Scientific Commons: J. Rossant

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes,...

Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival (2006)

EREMINA, V, CUI, SY, GERBER, H, FERRARA, N, Haigh, Jody, NAGY, A, ...

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. (2005)

Strumpf, D., Mao, C.A., Yamanaka, Yojiro, Ralston, A., Chawengsaksophak, K., Beck, F., ...

The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation (2004)

Ben Abdelkhalek, H., Beckers, A., Schuster-Gossler, K., Pavlova, M. N., Burkhardt, H., Lickert, H., ...

The floating head (flh) gene in zebrafish encodes a homeodomain protein, which is essential for notochord formation along the entire body axis. flh orthologs, termed Not genes, have been isolated...

Cdx2 is essential for axial elongation in mouse development. (2004)

Chawengsaksophak, K., De Graaf, W., Rossant, J., Deschamps, J., Beck, F.

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals (2003)

Trokovic, R., Trokovic, N., Hernesniemi, S., Pirvola, U., Weisenhorn, D. M. V., Rossant, J., ...

Functional annotation of mouse genome sequences. (2001)

Nadeau, H., Balling, R., Barsh, G., Beier, D., Brown, S. D. M., Bucan, M., ...

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation (1994)

Yamaguchi, TP, Harpal, K, Henkemeyer, M, Rossant, J

Of fin and fur: mutational analysis of vertebrate embryonic development (1992)

Rossant, J, Hopkins, N

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung (1992)

Moens, CB, Auerbach, AB, Conlon, RA, Joyner, AL, Rossant, J

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis (1991)

Rossant, J, Zirngibl, R, Cado, D, Shago, M, Giguere, V

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain (1988)

Davis, CA, Noble-Topham, SE, Rossant, J, Joyner, AL

Isolation and characterization of a novel trophoblast-specific cDNA in the mouse (1988)

Lescisin, KR, Varmuza, S, Rossant, J

In situ detection of b-galactosidase in lenses of transgenic mice with a g-crystallin/lacZ gene (1987)

Goring, DR, Rossant, J, Clapoff, S, Breitman, ML, Tsui, L-C

Transgenic mice carrying the gamma 2-crystallin promoter fused to the coding region of the bacterial lacZ gene were generated. The offspring of three founder mice expressed high levels of the enzyme...

Genetic ablation: Targeted expression of a toxin gene causes microphthalmia in transgenic mice (1987)

Breitman, ML, Clapoff, S, Rossant, J, Tsui, L-C, Glode, ML, Maxwell, IH, ...

Lineage-specific regulatory elements can be used to direct expression of a variety of genes to specific tissues in transgenic mice. If the hybrid constructs contain a gene encoding a cytotoxic gene...

Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse (1987)

Sanford, JP, Clark, HJ, Chapman, VM, Rossant, J

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

Uyttendaele, H., Ho, J., Rossant, J., Kitajewski, J.

Notch proteins function as receptors for membrane-bound ligands (Jagged and Delta-like) to regulate cell-fate determination. We have investigated the role of Notch signaling in embryonic endothelium...

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Nagy, A, Rossant, J, Nagy, R, Abramow-Newerly, W, Roder, J C

Several newly generated mouse embryonic stem (ES) cell lines were tested for their ability to produce completely ES cell-derived mice at early passage numbers by ES cell tetraploid embryo...

Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver.

Forrester, L M, Bernstein, A, Rossant, J, Nagy, A

Murine embryonic stem (ES) cells are permanent blastocyst-derived cell lines capable of contributing to a wide variety of tissues, including the germ line, after injection into host blastocysts....

Cardiac and neurological abnormalities in v-fps transgenic mice.

Yee, S P, Mock, D, Maltby, V, Silver, M, Rossant, J, Bernstein, A, ...

Transgenic mice that widely express the v-fps protein-tyrosine kinase develop several independent pathological conditions, in addition to a high tumor incidence. v-fps expression and protein-tyrosine...

Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.

Giguère, V, Shago, M, Zirngibl, R, Tate, P, Rossant, J, Varmuza, S

Retinoic acid is known to have profound effects on developmental processes. It has been implicated as a putative morphogen in the developing chick limb bud and regenerating amphibian limb blastema...

Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice.

Greer, P, Maltby, V, Rossant, J, Bernstein, A, Pawson, T

The mammalian c-fps/fes proto-oncogene encodes a 92-kilodalton cytoplasmic protein-tyrosine kinase (p92c-fes), which is expressed in immature and differentiated hematopoietic cells of the myeloid...

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

Lavigueur, A, Maltby, V, Mock, D, Rossant, J, Pawson, T, Bernstein, A

We have investigated the role of the p53 gene in oncogenesis in vivo by generating transgenic mice carrying murine p53 genomic fragments isolated from a mouse Friend erythroleukemia cell line or...

Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase.

Yee, S P, Mock, D, Greer, P, Maltby, V, Rossant, J, Bernstein, A, ...

src, abl, and fps/fes are prototypes for a family of genes encoding nonreceptor protein-tyrosine kinases. The oncogenic potential of the v-fps protein-tyrosine kinase was investigated by introduction...

Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.

Huszar, D, Balling, R, Kothary, R, Magli, M C, Hozumi, N, Rossant, J, ...

Using a Moloney leukemia virus vector containing the bacterial neo gene, we demonstrate that retrovirus vectors can be used to introduce genes into the mouse germ line. Infection of preimplantation...

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

Puri, M C, Rossant, J, Alitalo, K, Bernstein, A, Partanen, J

Vascular endothelial cells are critical for the development and function of the mammalian circulatory system. We have analyzed the role of the endothelial cell-specific receptor tyrosine kinase TIE...

Targeted mutagenesis: analysis of phenotype without germ line transmission.

Nagy, A, Rossant, J

The available techniques for directed gene manipulation in the mouse are unprecedented in any multicellular organism and make the mouse an invaluable tool for unraveling all aspects of mammalian...

A Large-Scale Gene-Trap Screen for Insertional Mutations in Developmentally Regulated Genes in Mice

Wurst, W., Rossant, J., Prideaux, V., Kownacka, M., Joyner, A., Hill, D. P., ...

We have used a gene-trap vector and mouse embryonic stem (ES) cells to screen for insertional mutations in genes developmentally regulated at 8.5 days of embryogenesis (dpc). From 38,730 cell lines...