Scientific Commons: J. S. Coombes

The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise (2007)

Peake, J. M., Suzuki, K., Coombes, J S

Interest in the relationship between inflammation and oxidative stress has increased dramatically in recent years, not only within the clinical setting but also in the fields of exercise biochemistry...

Patients with type 2 diabetes mellitus have an exaggerated brachial and central blood pressure response to exercise: relation to left ventricular hypertrophy (2007)

Sharman, J. E., Scott, J. A., Coombes, J. S., Prins, J. B., Leano, R., Marwick, T. H.

Background: A hypertensive response to exercise independently predicts cardiovascular mortality. Patients with type 2 diabetes mellitus (T2DM) have vascular abnormalities which may predispose to...

Manipulating training intensity and volume in already well-trained rats: Effect on skeletal muscle oxidative and glycolytic enzymes and buffering capacity (2007)

Laursen, P. B., Marsh, S. A., Jenkins, D. G., Coombes, J. S.

Well-trained endurance athletes undergo periods of high-intensity interval training (HIT) or high-volume training (HVT) to improve exercise performance, but little is known about the mechanistic...

Dietary intake of patients with chronic kidney disease entering the LORD trial: Adjusting for underreporting (2007)

Fassett, R. G., Robertson, I. K., Geraghty, D. P., Ball, M. J., Coombes, J. S.

Objective: The study objective was to determine the dietary intake of patients with chronic kidney disease before and after filtering for suspected underreporters and to investigate the impact of...

A new valid and reliable windtrainer VO2max protocol (2007)

Dalziel, W. M., Hannan, S. M., Watts, M. C., Coombes, J. S.

Aim. Maximal oxygen uptake (VO2max) cycling protocols usually require expensive laboratory ergometers where the athlete is unaccustomed to the cycling position. Recently, we developed a VO2max...

Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress (2007)

Lim, C. L., Wilson, G., Brown, L., Coombes, J. S., Mackinnon, L. T.

This study investigated the roles of endotoxemia and heat-induced tissue damage in the pathology of heat stroke. In groups of eight, male Wistar rats were treated with heat exposure only (HE), or...

Effects of bovine colostrum supplementation on immune variables in highly trained cyclists (2007)

Shing, C. M., Peake, J., Suzuki, K., Okutsu, M., Pereira, R., Stevenson, L., ...

Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol 102: 1113 - 1122, 2007. First published November 9, 2006; doi:10.1152/japplphysiol....

Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia (2007)

Sharman, J., McEniery, C., Dhakam, Z., Coombes, J. S., Wilkinson, I., Cockcroft, J.

Objectives Exercise brachial blood pressure (BP) is predictive of cardiovascular events. As a result of the amplification of pulse pressure, central BP (a stronger cardiovascular risk factor) differs...

Reduction in resting plasma granulysin as a marker of increased training load (2007)

Shing, C., Ogawa, K., Zhang, X., Nagatomi, R., Peake, J. M., Suzuki, K., ...

Acute exercise response of blood glucose to short-term exercise training in patients with type 2 diabetes (2007)

Hordern, M., Wood, P., Prins, J.B., Marwick, T.H., Coombes, J.S.

A one year home-based lifestyle intervention is effective in improving insulin sensitivity and glycaemic control in patients with type 2 diabetes. (2007)

Hordern, M., Smith, L., Beller, E., Prins, J.B., Marwick, T.H., Coombes, J.S.

Acute exercise response of blood glucose to short-term exercise training in patients with type 2 diabetes. (2007)

Hordern, M., Wood, P., Prins, J.B., Marwick, T.H., Coombes, J.S.

The effect of consecutive days of exercise on markers of oxidative stress (2007)

Shing, C. M., Peake, J. M., Ahern, S. M., Strobel, N. A., Wilson, G., Jenkins, D. G., ...

We examined the influence of 3 consecutive days of high-intensity cycling on blood and urinary markers of oxidative stress. Eight highly-trained male cyclists (VO2 76 4 mL center dot kg(-l)center dot...

Oxidative stress in half and full ironman triathletes (2007)

Knez, W. L., Jenkins, D. G., Coombes, J. S.

