Coffer, P.J., Jin, J. (Jing), Woodgett, J.R. (James)
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the cell, their actions are mediated by relatively few signalling...
Franklin, C C, Sanchez, V, Wagner, F, Woodgett, J R, Kraft, A S
Phorbol ester tumor promoters activate gene transcription by regulating both the synthesis and posttranslational modification of the activator protein 1 (AP-1) transcription factor, c-Jun and JunB...
Plyte, S E, Feoktistova, A, Burke, J D, Woodgett, J R, Gould, K L
We report the cloning of the skp1+ gene, a Schizosaccharomyces pombe homolog of the glycogen synthase kinase 3 (GSK-3) family whose members in higher eukaryotes are involved in cell fate...
Jang, K L, Pulverer, B, Woodgett, J R, Latchman, D S
Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This...
Grove, J R, Banerjee, P, Balasubramanyam, A, Coffer, P J, Price, D J, Avruch, J, ...
Two classes of human cDNA encoding the insulin/mitogen-activated p70 S6 kinase have been isolated; the two classes differ only in the 5' region, such that the longer polypeptide (p70 S6 kinase alpha...
Immunological evidence for two physiological forms of protein kinase C.
Our recently described purification scheme for rat brain protein kinase C yields an enzyme consisting of a 78/80-kilodalton (kDa) doublet upon sodium dodecyl sulfate-polyacrylamide gel...
Gould, K L, Woodgett, J R, Isacke, C M, Hunter, T
p36, a major in vivo substrate of protein-tyrosine kinases, is shown to be phosphorylated at serine 25, a site very close to the major site of tyrosine phosphorylation by pp60v-src, tyrosine 23 (J....
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.
Hughes, K, Nikolakaki, E, Plyte, S E, Totty, N F, Woodgett, J R
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase implicated in the cellular response to insulin. The enzyme is the mammalian homologue of the zeste-white3 (shaggy) homeotic gene of...
Berberich, I, Shu, G, Siebelt, F, Woodgett, J R, Kyriakis, J M, Clark, E A
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype...
Cook, D, Fry, M J, Hughes, K, Sumathipala, R, Woodgett, J R, Dale, T C
The Drosophila gene product Wingless (Wg) is a secreted glycoprotein and a member of the Wnt gene family. Genetic analysis of Drosophila epidermal development has defined a putative paracrine Wg...
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
Kiefer, F, Tibbles, L A, Anafi, M, Janssen, A, Zanke, B W, Lassam, N, ...
In mammalian cells, a specific stress-activated protein kinase (SAPK/JNK) pathway is activated in response to inflammatory cytokines, injury from heat, chemotherapeutic drugs and UV or ionizing...
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
Tibbles, L A, Ing, Y L, Kiefer, F, Chan, J, Iscove, N, Woodgett, J R, ...
Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. Cdc42 and the related small GTP binding...
Molecular cloning and expression of glycogen synthase kinase-3/factor A.
Glycogen synthase kinase-3 (GSK-3) is a protein-serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c-jun. Two...
Activation of mammalian DNA ligase I through phosphorylation by casein kinase II.
Prigent, C, Lasko, D D, Kodama, K, Woodgett, J R, Lindahl, T
Mammalian DNA ligase I has been shown to be a phosphoprotein. Dephosphorylation of purified DNA ligase I causes inactivation, an effect dependent on the presence of the N-terminal region of the...
Hughes, K, Ramakrishna, S, Benjamin, W B, Woodgett, J R
Multifunctional ATP-citrate lyase kinase (ACLK) exhibits several properties that are similar to glycogen-synthase kinase-3 (GSK-3). The molecular cloning of two distinct mammalian GSK-3 cDNAs and a...
Glycogen synthase kinase-3 (GSK-3), a protein-serine kinase implicated in cell-fate determination and differentiation, phosphorylates several regulatory proteins that are activated by...
Benjamin, W B, Pentyala, S N, Woodgett, J R, Hod, Y, Marshak, D
ATP citrate-lyase (CL), acetyl-CoA carboxylase (ACC) and glycogen synthase kinase-3 beta (GSK-3 beta) levels were measured in cytosol from 3T3-L1 cells during differentiation from fibroblasts into...
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Coffer, P J, Jin, J, Woodgett, J R
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the cell, their actions are mediated by relatively few signalling...
Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity.
Al-Murrani, S W, Woodgett, J R, Damuni, Z
Transient expression of I2PP2A, a potent inhibitor of protein phosphatase 2A (PP2A), in HEK-293 cells increased the concentration and DNA binding of the proto-oncogene c-Jun. In contrast, expression...
