Furst, Daniel E, Breedveld, F C, Kalden, J R, Smolen, J S, Burmester, G R, Bijlsma, JWJ, ...
As in previous years, the consensus group to consider the use of biological agents was constituted by rheumatologists from the Universities of Erlangen, Leiden, and Vienna in Europe in cooperation...
Stadick, H., Stockmeyer, B., Kuhn, R., Schrott, K.M., Kalden, J.R., Glennie, M.J., ...
Purpose: monoclonal antibodies are a novel treatment option for certain tumor patients. We evaluated the potential of antibody derivatives against epidermal growth factor receptor and G250, which are...
Swaak, A.J., Moutsopoulos, H.M., Dratwianka, B., Kalden, J.R., Tosi, S., Marchesoni, A., ...
OBJECTIVE: Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus (SLE). The aim...
Swaak, A.J., Rozman, B., Chwalinska-Sadowska, H, Bombardieri, S., Kovacs, A., Schneider, M., ...
OBJECTIVE: Most information available about the disease course of patients with systemic lupus erythematosus (SLE) is restricted to the first 5 yr after disease onset. Data about the disease course...
Range of antinuclear antibodies in "healthy" individuals (1997)
Tan, E.M., Feltkamp, T.E.W., Smolen, J.S., Dawkins, R., Fritzler, M.J., Gordon, T., ...
Strohscheer, I., Kleinert, R., Westphal, C., Schüller, J., Werner, K., Anders, O., ...
Peer Reviewed
Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.
Hahn, G, Stuhlmüller, B, Hain, N, Kalden, J R, Pfizenmaier, K, Burmester, G R
One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-macrophage system. In the present investigation, the modulation of blood monocyte activation was studied...
A rapid and simple method for the isolation of apoptotic DNA fragments.
Herrmann, M, Lorenz, H M, Voll, R, Grünke, M, Woith, W, Kalden, J R
Differential expression of Ia antigens by rheumatoid synovial lining cells.
Burmester, G R, Jahn, B, Rohwer, P, Zacher, J, Winchester, R J, Kalden, J R
The differential expression of Ia antigens was studied in freshly isolated rheumatoid nonlymphoid synovial lining cells (SLC) and rheumatoid synovial fibroblast cell lines cultured in the presence of...
Hartung, K, Baur, M P, Coldewey, R, Fricke, M, Kalden, J R, Lakomek, H J, ...
In a multicenter study more than 300 central European systemic lupus erythematosus (SLE) patients were examined for HLA-B, HLA-DR, and complement C4 phenotypes. For 174 SLE patients MHC haplotypes...
Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.
Hahn, G, Stuhlmüller, B, Hain, N, Kalden, J R, Pfizenmaier, K, Burmester, G R
One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-macrophage system. In the present investigation, the modulation of blood monocyte activation was studied...
A rapid and simple method for the isolation of apoptotic DNA fragments.
Herrmann, M, Lorenz, H M, Voll, R, Grünke, M, Woith, W, Kalden, J R
Differential expression of Ia antigens by rheumatoid synovial lining cells.
Burmester, G R, Jahn, B, Rohwer, P, Zacher, J, Winchester, R J, Kalden, J R
The differential expression of Ia antigens was studied in freshly isolated rheumatoid nonlymphoid synovial lining cells (SLC) and rheumatoid synovial fibroblast cell lines cultured in the presence of...
Hartung, K, Baur, M P, Coldewey, R, Fricke, M, Kalden, J R, Lakomek, H J, ...
In a multicenter study more than 300 central European systemic lupus erythematosus (SLE) patients were examined for HLA-B, HLA-DR, and complement C4 phenotypes. For 174 SLE patients MHC haplotypes...
The effect of hypophysectomy on the immune response
Kalden, J. R., Evans, Margaret M., Irvine, W. J.
Twenty-one-day-old rats were hypophysectomized or sham-operated and challenged with sheep red blood cells 5 or 21 days after operation. Although the sizes of the bodies and lymphoid organs were...
Anti-lymphocytic IgG given immediately after the injection of thyroglobulin in Freund's complete adjuvant suppressed the development of cellular and humoral immune reactions to thyroglobulin in rats...
Factors associated with coronary artery calcification in young female patients with SLE
Manger, K, Kusus, M, Forster, C, Ropers, D, Daniel, W G, Kalden, J R, ...
Retroviruses and autoimmune rheumatic diseases.
In autoimmune rheumatic diseases, retroviruses have been repeatedly discussed as important etiologic factors. However, despite a considerable amount of indirect evidence that retroviruses might...
Rubbert, A, Bock, E, Schwab, J, Marienhagen, J, Nüsslein, H, Wolf, F, ...
Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been...
IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus.