Introduction: Ultraendurance athletes who maintain a very high volume of exercise may, as a result of greater production of reactive oxygen species (ROS), be particularly susceptible to oxidative...

Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) Trial (2007)

Summers, M. J., Oliver, K. R., Coombes, J. S., Fassett, R. G.

Study Objective. To examine the effect of atorvastatin on cognitive function by testing two hypotheses: that atorvastatin 10 mg/day would impair cognitive function, and that other biochemical and...

Central pressure is augmented during exercise with increased age (2007)

Sharman, J. E., McEniery, C., Dhakam, Z., Coombes, J. S., Wilkinson, I., Cockcroft, J.

Metabolic syndrome in severe chronic kidney disease: prevalence, predictors, prognostic significance and effects of risk factor modification (2007)

Johnson, D.W., Armstrong, K., Campbell, S., Mudge, D., Hawley, C.M., Coombes, J.S., ...

The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise (2007)

Peake, J., Suzuki, K., Coombes, J. S.

Reduced central blood pressure in older adults following progressive resistance training (2007)

Taaffe, D. R., Galvao, D. A., Sharman, J. E., Coombes, J. S.

A one year home-based lifestyle intervention is effective in improving insulin sensitivity and glycaemic control in patients with type 2 diabetes (2007)

Hordern, M., Smith, L., Beller, E., Prins, J.B., Marwick, T.H., Coombes, J.S.

Effects of a short-term individualised exercise intervention on myocardial function in patients with type 2 diabetes: Influence of gender (2007)

Hordern, M., Smith, L., Jefferies, L., Prins, J. B., Marwick, T. H., Coombes, J. S.

Acute exercise response of blood glucose to short-term exercise training in patients with type 2 diabetes (2007)

Hordern, M., Wood, P., Prins, J. B., Marwick, T. H., Coombes, J. S.

A one-year home-based lifestyle intervention is effective in improving insulin sensitivity and glycaemic control in patients with type 2 diabetes (2007)

Hordern, M., Smith, L., Beller, E., Prins, J. B., Marwick, T. H., Coombes, J. S.

Lipoprotein (a) in ultra-endurance triathletes (2007)

Knez, W., Jenkins, D. G., Coombes, J. S.

Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction (2006)

Lexis, L. A., Fenning, A., Brown, L., Fassett, R. G., Coombes, J. S.

The aim of this study was to determine the effects of dietary antioxidant supplementation with a-tocopherol and a-lipoic acid on cyclosporine-induced alterations to erythrocyte and plasma redox...

Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise (2006)

Sharman, J. E., Lim, R., Qasem, A. M., Coombes, J. S., Burgess, M. I., Franco, J., ...

Exercise brachial blood pressure ( BP) predicts mortality, but because of wave reflection, central ( ascending aortic) pressure differs from brachial pressure. Exercise central BP may be clinically...

Effects of anitoxidant supplementation and exercise training on erythrocyte antioxidant enzymes (2006)

Marsh, S. A., Laursen, P. B., Coombes, J S

Effects of short-term exercise training on myocardial function in patients with Type II diabetes (2006)

Hordern, M. D., Smith, L.M., Zhang, X., Beller, E, Prins, J B, Marwick, T H, ...

Effects of bovine colostrum supplementation on exercise performance and immune parameters (2006)

Shing, C. M., Coombes, J S, Jenkins, D G, Peake, J. M., Suzuki, K., Okutsu, M., ...

Physical activity and self-reported health in patients with chronic kidney disease (2006)

Fassett, R., Robertson, I.K., Ball, M. J., Geraghty, D. P., Anderson, L., Smith, M., ...

Exercise training, antioxidant supplementation and endothelial cell protection (2006)

Marsh, S. A., Laursen, P., Pat, B. K., Gobe, G C, Coombes, J S

Effects of a short-term lifestyle intervention on myocardial function in patients with type II diabetes (2006)

Hordern, M. D., Smith, L., Beller, E, Prins, J B, Marwick, T H, Coombes, J S

Effects of a short-term exercise intervention on insulin sensitivity in type II diabetes (2006)

Hordern, M. D., Smith, L., Beller, E., Prins, J. B., Marwick, T. H., Coombes, J. S.

