Bertin-Maghit, SM, Capini, CJ, Bessis, N, Chornilier, J, Muller, S, Abbas, A, ...
Interleukin-1 beta (IL-1 beta) is a crucial cytokine in inflammation processes and has been implicated in the pathogenesis of several chronic inflammatory diseases. Strategies designed to blocking...
Vasilescu, A, Heath, SC, Diop, G, Do, H, Hirtzig, T, Hendel, H, ...
Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic...
Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression (2004)
Winkler, CA, Hendel, H, Carrington, M, Smith, MW, Nelson, GW, O'Brien, SJ, ...
Three haplotypes for the CCR2-CCR5 region previously have been shown to affect AIDS progression; however, it is not known if the protective and accelerating effects of the haplotypes are relatively...
Flores-Villanueva, PO, Hendel, H, Caillat-Zucman, S, Rappaport, J, Burgos-Tiburcio, A, Bertin-Maghit, S, ...
We tested the association of MHC ancestral haplotypes with rapid or slow progression to AIDS by comparing their frequencies in the French genetics of resistance/susceptibility to immunodeficiency...
Richardson, MW, Mirchandani, J, Silvera, P, Regulier, EG, Capini, C, Bojczuk, PM, ...
This study compared immune responses in rhesus macaques immunized with unmodified HIV-1 IIIB Tat, SHIV89.6P Tat, and carboxymethylated IIIB and 89.6P Tat toxoids. Immunization with either IIIB or...
Autoantibodies to TNF alpha in HIV-1 infection: prospects for anti-cytokine vaccine therapy (2001)
Capini, CJ, Richardson, MW, Hendel, H, Sverstiuk, A, Mirchandani, J, Regulier, EG, ...
Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine principally involved in the activation of lymphocytes in response to viral infection. TNF alpha also stimulates the production of...
Fischer-Smith, T, Croul, S, Sverstiuk, AE, Capini, C, L'Heureux, D, Regulier, EG, ...
Increases in circulating CD14+/CD16+ monocytes have been associated with HIV dementia; trafficking of these cells into the CNS has been proposed to play an important role in the pathogenesis of...
Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.
Ojwang, J O, Hampel, A, Looney, D J, Wong-Staal, F, Rappaport, J
Ribozymes are RNAs that possess the dual properties of RNA sequence-specific recognition, analogous to conventional antisense molecules, and RNA substrate destruction via site-specific cleavage. The...
Tada, H, Rappaport, J, Lashgari, M, Amini, S, Wong-Staal, F, Khalili, K
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen...
Michael, N L, Vahey, M T, D'Arcy, L, Ehrenberg, P K, Mosca, J D, Rappaport, J, ...
Current understanding of human immunodeficiency virus type 1 (HIV-1) transcription is based on unidirectional expression of transcripts with positive-strand polarity from the 5' long terminal repeat....
Chowdhury, M, Taylor, J P, Chang, C F, Rappaport, J, Khalili, K
A specific RNA sequence located in the leader of all human immunodeficiency virus type 1 (HIV-1) mRNAs termed the transactivation response element, or TAR, is a primary target for induction of HIV-1...
Tada, H, Lashgari, M, Rappaport, J, Khalili, K
We analyzed control sequences of the human papovavirus JC virus (JCV) to define the cis-acting elements that regulate specific expression of the viral early region genes in glial cells. Nuclear...
Sadaie, M R, Rappaport, J, Benter, T, Josephs, S F, Willis, R, Wong-Staal, F
Single nucleotide alterations were introduced into an infectious clone of human immunodeficiency virus type 1 to create a series of missense mutants in the tat coding region. Although mutations in a...
Rappaport, J, Cho, K, Saltzman, A, Prenger, J, Golomb, M, Weinmann, R
Genomic sequences for the large subunit of human RNA polymerase II corresponding to a part of the fifth exon were inserted into an expression vector at the carboxy-terminal end of the...
