Lymphoblastic leukaemia and non-Hodgkin's lymphoma (1996)
Lilleyman, J S, Pinkerton, C R
The outcome in childhood leukaemia has shown steady improvement over the last decade and efforts are now concentrated on the stratification of patients by risk factors which may avoid overtreatment...
Hinchliffe, R. F, Lilleyman, J. S
"A Wiley Medical Publication"
Ceftazidime as a single agent in the management of children with fever and neutropenia (1983)
Morgan, G., Duerden, B. I., Lilleyman, J. S.
Fifty consecutive episodes of fever in neutropenic children with malignant disease or aplastic anaemia were randomized to treatment with either ceftazidime alone or a combination of azlocillin and...
Application of fluorescence in situ hybridisation to chromosome analysis of aged bone marrow smears.
Hammond, D W, Hinchliffe, R F, Goyns, M H, Potter, A M, Lilleyman, J S
AIMS--To evaluate the reliability of fluorescence in situ hybridisation (FISH) in the retrospective cytogenetic assessment of old bone marrow smears stored for periods of up to 20 years. METHODS--A...
Chromosomes in childhood acute lymphoblastic leukaemia: karyotypic patterns in disease subtypes.
Wodzinski, M A, Watmore, A E, Lilleyman, J S, Potter, A M
To define further the clinical importance of cytogenetic analysis in acute lymphoblastic leukaemia (ALL) a prospective study was performed on 139 unselected children. Analyses were considered...
Mouse erythrocyte (M) rosette formation and colchicine sensitivity were compared for their ability to differentiate chronic lymphocytic leukaemia (CLL) from B cell non-Hodgkin's lymphoma (NHL) with...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Britton, J A, Anderson, L M, Richards, S M, Bailey, C C, Chessells, J M
AIMS--To assess the prevalence and degree of periodic acid Schiff (PAS) positivity in blast cells from children with lymphoblastic leukaemia (ALL); its association with other disease characteristics;...
Factor VIII inhibitor assay using skin puncture blood samples.
Hinchliffe, R F, Bellamy, G J, Lilleyman, J S
A method was developed for the measurement of factor VIII inhibitors by the Bethesda technique using small volumes of skin puncture blood. Human and porcine inhibitor concentrations on paired venous...
Frequency of coincident iron deficiency and beta-thalassaemia trait in British Asian children.
Hinchliffe, R F, Lilleyman, J S
A study was carried out to determine the frequency of combined iron deficiency and beta-thalassaemia trait in a cohort of British Asian children to see whether the trait protects iron status. Of 470...
Lilleyman, J S, Stevens, R F, Hann, I M, Gibson, B E, Britton, J A, Darbyshire, P J, ...
AIMS--Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the...
Lymphocyte subset counts in skin puncture and venous blood compared.
Cracknell, S E, Hinchliffe, R F, Lilleyman, J S
To determine whether skin puncture blood can be used reliably for CD4 lymphocyte counts, the numbers of the major subsets of lymphocytes were assessed in paired venous and skin puncture blood samples...
Granular acute lymphoblastic leukaemia of childhood: a morphological phenomenon.
Darbyshire, P J, Lilleyman, J S
Three hundred and twenty consecutive children with lymphoblastic leukaemia (ALL), treated on the Medical Research Council UKALL VIII schedule, had their Romanowsky stained diagnostic marrows reviewed...
Periodic acid-Schiff reaction and prognosis in lymphoblastic leukaemia.
Lilleyman, J S, Mills, V, Sugden, P J, Britton, J A
Diagnostic bone marrow smears from 132 patients with acute lymphoblastic leukaemia, (ALL) were stained simultaneously by the periodic acid-Schiff (PAS) reaction, and the blast cell positivity was...
Sex and acid phosphatase in childhood non-T lymphoblastic leukaemia.
Lilleyman, J S, Britton, J A, Laycock, B J, Sugden, P J
A semiquantitative assessment of blast cell acid phosphatase activity, expressed as a score, was made in 41 unselected children with newly diagnosed and untreated non-T acute lymphoblastic leukaemia...
Morphological metamorphosis in relapsing lymphoblastic leukemia.