Progressive resistance training and central blood pressure in older adults (2006)

Taaffe, D. R., Galvao, D. A., Sharman, J., Coombes, J. S.

The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists (2006)

Shing, C. M., Jenkins, D. G., Stevenson, L., Coombes, J. S.

Purpose: The aim of this experiment was to investigate the influence of low dose bovine colostrum supplementation on exercise performance in cyclists over a 10 week period that included 5 days of...

Dietary supplementation of vitamin E and -lipoic acid upregulates cell growth and signaling genes in rat myocardium (2006)

Marsh, S. A., Mason, S. R., Ward, L. C., Coombes, J. S.

Influence of high-intensity interval training on adaptations in well-trained cyclists (2005)

Laursen, P. B., Shing, C. M., Peake, J. M., Coombes, J. S., Jenkins, D. G.

Evidence for a non-antioxidant, dose-dependent role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells (2005)

Marsh, S. A., Pat, B. K., Gobe, G. C., Coombes, J. S.

Endothelial cell apoptosis contributes to atherosclerosis and may be exacerbated by oxidative stress. Results from clinical trials using antioxidant supplementation are equivocal and could be...

Exercise-induced muscle damage, plasma cytokines, and markers of neutrophil activation (2005)

Peake, J. M., Suzuki, K., Wilson, G., Hordern, M. D., Nosaka, K., Mackinnon, L. T., ...

Introduction: Unaccustomed eccentric exercise often results in muscle damage and neutrophil activation. We examined changes in plasma cytokines stress hormones, creatine kinase activity and myoglobin...

Plasma cytokine changes in relation to exercise intensity and muscle damage (2005)

Peake, J. M., Suzuki, K., Hordern, M. D., Wilson, G., Nosaka, K., Coombes, J. S.

The purpose of this study was to compare the effects of exercise intensity and exercise-induced muscle damage on changes in anti-inflammatory cytokines and other inflammatory mediators. Nine...

Acute exposure to cyclosporine does not increase plasma homocysteine in rats (2005)

Austen, SK, Fletcher, L. A., Fassett, R. G., Booth, C., Coombes, J. S.

There is interest in the postulate that cyclosporine a (CsA) contributes to the elevated homocysteine levels seen in organ transplant recipients, as hyperhomocysteinemia is now considered an...

Central systolic blood pressure is significantly elevated post maximal exercise in normotensive patients with type 2 diabetes mellitus (2005)

Sharman, J., Coombes, J. S., Scott, J., Prins, J. B., Marwick, T. H.

Timing of the radial pressure pulse predicts the degree of exercise-induced myocardial afterload in patients with type 2 diabetes mellitus (2005)

Sharman, J., Coombes, J. S., Scott, J., Prins, J. B., Marwick, T. H.

Consecutive days of high intensity training and its effect on markers of oxidative stress in highly trained cyclists (2005)

Peake, J. M., Shing, C. M., Strobel, N. A., Ahern, S. M., Jenkins, D. G., Coombes, J. S.

Markers of oxidative stress predict cardiac outcomes in patients with CKD (2005)

Wong, J., Coombes, J. S., Strobel, N. A., Hawley, C., Campbell, S., Johnson, D., ...

Sensitivity in determining systemic arterial stiffness using the timing of radial artery pressure wave reflections in patients with chronic kidney disease (2005)

Coombes, J S, Sharman, J, Anderson, L.M., Smith, M. K., Fassett, R.

Evidence for a non-antioxidant, dose-dependent role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells (2005)

Marsh, S. A., Pat, B. K., Gobe, G. C., Coombes, J. S.

Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men (2004)

Sharman, J. E., Gunaruwan, P., Knez, W. L., Schmitt, M., Marsh, S. A., Wilson, G. R., ...

AIMS: Alpha-lipoic acid (ALA) is a thiol compound with antioxidant properties used in the treatment of diabetic polyneuropathy. ALA may also improve arterial function, but there have been scant human...

The effect of exercise on large artery haemodynamics in healthy young men (2004)

McEniery, C. M., Sharman, J. E., Campbell, R., Coombes, J. S., Wilkinson, I. B., Cockcroft, J. R.

