1. There is evidence from in vivo studies for an interaction of mu- and delta-opioid ligands. In the present work this concept has been investigated using the mouse vas deferens and guinea-pig ileum...
Rupniak, N M, Patel, S, Marwood, R, Webb, J, Traynor, J R, Elliott, J, ...
1. Epibatidine is an analgesic substance, isolated from the skin of the poisonous frog Epipedobates tricolor, for which the mechanism of action was previously unknown. 2. The IC50 of synthetic...
Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells
Alt, A, Clark, M J, Woods, J H, Traynor, J R
There is evidence for interactions between mu and delta opioid systems both in vitro and in vivo. This work examines the hypothesis that interaction between these two receptors can occur...
Ko, M C H, Naughton, N N, Traynor, J R, Song, M S, Woods, J H, Rice, K C, ...
Orphanin FQ (OFQ), an endogenous peptide for ORL1 receptors, has been identified. Although the actions of OFQ have much in common with those of opioid peptides at the cellular level, behavioral...
Kosterlitz, H. W., Paterson, S. J., Robson, L. E., Traynor, J. R.
At the mu-sites of rabbit cerebellum, NaCl, LiCl, KCl, choline chloride and MnCl2 were tested for potentiation and inhibition of the binding of several opioids. Naloxone, (-)-bremazocine and...
Delta-opioid receptor binding sites in rodent spinal cord.
Traynor, J. R., Hunter, J. C., Rodriguez, R. E., Hill, R. G., Hughes, J.
1. The delta-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin showed an antinociceptive effect in the mouse tail-flick test, following intrathecal administration. This action was reversed by...
1. The agonist action of the opioid peptide dynorphin A(1-8) on the myenteric plexus-longitudinal muscle of the guinea-pig ileum has been characterized. 2. The endogenous opioid peptide dynorphin...
Franklin, T. G., Traynor, J. R.
1. The effects of pre-incubation with beta-funaltrexamine (beta-FNA) on the binding of [3H]-[D-Ala2, MePhe4, Gly-ol5]enkephalin ([3H]-DAMGO) to homogenates of guinea-pig brain and myenteric-plexus...
The use of [3H]-[D-Pen2,D-Pen5]enkephalin as a highly selective ligand for the delta-binding site.
Cotton, R., Kosterlitz, H. W., Paterson, S. J., Rance, M. J., Traynor, J. R.
The characteristics of the binding of [3H]-[D-Pen2,D-Pen5]enkephalin were determined in homogenates of guinea-pig and rat brain. In the guinea-pig, the maximum binding capacity for...