Human gamma delta T-cell recognition of Yersinia enterocolitica.
Young, J L, Goodall, J C, Beacock-Sharp, H, Gaston, J S
We have studied the human gamma delta T-cell response to Yersinia enterocolitica, a facultative intracellular bacterium which causes gastroenteritis and, particularly in human leucocyte antigen...
Interleukin-2 production and response by helper T-cell subsets in man.
Salmon, M, Kitas, G D, Gaston, J S, Bacon, P A
This study investigated the production of, and response to, the lymphokine interleukin-2 (IL-2) by functional subsets of human CD4+ T lymphocytes. Fresh peripheral blood mononuclear cells (PBMC) were...
Hassell, A B, Reynolds, D J, Deacon, M, Gaston, J S, Pearce, J H
Chlamydia trachomatis is a major cause of sexually transmitted disease, infertility and reactive arthritis in the Western world, and of trachoma in the developing world. There is evidence that the...
Gaston, J S, Rickinson, A B, Yao, Q Y, Epstein, M A
The cytotoxic T cell response to Epstein-Barr virus as measured by the regression assay was found to be impaired in a group of patients with active rheumatoid arthritis (RA). When these patients...
Gaston, J S, Scott, D G, Bacon, P A
An acute confusional state, which developed in a patient with polyarteritis nodosa (PAN), proved to be secondary to inappropriate secretion of antidiuretic hormone and consequent hyponatraemia. This...
Churg-Strauss vasculitis and ascaris infection.
Chauhan, A, Scott, D G, Neuberger, J, Gaston, J S, Bacon, P A
A patient with Churg-Strauss vasculitis presenting with mononeuritis multiplex, who developed obstructive jaundice, is described. On investigation the jaundice proved to be due to ascaris...
Fazal, N, Lammas, D A, Rahelu, M, Pithie, A D, Gaston, J S, Kumararatne, D S
Human CD4+, mycobacteria-specific, cytolytic T cell clones were used to lyse BCG-infected macrophages, and the effect on the subsequent growth and viability of the organisms was examined. The...
Life, P F, Viner, N J, Bacon, P A, Gaston, J S
We and others have previously shown that synovial fluid (SF) mononuclear cells (MC) from patients with both reactive arthritis and other inflammatory arthritides proliferate in vitro in response to...
Kumararatne, D S, Pithie, A S, Drysdale, P, Gaston, J S, Kiessling, R, Iles, P B, ...
The cytolytic capacity of mycobacterial antigen-stimulated peripheral blood mononuclear cells, from healthy Mantoux-positive volunteers and from patients with tuberculosis was investigated....
Kitas, G D, Salmon, M, Farr, M, Gaston, J S, Bacon, P A
Interleukin 2 (IL-2) production and proliferative responses of peripheral blood mononuclear cells (PBMC) stimulated with three concentrations of PHA were measured in 75 patients with rheumatoid...
Synovial T lymphocyte recognition of organisms that trigger reactive arthritis.
Gaston, J S, Life, P F, Granfors, K, Merilahti-Palo, R, Bailey, L, Consalvey, S, ...
Reactive arthritis (ReA) is believed to be "triggered' by infection with certain bacteria. When the proliferative responses of mononuclear cells (MC) obtained from the synovial fluid (SF) of ReA...
Yao, Q Y, Rickinson, A B, Gaston, J S, Epstein, M A
Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls,...
Ibbotson, J P, Lowes, J R, Chahal, H, Gaston, J S, Life, P, Kumararatne, D S, ...
Culture studies have suggested that Mycobacterium paratuberculosis may play a role in the aetiology of Crohn's disease. However, evidence of sensitization to mycobacterial antigens amongst patients...
Hassell, A B, Pilling, D, Reynolds, D, Life, P F, Bacon, P A, Gaston, J S
Synovial fluid mononuclear cells (SFMC) from patients with reactive arthritis (ReA) show marked proliferative responses to preparations of the organism triggering the arthritis. Initial studies with...
Synovial fluid antigen-presenting cell function in rheumatoid arthritis.
Viner, N J, Gaston, J S, Bacon, P A
We have previously demonstrated enhanced synovial fluid (SF) antigen-presenting cell (APC) function in inflammatory arthritis patients selected on the basis of marked SF mononuclear cell (MNC)...
Pithie, A D, Rahelu, M, Kumararatne, D S, Drysdale, P, Gaston, J S, Iles, P B, ...
BACKGROUND: Macrophage activation by cytokines provides only a partial explanation of antimycobacterial immunity in man. Because cytolytic T lymphocytes have been shown to contribute to immunity in...
Ben-Smith, A, Gaston, J S, Barber, P C, Winer, J B
OBJECTIVES: To characterise cultured T lymphocytes from nerve biopsies in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: Sural nerve...
Brunst, M., Shahmanesh, M., Sukthankar, A., Pearce, J. H., Gaston, J. S.
OBJECTIVES: To investigate local cellular immune responses in patients with acute urethritis. METHODS: We have established T cell lines from the urethral exudate and examined their phenotype by flow...
Shahmanesh, M., Brunst, M., Sukthankar, A., Pearce, J. H., Gaston, J. S.
OBJECTIVE: To study peripheral blood mononuclear cell (PBMC) proliferative response to Chlamydia trachomatis elementary bodies in (a) controls, (b) various stages of gonococcal (c) and non-gonococcal...