Lilleyman, J S, Britton, J A, Laycock, B J
Blast cell morphology was assessed at diagnosis and subsequent bone marrow relapse in 33 unselected patients with lymphoblastic leukemia (ALL). Each marrow was classified 'blind' according to the...
Cellular hyperviscosity as a cause of neurological symptoms in leukaemia.
Preston, F E, Sokol, R J, Lilleyman, J S, Winfield, D A, Blackburn, E K
Six patients with various forms of leukaemia had neurological signs and symptoms associated with an extremely high white blood cell count and increased whole blood (but not plasma) viscosity. All...
Junior Hospital Staff Contract
Brooks, A. P., Martin, J. F., Kirk, D., Tomich, J., Keogh, A. J., Farrand, D. J. E., ...
Application of fluorescence in situ hybridisation to chromosome analysis of aged bone marrow smears.
Hammond, D W, Hinchliffe, R F, Goyns, M H, Potter, A M, Lilleyman, J S
AIMS--To evaluate the reliability of fluorescence in situ hybridisation (FISH) in the retrospective cytogenetic assessment of old bone marrow smears stored for periods of up to 20 years. METHODS--A...
Chromosomes in childhood acute lymphoblastic leukaemia: karyotypic patterns in disease subtypes.
Wodzinski, M A, Watmore, A E, Lilleyman, J S, Potter, A M
To define further the clinical importance of cytogenetic analysis in acute lymphoblastic leukaemia (ALL) a prospective study was performed on 139 unselected children. Analyses were considered...
Mouse erythrocyte (M) rosette formation and colchicine sensitivity were compared for their ability to differentiate chronic lymphocytic leukaemia (CLL) from B cell non-Hodgkin's lymphoma (NHL) with...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Britton, J A, Anderson, L M, Richards, S M, Bailey, C C, Chessells, J M
AIMS--To assess the prevalence and degree of periodic acid Schiff (PAS) positivity in blast cells from children with lymphoblastic leukaemia (ALL); its association with other disease characteristics;...
Factor VIII inhibitor assay using skin puncture blood samples.
Hinchliffe, R F, Bellamy, G J, Lilleyman, J S
A method was developed for the measurement of factor VIII inhibitors by the Bethesda technique using small volumes of skin puncture blood. Human and porcine inhibitor concentrations on paired venous...
Frequency of coincident iron deficiency and beta-thalassaemia trait in British Asian children.
Hinchliffe, R F, Lilleyman, J S
A study was carried out to determine the frequency of combined iron deficiency and beta-thalassaemia trait in a cohort of British Asian children to see whether the trait protects iron status. Of 470...
Lilleyman, J S, Stevens, R F, Hann, I M, Gibson, B E, Britton, J A, Darbyshire, P J, ...
AIMS--Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the...
Lymphocyte subset counts in skin puncture and venous blood compared.
Cracknell, S E, Hinchliffe, R F, Lilleyman, J S
To determine whether skin puncture blood can be used reliably for CD4 lymphocyte counts, the numbers of the major subsets of lymphocytes were assessed in paired venous and skin puncture blood samples...
Granular acute lymphoblastic leukaemia of childhood: a morphological phenomenon.
Darbyshire, P J, Lilleyman, J S
Three hundred and twenty consecutive children with lymphoblastic leukaemia (ALL), treated on the Medical Research Council UKALL VIII schedule, had their Romanowsky stained diagnostic marrows reviewed...
Periodic acid-Schiff reaction and prognosis in lymphoblastic leukaemia.
Lilleyman, J S, Mills, V, Sugden, P J, Britton, J A
Diagnostic bone marrow smears from 132 patients with acute lymphoblastic leukaemia, (ALL) were stained simultaneously by the periodic acid-Schiff (PAS) reaction, and the blast cell positivity was...
Sex and acid phosphatase in childhood non-T lymphoblastic leukaemia.
Lilleyman, J S, Britton, J A, Laycock, B J, Sugden, P J
A semiquantitative assessment of blast cell acid phosphatase activity, expressed as a score, was made in 41 unselected children with newly diagnosed and untreated non-T acute lymphoblastic leukaemia...
