J. R. T. Dick

Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice (2006)

Bilsland, L.G., Dick, J.R.T., Pryce, G., Petrosino, S., Di Marzo, V., Baker, D., ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motoneurons in the spinal cord, brain stem, and motor cortex. However, despite...

Over-expression of parvalbumin in transgenic mice rescues motoneurons from injury-induced cell death (2005)

Dekkers, J., Bayley, P., Dick, J. R. T., Schwaller, Beat, Berchtold, M. W., Greensmith, L.

Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent...

Over-expression of parvalbumin in transgenic mice rescues motoneurons from injury-induced cell death (2005)

Dekkers, J., Bayley, P., Dick, J. R. T., Schwaller, Beat, Berchtold, M. W., Greensmith, L.

Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent...

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice (2005)

Kieran, D., Hafezparast, M., Bohnert, S., Dick, J.R.T., Martin, J., Schiavo, G., ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear,...

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice (2004)

Kieran, D., Kalmar, B., Dick, J.R.T., Riddoch-Contreras, J., Burnstock, G., Greensmith, L.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis1, 2. This condition has no...