Trace Chemical Contaminants in a New Human Pressure Chamber (2003)
Weathersby, P. K., Lillo, R. S., Flynn, E. T., Wyatt, J. R., Dorko, W. D.
The Naval Medical Research Institute received a large human pressure chamber complex in 1977 and began human exposures in 1981. An early incident of organic chemical contamination led to an evolution...
NRL'S Central Atmosphere Monitor Program. (2002)
To meet the operational requirement of having submarines remain submerged for periods up to 90 days, it is necessary to have a pure atmosphere for the survivability of the crew. This requires some...
Nitrogen Trifluoride Combustion and Suppression (2002)
Halon 1301 has been determined to be effective in suppressing the combustion of ethylene in a nitrogen trifluoride enriched atmosphere. Approximately 6.5% halon 1301 is required to extinguish a...
Laboratory Development of a Passive Sampling Device for Hydrazines in Ambient Air. (1998)
Taffe, P. A., Crossman, K. P., Rose-Pehrsson, S. L., Wyatt, J. R.
A passive sampling method applicable to personnel and area monitoring has been developed for the quantitation of hydrazine, monomethylhydrazine (MMH), and unsymmetrical dimethylhydrazine (UDMH) in...
Laboratory Evaluation of a Colorimetric Hydrazine Dosimeter. (1998)
Crossman, Karen P., Carver, P. T., Wyatt, J. R., Rose-Pehrsson, S. L., Thurow, Ardell
A passive, colorimetric dosimeter badge was manufactured for NASA by GMD Systems. The badge consisted of two indicators: para-dimethylaminobenzaldehyde (PDAB) and vanillin. When exposed to hydrazine...
Material Capability for Transport of Unsymmetrical Dimethylhydrazine. (1998)
Crossman, Karen P., Wyatt, J. R., Rose-Pehrsson, S. L.
Materials were evaluated for potential use as ambient air sample lines for unsymmetrical dimethylhydrazine (UDMH) and hydrazine. FEP (a fluorinated polymer) and high density polyethylene tubing...
Wyatt, J R, Vickers, T A, Roberson, J L, Buckheit, R W, Klimkait, T, DeBaets, E, ...
The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all...
Matveeva, O. V., Tsodikov, A. D., Giddings, M., Freier, S. M., Wyatt, J. R., Spiridonov, A. N., ...
Design of antisense oligonucleotides targeting any mRNA can be much more efficient when several activity-enhancing motifs are included and activity-decreasing motifs are avoided. This conclusion was...
Stoddart, Cheryl A., Rabin, Linda, Hincenbergs, Mara, Moreno, Mary E., Linquist-Stepps, Valerie, Leeds, Janet M., ...
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected...
Bennett, C F, Chiang, M Y, Wilson-Lingardo, L, Wyatt, J R
Phosphorothioate oligonucleotides were identified which directly inhibited human type II phospholipase A2 (PLA2) enzyme activity in a sequence specific manner. The minimum pharmacophore common to all...
Oligoribonucleotide duplexes containing one to four 2'-deoxynucleotide residues were used as substrates for ribonuclease V1 and RNase H. Either deoxyadenosine and/or deoxythymidine were incorporated...
Predicting oligonucleotide affinity to nucleic acid targets.
Mathews, D H, Burkard, M E, Freier, S M, Wyatt, J R, Turner, D H
A computer program, OligoWalk, is reported that predicts the equilibrium affinity of complementary DNA or RNA oligonucleotides to an RNA target. This program considers the predicted stability of the...
Wyatt, J R, Vickers, T A, Roberson, J L, Buckheit, R W, Klimkait, T, DeBaets, E, ...
The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all...
Matveeva, O. V., Tsodikov, A. D., Giddings, M., Freier, S. M., Wyatt, J. R., Spiridonov, A. N., ...
Design of antisense oligonucleotides targeting any mRNA can be much more efficient when several activity-enhancing motifs are included and activity-decreasing motifs are avoided. This conclusion was...
Stoddart, Cheryl A., Rabin, Linda, Hincenbergs, Mara, Moreno, Mary E., Linquist-Stepps, Valerie, Leeds, Janet M., ...
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected...
Bennett, C F, Chiang, M Y, Wilson-Lingardo, L, Wyatt, J R
Phosphorothioate oligonucleotides were identified which directly inhibited human type II phospholipase A2 (PLA2) enzyme activity in a sequence specific manner. The minimum pharmacophore common to all...
Oligoribonucleotide duplexes containing one to four 2'-deoxynucleotide residues were used as substrates for ribonuclease V1 and RNase H. Either deoxyadenosine and/or deoxythymidine were incorporated...
Predicting oligonucleotide affinity to nucleic acid targets.
Mathews, D H, Burkard, M E, Freier, S M, Wyatt, J R, Turner, D H
A computer program, OligoWalk, is reported that predicts the equilibrium affinity of complementary DNA or RNA oligonucleotides to an RNA target. This program considers the predicted stability of the...