Morphological metamorphosis in relapsing lymphoblastic leukemia.
Lilleyman, J S, Britton, J A, Laycock, B J
Blast cell morphology was assessed at diagnosis and subsequent bone marrow relapse in 33 unselected patients with lymphoblastic leukemia (ALL). Each marrow was classified 'blind' according to the...
Cellular hyperviscosity as a cause of neurological symptoms in leukaemia.
Preston, F E, Sokol, R J, Lilleyman, J S, Winfield, D A, Blackburn, E K
Six patients with various forms of leukaemia had neurological signs and symptoms associated with an extremely high white blood cell count and increased whole blood (but not plasma) viscosity. All...
Junior Hospital Staff Contract
Brooks, A. P., Martin, J. F., Kirk, D., Tomich, J., Keogh, A. J., Farrand, D. J. E., ...
Lennard, L, Hale, J P, Lilleyman, J S
1. 6-Mercaptopurine (6-MP) is used in the continuing chemotherapy of childhood acute lymphoblastic leukaemia. The formation of red blood cell (RBC) 6-thioguanine nucleotide (6-TGN) active...
The accumulation of mercaptopurine metabolites in age fractionated red blood cells.
Rostami-Hodjegan, A, Lennard, L, Lilleyman, J S
1. Red blood cells from four children with lymphoblastic leukemia were age fractionated on Percoll density gradients into 'young', 'middle-aged' and 'old' cells. 2. The rates of accumulation of the...
Lennard, L, Rees, C A, Lilleyman, J S, Maddocks, J L
6-Mercaptopurine is extensively used in the treatment of childhood lymphoblastic leukaemia to prolong the duration of remission achieved with other drugs. The response to remission maintenance...
LENNARD, L., WELCH, J., LILLEYMAN, J. S.
The current U.K. trial protocol (UKALL XI) for childhood lymphoblastic leukaemia demands mercaptopurine (MP) dose escalation in children who tolerate daily 75 mg/m2 MP (100% dose) without...
Lennard, L., Welch, J. C., Lilleyman, J. S.
Aims The response to 6-mercaptopurine (6MP) is highly variable. Its antileukaemic effect can be related to drug derived 6-thioguanine nucleotides (TGNs). The inherited level of thiopurine...
To estimate the incidence and causes of secondary thrombocytosis in children, a 12 month study of all patients attending a children's hospital and discovered to have a platelet count over two times...
Lennard, L, Gibson, B E, Nicole, T, Lilleyman, J S
Two children with acute lymphoblastic leukaemia (ALL) taking daily 6-mercaptopurine as part of a national UK therapeutic trial repeatedly developed profound myelosuppression on 25% of the standard...
A UK survey was carried out to discover the frequency, circumstances, and outcome of intracranial haemorrhage (ICH) complicating idiopathic thrombocytopenic purpura (ITP) of childhood. A...
Acute infantile thrombocytosis and vitamin K deficiency associated with intracranial haemorrhage.
Lorber, J, Lilleyman, J S, Peile, E B
A 5-week-old breast-fed girl presented unconscious and convulsing with heavily blood-stained CSF under increased pressure. This was associated with oozing from venepuncture sites, a grossly prolonged...
Liver disease complicating severe haemophilia in childhood.
McGrath, K M, Lilleyman, J S, Triger, D R, Underwood, J C
Liver biopsies were performed in 5 boys aged between 2 and 9 years with severe classical haemophilia who had persistently abnormal liver function tests. Abnormal histology was present in all; 4 had...
Height and lymphoblastic leukaemia.
Broomhall, J, May, R, Lilleyman, J S, Milner, R D
Two hundred and thirty six children with untreated lymphoblastic leukaemia were compared for height with the normal population by calculation of their mean standard deviation score. As a group, they...
T cell lymphocytosis with neutropenia.
A gross T cell lymphocytosis developed in an otherwise healthy 5 year old girl and has persisted for nearly 3 years. It is associated with neutropenia and seems to be typical of a rare adult disorder...
Haemophilia and T lymphocyte subsets.