Franklin, C C, Sanchez, V, Wagner, F, Woodgett, J R, Kraft, A S
Phorbol ester tumor promoters activate gene transcription by regulating both the synthesis and posttranslational modification of the activator protein 1 (AP-1) transcription factor, c-Jun and JunB...
Plyte, S E, Feoktistova, A, Burke, J D, Woodgett, J R, Gould, K L
We report the cloning of the skp1+ gene, a Schizosaccharomyces pombe homolog of the glycogen synthase kinase 3 (GSK-3) family whose members in higher eukaryotes are involved in cell fate...
Jang, K L, Pulverer, B, Woodgett, J R, Latchman, D S
Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This...
Grove, J R, Banerjee, P, Balasubramanyam, A, Coffer, P J, Price, D J, Avruch, J, ...
Two classes of human cDNA encoding the insulin/mitogen-activated p70 S6 kinase have been isolated; the two classes differ only in the 5' region, such that the longer polypeptide (p70 S6 kinase alpha...
Immunological evidence for two physiological forms of protein kinase C.
Our recently described purification scheme for rat brain protein kinase C yields an enzyme consisting of a 78/80-kilodalton (kDa) doublet upon sodium dodecyl sulfate-polyacrylamide gel...
Gould, K L, Woodgett, J R, Isacke, C M, Hunter, T
p36, a major in vivo substrate of protein-tyrosine kinases, is shown to be phosphorylated at serine 25, a site very close to the major site of tyrosine phosphorylation by pp60v-src, tyrosine 23 (J....
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.
Hughes, K, Nikolakaki, E, Plyte, S E, Totty, N F, Woodgett, J R
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase implicated in the cellular response to insulin. The enzyme is the mammalian homologue of the zeste-white3 (shaggy) homeotic gene of...
Berberich, I, Shu, G, Siebelt, F, Woodgett, J R, Kyriakis, J M, Clark, E A
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype...
Cook, D, Fry, M J, Hughes, K, Sumathipala, R, Woodgett, J R, Dale, T C
The Drosophila gene product Wingless (Wg) is a secreted glycoprotein and a member of the Wnt gene family. Genetic analysis of Drosophila epidermal development has defined a putative paracrine Wg...
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
Kiefer, F, Tibbles, L A, Anafi, M, Janssen, A, Zanke, B W, Lassam, N, ...
In mammalian cells, a specific stress-activated protein kinase (SAPK/JNK) pathway is activated in response to inflammatory cytokines, injury from heat, chemotherapeutic drugs and UV or ionizing...
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
Tibbles, L A, Ing, Y L, Kiefer, F, Chan, J, Iscove, N, Woodgett, J R, ...
Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. Cdc42 and the related small GTP binding...
Molecular cloning and expression of glycogen synthase kinase-3/factor A.
Glycogen synthase kinase-3 (GSK-3) is a protein-serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c-jun. Two...
Activation of mammalian DNA ligase I through phosphorylation by casein kinase II.
Prigent, C, Lasko, D D, Kodama, K, Woodgett, J R, Lindahl, T
Mammalian DNA ligase I has been shown to be a phosphoprotein. Dephosphorylation of purified DNA ligase I causes inactivation, an effect dependent on the presence of the N-terminal region of the...
Hughes, K, Ramakrishna, S, Benjamin, W B, Woodgett, J R
Multifunctional ATP-citrate lyase kinase (ACLK) exhibits several properties that are similar to glycogen-synthase kinase-3 (GSK-3). The molecular cloning of two distinct mammalian GSK-3 cDNAs and a...
Glycogen synthase kinase-3 (GSK-3), a protein-serine kinase implicated in cell-fate determination and differentiation, phosphorylates several regulatory proteins that are activated by...
Benjamin, W B, Pentyala, S N, Woodgett, J R, Hod, Y, Marshak, D
ATP citrate-lyase (CL), acetyl-CoA carboxylase (ACC) and glycogen synthase kinase-3 beta (GSK-3 beta) levels were measured in cytosol from 3T3-L1 cells during differentiation from fibroblasts into...
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Coffer, P J, Jin, J, Woodgett, J R
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the cell, their actions are mediated by relatively few signalling...
Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity.
Al-Murrani, S W, Woodgett, J R, Damuni, Z
Transient expression of I2PP2A, a potent inhibitor of protein phosphatase 2A (PP2A), in HEK-293 cells increased the concentration and DNA binding of the proto-oncogene c-Jun. In contrast, expression...
The links between axin and carcinogenesis
The products of the two mammalian Axin genes (Axin1 and its homologue Axin2) are essential for the degradation of β catenin, a component of Wnt signalling that is frequently dysregulated in cancer...