Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. (2008)
Maximov, A., Lao, Y., Li, H., Chen, X., Rizo, J., Soerensen, J. B., ...
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion (2006)
Deak, F., Shin, O. H., Tang, J., Hanson, P. I., Ubach, J., Jahn, R., ...
Li, L., Shin, O. H., Rhee, J. S., Arac, D., Rah, J. C., Rizo, J., ...
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? (2005)
Dulubova, I., Lou, X. L., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., ...
Rhee, J. S., Li, L., Shin, O. H., Rah, J. C., Rizo, J., Suedhof, T. C., ...
Structure/function analysis of Ca2+ binding to the C(2)A domain of synaptotagmin 1 (2002)
Fernandez-Chacon, R., Shin, O. H., Koenigstorfer, A., Matos, M. F., Meyer, A. C., Garcia, J., ...
Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C-2 domains that form Ca2+-dependent complexes with phospholipids. To examine the functional importance of Ca2+...
Antonin, W., Dulubova, I., Arac, D., Pabst, S., Plitzner, J., Rizo, J., ...
The SNAREs syntaxin 7, syntaxin 8, vti1b, and endobrevin/VAMP8 function in the fusion of late endosomes. Although the core complex formed by these SNAREs is very similar to the neuronal SNARE...
Synaptotagmin I functions as a calcium regulator of release probability. (2001)
Fernandez-Chacon, R., Koenigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., ...
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?
Ubach, J, Zhang, X, Shao, X, Südhof, T C, Rizo, J
C2-domains are widespread protein modules with diverse Ca2+-regulatory functions. Although multiple Ca2+ ions are known to bind at the tip of several C2-domains, the exact number of Ca2+-binding...
A conformational switch in syntaxin during exocytosis: role of munc18.
Dulubova, I, Sugita, S, Hill, S, Hosaka, M, Fernandez, I, Südhof, T C, ...
Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical autonomously folded N-terminal domain, a C-terminal SNARE motif and a transmembrane region. The SNARE motif binds to...
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1
Li, L. Y., Rizo, J., Südhof, T. C., ...
Synaptotagmin 1 likely acts as a Ca2+ sensor in neurotransmitter release by Ca2+-binding to its two C2 domains. This notion was strongly supported by the observation that a mutation in the C2A domain...
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?
Ubach, J, Zhang, X, Shao, X, Südhof, T C, Rizo, J
C2-domains are widespread protein modules with diverse Ca2+-regulatory functions. Although multiple Ca2+ ions are known to bind at the tip of several C2-domains, the exact number of Ca2+-binding...
A conformational switch in syntaxin during exocytosis: role of munc18.
Dulubova, I, Sugita, S, Hill, S, Hosaka, M, Fernandez, I, Südhof, T C, ...
Syntaxin 1, an essential protein in synaptic membrane fusion, contains a helical autonomously folded N-terminal domain, a C-terminal SNARE motif and a transmembrane region. The SNARE motif binds to...
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1
Li, L. Y., Rizo, J., Südhof, T. C., ...
Synaptotagmin 1 likely acts as a Ca2+ sensor in neurotransmitter release by Ca2+-binding to its two C2 domains. This notion was strongly supported by the observation that a mutation in the C2A domain...
Sukumar, M., Rizo, J., Wall, M., Dreyfus, L. A., Kupersztoch, Y. M., Gierasch, L. M.
The heat-stable enterotoxin b (STb) is secreted by enterotoxigenic Escherichia coli that cause secretory diarrhea in animals and humans. It is a 48-amino acid peptide containing two disulfide...