisiting the effects of blade geometry on rotor behaviour in descending flight (2004)
Newman, S., Brown, R., Perry, J., Khelifa, M., Modha, A., Arlin, G.
A set of simple, testable hypotheses for the behaviour of the rotor flow in axial flight is derived from a fusion of experimental, numerical and theoretical ideas. Although it is unlikely that all of...
J. Strassner, Intelliden Corporation, M. Scherling, B. Quinn, S. Herzog, A. Huynh, ...
This document is a glossary of policy-related terms. It provides abbreviations, explanations, and recommendations for use of these terms. The document takes the approach and format of RFC 2828, which...
Structural variation of the pseudoautosomal region between and within inbred mouse strains.
Kipling, D, Wilson, H E, Thomson, E J, Lee, M, Perry, J, Palmer, S, ...
The pseudoautosomal region (PAR) is a segment of shared homology between the sex chromosomes. Here we report additional probes for this region of the mouse genome. Genetic and fluorescence in situ...
Caroff, M, Chaby, R, Karibian, D, Perry, J, Deprun, C, Szabó, L
Structural and immunological differences between the two components that are usually present in unequal quantities in Bordetella pertussis endotoxin preparations and are visualized by sodium dodecyl...
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Nitrous oxide, by inactivating cobalamin in vivo, produces a suitable animal model for cobalamin 'deficiency.' The synthesis of folate polyglutamate with tetrahydrofolate as substrate is severely...
Deacon, R, Chanarin, I, Lumb, M, Perry, J
The activity of the two folate dependent enzymes supplying carbon 2 and carbon 8 of the purine nucleus was assayed in the bone marrow of rats and man, as well as in rat livers. The activity of both...
Methylation of DNA in megaloblastic anaemia.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Methylation of cytosine residues in DNA samples, collected before and serially after cobalamin treatment from patients with cobalamin deficiency, was studied using restriction endonucleases Hpa II...
Regulation of 5-methyltetrahydrofolate synthesis.
Lumb, M, Bottiglieri, T, Deacon, R, Perry, J, Chanarin, I
After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the...
Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.
Lumb, M, Deacon, R, Perry, J, Chanarin, I
Rats were exposed to nitrous oxide, which inactivates cob(I)alamin (Cbl). As in air-breathing rats methionine administration led to the conversion of hepatic 5-methyltetrahydrofolate (MeH4 folate)...
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
Lumb, M, Chanarin, I, Deacon, R, Perry, J
Methionine given parenterally to rats caused rapid disappearance of methyltetrahydrofolate from the liver and a corresponding rise in tetrahydrofolate and formyl-tetrahydrofolate concentrations. When...
Deacon, R, Perry, J, Lumb, M, Chanarin, I
N2O oxidizes and inactivates cob[I]alamin, and animals exposed in this way serve as models for cobalamin 'deficiency'. Such animals show a fall in activity of glycinamide ribotide transformylase and...
Folate polyglutamate synthetase activity in the cobalamin-inactivated rat.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Exposure to N2O inactivates cob[I]alamin and interferes with the activity of methionine synthetase, of which cob[I]alamin is a coenzyme. Less directly, it stops the formation of folate polyglutamate...
Lumb, M, Deacon, R, Perry, J, Chanarin, I, Minty, B, Halsey, M J, ...
Rats exposed to N20 show a decrease in liver folate to about 25% of the initial value after 10 days. There is a transient increase in the amount of 5-methylterrahydropteroylpolyglutamate in the first...
Use of medicines in general practice.
The prescriptions issued by general practitioners to a population of about 40 000 people were studied. During one year 53-8% of all males and 65-7% of all females had at least one drug dispensed. The...
Structural variation of the pseudoautosomal region between and within inbred mouse strains.
Kipling, D, Wilson, H E, Thomson, E J, Lee, M, Perry, J, Palmer, S, ...
The pseudoautosomal region (PAR) is a segment of shared homology between the sex chromosomes. Here we report additional probes for this region of the mouse genome. Genetic and fluorescence in situ...
Caroff, M, Chaby, R, Karibian, D, Perry, J, Deprun, C, Szabó, L
Structural and immunological differences between the two components that are usually present in unequal quantities in Bordetella pertussis endotoxin preparations and are visualized by sodium dodecyl...
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Nitrous oxide, by inactivating cobalamin in vivo, produces a suitable animal model for cobalamin 'deficiency.' The synthesis of folate polyglutamate with tetrahydrofolate as substrate is severely...
Deacon, R, Chanarin, I, Lumb, M, Perry, J
The activity of the two folate dependent enzymes supplying carbon 2 and carbon 8 of the purine nucleus was assayed in the bone marrow of rats and man, as well as in rat livers. The activity of both...
Methylation of DNA in megaloblastic anaemia.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Methylation of cytosine residues in DNA samples, collected before and serially after cobalamin treatment from patients with cobalamin deficiency, was studied using restriction endonucleases Hpa II...
Regulation of 5-methyltetrahydrofolate synthesis.
Lumb, M, Bottiglieri, T, Deacon, R, Perry, J, Chanarin, I
After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the...
Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.
Lumb, M, Deacon, R, Perry, J, Chanarin, I
Rats were exposed to nitrous oxide, which inactivates cob(I)alamin (Cbl). As in air-breathing rats methionine administration led to the conversion of hepatic 5-methyltetrahydrofolate (MeH4 folate)...
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
Lumb, M, Chanarin, I, Deacon, R, Perry, J
Methionine given parenterally to rats caused rapid disappearance of methyltetrahydrofolate from the liver and a corresponding rise in tetrahydrofolate and formyl-tetrahydrofolate concentrations. When...
Deacon, R, Perry, J, Lumb, M, Chanarin, I
N2O oxidizes and inactivates cob[I]alamin, and animals exposed in this way serve as models for cobalamin 'deficiency'. Such animals show a fall in activity of glycinamide ribotide transformylase and...
Folate polyglutamate synthetase activity in the cobalamin-inactivated rat.
Perry, J, Chanarin, I, Deacon, R, Lumb, M
Exposure to N2O inactivates cob[I]alamin and interferes with the activity of methionine synthetase, of which cob[I]alamin is a coenzyme. Less directly, it stops the formation of folate polyglutamate...
Lumb, M, Deacon, R, Perry, J, Chanarin, I, Minty, B, Halsey, M J, ...
Rats exposed to N20 show a decrease in liver folate to about 25% of the initial value after 10 days. There is a transient increase in the amount of 5-methylterrahydropteroylpolyglutamate in the first...