J. Q. Cheng

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Cheng, J Q, Ruggeri, B, Klein, W M, Sonoda, G, Altomare, D A, Watson, D K, ...

We previously demonstrated that the putative oncogene AKT2 is amplified and overexpressed in some human ovarian carcinomas. We have now identified amplification of AKT2 in approximately 10% of...

High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.

Bianchi, A B, Mitsunaga, S I, Cheng, J Q, Klein, W M, Jhanwar, S C, Seizinger, B, ...

Malignant mesotheliomas (MMs) are aggressive tumors that develop most frequently in the pleura of patients exposed to asbestos. In contrast to many other cancers, relatively few molecular alterations...

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

Cheng, J Q, Godwin, A K, Bellacosa, A, Taguchi, T, Franke, T F, Hamilton, T C, ...

We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to...

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Cheng, J Q, Ruggeri, B, Klein, W M, Sonoda, G, Altomare, D A, Watson, D K, ...

We previously demonstrated that the putative oncogene AKT2 is amplified and overexpressed in some human ovarian carcinomas. We have now identified amplification of AKT2 in approximately 10% of...

High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas.

Bianchi, A B, Mitsunaga, S I, Cheng, J Q, Klein, W M, Jhanwar, S C, Seizinger, B, ...

Malignant mesotheliomas (MMs) are aggressive tumors that develop most frequently in the pleura of patients exposed to asbestos. In contrast to many other cancers, relatively few molecular alterations...

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

Cheng, J Q, Godwin, A K, Bellacosa, A, Taguchi, T, Franke, T F, Hamilton, T C, ...

We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to...