Atrial extracellular matrix remodeling in patients with atrial fibrillation (2008)
Polyakova, V., Miyagawa, S., Szalay, Z., Risteli, J., Kostin, S.
Background: Atrial fibrillation (AF) is the most frequent clinical arrhythmia. Atrial fibrosis is an important factor in initiating and maintaining AF. However, the collagen turnover and its...
Jukkola, A, Risteli, J, Autio-Harmainen, H, Risteli, L
The aim of the present study was to find out whether the basement-membrane proteins laminin and type IV collagen are involved in the development of aminonucleoside-induced nephrosis. These proteins...
Smedsrød, B, Melkko, J, Risteli, L, Risteli, J
The fate of the circulating C-terminal propeptide of type I procollagen (PICP) was studied. Trace amounts of 125I-PICP administered intravenously to rats disappeared from the blood with an initial...
Purification and characterization of the N-terminal propeptide of human type III procollagen.
Niemelä, O, Risteli, L, Parkkinen, J, Risteli, J
The N-terminal propeptide of type III procollagen was purified from human ascitic fluid by using (NH4)2SO4 precipitation, DEAE-Sephacel chromatography at pH 8.6, Sephacryl S-300 chromatography and...
Odermatt, E, Risteli, J, Van Delden, V, Timpl, R
Intima collagen was obtained from pepsin digests of human placenta in two forms, which differ to some extent in the size of their constituent polypeptide chains (Mr 50 000-70 000). These chains are...
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase.
Tryggvason, K, Majamaa, K, Risteli, J, Kivirikko, K I
Prolyl 3-hydroxylase was purified up to about 5000-fold from an (NH4)2SO4 fraction of chick-embryo extract by a procedure consisting of affinity chromatography on denatured collagen linked to...
Immunochemical distinction between two different chains of type IV collagen.
Risteli, J, Schuppan, D, Glanville, R W, Timpl, R
Antisera against mouse and human basement-membrane type IV collagen showed in radioimmunoassays distinct binding with large pepsin fragments obtained from the C-terminal portions of alpha 1 (IV)- and...
The relationship between the changes in the four enzyme activities catalysing intracellular post-translational modifications in collagen biosynthesis were studied in rat liver as a function of age...
Risteli, J, Tuderman, L, Kivirikko, K I
Prolyl hydroxylase was purified from newborn rats by affinity chromatography using poly(L-proline), and antiserum to the enzyme was prepared in rabbits. The rat prolyl hydroxylase was similar to the...
Risteli, J, Tuderman, L, Tryggvason, K, Kivirikko, K I
After severe hepatic injury induced by dimethylnitrosamine, approximately a 4-fold increase in hepatic prolyl 4-hydroxylase activity occurred within 4 days, whereas the increases in total...
Jukkola, A, Risteli, J, Risteli, L
When subconfluent cultures of primary human skin fibroblasts are incubated for 20 h in the presence of 5% neutral dextran, the newly synthesized procollagens are shifted from the medium into the...
Collagen synthesis in intact skin is suppressed during wound healing.
Ihlberg, L, Haukipuro, K, Risteli, L, Oikarinen, A, Kairaluoma, M I, Risteli, J
OBJECTIVE: Simultaneous monitoring of total collagen synthesis as well as synthesis in intact skin and in the wound to verify the higher priority of wound healing after surgery. SUMMARY BACKGROUND...
Synthesis of type I collagen in healing wounds in humans.
Haukipuro, K, Melkko, J, Risteli, L, Kairaluoma, M, Risteli, J
To quantify wound healing in surgical patients, samples of wound fluid were collected through a silicone rubber tube for 7 postoperative days and their concentrations of the carboxyterminal...
Aminoterminal propeptide of type III procollagen in healing wound in humans.
Haukipuro, K, Risteli, L, Kairaluoma, M I, Risteli, J
For quantitative analysis of wound healing in surgical patients, samples of wound fluid were collected through a silicone rubber tube and their concentration of the aminoterminal propeptide of type...
Jukkola, A, Risteli, J, Autio-Harmainen, H, Risteli, L
The aim of the present study was to find out whether the basement-membrane proteins laminin and type IV collagen are involved in the development of aminonucleoside-induced nephrosis. These proteins...
Smedsrød, B, Melkko, J, Risteli, L, Risteli, J
The fate of the circulating C-terminal propeptide of type I procollagen (PICP) was studied. Trace amounts of 125I-PICP administered intravenously to rats disappeared from the blood with an initial...
Jukkola, A, Risteli, J, Risteli, L
When subconfluent cultures of primary human skin fibroblasts are incubated for 20 h in the presence of 5% neutral dextran, the newly synthesized procollagens are shifted from the medium into the...
Purification and characterization of the N-terminal propeptide of human type III procollagen.
Niemelä, O, Risteli, L, Parkkinen, J, Risteli, J
The N-terminal propeptide of type III procollagen was purified from human ascitic fluid by using (NH4)2SO4 precipitation, DEAE-Sephacel chromatography at pH 8.6, Sephacryl S-300 chromatography and...
Odermatt, E, Risteli, J, Van Delden, V, Timpl, R
Intima collagen was obtained from pepsin digests of human placenta in two forms, which differ to some extent in the size of their constituent polypeptide chains (Mr 50 000-70 000). These chains are...
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase.
Tryggvason, K, Majamaa, K, Risteli, J, Kivirikko, K I
Prolyl 3-hydroxylase was purified up to about 5000-fold from an (NH4)2SO4 fraction of chick-embryo extract by a procedure consisting of affinity chromatography on denatured collagen linked to...
Immunochemical distinction between two different chains of type IV collagen.