Exercise, oxidative stress and antioxidant supplements (2004)

Coombes, J. S., Strobel, N. A., Fletcher, L. A.

Cardiovascular implications of exposure to traffic air pollution during exercise (2004)

Sharman, J. E., Cockcroft, J. R., Coombes, J. S.

Regular aerobic exercise is recommended by physicians to improve health and longevity. However, individuals exercising in urban regions are often in contact with air pollution, which includes...

Endurance exercise, plasma oxidation and cardiovascular risk (2004)

Sharman, J. E., Geraghty, D. P., Shing, C., Fraser, D. I., Coombes, J. S.

Objective-Although physical activity is beneficial to health, people who exercise at high intensities throughout their lifetime may have increased cardiovascular risk. Aerobic exercise increases...

Relationship between homocysteine and cardiorespiratory fitness is sex-dependent (2004)

Coombes, J. S., Fraser, D. I., Sharman, J. E., Booth, C., Sharman, James

Elevated plasma homocysteine is recognized as an independent risk factor for cardiovascular disease. Recently, there have been conflicting reports of the relationship between physical activity and...

Relationship between homocysteine and cardiorespiratory fitness is sex-dependent (2004)

Coombes, J S, Fraser, D. I., Sharman, J, Booth, C.

Cardiovascular implications of exposure to traffic air pollution during exercise (2004)

Sharman, J, Cockcroft, J.R., Coombes, J S

Left ventricular diastolic dysfunction can predict impaired aerobic capacity in type 2 diabetic patients (2004)

Hordern, M. D., Fang, Z. Y., Ritchie, C. B., Coombes, J. S., Marwick, T. H.

Oxidative stress associated with training and competing in an ironman triathlon (2004)

Knez, W. L., Sharman, J. E., Jenkins, D. G., Coombes, J. S.

Bcl-2 levels are increased in endothelial cells by antioxidant supplementation but not exercise training (2004)

Marsh, S. A., Laursen, P. B., Coombes, J. S.

Dietary supplementation of vitamin E and alpha-lipoic acid upregulates cell growth and signaling genes in rat myocardium (2004)

Marsh, S. A., Mason, S. R., Ward, L. C., Coombes, J. S.

Cyclosporine induced changes to redox balance in plasma and erythrocytes is time course dependent (2004)

Coombes, J. S., Fletcher, L. A., Richards, R, Fassett, R.

Antioxidant supplementation, cyclosporine and glomerular filtration rate in renal transplant recipients (2004)

Fassett, R., Blackhall, M. L., Coombes, J. S.

Endurance exercise, plasma oxidation and cardiovascular risk (2004)

Sharman, J, Geraghty, D. P., Shing, C. M., Fraser, D. I., Coombes, J S

Objective-Although physical activity is beneficial to health, people who exercise at high intensities throughout their lifetime may have increased cardiovascular risk. Aerobic exercise increases...

Nitric oxide does not significantly contribute to altered pulse pressure amplification during aerobic exercise (2004)

Sharman, J. E., McEniery, C. M., Campbell, R., Pusalkar, P., Wilkinson, I. B., Coombes, J. S., ...

Central pressure during exercise is significantly increased with age and hypercholesterolaemia (2004)

Sharman, J. E., McEniery, C., Dhakam, Z. R., Coombes, J. S., Wilkinson, I. B., Cockroft, J. R.

Prolonged exposure to automotive pollution increases the susceptibility of plasma to oxidation (2003)

Sharman, J, Coombes, J S, Geraghty, D. P., Fraser, D. I.

The effects of exercise training and antioxidant supplementation on endurance performance and antioxidant enzyme defences (2003)

Marsh, S. A., Laursen, P. B., Coombes, J. S.

Consecutive days of high intensity training and its effect on markers of oxidative stress in highly trained cyclists (2003)

Shing, C., Ahern, S. M., Coombes, J. S., Jenkins, D. G.

Effects of electrical muscle stimulation on energy expenditure (2003)

Hayter, T., Knez, W. L., Brancato, T., Coombes, J. S.