Walker, D A, Hinchliffe, R F, Lilleyman, J S
Number of circulating lymphocytes and T cell subsets were assessed in 13 boys with severe haemophilia and 12 age matched controls. There was no significant difference between the two groups. This...
Royds, J A, Lilleyman, J S, Timperley, W R, Taylor, C B
Serial measurements of enolase in the cerebrospinal fluid were made in 19 children with lymphoblastic leukaemia undergoing their first 6 weeks of antineoplastic treatment. The neurone-specific gamma...
Nabilone: an alternative antiemetic for cancer chemotherapy.
Dalzell, A M, Bartlett, H, Lilleyman, J S
A prospective randomised double blind crossover trial was conducted comparing the new synthetic cannabinoid nabilone with oral domperidone in a group of children receiving repeated identical courses...
Dolan, G, Lilleyman, J S, Richards, S M
Children from the UKALL V trial were studied to assess the clinical importance of myelosuppression during uninterrupted 'maintenance' treatment of 'standard risk' lymphoblastic leukaemia. Those...
Importance of 6-mercaptopurine dose in lymphoblastic leukaemia.
To explore the possibility that higher total dosage of 'maintenance' treatment may have contributed to the recent improvement in outlook of children in the United Kingdom with lymphoblastic...
Harrison, J. F., Lilleyman, J. S.
Unequivocal lymphoblastic leukaemia in a 4-year-old boy was followed 3 years later by equally unequivocal myeloblastic leukaemia in his 20-year-old brother. The boy achieved complete remission and...
Long-term management after splenectomy. Lifelong penicillin unproved in trials...
Makris, M., Greaves, M., Winfield, D. A., Preston, F. E., Lilleyman, J. S.
Lennard, L., Davies, H. A., Lilleyman, J. S.
The cytotoxic activity of 6-mercaptopurine (6-MP) is affected by thiopurine methyltransferase (TPMT), a genetically regulated and variable intracellular enzyme. 6-Thioguanine (6-TG), a closely...
Childhood lymphoblastic leukaemia: sex difference in 6-mercaptopurine utilization.
Lilleyman, J. S., Lennard, L., Rees, C. A., Morgan, G., Maddocks, J. L.
Twelve boys and 10 girls on similar long term remission maintenance treatment for lymphoblastic leukaemia had 79 random assays of their red cell 6 thioguanine nucleotide ( 6TGN ) concentrations...
Lennard, L., Lilleyman, J. S., Maddocks, J. L.
The effect of folic acid supplements on 6-mercaptopurine remission maintenance therapy in lymphoblastic leukaemia (ALL) was investigated in a retrospective longitudinal study of 10 children. Red cell...
Scarffe, J. H., Hann, I. M., Evans, D. I. K., Jones, P. Morris, Palmer, M. K., Lilleyman, J. S., ...
Pretreatment marrow blast cells were studied in 38 boys and 27 girls (aged 1-14) with acute lymphoblastic leukaemia by flow cytometry after staining with propidium iodide.
T lymphoblastic leukaemia and the central nervous system.
Lilleyman, J. S., Sugden, P. J.
Of 100 children and adolescents with lymphoblastic leukaemia (ALL) seen over a 6-year period, 25 developed clinically evident infiltration of the central nervous system (CNS), despite early treatment...
Significance of non-standard Philadelphia chromosomes in chronic granulocytic leukaemia.
Potter, A. M., Watmore, A. E., Cooke, P., Lilleyman, J. S., Sokol, R. J.
One hundred and nineteen unselected and similarly treated patients with Ph1-positive chronic granulocytic leukaemia (CGL) had the precise nature of their chromosome rearrangements producing the Ph1...
Lennard, L., Welch, J., Lilleyman, J. S.
As part of a programme assessing the pharmacokinetics of oral thiopurines given for lymphoblastic leukaemia, we assayed intracellular metabolites of mercaptopurine in children from all over the...
Eden, O. B., Shaw, M. P., Lilleyman, J. S., Richards, S.
Ten per cent of children entered into the national leukaemia study UKALL VIII were under 2 years at diagnosis. The 6 year event-free survival of this cohort was 39%. Specific adverse features were...