Risteli, J, Schuppan, D, Glanville, R W, Timpl, R
Antisera against mouse and human basement-membrane type IV collagen showed in radioimmunoassays distinct binding with large pepsin fragments obtained from the C-terminal portions of alpha 1 (IV)- and...
The relationship between the changes in the four enzyme activities catalysing intracellular post-translational modifications in collagen biosynthesis were studied in rat liver as a function of age...
Risteli, J, Tuderman, L, Kivirikko, K I
Prolyl hydroxylase was purified from newborn rats by affinity chromatography using poly(L-proline), and antiserum to the enzyme was prepared in rabbits. The rat prolyl hydroxylase was similar to the...
Risteli, J, Tuderman, L, Tryggvason, K, Kivirikko, K I
After severe hepatic injury induced by dimethylnitrosamine, approximately a 4-fold increase in hepatic prolyl 4-hydroxylase activity occurred within 4 days, whereas the increases in total...
Collagen synthesis in intact skin is suppressed during wound healing.
Ihlberg, L, Haukipuro, K, Risteli, L, Oikarinen, A, Kairaluoma, M I, Risteli, J
OBJECTIVE: Simultaneous monitoring of total collagen synthesis as well as synthesis in intact skin and in the wound to verify the higher priority of wound healing after surgery. SUMMARY BACKGROUND...
Synthesis of type I collagen in healing wounds in humans.
Haukipuro, K, Melkko, J, Risteli, L, Kairaluoma, M, Risteli, J
To quantify wound healing in surgical patients, samples of wound fluid were collected through a silicone rubber tube for 7 postoperative days and their concentrations of the carboxyterminal...
Aminoterminal propeptide of type III procollagen in healing wound in humans.
Haukipuro, K, Risteli, L, Kairaluoma, M I, Risteli, J
For quantitative analysis of wound healing in surgical patients, samples of wound fluid were collected through a silicone rubber tube and their concentration of the aminoterminal propeptide of type...
Guseva, N G, Anikina, N V, Myllylä, R, Risteli, L, Risteli, J, Chochlova, J V, ...
The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of...
Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis.
Kröger, H, Risteli, J, Risteli, L, Penttilä, I, Alhava, E
OBJECTIVES--Previous reports indicate that serum osteocalcin (serum bone GLA protein (S-BGP)) and carboxyterminal propeptide of type I procollagen (PICP) can be used as indicators of bone formation...
Increased type I collagen degradation correlates with disease severity in rheumatoid arthritis.
Hakala, M, Risteli, L, Manelius, J, Nieminen, P, Risteli, J
OBJECTIVES--To assess the extent and clinical significance of type I collagen degradation in rheumatoid arthritis (RA). METHODS--Serum samples from 90 consecutive patients with RA from a...
Hakala, M, Aman, S, Luukkainen, R, Risteli, L, Kauppi, M, Nieminen, P, ...
OBJECTIVE--To assess the potential of markers of collagen metabolism to reflect disease processes in rheumatoid arthritis (RA). METHODS--Serum (S) and synovial fluid (SF) from 59 patients with RA,...
Aman, S, Risteli, J, Luukkainen, R, Risteli, L, Kauppi, M, Nieminen, P, ...
OBJECTIVES—To assess the predictive significance of synovial fluid (SF) analysis for progressive radiological knee joint destruction in arthritis. METHODS—Altogether 55 patients with arthritis...
Type I collagen degradation does not diminish with RA disease duration
Hakala, M, Aho, K, Aman, S, Luukkainen, R, Kauppi, M, Risteli, J
OBJECTIVE—To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA). METHODS—The serum concentrations of cross linked carboxyterminal telopeptide...
Kauppila, S., Saarela, J., Stenbäck, F., Risteli, J., Kauppila, A., Risteli, L.
Malignant ovarian tumors induce a strong fibro-proliferative reaction characterized by the active production of type I and type III procollagen both locally in the ovary as well as more remotely in...
Increased degradation of type I collagen in patients with inflammatory bowel disease.
Silvennoinen, J, Risteli, L, Karttunen, T, Risteli, J
To assess the mechanisms of osteopenia in inflammatory bowel disease (IBD), the serum markers of bone formation (osteocalcin and carboxyterminal propeptide of type I procollagen (PICP)) and bone...
Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas.
Nuorva, K., Soini, Y., Kamel, D., Autio-Harmainen, H., Risteli, L., Risteli, J., ...
We analyzed the p53 protein immunohistochemically in bronchial dysplasias or squamous cell carcinomas in situ and in squamous cell lung carcinomas occurring in the same patients. The polyclonal...
Collagen synthesis activity in the aqueous humour of eyes with glaucoma surgery: a pilot study.
Tuulonen, A, Risteli, J, Risteli, L, Välimäki, J, Airaksinen, P J
AIMS: The purpose of this pilot study was to test whether the rate of collagen synthesis is measurable in the aqueous humour samples in reoperated and previously unoperated eyes. METHODS: The...
Jukkola, A, Kauppila, S, Risteli, L, Vuopala, K, Risteli, J, Leisti, J, ...
We describe the clinical findings and biochemical features of a male child suffering from a so far undescribed lethal connective tissue disorder characterised by extreme hypermobility of the joints,...
Radiological and biochemical resolution of nutritional rickets with calcium
Oginni, L, Sharp, C, Badru, O, Risteli, J, Davie, M, Worsfold, M, ...
Aims: To determine the response to oral calcium in Nigerian children with rickets.
Koivula, M, Aman, S, Karjalainen, A, Hakala, M, Risteli, J
Objectives: To assess the possible presence in patients with rheumatoid arthritis (RA) of autoantibodies recognising citrullinated peptides derived from type I and II collagens.