Ensoli, B, Lusso, P, Schachter, F, Josephs, S F, Rappaport, J, Negro, F, ...
Human Herpes virus-6 (HHV-6) can co-infect with HIV-1 human CD4+ T-cells, leading to accelerated cell death, and factors in HHV-6-infected cells stimulate HIV-1 LTR directed gene expression. In this...
Nuclear factors in human brain cells bind specifically to the JCV regulatory region.
Khalili, K, Rappaport, J, Khoury, G
The human polyomavirus, JCV, differs from other papovaviruses in its tissue tropism for human glial cells. Transcription of the early region of the virus, at least in part, contributes to the tissue...
Taylor, J P, Pomerantz, R, Bagasra, O, Chowdhury, M, Rappaport, J, Khalili, K, ...
The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy. Tat, a potent activator of HIV-1 gene expression,...
Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.
Ojwang, J O, Hampel, A, Looney, D J, Wong-Staal, F, Rappaport, J
Ribozymes are RNAs that possess the dual properties of RNA sequence-specific recognition, analogous to conventional antisense molecules, and RNA substrate destruction via site-specific cleavage. The...
Tada, H, Rappaport, J, Lashgari, M, Amini, S, Wong-Staal, F, Khalili, K
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen...
Michael, N L, Vahey, M T, D'Arcy, L, Ehrenberg, P K, Mosca, J D, Rappaport, J, ...
Current understanding of human immunodeficiency virus type 1 (HIV-1) transcription is based on unidirectional expression of transcripts with positive-strand polarity from the 5' long terminal repeat....
Chowdhury, M, Taylor, J P, Chang, C F, Rappaport, J, Khalili, K
A specific RNA sequence located in the leader of all human immunodeficiency virus type 1 (HIV-1) mRNAs termed the transactivation response element, or TAR, is a primary target for induction of HIV-1...
Tada, H, Lashgari, M, Rappaport, J, Khalili, K
We analyzed control sequences of the human papovavirus JC virus (JCV) to define the cis-acting elements that regulate specific expression of the viral early region genes in glial cells. Nuclear...
Sadaie, M R, Rappaport, J, Benter, T, Josephs, S F, Willis, R, Wong-Staal, F
Single nucleotide alterations were introduced into an infectious clone of human immunodeficiency virus type 1 to create a series of missense mutants in the tat coding region. Although mutations in a...
Rappaport, J, Cho, K, Saltzman, A, Prenger, J, Golomb, M, Weinmann, R
Genomic sequences for the large subunit of human RNA polymerase II corresponding to a part of the fifth exon were inserted into an expression vector at the carboxy-terminal end of the...
Ensoli, B, Lusso, P, Schachter, F, Josephs, S F, Rappaport, J, Negro, F, ...
Human Herpes virus-6 (HHV-6) can co-infect with HIV-1 human CD4+ T-cells, leading to accelerated cell death, and factors in HHV-6-infected cells stimulate HIV-1 LTR directed gene expression. In this...
Nuclear factors in human brain cells bind specifically to the JCV regulatory region.
Khalili, K, Rappaport, J, Khoury, G
The human polyomavirus, JCV, differs from other papovaviruses in its tissue tropism for human glial cells. Transcription of the early region of the virus, at least in part, contributes to the tissue...
Taylor, J P, Pomerantz, R, Bagasra, O, Chowdhury, M, Rappaport, J, Khalili, K, ...
The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy. Tat, a potent activator of HIV-1 gene expression,...
Using a newly constructed data panel on U.S. locality attributes, this paper sketches four sets of empirical facts on economic growth across U.S. counties. A first set of facts focuses on the time...
Why Do the Poor Live in Cities?.
Glaeser, E.L., Kahn, M.E., Rappaport, J.
More than 17 percent of households in American central cities live in poverty; in American suburbs, just 7.4 percent of households live in poverty. The income elasticity of demand for land is too low...