J. R. Goldenring

Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.

Canfield, V, West, A B, Goldenring, J R, Levenson, R

The gastric mucosa of mammalian stomach contains several differentiated cell types specialized for the secretion of acid, digestive enzymes, mucus, and hormones. Understanding whether each of these...

Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations.

Vallano, M L, Goldenring, J R, Buckholz, T M, Larson, R E, DeLorenzo, R J

Both cAMP- and calmodulin-dependent kinases are proposed regulators of microtubule function by means of their ability to phosphorylate microtubule-associated protein 2(MAP 2). A cAMP-dependent...

Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells.

Tang, L H, Stoch, S A, Modlin, I M, Goldenring, J R

Rab proteins, which are ras-like low-molecular-mass GTP-binding proteins, are postulated to act as specific regulators of membrane trafficking in exocytosis and endocytosis. Previously, we reported a...

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein.

Dransfield, D T, Bradford, A J, Smith, J, Martin, M, Roy, C, Mangeat, P H, ...

cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was...

Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gastric parietal cells.

Dransfield, D T, Yeh, J L, Bradford, A J, Goldenring, J R

The type-II cAMP-dependent protein kinase (A-Kinase) partitions primarily into the particulate fraction in gastric parietal cells. Localization of this kinase to particular subcellular domains is...

Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles.

Calhoun, B C, Goldenring, J R

The tubulovesicles of gastric parietal cells sequester H+/K+-ATPase molecules within resting parietal cells. Stimulation of parietal cell secretion elicits delivery of intracellular H+/K+-ATPase to...

Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent protein kinase II.

Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E

Iontophoretic injection of Ca2+ causes reduction of I0A (an early rapidly activating and inactivating K+ current) and I0C (a late Ca2+-dependent K+ current) measured across the isolated type B soma...

Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation.

Basson, M D, Goldenring, J R, Tang, L H, Lewis, J J, Padfield, P, Jamieson, J D, ...

Small GTP-binding proteins are important regulators of intracellular traffic. The presence of several small GTP-binding proteins was documented in subfractions of rabbit parietal cells. Upon maximal...

Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.

Canfield, V, West, A B, Goldenring, J R, Levenson, R

The gastric mucosa of mammalian stomach contains several differentiated cell types specialized for the secretion of acid, digestive enzymes, mucus, and hormones. Understanding whether each of these...

Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations.

Vallano, M L, Goldenring, J R, Buckholz, T M, Larson, R E, DeLorenzo, R J

Both cAMP- and calmodulin-dependent kinases are proposed regulators of microtubule function by means of their ability to phosphorylate microtubule-associated protein 2(MAP 2). A cAMP-dependent...

Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells.

Tang, L H, Stoch, S A, Modlin, I M, Goldenring, J R

Rab proteins, which are ras-like low-molecular-mass GTP-binding proteins, are postulated to act as specific regulators of membrane trafficking in exocytosis and endocytosis. Previously, we reported a...

Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation.

Basson, M D, Goldenring, J R, Tang, L H, Lewis, J J, Padfield, P, Jamieson, J D, ...

Small GTP-binding proteins are important regulators of intracellular traffic. The presence of several small GTP-binding proteins was documented in subfractions of rabbit parietal cells. Upon maximal...

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein.

Dransfield, D T, Bradford, A J, Smith, J, Martin, M, Roy, C, Mangeat, P H, ...

cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was...

Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gastric parietal cells.

Dransfield, D T, Yeh, J L, Bradford, A J, Goldenring, J R

The type-II cAMP-dependent protein kinase (A-Kinase) partitions primarily into the particulate fraction in gastric parietal cells. Localization of this kinase to particular subcellular domains is...

Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles.

Calhoun, B C, Goldenring, J R

The tubulovesicles of gastric parietal cells sequester H+/K+-ATPase molecules within resting parietal cells. Stimulation of parietal cell secretion elicits delivery of intracellular H+/K+-ATPase to...

Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent protein kinase II.

Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E

Iontophoretic injection of Ca2+ causes reduction of I0A (an early rapidly activating and inactivating K+ current) and I0C (a late Ca2+-dependent K+ current) measured across the isolated type B soma...