Winkler, T H, Jahn, S, Kalden, J R
We describe the production of six mouse-human heterohybridomas secreting human IgG anti-dsDNA antibodies derived from patients with systemic lupus erythematosus (SLE). Peripheral blood cells used for...
Doldi, K, Manger, B, Koch, B, Riemann, J, Hermanek, P, Kalden, J R
Fifteen patients with colorectal tumours, 15 patients with Crohn's disease (CD) and two groups of normal controls were investigated for the presence of spontaneous suppressor cell activity (SSCA) in...
Peter, H H, Kalden, J R, Seeland, P, Diehl, V, Eckert, G
Based on 51Cr release from an allogeneic human melanoma cell (M1) cell-mediated (CMC) and antibody-dependent cellular cytotoxicity (ADCC) were determined in twenty-eight melanoma patients, thirty-one...
Siewertsen, H C, Peter, H H, Kalden, J R, Wysk, J, Eckert, G, Oehl, S, ...
The influence of continuous-flow blood separator leucophoresis on these in vitro functions of human lymphocytes was studied. In ten separation experiments, lymphocyte functions were examined in the...
Constant isotype pattern of anti-dsDNA antibodies in patients with systemic lupus erythematosus.
Winkler, T H, Henschel, T A, Kalies, I, Baenkler, H W, Skvaril, F, Kalden, J R
The isotype profile, particularly emphasizing IgG subclass distribution, of dsDNA antibodies in patients with systemic lupus erythematosus was evaluated using an especially adapted ELISA technique....
Antibody binding of macromolecular DNA and RNA in the plasma of SLE patients.
Krapf, F, Herrmann, M, Leitmann, W, Kalden, J R
Plasmapheresis fluids from 20 patients with clinically active SLE, from three patients with Waldenstrom's disease, from three patients with rheumatoid arthritis, two patients with myasthenia gravis...
Kalden, J. R., Williamson, W. G., Irvine, W. J.
Experimental thymitis and a partial neuromuscular block was produced in guinea-pigs by immunization with the subcellular fractions of calf thymus and skeletal muscle homogenates. A significant...
Harrer, T, Wolf, B, Näger, W, Schwarz, W, Bergner, D, Kalden, J R
Zinc is a mitogen for peripheral blood mononuclear cells (PBMC). The optimal mitogenic concentration was found to be 0.05 mmol/l (327 micrograms/dl), four times higher than physiological serum...
Nüsslein, H G, Träg, T, Winter, M, Dietz, A, Kalden, J R
The role of T cells for IL-4-induced IgE synthesis by peripheral blood mononuclear cells (PBMC) was investigated. The removal of monocytes from PBMC abolished IL-4-induced IgE synthesis. When PBMC...
Horneff, G, Sack, U, Kalden, J R, Emmrich, F, Burmester, G R
Anti-CD4 MoAbs have been successfully used in initial treatment trials of rheumatoid arthritis. One remarkable feature of this therapy was the early reduction of synovitis along with a decrease of...
A soluble form of the human transferrin receptor is released by activated lymphocytes in vitro.
Woith, W, Nüsslein, I, Antoni, C, Dejica, D I, Winkler, T H, Herrmann, M, ...
Soluble transferrin receptors (sTfR) were detected in culture supernatants of activated human peripheral blood mononuclear cells (PBMC) using a sandwich ELISA technique with two non-cross-reacting...
Studies on experimental autoimmune thymitis in guinea-pigs
Kalden, J. R., Williamson, W. G., Johnston, R. J., Irvine, W. J.
Normal and thymectomized outbred guinea-pigs were immunized with extracts of calf thymus, calf skeletal muscle or calf heart muscle emulsified in Freund's complete adjuvant. Immunization with either...
Kalden, J. R., Williamson, W. G., Irvine, W. J.
Experimental thyroiditis was produced by a single injection of homologous thyroglobulin in Freund's complete adjuvant when this was given along with an intracutaneous injection of Bordetella...
Kalden, J. R., Williamson, W. G., Irvine, W. J.
Experimental thymitis and a partial neuromuscular block was produced in guinea-pigs by immunization with homologous thymus or skeletal muscle tissue in Freund's complete adjuvant. A boosting...
TSUZAKA, K, WINKLER, T H, KALDEN, J R, REICHLIN, M
We report that four systemic lupus erythematosus (SLE) patient sera containing anti-dsDNA antibodies, three affinity-purified anti-dsDNA IgG, and a human anti-dsDNA MoAb (33.H11) immunoprecipitate...
Lead induced anaemia due to traditional Indian medicine: a case report
Spriewald, B. M., Rascu, A., Schaller, K. H., Angerer, J., Kalden, J. R., Harrer, T.
Lead intoxication in adults without occupational exposure is a rare and unexpected event. The case of a western European is reported who had severe anaemia after ingestion of several ayurvedic drugs,...